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2022 Vol. 19, No. 19 Published: 2022-07-05

	5	Study on serum lipidomics of non-alcoholic fatty liver disease patients based on UPLC-Q-Orbitrap / MS technology
		TIAN Jiyun DU Shengnan GAO Jingjing YUAN Yifu CAO Qin▲ JIANG Yuanye▲
		Objective To study the characteristics of lipid metabolism in patients with non-alcoholic fatty liver disease (NAFLD) based on serum lipidomics. Methods A total of 30 NAFLD patients and 30 normal people in Putuo District Central Hospital of Shanghai from January 2020 to January 2021 were included in the study. UPLC-Q-Orbitrap / MS was used for lipidomics analysis of serum of two groups. Principal component analysis and orthogonal partial least squares discriminant analysis were used for multidimensional statistical analysis of data, metabolites with VIP value >1 and P < 0.05 were used as differential lipid biomarkers. Results There were statistically significant differences in body mass index, alkaline phosphatase, total protein, cholinesterase, urea, and triglyceride between two groups (P < 0.05). There were no significant differences in age, gender, total bilirubin, direct bilirubin, albumin, γ-glutamic transpeptidase, alanine aminotransferase, aspartate aminotransferase, total bile acid, creatinine, uric acid, glomerular filtration rate, high density lipoprotein cholesterol, low density lipoprotein cholesterol, and total cholesterol between two groups (P > 0.05). A total of 181 differential lipid biomarkers were screened, including triglyceride, diglyceride, sphingomyelin, phosphatidylserine, phosphatidylcholines, phosphatidylinositols, phosphatidylglycerides, phosphatidylethanolamines, O-acyl-ω-hydroxy fatty acid, monoglyceride, lysophosphatidylinositol, lysophosphatidylglyceride, lysophosphatidylethanolamine, lysoph- osphatidylcholine, and ceramide. Conclusion Lipid metabolism in NAFLD patients is significantly different from that in the normal population, 181 lipid biomarkers screened in this study can be used as potential new targets for NAFLD.
		2022 Vol. 19 (19): 5-11 [Abstract] ( 50 ) HTML (1 KB) PDF (1177 KB) ( 155 )

	12	Effect of Rapamycin on rats with non-alcoholic fatty liver disease
		TAN Liping1 CHEN Wenhui2 SHI Anhua3 WU Junzi1 ZHU Xiaosong1 ZHANG Shan1
		Objective To investigate the effect of Rapamycin on rats with non-alcoholic fatty liver disease (NAFLD) and its mechanism. Methods Twenty-four clean grade male SD rats, weighing 180-220 g, were selected, and eight of them were randomly selected as normal group and fed ordinary diet. The remaining 16 animals were fed high-sugar and high-fat diet to construct NAFLD model. Six weeks later, the model was successfully built, and after this, they were divided into model group and Rapamycin group according to random number table method, with eight animals in each group. Rapamycin group was given 2.8 mg/(kg·d) of Rapamycin intragastric administration, normal group and model group were given the same amount of normal saline intragastric administration for four weeks. After the experiment, hematoxylin-eosin staining and oil red O staining were used to observe the pathological changes of liver tissues in each group. Serum total cholesterol (TC), triglyceride (TG), glutamic-oxalacetic transaminase (GOT), glutamic-pyruvic transaminase (GPT), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C) levels, and liver tissue TC and TG levels were detected and compared among all groups. The expression levels of autophagy associated protein (Beclin1, ATG5), microtubule associated protein 1 light chain 3B (LC3B)-Ⅱ / LC3B-Ⅰ, and ubiquitin binding protein p62 in liver tissues of all groups were detected and compared. Results No obvious abnormality was observed in the morphology of liver cells in the normal group. In the model group, hematoxylin-eosin staining showed that there were fat vacuoles of different sizes in most liver cells, and oil red O staining showed that lipids in most liver cells were dyed orange. In Rapamycin group, there were less fat vacuoles and orange-red in liver tissue by hematoxylin-eosin staining and oil red O staining. Serum TC, TG, LDL-C, GOT, GPT, and liver tissue TC and TG levels in model group were higher than that in normal group, while serum HDL-C level was lower than that in normal group (P ＜ 0.05 or P ＜ 0.01). Serum TC, TG, LDL-C, and HDL-C levels in Rapamycin group were higher than those in model group, while serum GOT, GPT, and liver TC and TG levels were lower than those in model group (P ＜ 0.05 or P ＜ 0.01). The expression levels of Beclin1, LC3B-Ⅱ/ LC3B-Ⅰ, and ATG5 in the model group were lower than those in the normal group, while ubiquitin binding protein p62 was higher than that in the normal group (P ＜ 0.05). The expression levels of Beclin1, LC3B-Ⅱ/ LC3B-Ⅰ, and ATG5 in Rapamycin group were higher than those in model group, while ubiquitin binding protein p62 was lower than that in model group (P ＜ 0.05 or P ＜ 0.01). Conclusion Rapamycin has protective effect on NAFLD rats, and its mechanism may be related to enhance the level of autophagy in liver tissue.
		2022 Vol. 19 (19): 12-15 [Abstract] ( 56 ) HTML (1 KB) PDF (1410 KB) ( 26 )

