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| Research progress on the injury molecular mechanism of small cell lung cancer injury |
| SONG Xiaofeng1 LYU Xing1 GE Shuhua1▲ LI Tian2▲ |
1.Department of Respiratory, Air Force Medical University, Shaanxi Province, Xi’an 710032, China;
2.School of Basic Medicine, Fourth Military Medical University, Shaanxi Province, Xi’an 710032, China |
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Abstract Lung cancer is a major public health problem affecting the health of Chinese people. Small cell lung cancer (SCLC) is a relatively small subtype of lung cancer, with a very low survival rate and poor prognosis. Compared to non-small cell lung cancer, research on SCLC has been slow, and many treatment principles still rely on findings from 20 years ago. This article provides a potential introduction to the background, overview, and epidemiology of SCLC, and focuses on the pathogenesis of SCLC, including oxidative stress, apoptosis, and autophagy. And this article discusss the related research progress of SCLC nursing, analyzes the potential directions, and aim to provide reference for the clinical diagnosis and treatment of SCLC.
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[1] Bogart JA，Waqar SN，Mix MD. Radiation and Systemic Therapy for Limited-Stage Small-Cell Lung Cancer [J]. J Clin Oncol，2022，40（6）：661-670.
[2] Pang LL，Gan JD，Huang YH，et al. Investigation of the optimal platinum-based regimen in the postoperative adjuvant chemotherapy setting for early-stage resected non-small lung cancer： a Bayesian network meta-analysis [J]. BMJ Open，2022，12（6）：e057098.
[3] Yang JJ，Yu D，White E，et al. Prediagnosis Leisure-Time Physical Activity and Lung Cancer Survival： A Pooled Analysis of 11 Cohorts [J]. JNCI Cancer Spectr，2022，6（2）：pkac009.
[4] Iams WT，Porter J，Horn L. Immunotherapeutic approaches for small-cell lung cancer [J]. Nat Rev Clin Oncol，2020， 17（5）：300-312.
[5] Zugazagoitia J，Paz-Ares L. Extensive-Stage Small-Cell Lung Cancer：First-Line and Second-Line Treatment Options [J]. J Clin Oncol，2022，40（6）：671-680.
[6] Huang Y，Cho HJ，Stranger BE，et al. Sex dimorphism in response to targeted therapy and immunotherapy in non-small cell lung cancer patients：a narrative review [J]. Transl Lung Cancer Res，2022，11（5）：920-934.
[7] Lim JU，Kang HS. A narrative review of current and potential prognostic biomarkers for immunotherapy in small-cell lung cancer [J]. Ann Transl Med，2021，9（9）：809-810.
[8] Maki KG，Liao K，Lowenstein LM，et al. Factors Associated With Obtaining Lung Cancer Screening Among Persons Who Smoke [J]. MDM Policy Pract，2021，6（2）：23814683 211067810.
[9] Chen Y，Jin Y，Hu X，et al. Infiltrating T lymphocytes in the tumor microenvironment of small cell lung cancer：a state of knowledge review [J]. J Cancer Res Clin Oncol，2022，148（4）：881-895.
[10] Yuan M，Zhao Y，Arkenau HT，et al. Signal pathways and precision therapy of small-cell lung cancer [J]. Signal Transduct Target Ther，2022，7（1）：187.
[11] Zhang Y，Holland E，Dinh A，et al. Bombesin-drug conjugates in targeted therapy for small cell lung cancer [J]. Am J Cancer Res，2022，12（3）：927-937.
[12] Hayes JD，Dinkova-Kostova AT，Tew KD. Oxidative Stress in Cancer [J]. Cancer Cell，2020，38（2）：167-197.
[13] Sanati M，Afshari AR，Kesharwani P，et al. Recent trends in the application of nanoparticles in cancer therapy： The involvement of oxidative stress [J]. J Control Release，2022，348：287-304.
[14] Liu R，Peng L，Zhou L，et al. Oxidative Stress in Cancer Immunotherapy：Molecular Mechanisms and Potential Applications [J]. Antioxidants （Basel），2022，11（5）：853.
