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2022 Vol. 19, No. 22
Published: 2022-08-05
 
 
5 Effect of sparrow-pecking moxibustion on primary dysmenorrhea rats based on EP2/NLRP3 signal pathway
HU Jing WEI Wan GAO Hui XU Gang YANG Huayuan
Objective To investigate the regulation of prostaglandin E receptor 2 (EP2) / Nod-like receptor protein 3 (NLRP3) and its anti-inflammatory mechanism in primary dysmenorrhea rats by sparrow-pecking moxibustion. Methods A total of 24 female SD rats were divided into blank group, model group, sprrow-pecking moxibustion group, and agonist group, with six rats in each group. Except blank group, the primary dysmenorrhea model was established for the other three groups, blank group received the same dose of normal saline daily. Blank group and model group were not treated; in sparrow-pecking moxibustion group, sānyīnjiāo and gu?觀nyuán acupoints were selected for treatment after daily modeling; agonist group was intraperitoneally injected with Treprostinil daily after modeling, followed by sparrow-pecking moxibustion treatment, which was the same as the sparrow-pecking moxibustion group. The latent time and number of torsion were observed in each group; HE staining was used to observe the pathological conditions of uterus; the expressions of EP2, NLRP3, and caspase-1 proteins were detected by immunohistochemistry. Results Compared with blank group, the latent time was shortened and the number of torsion was increased in model group (P < 0.01); compared with model group, the latent time was prolonged and the number of torsion was decreased in sparrow-pecking moxibustion group (P < 0.01); compared with sparrow-pecking moxibustion group, the latent time was shortened and the number of torsion was increased in agonist group (P < 0.01). In blank group, the uterine tissue morphology was regular, there were a few lymphocytes in the interstitium of muscle cells, and no neutrophil infiltration; in model group and agonist group, small uterine vessels showed dilation and hyperemia, and inflammatory cells such as lymphocytes and eosinophils were infiltrated outwards as focal groups; in sparrow-pecking moxibustion group, the degree of interstitial hyperemia and edema and infiltration of inflammatory cells were less than that in model group, a few inflammatory cells infiltrated between muscle walls and only a few small blood vessels hyperemia were observed. Compared with blank group, the protein expressions of EP2, NLRP3, and caspase-1 were increased in model group (P < 0.01); compared with model group, the protein expressions of EP2, NLRP3, and caspase-1 were decreased in sparrow-pecking group (P < 0.01); compared with sparrow-pecking group, the protein expressions of NLRP3 and caspase-1 were increased in agonist group, while the protein expression of EP2 in sparrow-pecking group and agonist group was not significantly different (P > 0.05). Conclusion Sparrow-pecking moxibustion can improve the infiltration of inflammatory cells in the uterus, and regulate the inflammatory response of dysmenorrhea rats by regulating EP2/NLRP3 signal pathway.
2022 Vol. 19 (22): 5-8,19 [Abstract] ( 17 ) HTML (1 KB)  PDF (1456 KB)  ( 43 )
9 Visual analysis of rehabilitation related studies in chronic fatigue syndrome
LI Yuanyuan1 ZOU Yihuai1 WU Kang1 XU Tianjiao1 HU Xiaojie2 CHEN Chen1 LI Kuangshi2
Objective To explore the development of chronic fatigue syndrome (CFS) through visual analysis of rehabilitation related research. Methods Web of Science core collection and Scopus database were used as data sources, literatures related to CFS rehabilitation from the inception of the database to October 2021 were retrieved, and CiteSpace software was used to analyze authors, countries, keywords, and references. Results A total of 174 literatures were included. Four collaborative groups were formed among the authors. The biggest contributor was the England. There were 12 key words with intermediate centrality ≥ 0.1, forming 11 kinds of clusters. The most frequently cited literature was Comparison of adaptive pacing therapy, cognitive behaviour therapy, graded exercise therapy, and specialist medical care for chronic fatigue syndrome (PACE): a randomised trial. Conclusion Clinical studies on CFS rehabilitation are increasing day by day. In the future, researchers should pay more attention to this disease, strengthen the research on the central mechanism, and give full play to the advantages of traditional Chinese medicine to find an effective rehabilitation therapy for this disease.
2022 Vol. 19 (22): 9-12,24 [Abstract] ( 25 ) HTML (1 KB)  PDF (1856 KB)  ( 30 )
13 Study on medication rule and action mechanism of coronary heart disease complicated with depression based on data mining and network pharmacology
LI Dongfang1 HUANG Lexi2 HOU Jiqiu1 LI Yan3 ZHAO Haibin1
Objective To analyze the medication rules of traditional Chinese medicine in the treatment of coronary heart disease complicated with depression by data mining, and to explore the potential mechanism of the core drugs. Methods CNKI, Wanfang Data, VIP, and China Biomedical Literature Service System were searched from January 2001 to July 2021 on the literature on the treatment of coronary heart disease complicated by depression with traditional Chinese medicine, the prescription database, was built and the traditional Chinese medicine inheritance assistance platform software was used to analyze the medication rules of prescriptions. The BATMAN-TCM traditional Chinese medicine analysis software was further used to analyze the genome encyclopedia pathway of the core drug compatibility to reveal the potential mechanism of action. Results A total of 70 prescriptions were included, involving 108 traditional Chinese medicines. The top six prescriptions were Bupleurum, Baishao, Chuanxiong, Salvia, Poria, and Suanzaoren. The four qi of the drug were mainly warm, and the five flavors were mostly bitter, acrid, and sweet. Eventually evolved to get eight new prescriptions. BATMAN-TCM analysis showed that there were 33 diseases with ≥four enriched targets in the combination of Bupleurum, Baishao, Chuanxiong, Poria, and Suanzaoren, and there were 37 biological pathways. Its mechanism of action might be through transient receptor potential channel, calcium signaling pathway, and cyclic guanosine monophosphate-protein kinase G signaling pathway in the treatment of coronary heart disease complicated with depression. Conclusion The combination of traditional Chinese medicine inheritance platform and network pharmacology is used to conduct data mining on the prescription rules and potential mechanism of Chinese medicine in the treatment of coronary heart disease complicated with depression, which can provide reference for clinical treatment and basic research of the disease.
2022 Vol. 19 (22): 13-19 [Abstract] ( 17 ) HTML (1 KB)  PDF (1596 KB)  ( 208 )
20 Study on the mechanism of autophagy regulation in neural repair in rats with subacute ischemic stroke
ZHOU Ping1 XU Weijie1 ZANG Rui2 LI Youkuan1 WU Yuming1
Objective To explore the mechanism of autophagy regulation in neural repair in rats with subacute ischemic stroke. Methods A total of 96 SPF male SD rats aged eight weeks old from 250-280 g were divided into sham operation group, model group, Rapamycin group, and 3-methyladenine group according to random number table method, with 24 rats in each group. The model group, Rapamycin group, and 3-methyladenine group were used to establish the left middle cerebral artery occlusion reperfusion model of rats, and Zea-Longa score of 1-3 points indicated that the model was successful. In the sham operation group, all other steps were the same except the insertion of the thread plug. Rapamycin group was given Rapamycin (8 ng dissolved in 5 μl 0.1%DMAO), 3-methyladenine group was given 3-methyladenine (100 μg dissolved in 5 μl 0.1%DMAO), sham operation group and model group were given 5 μl 0.1%DMAO solution, all pumped through the lateral ventricle. After injection, the four groups kept the needle for 5 minutes, once a day, for seven consecutive days. At the end of the experiment, the changes of neural function and autophagy related indexes in the penumbra area of rats with subacute ischemic stroke were investigated by modified neurological severity score (mNSS), TTC staining, fluorescence staining, Western blot, and immunofluorescence. Results The mNSS, percentage of the infarct volume, percentage of microtubule-associated protein light chain 3 (LC3) positive cells, Beclin-1, and LC3-Ⅱ/LC3-Ⅰ protein levels in model group were higher than those in sham group, and the proportion of neuronal nuclei (NeuN) positive cells was lower than sham group, the differences were statistically significant (P ＜ 0.05 or P ＜ 0.01). The mNSS and percentage of the infarct volume of Rapamycin group were lower than those of model group, proportion of LC3 positive cells, Beclin-1, and LC3-Ⅱ/LC3-Ⅰ protein level, proportion of NeuN positive cells were higher than those of model group, the differences were statistically significant (P ＜ 0.05 or P ＜ 0.01). The mNSS and proportion of the infarct volume of 3-methyladenine group were higher than those of model group, proportion of LC3 positive cells, Beclin-1, and LC3-Ⅱ/LC3-Ⅰ protein level, proportion of NeuN positive cells were lower than those of model group, the differences were statistically significant (P ＜ 0.05 or P ＜ 0.01). Conclusion Activation of autophagy in rats with subacute ischemic stroke has a neuroprotective effect, while inhibition of autophagy increases the neurological damage. Moderate autophagy may be the key to the study of ischemic stroke.
