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| Exploration the medication rules of Professor Bai Yanping in treatment of vitiligo based on data mining |
| LIU Jiayi1 LIU Saisai1 LUO Sha1 LIU Qianwei1 CAI Rui1 BAI Yanping2 |
1.School of Clinical Medicine, Beijing University of Chinese Medicine, Beijing 100029, China;
2.Department of Dermatology and Venereology, China-Japan Friendship Hospital, Beijing 100029, China
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Abstract Objective To analyze the medication rules of Professor Bai Yanping in the treatment of vitiligo based on data mining technology. Methods The Chinese medicine prescriptions for vitiligo treated by Professor Bai Yanping in China-Japan Friendship Hospital from April 2010 to September 2020 were collected. The frequency, classification, efficacy, four nature, five flavours, and channel tropism of Chinese medicine were analyzed descriptively. The potential drug combinations were explored through association rules and cluster analysis, and data visualization was realized through network diagram. Results A total of 535 prescriptions and 221 Chinese medicines were included in the study. In terms of drug natures, warm drugs were the main drugs, followed by cold and plain drugs. In the aspect of drug flavours, bitter drugs were the most, followed by sweet and pungent drugs. In the aspect of drug channel tropism, the frequency of drugs entering liver channel was the highest. In the classification of Chinese medicine, tonifying deficiency medicine was the most used. The most commonly used drug for treatment was Psoraleae Fructus. Forty-one drug combinations of vitiligo were obtained by association rule analysis. Two potential new prescriptions were obtained by cluster analysis. Conclusion The medication rules obtained in this study is consistent with professor Bai Yanping’s theory of treating vitiligo based on treating from etiology of deficiency, treatment with both attack and supplementation, nourishing blood and dispelling wind, ridding the body of white， and harmonizing yin and yang, the efficacy of which is remarkable.
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