	16	Bibliometric and visual analysis of traditional Chinese medicine in the treatment of atherosclerosis based on CiteSpace
		XUE Wenjing HU Yuanhui YANG Yige CHAI Ruoning XU Rongrong
		Objective To explore the research status, hotspots, and trends of traditional Chinese medicine in the field of atherosclerosis in recent five years, and to make quantitative, co-occurrence and visual analysis of relevant literatures. Methods Literatures related to the treatment of atherosclerosis with traditional Chinese medicine from January 2015 to January 2020 were retrieved from China National Knowledge Infrastructure database. After screening, the literatures were imported into CiteSpace to analyze the number of published articles, co-occurrence analysis of authors and institutions, co-occurrence analysis and cluster analysis of keywords, etc. Results Since 2015, the number of traditional Chinese medicine publications in the field of atherosclerosis had been on the rise. There were a large number of scattered authors on the application of traditional Chinese medicine in the field of atherosclerosis, as well as relatively stable and high-yield research teams. The main research institutions were more dispersed. Hot keywords form ten clusters. From 2018 to 2020, network pharmacology had become a hot topic. Conclusion The number of articles published by traditional Chinese medicine in the field of atherosclerosis is generally on the rise, and the study of the law, mechanism, and complications of atherosclerosis medication has become a hot spot and main trend in recent years.
		2022 Vol. 19 (19): 16-19,24 [Abstract] ( 57 ) HTML (1 KB) PDF (2740 KB) ( 157 )

	20	Content determination and cluster analysis of phenylphthalides in Radix Angelica Sinensis from different habitats
		GONG Tao YANG Wei WANG Xia ZHOU Deyong GONG Jianting LI Li SONG Jingmei HU Yinyan
		Objective To establish an high performance liquid chromatography method for content determination of four kinds of phenylphthalides in Radix Angelicae Sinensis, and to evaluate its quality by cluster analysis. Methods The Agilent Eclipse Plus C18 column (4.6 mm×150 mm, 3.5 μm) was used as the column. The mobile phase was composed of acetonitrile-water with gradient elution at a flow rate of 1 ml/min. The column temperature was 35℃. The detection wavelength were set at 284 nm for senkyunolide I and senkyunolide A, 326 nm for ligustilide, and 260 nm for 3-butylidenephthalide. SPSS 26.0 statistical software was performed on cluster analysis. Results All the four components could achieve baseline separation with good liner relationships (r = 0.9999), and the calibration curves of senkyunolide I, senkyunolide A, ligustilide and 3-butylidenephthalide were in good linearity over the range of 5.85×10-3 to 0.234 μg, 1.12×10-2 to 0.446 μg, 0.416 to 16.64 μg, 5.20×10-3 to 0.208 μg. The average recoveries were between 98.33% and 102.22%, with the RSD between 1.36% and 3.61%. The samples of Radix Angelica Sinensis from different habitats could be divided into two species according to the content in different parts. For Radix Angelicae Sinensis head, the ones from Yunnan Qujing 1, Yunnan Baiyao Base 1 and Yunnan Nujiang were grouped together, and the others were grouped together. For Radix Angelicae Sinensis body, the ones from Yunnan Qujing 1, Yunnan Nujiang 2, Hubei Shennongjia, and Yunnan Baiyao Base 1 were grouped together, and the others were grouped together. Conclusion The method is simple, accurate and specific, for the determination of four phenylphthalides in Radix Angelicae Sinensis, which can provide reference for the quality evaluation and comprehensive development and utilization of Angelica Sinensis.
		2022 Vol. 19 (19): 20-24 [Abstract] ( 24 ) HTML (1 KB) PDF (1810 KB) ( 38 )