2022 Vol. 19 (22): 20-24 [Abstract] ( 24 ) HTML (1 KB)  PDF (2755 KB)  ( 31 )
25 Bibliometric analysis on nutrition research about inflammatory bowel disease based on Web of Science
GU Junyi LIN Zheng ZHOU Meijing GU Zijun WANG Mi SUN Caiyun ZHU Zhanhui
Objective To understand the current situation and development trends of nutrition research on inflammatory bowel disease in recent ten years by bibliometric analysis. Methods The Web of Science core collection database was used as the data source to search the literatures related to inflammatory bowel disease nutrition from January 2011 to December 2020. The data analysis function of the database was used to make quantitative analysis on the annual number of documents published and the distribution of funding institutions, and CiteSpace software was used to make visual analysis on the distribution of countries, authors published and keywords. Results A total of 1 339 papers were included, of which China ranked third in the number of published papers. Most of the funding institutions are concentrated in the United States. Among which China ranked third in the number of published papers. Most funding agencies were concentrated in the United States. Russell RK was a prolific author in this field; in addition to disease types and nutrition, many keywords appeared in the literature were children, management, plant extraction and antioxidant. Conclusion Nutrition-related research on inflammatory bowel disease is in a steady development stage, with the number of publications in China leading the world, and the United States taking the dominant position in this field. Research focuses on childhood nutrition, dietary management and antioxidant phytonutrients.
2022 Vol. 19 (22): 25-29 [Abstract] ( 16 ) HTML (1 KB)  PDF (2003 KB)  ( 149 )
30 Based  on TLR4/NF-κB signaling pathway study the pain mechanism of  Dexmedetomidine on central pain in rats after stroke
HUANG Dingli ZOU Wanyun ZHANG Ying LIU Qing
Objective To observe the analgesic effect of intraperitoneal injection of Dexmedetomidine on central pain (CPSP) after stroke in rats through TLR4/NF-κB signaling pathway. Methods Thirty SD rats were selected randomly from 90 SD rats for sham operation group, and the remaining 60 rats were modeled by injecting type Ⅳ collagenase into ventralis posterolateral nucleus (VPL). The thermal withdrawal latency (TWL) was measured three days after modeling. The rats with reduced TWL were divided into model group and intervention group by random number table method, with 30 rats in each group. The intervention group was intraperitoneal injected Dexmedetomidine 50 μg/kg for seven consecutive days and the model group was injected with the same amount of narmal saline. TWL values of rats were measured one day before modeling (T0), 10 d after modeling (T1), 17 d after modeling (T2), and 31 d after modeling (T3). Western blot was used to detect protein expression in VPL at T3. The changes of VPL microglia and neurons were observed by immunofluorescence. The release of inflammatory mediators in VPL was detected by enzyme-linked immunosorbent assay. Results In model group and intervention group, TWL at T1-T3 was lower than T0, TWL at T2-T3 was lower than T1, and TWL at T3 was lower than T2 (P ＜ 0.05). The TWL at T1-T3 in the model group was lower than that in the sham operation group, and the TWL at T1-T3 in the intervention group was higher than that in the sham operation group (P ＜ 0.05). Compared with sham operation group, the expression of TLR4 and pNF-κB in VPL of model group was significantly increased (P ＜ 0.05). Compared with model group, the expression of TLR4 and pNF-κB in VPL of intervention group was decreased (P ＜ 0.05). There was no significant difference in NF-κB expression in VPL among the three groups (P ＞ 0.05). Compared with sham operation group, the number of VPL neurons in model group decreased (P ＜ 0.05); compared with model group, there was no significant difference in the number of VPL neurons in the intervention group (P ＞ 0.05). The levels of IbA-1, tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, and IL-6 in VPL of model group were increased compared with that of sham operation group (P ＜ 0.05), while the levels of IBA-1 and inflammatory factors TNF-α, IL-1β, and IL-6 in VPL of intervention group were decreased compared with that in model group (P ＜ 0.05). Conclusion Dexmedetomidine treat the CPSP may inhibit the proliferation and activation of microglial cells and the progression of neuroinflammation through the TLR4/NF-κB signaling pathway.
2022 Vol. 19 (22): 30-33,38 [Abstract] ( 15 ) HTML (1 KB)  PDF (1239 KB)  ( 32 )
34 Epigenetic regulation and its mechanism of action in bronchial asthma research progress
YANG Yang1 SU Chang2 ZHANG Qiuyan3 HUANG Shuchun1 KUANG Huifang1
Bronchial asthma is a common respiratory disease in the world, with a high incidence and recurrent disease, which seriously affects human health. In recent years, epigenetic mechanisms mediating the pathological mechanism of bronchial asthma induced by exposure to allergens, air pollutants, viral infections, and other environmental factors have attracted much attention, providing a new way to elucidate the interaction between genes and the environment. This article reviews the roles and mechanisms of DNA methylation, histone methylation, histone acetylation, and non-coding RNA in the occurrence and development of asthma, in order to clarify the epigenetic regulation mechanism of asthma and provide a new target for the treatment of asthma.
2022 Vol. 19 (22): 34-38 [Abstract] ( 19 ) HTML (1 KB)  PDF (549 KB)  ( 281 )
39 Epidemiology and treatment status of Graves disease in children
SHI Hongjiao ZHANG Yili ZHAO Tong CUI Lanwei
Graves disease is a common autoimmune disease with unknown pathogenesis. The incidence of children is significantly lower than that of adults, the incidence varies from place to place, but the overall trend is increasing year by year. The most common laboratory test is the change of thyroid function, and the clinical manifestations include hypermetabolism symptoms and other manifestations such as accelerated growth. At present, oral Methimazole is the first choice for the treatment of children with Graves disease, which is convenient to treat and has few adverse reactions. For children who have not improved after long-term oral antithyroid drug treatment, iodine therapy can be considered, which will significantly improve the remission rate of children. This article reviews the status of Graves disease in children.
2022 Vol. 19 (22): 39-41 [Abstract] ( 18 ) HTML (1 KB)  PDF (401 KB)  ( 42 )
42 Application progress of ultrasound elastography in breast diseases
DONG Meng ZHANG Bingyi XING Boyuan
At present, the incidence and mortality of breast cancer show a significant upward trend. Early detection, diagnosis and treatment are very important for breast cancer patients. Two-dimensional ultrasound has low specificity in diagnosing breast cancer, and ultrasound elastography (UE) can evaluate the hardness characteristics of breast tissue on the basis of two-dimensional ultrasound, thereby providing effective information for accurate diagnosis and treatment of breast cancer. UE techniques are mainly divided into two categories: strain elastography and shear wave elastography. The clinical application of UE is not only reflected in the identification of benign and malignant breast nodules, but also has great value in adjusting the BI-RADS classification, monitoring the efficacy of neoadjuvant chemotherapy, and evaluating the prognosis of breast cancer patients. This paper reviews the basic principles, diagnostic methods and clinical applications of breast diseases of UE.
2022 Vol. 19 (22): 42-45,61 [Abstract] ( 16 ) HTML (1 KB)  PDF (549 KB)  ( 128 )
46 Research progress in the application of cervical spin sagittal balance in the diagnosis and treatment of cervical spondylosis
JI Chunlei1 MA Xun2▲ LI Qiang2
The normal shape of the cervical spine is physiological sagittal lordosis, and the sagittal balance of the cervical spine can reflect the arrangement of the cervical spine in the sagittal position. By evaluating the sagittal balance of the cervical spine, it can not only reflect the degeneration of the cervical spine to a certain extent, but also help spine surgeons choose and formulate relevant treatment methods. This article reviews the relevant literature at home and abroad in recent years, and provides the latest review of the sagittal balance of the cervical spine. This paper reviews the application of cervical spin sagittal balance in the diagnosis of cervical spondylosis and selection of related treatment methods, including the measurement and significance of cervical sagittal parameters, clinical evaluation, conservative treatment, and surgical treatment selection.
2022 Vol. 19 (22): 46-49,65 [Abstract] ( 16 ) HTML (1 KB)  PDF (606 KB)  ( 68 )
50 Research progress on the effect of SGLT2 inhibitors on osteoporosis in type 2 diabetes mellitus
LIU Siqi1 GUO Ying2 ZHANG Chunlan2 ZHAO Na2 WANG Juanli3



[Abstract] Osteoporosis is a common complication of diabetes mellitus patients, which seriously affects the quality of life of patients. As a new type of hypoglycemic drug sodium-glucose transporter 2 (SGLT2) inhibitors are widely used in clinical, their effects on bone metabolism have also received widespread attention. Although the drug has good performance in lowering glucose and blood pressure, it may affect bone metabolism and increase the risk of fracture. In order to better guide the clinical use of SGLT2 inhibitors, related factors of osteoporosis caused by SGLT2 inhibitors were described in detail by referring to relevant literatures at home and abroad. The influence of bone metabolism, osteoporosis and even fracture may be related to the imbalance of calcium and phosphorus homeostasis and the increase of parathyroid hormone. However, it is still controversial whether the above consequences are actually related to the use of SGLT2 inhibitors. For diabetic patients with high fracture risk, it should be the consensus of clinicians to fully evaluate the risk of fracture before using these medications.