[15] Heydarzadeh S，Kia SK，Zarkesh M，et al. The Cross-Talk between Polyphenols and the Target Enzymes Related to Oxidative Stress-Induced Thyroid Cancer [J]. Oxid Med Cell Longev，2022，2022：2724324.
[16] Xu S，Lam SK，Cheng PN，et al. Recombinant human arginase induces apoptosis through oxidative stress and cell cycle arrest in small cell lung cancer [J]. Cancer Sci，2018，109（11）：3471-3482.
[17] Diepstraten ST，Anderson MA，Czabotar PE，et al. The manipulation of apoptosis for cancer therapy using BH3-mimetic drugs [J]. Nat Rev Cancer，2022，22（1）：45-64.
[18] Xu L，Huang X，Lou Y et al. Regulation of apoptosis，autophagy and ferroptosis by non-coding RNAs in metastatic non-small cell lung cancer[J]. Exp Ther Med，2022，23（5）：352.
[19] Fung S，Knoefel WT，Krieg A. Clinicopathological and Prognostic Significance of Inhibitor of Apoptosis Protein （IAP） Family Members in Lung Cancer：A Meta-Analysis [J]. Cancers，2021，13（16）：4098.
[20] Lam LT，Lin X，Faivre EJ，et al. Vulnerability of Small-Cell Lung Cancer to Apoptosis Induced by the Combination of BET Bromodomain Proteins and BCL2 Inhibitors [J]. Mol Cancer Ther，2017，16（8）：1511-1520.
[21] Huo Z，Su Y，Dong Y，et al. Rho-kinase inhibition by Fasudil promotes tumor maturation and apoptosis in small-cell lung cancer [J]. Am J Transl Res，2020，12（8）：4354-4370.
[22] Liu H，Wei S，Zhang L，et al. Secreted Phosphoprotein 1 Promotes the Development of Small Cell Lung Cancer Cells by Inhibiting Autophagy and Apoptosis [J]. Pathol Oncol Res，2019，25（4）：1487-1495.
[23] Chang KJ，Yin JZ，Huang H，et al. Arsenic trioxide inhibits the growth of cancer stem cells derived from small cell lung cancer by downregulating stem cell-maintenance factors and inducing apoptosis via the Hedgehog signaling blockade [J]. Transl Lung Cancer Res，2020，9（4）：1379-1396.
[24] Li D，Tong Q，Lian Y，et al. Inhibition of lncRNA KCNQ1OT1 Improves Apoptosis and Chemotherapy Drug Response in Small Cell Lung Cancer by TGF-beta1 Mediated Epithelial-to-Mesenchymal Transition [J]. Cancer Res Treat，2021，53（4）：1042-1056.
[25] Wang X，Li W，Zhang N，et al. Opportunities and challenges of co-targeting epidermal growth factor receptor and autophagy signaling in non-small cell lung cancer [J]. Oncol Lett，2019，18（1）：499-506.
[26] Rezaei S，Mahjoubin-Tehran M，Aghaee-Bakhtiari SH，et al. Autophagy-related MicroRNAs in chronic lung diseases and lung cancer [J]. Crit Rev Oncol Hematol，2020， 153：103063.
[27] Wang J，Gong M，Fan X，et al. Autophagy-related signaling pathways in non-small cell lung cancer [J]. Mol Cell Biochem，2022，477（2）：385-393.
[28] Shen W，Zhang W，Ye W，et al. SR9009 induces a REV-ERB dependent anti-small-cell lung cancer effect through inhibition of autophagy [J]. Theranostics，2020，10（10）：4466-4480.
[29] Yan Y，Shao X，Gu W，et al. Recombinant virus expressing hIFN-lambda1 （rL-hIFN-lambda1） has important effects on endoplasmic reticulum stress，autophagy and apoptosis in small cell lung cancer [J]. Transl Cancer Res，2020，9（9）：5209-5217.
[30] Shen Y，Zhou Y，Hou J，et al. Application effects of evidence-based nursing in pain nursing of advanced lung cancer [J]. Am J Transl Res，2021，13（8）：9479-9484. |
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