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| Study of correlation between endogenous sex hormone levels and left ventricular ejection fraction in postmenopausal patients with chronic heart failure |
| ZHANG Haiyang1 FENG Jingru2 LI Fan3 WANG Jing1 ZHAO Na1 BI Shengli2 LI Xinjun1 |
1.Department of Cardiology, the Second Affiliated Hospital of Hebei North University, Hebei Province, Zhangjiakou 075100, China;
2.Department of Obstetrics and Gynecology, the Second Affiliated Hospital of Hebei North University, Hebei Province, Zhangjiakou 075100, China; 3.Department of Laboratory, the Second Affiliated Hospital of Hebei North University, Hebei Province, Zhangjiakou 075100, China
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Abstract Objective To investigate and analyze the correlation between endogenous sex hormone levels and left ventricular ejection fraction (LVEF) in postmenopausal patients with chronic heart failure. Methods A total of 125 postmenopausal inpatients diagnosed with chronic heart failure in the Second Affiliated Hospital of Hebei North University (hereinafter referred to as “our hospital”) from March 2019 to October 2021 were selected as the study objects. According to the New York Heart Association cardiology grading scheme, they were divided into cardiac functionⅡ (34 cases), Ⅲ (42 cases), Ⅳ (49 cases) groups. At the same time, 30 menopausal patients without heart failure admitted to our hospital were selected as the non-heart failure group. Testosterone (T), estradiol (E2), luteinizing hormone (LH), follicle stimulating hormone (FSH), prolactin (PRL), progesterone (PROG), and LVEF in the four groups were collected and compared. Spearman correlation coefficient was further used to analyze the correlation between endogenous sex hormone levels and LVEF in postmenopausal patients with chronic heart failure. Results E2 and LVEF of cardiac function Ⅱ, Ⅲ, and Ⅳ groups were lower than those of non-heart failure group, while PRL was higher than that of the non-heart failure group, E2 and LVEF in cardiac function Ⅲ and Ⅳ groups were lower than those in cardiac function Ⅱ group, while PRL was higher than those in cardiac function Ⅱ group, E2 and LVEF in cardiac function Ⅳ group were lower than those in cardiac function Ⅲ group, and PRL was higher than those in cardiac function Ⅲ group, the differences were statistically significant (P＜0.05). Correlation analysis showed that E2 was positively correlated with LVEF in postmenopausal patients with chronic heart failure (rs＞0, P＜0.05), while PRL was negatively correlated with LVEF (rs＜0, P＜0.05). Conclusion There is a close correlation between E2, PRL levels, and LVEF in postmenopausal patients with chronic heart failure. Monitoring the above indexes can provide a reference for the evaluation and judgment of cardiac function in postmenopausal patients with chronic heart failure.
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