2022 Vol. 19 (22): 50-53 [Abstract] ( 19 ) HTML (1 KB)  PDF (496 KB)  ( 243 )
54 Research progress on rationality of lymph node status involved in cervical cancer staging system
CHANG Hong WU Yumei
Cervical cancer is the most common malignant tumor of the female reproductive system. In the past, clinical staging was used, in 2018, the International Federation of Obstetrics and Gynecology first proposed to set the lymph node metastasis diagnosed by imaging and pathology as stage ⅢC, reflecting that lymph node positivity was independent risk factors for prognosis of patients with cervical cancer. At the same time, the number of lymph node metastases, the size of the local tumor and the degree of parametrial invasion are also important determinants of prognosis. Imaging can diagnose lymph node metastasis by color doppler ultrasound, CT, MRI, PET/CT, etc. After lymphadenectomy whether or not combine abdominal aortic lymphadenectomy, patients with locally advanced disease can also undergo pathological diagnosis of lymph node metastasis after retroperitoneal lymphadenectomy. Concurrent chemoradiotherapy is recommended for the treatment of patients with confirmed lymph node metastasis. This article reviews the studies on the involvement of lymph node status in the staging of cervical cancer.
2022 Vol. 19 (22): 54-57 [Abstract] ( 15 ) HTML (1 KB)  PDF (503 KB)  ( 34 )
58 Research progress on the injury molecular mechanism of small cell lung cancer injury
SONG Xiaofeng1 LYU Xing1 GE Shuhua1▲ LI Tian2▲
Lung cancer is a major public health problem affecting the health of Chinese people. Small cell lung cancer (SCLC) is a relatively small subtype of lung cancer, with a very low survival rate and poor prognosis. Compared to non-small cell lung cancer, research on SCLC has been slow, and many treatment principles still rely on findings from 20 years ago. This article provides a potential introduction to the background, overview, and epidemiology of SCLC, and focuses on the pathogenesis of SCLC, including oxidative stress, apoptosis, and autophagy. And this article discusss the related research progress of SCLC nursing, analyzes the potential directions, and aim to provide reference for the clinical diagnosis and treatment of SCLC.
2022 Vol. 19 (22): 58-60 [Abstract] ( 8 ) HTML (1 KB)  PDF (485 KB)  ( 63 )
62 Research progress of Chinese medicine combined with massage in the treatment of functional constipation in children
HUANG Ju FENG Yanhua LIU Jinlan
Functional constipation in children is one of the common diseases of the digestive system in children, which is easy to repeat. Massage treatment of functional constipation in children is easy to operate, green and safe, and the children have good compliance. Combining Chinese medicine decoctions, granules, ointments, and acupoint application can enhance the curative effect. It can be selected according to the children’s acceptance. This article summarizes the research progress of Chinese medicine combined with massage manipulation in the treatment of children with functional constipation.
2022 Vol. 19 (22): 62-65 [Abstract] ( 21 ) HTML (1 KB)  PDF (653 KB)  ( 94 )
66 The role of comprehension in postgraduate education of Chinese medicine and its improving path
LI Wenjing1 JIANG Feng2 SU Xin1
Comprehension is the key factor in learning traditional Chinese medicine well and the essential quality for traditional Chinese medicine. It affects the clinical efficacy of traditional Chinese medicine to a certain extent and promotes the innovation and development of traditional Chinese medicine theoretical system. However, comprehension, as a necessary way of thinking in traditional Chinese medicine learning, has the characteristics of personal understanding and is difficult to be mastered. The formation of comprehension is inseparable with traditional Chinese cultural and solid professional basic knowledge, and continuous thinking and experience in personal practice are crucial, therefore, cultivation is significant to the improvement of comprehension. The college training mode has deficiencies in the cultivation of traditional Chinese medicine students’ comprehension, it is necessary to strengthen the cultivation of student’s comprehension in the process of postgraduate education of traditional Chinese medicine, laying solid foundation of traditional culture, strengthening the teaching of traditional Chinese medicine classics, the early clinical and multiple clinical and repeated clinical, changing the force-feeding education, fully mobilizing students’ subjective initiative, stimulating interest in learning. At the same time, we should pay attention to the education of medical ethics, strengthen the ambition to study traditional Chinese medicine, and reinforce the sense of responsibility and mission as a doctor, which will help to improve the quality of training of traditional Chinese medicine talents and promote the academic inheritance and innovative development of traditional Chinese medicine.
2022 Vol. 19 (22): 66-70 [Abstract] ( 16 ) HTML (1 KB)  PDF (746 KB)  ( 50 )
71 Application effect of 3D printing technology in clinical teaching of percutaneous nephroscopy during standardized training for resident physicians
YAN Fengqi JIAO Yong CUI Dong HE Dali WAN Xiaoqiong ZHANG Bo
Objective To explore the application effect of 3D printing technology in clinical teaching of percutaneous nephroscopy during standardized training for resident physicians. Methods A total of 60 resident physicians participated standardized training in the Department of Urology of the Second Affiliated Hospital of Air Force Military Medical University from October 2019 to October 2021 were selected as the research objects, and they were divided into observation group (3D printing technology + traditional teaching method) and control group (traditional teaching method) according to the random number table method, with 30 cases in each group. The results of theory assessment, skill assessment, and teaching satisfaction of residents in the two groups before and after admission were recorded and compared. Results The theoretical test scores of the two groups after admission were higher than those of the two groups before admission, and the difference was statistically significant (P ＜ 0.05). After admission, the percutaneous nephrolithotomy skills assessment results in both groups were higher than those before admission, and the observation group was higher than the control group, the differences were statistically significant (P ＜ 0.05). A total of 60 satisfaction evaluation questionnaires were sent out and 60 were recovered with effective recovery of 100%. The scores of comprehension, acceptance, participation, interest, and skill improvement in the observation group were higher than those in the control group, and the differences were statistically significant (P ＜ 0.05). Conclusion The teaching method of 3D printing technology can improve the operation level of percutaneous nephrolithotomy puncture skills in the standardized training of residents, and also improve the satisfaction of clinical teaching in the standardized training of residents.
2022 Vol. 19 (22): 71-74 [Abstract] ( 15 ) HTML (1 KB)  PDF (657 KB)  ( 31 )
75 Exploratory analysis on the connotation and characteristics of university quality culture
WANG Haiyan GUO Hongwei
The quality of university is the reflection of university culture, which determines the development of university quality. The fundamental task of the construction of university quality culture is talent cultivation. Talent cultivation has the feature of times, characteristics, openness, and corresponding forms, which determines the uniqueness of university quality culture. The establishment of university quality culture has become not only the need for universities to improve their quality image and core competitiveness, but also the need to establish brands and to enforce the cohesion. Furthermore, it is also the key to the success of university development.
2022 Vol. 19 (22): 75-78,87 [Abstract] ( 13 ) HTML (1 KB)  PDF (688 KB)  ( 38 )
79 Application effect of continuous clinical situation practice training teaching in strengthening practice training of midwifery technology in higher vocational colleges#br#
XU Jiehuan1 LI Yaojun1 LIAN Ping1 YANG Chengying2 XIANG Lin1
Objective To discuss the application effect of continuous clinical situation practice teaching in midwifery technology strengthening practice training in higher vocational colleges. Methods In this study, a total of 110 students from two midwifery classes Grade 2019 in Changsha Health Vocational College were selected as the research objects. Among them, Class 1 was the control group (54 students), the teaching method of students’ individual practice supplemented by teacher guidance was adopted, and traditional skills assessment was used as the assessment standard, Class 2 was the experimental group (56 students), continuous clinical scenarios were used to strengthen the training teaching method, and continuous clinical scenarios were used to assess skills. Students of the two groups were compared in skill assessment, practice evaluation, and evaluation of different training teaching. Results The experimental group achieved higher training performance than the control group, the difference was statistically significant (P ＜ 0.05). A total of 110 questionnaires were sent out and 110 were effectively received with effective recovery of 100%. The self-evaluation scores of problem-solving ability, interpersonal communication ability, and teamwork ability in the experimental group were higher than those in the control group, and the differences were statistically significant (P ＜ 0.05). The approval rate of professional attitude, communication and cooperation ability, midwifery core ability, information application ability, and satisfaction of the experimental group were higher than those of the control group, and the differences were statistically significant (P ＜ 0.05). Conclusion In the practice training of midwifery technology in higher vocational colleges, the continuous clinical situation practice training teaching method can effectively improve the quality of skill practice teaching and talent training, and increase the clinical adaptability of students.
2022 Vol. 19 (22): 79-82,91 [Abstract] ( 14 ) HTML (1 KB)  PDF (742 KB)  ( 52 )
83 Study on strategies of maintaining national culture security via English teaching in the universities of Chinese medicine
YAN Li1 KONG Xiangguo1 CHENG Wang2 WANG Shanshan1
In the process of internationalization of higher education, the overt communication and implicit penetration of western ideology and its discourse system, to some extent, has impacted Chinese traditional culture and value system, making Chinese culture security face both international and domestic challenges. The study on how college English teaching undertakes the important mission of safeguarding national culture security would contribute to the current construction of “national consciousness” and the in-depth practice of “course ideology and politics” in foreign language education. This paper expounds the status quo and problems of college English teaching and puts forward four strategies to maintain Chinese culture security, taking Chinese medicine universities for example. It points out that deepening the teaching of traditional Chinese medicine culture related courses, highlighting the traditional Chinese medicine characteristic culture content, strengthening the appreciation of traditional Chinese medicine philosophy and culture, and enhancing the cultural demands of English learning from the internal and external variables of curricula, textbooks, teachers, and students respectively should be taken, in order to realize the reconstruction of college English teaching as an ecological system and achieve the “win-win” outcome of Chinese cultural communication and Chinese-western cultural exchange.
