右美托咪定联用氢吗啡酮对癌性爆发痛的镇痛效果及安全性

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Abstract Objective To study the analgesic effect and safety of Dexmedetomidine combined with Hydromorphone on breakthrough cancer pain (BTcP). Methods Ninety-six patients with BTcP in Liyang Branch, Jiangsu Provincial People’s Hospital from February 2020 to February 2021 were selected, they were divided into control group and observation group, with 48 cases in each group. The control group was treated with Hydromorphone for analgesia, and observation group was treated with Dexmedetomidine combined with Hydromorphone for analgesia. The analgesic effect (drug onset time, drug action time, dosage of self-controlled Hydromorphone, dosage of remedial analgesia, numerical rating scale [NRS] score, and pain degree) were compared between two groups within seven days of treatment; sleep quality (Athens insomnia scale [AIS] score) and quality of life (Spitzer quality of life index [SQOL] score) were compared before and after seven days of treatment; the total incidence of adverse reactions and satisfaction of analgesia during treatment were compared. Results Drug onset time in observation group was shorter than that in control group, drug action time was longer than that in control group, the dosage of self-controlled Hydromorphone and dosage of remedial analgesia were less than those in control group, and NRS score of BTcP attack and severity were lower than those in control group (P < 0.05). Seven days after treatment, AIS scores of two groups were lower than those before treatment, SQOL scores of two groups were higher than those before treatment, and AIS score of observation group was lower than that of control group, and SQOL score was higher than that of control group (P < 0.05). There was no significant difference in the total incidence of adverse reactions between two groups (P > 0.05). The analgesic satisfaction of observation group was better than that of control group (P < 0.05). Conclusion Dexmedetomidine combined with Hydromorphone in BTcP analgesic effect is obvious, can reduce the degree of pain, improve sleep quality and quality of life, will not increase the occurrence of adverse reactions, and patients have high satisfaction with analgesia, which is worthy of clinical promotion.

Key words： Breakthrough cancer pain Dexmedetomidine Hydromorphone Analgesic effect Security

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	PAN Yanping1 WANG Ying1 WANG Zhenhong2

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PAN Yanping1 WANG Ying1 WANG Zhenhong2. Analgesic effect and safety of Dexmedetomidine combined with Hydromorphone on breakthrough cancer pain[J]. 中国医药导报, 2022, 19(22): 100-103.

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https://www.yiyaodaobao.com.cn/EN/ OR https://www.yiyaodaobao.com.cn/EN/Y2022/V19/I22/100

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