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| Epigenetic regulation and its mechanism of action in bronchial asthma research progress |
| YANG Yang1 SU Chang2 ZHANG Qiuyan3 HUANG Shuchun1 KUANG Huifang1#br# |
1.College of Traditional Chinese Medicine, Hunan University of Chinese Medicine, Hunan Province, Changsha 410208, China;
2.Xiangxing College, Hunan University of Chinese Medicine, Hunan Province, Changsha 410208, China;
3.School Hospital of Hunan University of Chinese Medicine, Hunan Province, Changsha 410208, China |
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Abstract Bronchial asthma is a common respiratory disease in the world, with a high incidence and recurrent disease, which seriously affects human health. In recent years, epigenetic mechanisms mediating the pathological mechanism of bronchial asthma induced by exposure to allergens, air pollutants, viral infections, and other environmental factors have attracted much attention, providing a new way to elucidate the interaction between genes and the environment. This article reviews the roles and mechanisms of DNA methylation, histone methylation, histone acetylation, and non-coding RNA in the occurrence and development of asthma, in order to clarify the epigenetic regulation mechanism of asthma and provide a new target for the treatment of asthma.
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