2022 Vol. 19 (22): 83-87 [Abstract] ( 18 ) HTML (1 KB)  PDF (869 KB)  ( 173 )
88 Effect of silver needle acupuncture in the treatment of myofascial pain syndrome
PI Duobo1 ZHANG Min1 ZHU Shali1▲ ZHANG Ying2
Objective To analyze the effect of silver needle acupuncture in the treatment of myofascial pain syndrome and its pain relief effect. Methods A total of 180 patients with myofascial pain syndrome diagnosed and treated in the Department of Pain, Affiliated Hospital of Shaoxing University from January 2019 to December 2020, after numbering the admission sequence, they were divivided included into group A and group B according to the random number table method, with 90 cases in each group. Group A was treated with ozone injection, and group B was treated with ozone injection combined with silver needle. The overall curative effect and visual analogue scale (VAS) score, pain mediators, inflammatory factor levels were compared between the two groups before and after treatment. Results The total effective of group B was batter than that of group A (P ＜ 0.05). After treatment, the VAS score of the two groups was lower than that before treatment, and group B was lower than group A (P ＜ 0.05). After treatment, 5-hydroxytryptamine, prostaglandin E2, and endothelin-1 in group B were lower than those in group A, and group B was lower than group A (P ＜ 0.05). After treatment, the tumor necrosis factor-α, interleukin (IL)-1 β, and IL-6 was lower than that before treatment, and group B was lower than that in group A (P ＜ 0.05). Conclusion Silver needle is effective in treating myofascial pain syndrome, which can relieve pain, improve the level of pain mediators and inflammatory factors, and is worthy of promotion.
2022 Vol. 19 (22): 88-91 [Abstract] ( 16 ) HTML (1 KB)  PDF (601 KB)  ( 28 )
92 Clinical value of laparoscopy combined with duodenoscopy in the treatment of choledocholithiasis 
ZHAO Zhixin CHEN Gengzhen▲ XU Ruirui ZHUANG Chaoping HAN Hui WANG Meizi YOU Shaoqin
Objective To investigate the clinical value of laparoscopy combined with duodenoscopy in the treatment of choledocholithiasis. Methods A total of 60 patients with choledocholithiasis admitted to the Second Affiliated Hospital of Shantou University Medical College from July 2019 to February 2021 were selected as the research subjects and they were divided into two groups according to the random number table method, with 30 cases in each group. The research group underwent laparoscopic cholecystectomy (LC)+laparoscopic common bile duct exploration (LCBDE)+endoscopic nasobiliary drainage (ENBD), the control group received LC+LCBDE+T tube drainage. The intraoperative and postoperative conditions of the two groups were compared. Results The extubation time and hospital stay in the study group were shorter than those in the control group, and the hospitalization costs was less than those in the control group, with statistically significant differences (P ＜ 0.05). There were no significant differences in operation time, intraoperative blood loss, bile drainage, and gastrointestinal recovery time between the two groups (P ＞ 0.05). Postoperative re-examination found that the increase rate of blood and urine amylase and abnormal liver function rate in the study group were lower than those in the control group, and the differences were statistically significant (P ＜ 0.05). There were no statistical significance difference in the incidence of postoperative pancreatitis and bile leakage between the two groups (P ＞ 0.05). Conclusion Laparoscopic combined with duodenoscope placement of nasobiliary duct is safe and effective in the treatment of choledocholithiasis, and have quickly recover after operation with drfinite curative effect.
2022 Vol. 19 (22): 92-95 [Abstract] ( 14 ) HTML (1 KB)  PDF (528 KB)  ( 30 )
96 Effects of epidural and thoracic paravertebral nerve block on analgesia, oxidative stress, and immune function in patients undergoing radical resection of lung cancer
LI Xiang SUN Qichao DING Hairu
Objective To investigate the effects of epidural and thoracic paravertebral nerve block on analgesia, oxidative stress, and immune function in patients undergoing radical resection of lung cancer. Methods A total of 86 patients undergoing radical resection of lung cancer in Rugao Hospital Affiliated to Nantong University from June 2017 to May 2020 were selected, they were divided into epidural group (underwent epidural nerve block, 43 cases) and thoracic paravertebral group (underwent thoracic paravertebral nerve block, 43 cases) by random number table method. Operation time and anesthesia maintenance time were compared between two groups; visual analogue scale (VAS) scores were compared between two groups at 4, 12, 24, and 48 h postoperatively; stress response and immune function indexes were compared between two groups before operation and at 4, 12, and 48 h postoperatively. Results There were no statistically significant differences in operation time and anesthesia maintenance time between two groups (P > 0.05). Comparison of VAS scores at different time points between the two groups showed statistical significance (P < 0.05). VAS scores in thoracic paravertebral group at 4, 12, 24, and 48 h postoperatively were lower than those in epidural group (P < 0.05). The levels of Cor and Ang Ⅱ in two groups at 4, 12, and 48 h postoperatively were higher than those before operation (P < 0.05). The levels of Cor and Ang Ⅱ in thoracic paravertebral group were lower than those in epidural group at 4, 12, and 48 h postoperatively (P < 0.05). CD3+, CD4+, CD8+, and CD4+/CD8+ at 4, 12, and 48 h postoperatively were lower than those before operation (P < 0.05). CD3+, CD4+, and CD4+/CD8+ in thoracic paravertebral group at 4, 12, and 48 h postoperatively were higher than those in epidural group (P < 0.05). Conclusion Compared with epidural nerve block, thoracic paravertebral nerve block can alleviate the postoperative radical resection of lung cancer patients pain, reduce oxidative stress, and reduce immune suppression.
2022 Vol. 19 (22): 96-99 [Abstract] ( 17 ) HTML (1 KB)  PDF (512 KB)  ( 72 )
100 Analgesic effect and safety of Dexmedetomidine combined with Hydromorphone on breakthrough cancer pain
PAN Yanping1 WANG Ying1 WANG Zhenhong2
Objective To study the analgesic effect and safety of Dexmedetomidine combined with Hydromorphone on breakthrough cancer pain (BTcP). Methods Ninety-six patients with BTcP in Liyang Branch, Jiangsu Provincial People’s Hospital from February 2020 to February 2021 were selected, they were divided into control group and observation group, with 48 cases in each group. The control group was treated with Hydromorphone for analgesia, and observation group was treated with Dexmedetomidine combined with Hydromorphone for analgesia. The analgesic effect (drug onset time, drug action time, dosage of self-controlled Hydromorphone, dosage of remedial analgesia, numerical rating scale [NRS] score, and pain degree) were compared between two groups within seven days of treatment; sleep quality (Athens insomnia scale [AIS] score) and quality of life (Spitzer quality of life index [SQOL] score) were compared before and after seven days of treatment; the total incidence of adverse reactions and satisfaction of analgesia during treatment were compared. Results Drug onset time in observation group was shorter than that in control group, drug action time was longer than that in control group, the dosage of self-controlled Hydromorphone and dosage of remedial analgesia were less than those in control group, and NRS score of BTcP attack and severity were lower than those in control group (P < 0.05). Seven days after treatment, AIS scores of two groups were lower than those before treatment, SQOL scores of two groups were higher than those before treatment, and AIS score of observation group was lower than that of control group, and SQOL score was higher than that of control group (P < 0.05). There was no significant difference in the total incidence of adverse reactions between two groups (P > 0.05). The analgesic satisfaction of observation group was better than that of control group (P < 0.05). Conclusion Dexmedetomidine combined with Hydromorphone in BTcP analgesic effect is obvious, can reduce the degree of pain, improve sleep quality and quality of life, will not increase the occurrence of adverse reactions, and patients have high satisfaction with analgesia, which is worthy of clinical promotion.
2022 Vol. 19 (22): 100-103 [Abstract] ( 21 ) HTML (1 KB)  PDF (577 KB)  ( 29 )
104 Medication rule analysis of Professor Lü Wenliang in the treatment of chronic hepatitis B based on data mining
QIANG Rui FENG Jiaqi LYU Wenliang
Objective To explore the medication rule of Professor Lü Wenliang in the treatment of chronic hepatitis B based on data mining, and to hope to provide reference for clinical treatment. Methods From January 2020 to July 2021, patients clearly diagnosed with chronic hepatitis B visited the expert outpatient clinic of Professor Lü at Department of Infectious Diseases, Guang’anmen Hospital, Chinese Academy of Chinese Medical Sciences were selected, and the clinical cases were real, complete and effective. The clinical case data were screened and a database was constructed, and data mining methods such as frequency statistics, association rule analysis, cluster analysis, complex system entropy clustering, and entropy tomographic clustering analysis were used to explore their medication rules. Results A total of 116 prescriptions were included, involving 153 traditional Chinese medicines. There were 13 traditional Chinese medicines with the use frequency of more than 50%, among which, the use frequency of raw Astragali Radix exceeded 95%. There were a total of ten drug combinations with frequency of usage ≥76, of which raw Astragali Radix, Scutellariae Radix, fried Atractylodis Macrocephalae Rhizoma, Saposhnikoviae Radix, Coptidis Rhizoma, Poria, scorched Crataegi Fructus, fried Armeniacae Semen Amarum, Phellodendri Chinensis Cortex were nine high frequency drugs. The drug properties were mainly cold and warm, and the drug tastes were mainly bitter and sweet, which were mainly attributed to the spleen, stomach, lung and liver channels. In the end, 14 pairs of core drug combinations and 14 new derivatives were selected and extracted. Conclusion Professor Lü takes the main treatment methods of enhancing qi and invigorating spleen, simultaneously dispersing stagnated liver qi, clearing dampness and heat, and directly eliminating poisonous pathogens, and can increase or decrease the drug according to the dynamic changes of  the patient’s symptoms and disease stage. This study can provide a reference for Chinese medicine treatment of chronic hepatitis B.
