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| Data mining analysis of mice model of allergic rhinitis induced by ovalbumin |
| YAN Jiaxin1 JIA Mingyue2 XIAO Siyao2 FAN Jiajia1 LUO Xue1 ZHANG Shunan2 |
1.Graduate School, Beijing University of Chinese Medicine, Beijing 100029, China;
2.Department of Traditional Chinese Medicine for Pulmonary Diseases of Respiratory Medicine Center of China-Japan Friendship Hospital National Center for Respiratory Medicine Institute of Respiratory Medicine of Chinese Academy of Medical Sciences National Clinical Research Center for Respiratory Diseases Collaborating Centre for WHO Tobacco Cessation and Respiratory Diseases Prevention, Beijing 100029, China
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Abstract Objective To analyze the mice model of allergic rhinitis (AR) induced by ovalbumin (OVA). Methods Animal experimental literatures on mice model of AR induced by OVA published from July 2017 to June 2022 were retrieved from PubMed, and a database was constructed with animal species, sex, positive drugs, modeling methods, sensitizing drugs, administration dose, and behavioral evaluation as items, and data mining was carried out. The modeling elements, materials, and behavioral evaluation methods of mice model of AR induced by OVA were analyzed. Results A total of 156 literatures were selected, among which the most used were BALB/c female mice, most of which did not have a positive control group. Among the literatures with a positive control group, glucocorticoid was the most used, and the most commonly used modeling method was intraperitoneal injection based sensitization + local excitation. OVA manufacturers’ choice was mainly American Sigma-Aldrich, sensitizing adjuvant was mainly Al(OH)3. The most commonly used doses in the basal sensitization phase were 50 μg OVA and 1 mg Al (OH)3, and the volume of the solution was 200 μl for a single intraperitoneal injection. The most frequently used doses were given once every one week, for a total of three times. The most commonly used local excitation dose was single OVA of 500 μg, single nasal drip solution volume of 20 μl, and the most commonly used frequency was six days of continuous nasal drip. Nasal mucosa was the most sampled item, followed by blood. The most frequently observed behavior evaluation is sneezing + nose scratching, and the observation time is mostly ten minutes. Conclusion The specific conditions of mice model of AR induced by OVA are complex and the options are diverse, so researchers should combine the literature and research obj- ectives to select.
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