2022 Vol. 19 (22): 104-109,113 [Abstract] ( 17 ) HTML (1 KB)  PDF (1968 KB)  ( 79 )
110 Discussion on the characteristics of traditional Chinese medicine pathogenesis of early liver cirrhosis of chronic hepatitis B
ZHAI Changming1 LU Fang1 GAO Ya2
Hepatitis B virus (HBV) infection is the most common cause of liver cirrhosis in China. However, due to the long-term and occult progression of liver cirrhosis, the diagnosis and treatment of early liver cirrhosis is still a world problem to be solved. From the perspective of traditional Chinese medicine, HBV should be the evil of dampness and heat, the deficiency of vital qi in the body is an important cause of chronic HBV infection, and phlegm turbidity and blood stasis are the pathological basis of liver fibrosis/cirrhosis, and “fire, dampness, deficiency, phlegm and blood stasis” are the core pathogenesis of early liver cirrhosis. Compared with modern medicine, traditional Chinese medicine has its unique advantages. It can apply decoction based on syndrome differentiation according to the pathogenesis, and intervene in advance through non-drug means such as acupuncture, massage and guidance, so as to jointly play the role of “prevention before disease and treatment before disease”.
2022 Vol. 19 (22): 110-113 [Abstract] ( 18 ) HTML (1 KB)  PDF (644 KB)  ( 46 )
114 Li Dake’s experience in treating remitting seronegative symmetrical synovitis with pitting edema based on the theory of phlegm, fluid retention, water and qi disease
SUN Zirui1 LI Dake2 WANG Shiyuan3
As a rare rheumatic disease with no strict and unified diagnostic criteria, remitting seronegative symmetrical synovitis with pitting edema is characterized by sudden appearance of symmetrical edema at the end of the extremities. Currently, most modern physicians use drugs empirically, and think that the pathogenesis is arthralgia caused by damp-heat pathogen, but there are still some patients who have poor efficacy from the perspective of clearing heat and promoting diuresis. At present, Professor Li Dake analyzes the pathogenic characteristics of phlegm, fluid retention, water and qi disease, and tries to describe the pathogenesis of this disease with the theory of phlegm, fluid retention, water and qi disease. She maintaines that the pathogenesis of this disease results from the lung qi failing in dispersing and the fighting of wind with water; dysfunction of spleen in transportation and fluid-dampness stagnancy; deficiency of kidney yang and dysfunction of qi in transformation; dysfunction of sanjiao and imbalance of water qi. It can be treated by ventilating lung qi for diuresis to generate body fluid, invigorating spleen and eliminating dampness, to promote transportation, warming kidney yang to assist qi in transformation, and regulating sanjiao and smoothing waterway, so as to give full play to the role of traditional Chinese medicine in preventing and treating remitting seronegative symmetrical synovitis with pitting edema syndrome, and open up new ideas for clinical diagnosis and treatment and case specific diagnosis and treatment strategies.
2022 Vol. 19 (22): 114-117,122 [Abstract] ( 13 ) HTML (1 KB)  PDF (807 KB)  ( 15 )
118 Medication rule of traditional Chinese medicine in the treatment of hypertensive early renal damage
CHEN Kaili1 ZHANG Danhua1 XU Peicong1 WANG Baolin1 DENG Wei2
Objective To study the medication rule of traditional Chinese medicine in the treatment of hypertensive early renal damage. Methods A database was established by collecting hypertensive early renal damage related journal articles recorded on CNKI, VIP and Wanfang database from inception to December 2021, and the frequency, nature and flavour and channel tropism, association rules, complex network visualization, system cluster analysis were conducted for the Chinese medicines that met the standards. Results Among the 69 Chinese herbal compounds that met the standard. It involved 140 Chinese medicines. Astragali Radix, Salviae Miltiorrhizae Radix Et Rhizoma, Cornifructus, Poria, Dioscoreae Rhizoma were the most used, the four nature of drugs were mainly flat, the five tastes were mostly sweet, bitter and spicy, and the channel tropism were mainly liver, spleen and kidney channels. In the results of association rules, there were seven binomial associations and seven three-term associations. The systematic clustering results were classified into four categories. Conclusion Traditional Chinese medicine in the treatment of hypertensive early renal damage mainly focuses on tonifying and replenishing liver and kidney, invigorating qi and strengthening spleen, calming the liver to stop the wind, draining turbidity and removing blood stasis, and treating both manifestation and root cause of disease.
2022 Vol. 19 (22): 118-122 [Abstract] ( 22 ) HTML (1 KB)  PDF (1319 KB)  ( 155 )
123 Medication rule analysis of Ma Peizhi and He Jiheng in treating clinical medical records of stomach pain based on data mining
CHEN Quan1 SUN Lixia1 DAI Heng1 GAO Weiju1 WANG Xiaohong1 WU Yuanyuan1 ZHU Yao2 ZHOU Nan3
Objective To analyze medication rule of Ma Peizhi and He Jiheng in treating clinical medical records of stomach pain based on data mining. Methods The clinical medical records about Ma Peizhi and He Jiheng in the diagnosis and treatment of stomach pain were collected from Meng He Ma Peizhi Medical Records, The Collection of Medical Records and Sayings from Four Doctors in Meng He, He Jiheng Medical Records and Zhi Chan Medical Records. Their prescription was analyzed by Medcase data processing platform through frequency analysis, association analysis, cluster analysis data mining method. Results A total of 126 times were collected in this study. Ma Peizhi medical records were 44 times and He Jiheng medical records were 82 times. Fifteen kinds of pathological factors, 33 kinds of treatment principles, and 96 kinds of drugs involved in Ma Peizhi medical records, six kinds of drug pairs, one kind of three-group-drugs and three new prescriptions were analyzed. Thirty-five kinds of pathological factors, 20 kinds of treatment principles, 119 kinds of drugs involved in He Jiheng medical records, seven kinds of drug pairs, two kinds of three -group-drugs and three new prescriptions were analyzed. Conclusion Ma Peizhi is good at flexibly adjusting the treatment principles according to the transformation law of pathogenesis in the process of stomach pain. He Jiheng is attaching importance to the influence of qi inversion on the incidence of stomach pain, and often treating stomach pain mainly by dredging and reducing qi inversion.
2022 Vol. 19 (22): 123-127 [Abstract] ( 29 ) HTML (1 KB)  PDF (1088 KB)  ( 19 )
128 Theoretical combing and application experience of clearing lung and invigorating spleen method in the treatment of allergic rhinitis
QU Jing ZHI Nan LIAN Haihong CAO Shan
The method of clearing lung and invigorating spleen is an innovative method for the treatment of allergic rhinitis with lung heat and spleen dampness syndrome based on inheritance and practice. This paper combs the occurrence of allergic rhinitis with lung heat and spleen dampness syndrome, that is, the insidious pathogen of dampness heat is the internal basis, exuberance of lung heat, spleen deficiency and dampness aggregation, dampness heat cementation, and invading nasal orifices are important pathogenesis. It is pointed out that it is mainly due to the lung, related to the spleen, and the pathogenic factors are heat and dampness cementation. Therefore, the method of clearing lung and invigorating spleen is proposed. The specific herbs are analyzed from two angles, one is the primary and secondary drugs, which are different from monarch, minister, assistant and envoy; secondly, in terms of nature and flavour, it is divided into three categories: cold herbs clearing lung heat, tasteless flavor herbs invigorating spleen for promoting diuresis and spicy warm herbs dispelling wind for opening orifices. After years of practice and clinical research, this prescription has been proved to be safe and effective. This time, the key points of syndrome differentiation of lung heat and spleen dampness syndrome are summarized, which is convenient for clinical popularization. In the diagnosis and treatment of patients, the commonly used adjusted herbs are sorted out under the guidance of theory in different specific situations. Finally, an example of medical records is shown.
2022 Vol. 19 (22): 128-131 [Abstract] ( 18 ) HTML (1 KB)  PDF (622 KB)  ( 44 )
132 Discussion on the medication rules of urticaria in Song Dynasty based on data mining
ZHANG Xiaoyan1 CHENG Haoyang1 QU Jianhua2
Objective To explore the medication rules of urticaria in Song Dynasty based on data mining, in order to provide reference for clinical treatment. Methods The literature on the treatment of urticaria in the Song Dynasty surgical classics of Chinese Medical Code was collected and sorted out, and the prescription and drug information was extracted. The prescription database was established by Microsoft Office Excel 2019, and the medication frequency, drug category, four nature of drugs and five flavors and channel tropism were counted. IBM SPSS Statistics 22.0 and IBM SPSS Modeler 14.1 software were used for association rule analysis and cluster analysis of high-frequency drugs (frequency > 10 ). Results A total of 97 prescriptions and 161 Chinese traditional medicines were included, among which the top three were Saposhnikoviae Radix, Glycyrrhizae Radix Et Rhizoma, Tribulus Terrestris. Superficies-relieving drugs and tonifying deficiency drugs were the most widely used. The drug properties were mainly warm, cold and flat drugs, drug tastes were mainly bitter, spicy and sweet tastes, which mainly belong to the liver, spleen and lung channels. Six core drug combinations were obtained by high frequency drug cluster analysis. Conclusion The treatment of urticaria in Song Dynasty mainly focuses on relieving the surface and dispelling cold, dispelling wind and clearing heat, tonifying qi and blood, emphasizing the combination of strengthening vital qi to eliminate pathogenic factor, qi and blood, and the harmony of mind and body, which can be used for clinical reference.
2022 Vol. 19 (22): 132-135,148 [Abstract] ( 22 ) HTML (1 KB)  PDF (1728 KB)  ( 15 )
136 Clinical effect of Qingshen Guanchang Fluid on chronic renal failure
YANG Yuanyuan LIU Shifu LYU Wei
Objective To study the clinical efficacy of Qingshen Guanchang Fluid in the treatment of chronic renal failure. Methods A total of 66 patients with chronic renal failure admitted to Department of Nephrology, Wuhu Hospital of Traditional Chinese Medicine from January 2018 to January 2021 were selected as the research objects. They were divided into the control group and the observation group according to the random number table method, with 33 cases in each group. The control group was treated with basic therapy, while the observation group was treated with Qingshen Guanchang Fluid on the basis of the control group. Traditional Chinese medicine symptom scores, renal function indexes, laboratory related indexes, clinical efficacy and adverse reactions were compared between the two groups. Results After treatment, the scores of traditional Chinese medicine symptoms in the two groups were lower than those before treatment, and that in the observation group was lower than that in the control group (P < 0.01). After treatment, the levels of serum creatinine, urea nitrogen, uric acid, and cystatin C in the two groups were lower than those before treatment, and those in the observation group were lower than those in the control group (P < 0.05). After treatment, the levels of serum calcium, phosphorus, and potassium in the two groups were lower than those before treatment, and those in the observation group were lower than those in the control group (P < 0.05). After treatment, the clinical effect of the observation group was better than that of the control group (P < 0.05). There was no significant difference in the total incidence of adverse reactions between the two groups (P > 0.05). Conclusion Qingshen Guanchang Fluid is safe and effective in the treatment of chronic renal failure.
2022 Vol. 19 (22): 136-139 [Abstract] ( 23 ) HTML (1 KB)  PDF (595 KB)  ( 33 )
140 Clinical application of 3D-slicer combined with Sina/MosoCam assisted neuroendoscopy in the treatment of supratentorial hypertensive intracerebral hemorrhage
WANG Wenju1* WU Yuanshan2* CAI Qiang1▲ LI Zhiyang1 SONG Ping1 WEI Hangyu1 ZHOU Long1 LEI Pan1
Objective To investigate the clinical application and efficacy of 3D-slicer combined with Sina/MosoCam assisted neuroendoscopy in the treatment of supratentorial hypertensive intracerebral hemorrhage. Methods A total of 50 patients with supratentorial hypertensive intracerebral hemorrhage admitted to the Department of Neurosurgery, People Hospital of Wuhan University from June 2019 to September 2021 were selected. According to the design and selection of surgical approach, the patients were divided into 3D-slicer group (21 cases) and CT group (29 cases). CT group used CT-assisted localization, in the 3D-slicer group, 3D-slicer combined with Sina/MosoCam software was used for surgical approach design and selection. The hematoma clearance rate on the 1st postoperative day, operation time, postoperative rebleeding rate, catheterization time, intracranial infection rate, Glasgow coma scale (GCS) score and modified Rankin scale (mRS) score at discharge were compared between the two groups. Results There was no rebleeding in the two groups. There were statistically significant differences in hematoma clearance rate and operation time between two groups (P < 0.05). There were no significant differences in intracranial infection, catheterization time, discharge GCS score, and mRS score between two groups (P > 0.05). Conclusion 3D-slicer combined with Sina/MosoCam software assisted neuroendoscopy in the treatment of hypertensive intracranial hemorrhage has guiding significance in preoperative surgical approach design and postoperative evaluation, and has certain advantages in overall efficacy.
2022 Vol. 19 (22): 140-143 [Abstract] ( 18 ) HTML (1 KB)  PDF (819 KB)  ( 30 )
144 Diagnosis of benign and malignant breast lesions by conventional ultrasound, superb microvascular imaging combined with ultrasonic elastography
LIU Erqiu LIU Lijuan DENG Yijing LUO Jinfu DAI Haixia HUANG Xing XU Xiaohong
Objective To study the diagnostic efficacy of conventional ultrasound, superb microvascular imaging (SMI) combined with ultrasonic elastography. Methods A total of 301 female patients who underwent breast ultrasound examination and were confirmed by pathology in the Affiliated Hospital of Guangdong Medical University from August 2019 to June 2021 were selected. The characteristics of conventional ultrasound, elastic score, and SMI blood flow classification of benign and malignant breast lesions were compared, and the diagnostic efficacy of conventional ultrasound, SMI blood flow classification, and elasticity score in benign and malignant breast lesions were analyzed. Results There were 268 benign and 33 malignant lesions in 301 patients. There were statistically significant differences in lesion morphology (aspect ratio), margin, internal echo, calcification, color Doppler flow imaging, elastic score， and SMI blood flow classification between benign and malignant lesions (P < 0.05). Lesion morphology (aspect ratio), margin, elastic score， and SMI blood flow classification were independent influencing factors for the identification of breast malignant lesions (OR > 1, P < 0.05). The specificity, positive predictive value, and accuracy of combined detection of benign and malignant breast lesions were the highest. Conclusion Conventional ultrasound, SMI blood flow classification combined with elastic score may be a more reliable method for the diagnosis of benign and malignant breast lesions.
2022 Vol. 19 (22): 144-148 [Abstract] ( 23 ) HTML (1 KB)  PDF (1127 KB)  ( 29 )
149 Feasibility study of TVS-CEUS in preoperative clinical staging diagnosis of cervical cancer
WANG Yingluan1 LIU Ying1▲ WANG Laidong2 CUI Yanling2 YANG Chunxiao3 ZHANG Haipeng4
Objective To evaluate the value of transvaginal contrast-enhanced ultrasound (TVS-CEUS) in preoperative diagnosis and clinical staging of cervical cancer, and to explore the feasibility of clinical staging. Methods A total of 81 patients with cervical cancer confirmed by surgery and pathology were selected from September 2011 to December 2020 in Zibo Municipal Hospital of Shandong Province. All patients underwent transvaginal color Doppler ultrasound (TVCDS) and TVS-CEUS examination before surgery to evaluate the nature of lesions and perform preoperative staging; the differences between benign and malignant lymph nodes were observed. Results The detection rate of cervical cancer of TVS-CEUS was higher than that of TVCDS, and the difference was statistically significant (P < 0.05). The diagnostic coincidence rate of TVCDS was 73.08% (57/78), and Kappa value was 0.536; the diagnostic coincidence rate of TVS-CEUS was 89.74% (70/78), and Kappa value was 0.824. The sonographic appearance of pelvic metastatic lymph nodes was later than the surrounding normal soft tissue with diffuse uniform low enhancement and no clear boundary with the surrounding tissue. Conclusion TVS-CEUS can improve the diagnostic ability and staging accuracy of cervical cancer, and has certain value in the determination of the nature of pelvic enlarged lymph nodes.
2022 Vol. 19 (22): 149-152 [Abstract] ( 20 ) HTML (1 KB)  PDF (1354 KB)  ( 25 )
153 Comparison of the efficacy of Paliperidone and Aripiprazole in the treatment of schizophrenia
ZHANG Rui1 YANG Chun2▲
Objective To compare the efficacy of Paripipidone and Aripiprazole in the treatment of schizophrenia. Methods From November 2018 to October 2021, 102 patients with schizophrenia admitted to the the 904th Hospital of the Joint Logistics Support Force of the Liberation Army were randomly divided into Paliperidone group (treated with Paliperidone) and Aripiprazole group (treated with Aripiprazole), with 51 cases in each group. Patients of the two groups were evaluated for the treatment effect after three months of continuous treatment. The positive and negative symptom scale (PANSS) scores, clinical efficacy, neuromodulin 1 (NRG1), and neuron-specific enolase (NSE) levels were compared between the two groups. The adverse reactions during the treatment of the two groups were compared. Results There were significant differences in PANSS score betwee groups, time points, and interaction between groups (P ＜ 0.05). Further pairwise comparison, intra group comparison: compared with before treatment, the PANSS scores of the two groups decreased after one month and three months of treatment (P ＜ 0.05). Compared with one month after treatment, the PANSS scores of the two groups decreased after three months of treatment (P ＜ 0.05). Comparison between groups: the PANSS scores of Paliperidone group after one month and three months of treatment were lower than those of Aripiprazole group (P ＜ 0.05). The clinical effect of paripipidone group was better than Aripiprazole group (P ＜ 0.05). After treatment, the levels of NRG1 in the two groups were higher than those before treatment, and the level of NRG1 in the Paliperidone group was higher than that in the Aripiprazole group (P ＜ 0.05). After treatment, the NSE level of the two groups decreased, and the NSE level of the Paliperidone group was lower than that of the Aripiprazole group (P ＜ 0.05). There was no significant difference in the total incidence of adverse reactions between two groups (P ＞ 0.05). Conclusion Compared with Aripiprazole, Paliperidone in the treatment of schizophrenia can effectively relieve clinical symptoms, improve clinical efficacy, regulate serum neuregulin levels, and is safe and reliable.
2022 Vol. 19 (22): 153-156 [Abstract] ( 17 ) HTML (1 KB)  PDF (535 KB)  ( 23 )
157 Analysis and exploration for hospital’s management of to the praise from patients
JIN Qi CHEN Yuheng ZHOU Yan ZHANG Ping
In recent years, Chinese national health administrative department has promulgated plans for improving medical services, which required the hospital management and services to be more scientific, refined, and standardized. Patients’ praise is an effective indicator that reflects patients’ satisfaction with medical treatment, smooth communication between doctors, and patients, and harmonious doctor-patient relationship, which has always been valued by hospital management departments and medical staff. Through relevant research, this paper analyzes the management of patient praise in hospitals and puts forward reasonable suggestions: on the basis of the existing traditional praise, electronic praise methods should be expanded; patient praise can be properly incorporated into the performance appraisal system; real stories of the world and carry forward the medical humanistic spirit to build a more harmonious doctor-patient relationship.
2022 Vol. 19 (22): 157-159 [Abstract] ( 13 ) HTML (1 KB)  PDF (466 KB)  ( 20 )
160 Influence of hospital quality control management measures based on FOCUS-PDCA on environmental hygiene disinfection effect and hand hygiene#br#
WU Wenjuan ZHENG Shuifeng ZHONG Nan LUO Xin▲
Objective To investigate the application effect of hospital quality control management measures based on find-organize-clarify-understand-select-plan-do-check-act（FOCUS-PDCA) model on the disinfection effect of environmental hygiene and hand hygiene in primary hospitals. Methods In January 2021, Xixi Hospital in Hangzhou began to apply the quality control management measures based on FOCUS-PDCA to manage the prevention and control of hospital infection. The period from January to December 2020 before the application of the new quality control management measures was selected as the control period, and the period from January to December 2021 after the application of the new quality control management measures was selected as the observation period. At the same time, a total of 80 medical staff from various departments in the hospital were selected for inclusion in the study. The monitoring of disinfection and hygiene in the hospital before and after the implementation of FOCUS-PDCA were compared. At the same time, the scores of infection control knowledge, hygiene, and disinfection skills of medical staff in the hospital and the qualified status of hand hygiene of medical staff were compared. Results After the implementation of FOCUS-PDCA, the test pass rate of the in-hospital environmental samples was higher than that before the implementation, and the difference was statistically significant (P ＜ 0.05). After the implementation of FOCUS-PDCA, the scores of infection control knowledge and sanitation and disinfection skills of the medical staff in the hospital were higher than those before the implementation, and the differences were statistically significant (P ＜ 0.05). The qualified rate of hand hygiene of medical staff in the hospital before contact with patients, before aseptic operation, after risky operation, and after contact with patients were higher than that before implementation, and the differences were statistically significant (P ＜ 0.05). Conclusion The hospital infection quality control management measures based on FOCUS-PDCA can significantly improve the disinfection effect of environmental hygiene in the prevention and control of hospital infection, enhance the awareness of hand hygiene and the implementation of hospital infection prevention and control among medical staff, and promote the standardization of nosocomial infection prevention and control.
2022 Vol. 19 (22): 160-163,180 [Abstract] ( 15 ) HTML (1 KB)  PDF (678 KB)  ( 69 )
164 Effects of four-level rehabilitation guided by quantitative assessment combined with high-fat and low-glucose enteral nutrition on mechanical ventilation in chronic obstructive pulmonary disease
LI Minmin XU Haixia YANG Lili▲
Objective To analyze the effects of four-level rehabilitation guided by quantitative assessment combined with high-fat and low-glucose enteral nutrition on mechanical ventilation in chronic obstructive pulmonary disease (COPD). Methods A total of 110 COPD patients admitted to Huaian First Hospital Affiliated to Nanjing Medical University from February 2020 to February 2021 were included and divided into control group and experimental group by random number table method, with 55 cases in each group. The control group received high-fat and low-sugar enteral nutrition, and the experimental group received four-level rehabilitation guided by quantitative evaluation on the basis of the control group. The blood gas indexes, respiratory function, immune function, off-line situation, and neurological function scores before and after training were compared between the two groups. Results Partial pressure of oxygen in artery and pulse oxygen saturation in the experimental group were higher than those in the control group, partial pressure of carbon dioxide was lower than that in the control group, while forced vital capcacity, forced expiratory volume in the first second, and peak expiratory flow were higher than those in the control group, and the differences were statistically significant (P ＜ 0.05). The immune function of the experimental group was higher than that of the control group, the off-line time was shorter than that of the control group, while the success rate of off-line was higher than that of the control group, and the differences were statistically significant (P ＜ 0.05). After training, the scores of transfer, travel, communication, social cognition, self-care ability, and sphincter control in the two groups were higher than those before training, while the experimental group was higher than the control group, and the differences were statistically significant (P ＜ 0.05). Conclusion Applying the four-level rehabilitation guided by quantitative assessment in COPD mechanical ventilation can improve its nutritional status, shorten the time of mechanical ventilation, and promote the rapid recovery of respiratory function and neurological function.
2022 Vol. 19 (22): 164-167 [Abstract] ( 14 ) HTML (1 KB)  PDF (591 KB)  ( 29 )
168 Effect of coordinated nursing health guidance on coping style, self-efficacy, and quality of life of elderly female patients with osteoporosis
LI Qiaoling1 ZHANG Huili2 WANG Can3▲
Objective To explore the effect of coordinated nursing health guidance on coping style, self-efficacy, and quality of life of elderly female patients with osteoporosis. Methods From July 2020 to June 2021, 98 elderly female patients with osteoporosis in Wuxi Branch of Ruijin Hospital Affiliated to Shanghai Jiao Tong University were selected as the research subjects. According to random number table method, they were divided into control group and observation group, with 49 cases in each group. The control group adopted routine nursing, and the observation group adopted systematic nursing and health guidance. The coping style, self-efficacy scores and quality of life of the two groups were compared before and after intervention. Results After intervention, the face scores of the two groups were higher than before intervention, and the avoidance and yield scores were lower than before intervention, the face score of the observation group was higher than the control group, and the avoidance and yield scores were lower than the control group, the differences were statistically significant (P ＜ 0.05); quality of life and self-efficacy scores of the two groups were higher than before intervention, and those of the observation group were higher than those of the control group, the differences were statistically significant (P ＜ 0.05). Conclusion The application of collaborative nursing health guidance for elderly female patients with osteoporosis can improve patients’ self-efficacy, improve coping styles, enhance the score of quality of life, and benefit the prognosis of patients, which is worthy of reference and promotion in all departments.
2022 Vol. 19 (22): 168-171 [Abstract] ( 13 ) HTML (1 KB)  PDF (599 KB)  ( 67 )
172 Effect of Rhubarb apply umbilical combined with auricular point sticking on intestinal cleaning preparation and abdominal pain and distension during colonoscopy
JIANG Qian1 XU Yan1 LI Dan1 TAO Yilil DU Ling2▲
Objective To observe the effect of Rhubarb apply umbilical combined with auricular point sticking on intestinal cleaning preparation and abdominal pain and distension during colonoscopy. Methods A total of 120 patients receiving colonoscopy in Changzhou Hospital of Traditional Chinese Medicine in Jiangsu Province from January 2019 to January 2022 were selected by random number table method. The patients were divided into Rhubarb apply umbilical group (Rhubarb apply umbilical), auricular acupoint sticking magnetic group (auricular point sticking) and combined group (Rhubarb apply umbilical combined auricular point sticking) by random number table method, with 40 cases in each group. All three groups were treated with oral polyethylene glycol electrolyte powder for intestinal preparation, and continued intervention for three days. The intestinal cleaning preparation rate and abdominal pain and abdominal distension were compared among the three groups. Results The scores of Boston intestinal preparation scale and total scores, qualified rate of preparation cleaning, easy observation rate of intestinal bubbles, and detection rate of first polyp in the combined group were higher than those in the Rhubarb apply umbilical group and auricular acupoint sticking magnetic group (P ＜ 0.01). There was no significant difference in the detection rate of polyps among the three groups (P ＞ 0.05). After examination, visual analogue scale scores of abdominal pain and abdominal distention of Rhubard apply umbilical group and aurrcular acupoint sticking magnetic group were higher than before, and visual analogue scale of abdominal pain, abdominal distention and bubble scores of intestinal parts in the combined group were lower than those in the Rhubarb apply umbilical group and auricular acupoint sticking magnetic group (P ＜ 0.01). Conclusion Rhubarb umbilical application combined with auricular acupuncture can improve intestinal preparation for colonoscopy, reduce intestinal bubbles, improve the detection rate of intestinal polyps, and reduce abdominal distension and abdominal pain.
2022 Vol. 19 (22): 172-175 [Abstract] ( 16 ) HTML (1 KB)  PDF (559 KB)  ( 210 )
176 Application value of whole-course seamless nursing intervention mode in the treatment of patients with ankylosing spondylitis with adamumab in outpatient department
XIA Yingying1 CHENG Jing2▲
Objective To investigate the application value of whole-course seamless nursing intervention mode in the treatment of patients with ankylosing spondylitis with adamumab in outpatient department. Methods A total of 100 patients with ankylosing spondylitis in Xinhua Hospital Affiliated to Medical College of Shanghai Jiao Tong University from June 2019 to June 2020 were selected. According to the odd and even grouping method, they were divided into observation group and control group, with 50 cases in each group. The control group was given routine nursing guidance, and the observation group was given whole-process seamless nursing intervention mode on the basis of the control group. Bath ankylosing spondylitis metroloty index (BASDAI), bath ankylosing spondyltis functional index (BASFI), patient global assessment (PGA), the 36-item short form health survey, and satisfaction of nursing service were compared between the two groups before, 3 months, 6 months, and 1 year of nursing. Results Overall analysis showed that there were statistically significant differences between groups, time points and interactions (P ＜ 0.05). The BASDAI, BASFI, and PGA of nursing 3 months, 6 months, and 1 year in both groups were lower than those before nursing (P ＜ 0.05); BASDAI, BASFI, and PGA of nursing for 6 months were lower than those of nursing for 3 months, and BASDAI, BASFI, and PGA of nursing for 1 year were lower than those of nursing for 3 months and nursing for 6 months (P ＜ 0.05); comparison between groups: BASDAI, BASFI, and PGA in observation group were lower than those in control group (P ＜ 0.05); after nursing, the quality of life index of both groups were higher than before, and the observation group was higher than the control group (P ＜ 0.05). Nursing service satisfaction of observation group was higher than control group (P ＜ 0.05). Conclusion The whole process of seamless nursing can promote the treatment of ankylosing spondylitis with adalimumab, can control the disease, improve the quality of life and satisfaction, and can be promoted.
2022 Vol. 19 (22): 176-180 [Abstract] ( 11 ) HTML (1 KB)  PDF (704 KB)  ( 52 )
181 Application effect of the concept of enhanced recovery after surgery in perioperative nursing of children with high ligation of hernia sac
CHEN Jia WU Pei
Objective To explore the application effect of the concept of enhanced recovery after surgery in perioperative nursing of children with high ligation of hernia sac. Methods Eighty children with inguinal hernia who received high ligation of hernia sac in Nantong Maternal and Child Health Hospital from January 2020 to June 2021 were selected as the study subjects. They were divided into control group and observation group by random number table method, with 40 cases in each group. The control group received routine perioperative nursing, while the observation group received routine perioperative nursing based on the concept of rapid rehabilitation surgery. Perioperative indicators, postoperative pain, postoperative complication rate, and nursing satisfaction of family members of two groups were observed. Results After intervention, postoperative average time to eat, time to get out of bed, bowel sound, exhaust time, and hospital stay in terms of the observation group were shorter than the control group, and the differences were statistically significant (P ＜ 0.05); the 24 h postoperative pain in the observation group was lighter than that in the control group, and the total incidence of postoperative complications was lower than that in the control group, and the differences were statistically significant (P ＜ 0.05); the satisfaction scores of disease observation, health education, ward management, nursing measuress, and complication prevention in the observation group were higher than those in the control group, and the differences were statistically significant (P ＜ 0.05). Conclusion Perioperative nursing based on the concept of enhanced recovery after surgery in the treatment of high ligation of the hernia sac can effectively reduce the postoperative pain degree of children, speed up postoperative recovery, and improve the nursing satisfaction of their families.
2022 Vol. 19 (22): 181-184,196 [Abstract] ( 13 ) HTML (1 KB)  PDF (750 KB)  ( 98 )
185 Application of health belief model in health education of patients with chronic obstructive pulmonary disease
WANG Yanxia CAO Jingdi LU Ping YU Ye
Objective To explore the application of health belief model in health education for patients with chronic obstructive pulmonary disease (COPD). Method A total of 94 COPD patients admitted to the Department of Respiratory Medicine of Shanghai East China Hospital from January 2018 to August 2021 were divided into observation group (46 cases) and control group (48 cases) by random number table method. The control group received routine health education, while the observation group received health education under the health belief model. The effects of the two groups on the mastery of relevant indicators, compliance with respiratory function exercise, satisfaction, and quality of life were compared. Results After education, the scores of rehabilitation exercise knowledge, treatment knowledge, and basic knowledge in the two groups were higher than those before education, while those of the observation group were higher than those of the control group, and the differences were statistically significant (P ＜ 0.05). The compliance of rehabilitation exercise in the observation group was better than that in the control group, and the difference was statistically significant (P ＜ 0.05). The scores of self-care ability in the two groups were higher than those before education, while those of the observation group were higher than those of the control group, and the differences were statistically significant (P ＜ 0.05). The educational satisfaction of the observation group was higher than that of the control group, and the difference was statistically significant (P ＜ 0.05). After education, the scores of disease impact, activity limitation, and nursing symptoms in the two groups were lower than those before education, while those of the observation group were lower than the control group, and the differences were statistically significant (P ＜ 0.05). Conclusion The health education effect of COPD patients under the health belief model is better, which can significantly improve patients’ compliance, self-care ability and quality of life.
2022 Vol. 19 (22): 185-188 [Abstract] ( 24 ) HTML (1 KB)  PDF (545 KB)  ( 126 )
189 Application of early warning scores for childrem combined with PDCA cycle in the triage and condition assessment of children with hand, foot, and mouth disease in outpatient clinics
ZHANG Yujing1 WANG Meilong1 HAO Hongli1 WANG Jiali1 YANG Ying2▲
Objective To explore the application of early warning scores for children combined with PDCA cycle in triage and condition assessment of children with hand, foot, and mouth disease in outpatient service of infectious department. Methods From January 2020 to July 2021, a total of 1 256 children with hand, foot, and mouth disease who were admitted to the outpatient department of the Department of Infectious Diseases of the Children’s Hospital Affiliated to the Capital Institute of Pediatrics were selected as the research objects. The patients were divided into observation group (628 cases) and control group (628 cases) by random number table method. The control group was given routine disease assessment and triage and PDCA cycle mode intervention, while the observation group was given early warning scores for children combined with PDCA cycle mode intervention. The early warning scores for children in the observation group were analyzed, while the triage and condition evaluation, treatment effect, complication rate, and parent satisfaction were compared between the two groups. Results The reasonable rate of the observation group was higher than that of the control group, and the difference was statistically significant (P ＜ 0.05). The total treatment time, antipyretic time, and rash and herpes subsidence time in the observation group were shorter than those in the control group, and the differences were statistically significant (P ＜ 0.05). The total incidence of complications in the observation group was lower than that in the control group, and the difference was statistically significant (P ＜ 0.05). The satisfaction of parents in the observation group was higher than that in the control group, and the difference was statistically significant (P ＜ 0.05). Conclusion The application of early warning score for children combined with PDCA cycle model in the outpatient department of infectious diseases for children with hand, foot and mouth disease has a significant effect, which can better complete the disease assessment and triage work, and screen out critically ill children at the first time and treat them symptomatically, thereby significantly reducing treatment time, reduce the incidence of complications, improve parental satisfaction, it is recommended to promote.
2022 Vol. 19 (22): 189-192 [Abstract] ( 18 ) HTML (1 KB)  PDF (572 KB)  ( 8 )
193 Influence of targeted nursing based on target management theory on pulmonary function, medical compliance, and prognosis of children with bronchial pneumonia
ZHU Xiaoyu XU Dan ZHOU Min▲
Objective To explore the effect of targeted nursing based on target management theory on the pulmonary function, compliance behavior, and prognosis of children with bronchial pneumonia. Methods A total of 118 children with bronchial pneumonia who were admitted to the Department of Pediatrics of the First Affiliated Hospital of the Air Force Military Medical University of Chinese People’s Liberation Army from July 2019 to June 2020 were selected and divided into control group and observation group by random number table method, with 59 cases in each group. The control group received routine targeted nursing, while the observation group received targeted nursing based on target management theory. The improvement of clinical symptoms, lung function, and prognosis were compared between the two groups. Results The time required for the disappearance of lung rales, fever, cough, and breathlessness in the observation group were shorter than those in the control group, and the differences were statistically significant (P ＜ 0.05). After nursing, the levels of vital capacity (VC), forced vital capcacity (FVC), and forced expiratory volume in the first second (FEV1) in the two groups were higher than those before nursing, and the differences were statistically significant (P ＜ 0.05). After nursing, the levels of VC, FVC, FEV1, and peak expiratory flow in the observation group were higher than those in the control group, and the differences were statistically significant (P ＜ 0.05). The recurrence rate in the observation group was lower than that in the control group, and the difference was statistically significant (P ＜ 0.05). Conclusion Targeted nursing based on target management theory can improve the symptoms and lung function of children with bronchial pneumonia, and the recurrence rate is low, which is worthy of clinical application.
2022 Vol. 19 (22): 193-196 [Abstract] ( 13 ) HTML (1 KB)  PDF (583 KB)  ( 29 )
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