	25	Effect of Mongolian medicine Agaru-25 on pulmonary fibrosis in mice#br#
		JIA Ruo1 WANG Yongqing1 YANG Yumin2 LI Yanhua2 SU Baoke2 LIU Lixin2
		Objective The effect of Mongolian medicine Agaru-25 on pulmonary fibrosis in mice. Methods Seventy-two healthy SPF C57BL/6 mice were selected, ten mice were randomly selected as normal group, Bleomycin was injected into the trachea of the other 62 mice after anesthesia to establish pulmonary fibrosis model. On the 28th day of modeling, seven mice died. After successful molding, the mice were divided into model group (n = 10), Western medicine group (n = 9, 13 mg/ml), Mongolian high group (n = 9, 6.5 mg/ml), Mongolian middle group (n = 9, 3.25 mg/ml), Mongolian low group (n = 9), and Chinese medicine group (n = 9) according to random number table method, after eight weeks of intragastric administration, mice in each group were sacrificed for sampling. Immunohistochemical staining and Masson staining were used to observe the pathological changes and fibrosis of lung tissues, Western blot was used to detect the expression of transforming growth factor -β1 (TGF-β1), receptor phosphate cytoplasmic protein (p-Smad3), fibronectin (FN) and, osteopontin (OPN) in lung tissues, and Tunel was used to detect the apoptosis rate. Results Compared with model group, the pathological morphology of lung tissue in Mongolian high group, Mongolian middle group and Mongolian low group was significantly improved, the percentage of collagen fiber area in model group was higher than that in normal group, the percentage of collagen fiber area in each administration group was lower than that in model group, and the percentage of collagen fiber area in Mongolian group was lower than that in other administration groups, and the differences were statistically significant (P ＜ 0.05). The protein expressions of TGF-β1, p-Smad3, FN, and OPN in the treatment group were lower than those in the model group, and the protein expressions of TGF-β1, p-Smad3, FN, and OPN in the Mongolian high group were lower than those in the other Mongolian medicine groups, and Mongolian middle group were lower than Mongolian low group, and the differences were statistically significant (P ＜ 0.05). The apoptosis rate of the each Mongolian medicine groups was lower than that of the model group, and the apoptosis rate of Mongolians group was lower than that of other Mongolian medicine groups, and Mongolian middle group were lower than Mongolian low group, and the differences were statistically significant (P ＜ 0.05). Conclusion The anti-pulmonary fibrosis mechanism of the Mongolian medicine Agaru-25 may be related to the inhibition of the TGF-β/Smad signaling pathway.
		2022 Vol. 19 (19): 25-28,33 [Abstract] ( 23 ) HTML (1 KB) PDF (1630 KB) ( 23 )

	29	Analysis of Professor Cheng Weiping’s medication rule in the treatment of ischemic stroke based on data mining
		LIU Yue1 CHENG Guangyu2 CHENG Weiping3
		Objective To summarize the prescription and medication rule of Professor Cheng Weiping in the treatment of ischemic stroke. Methods The electronic medical record data of Professor Cheng Weiping in outpatient department of First Affiliated Hospital, Heilongjiang University of Chinese Medicine from January 2018 to June 2021 were extracted, related medical records were screened, processed and input into traditional Chinese medicine inheritance computing platform V3.0. Statistical methods such as frequency analysis, cluster analysis and association rules were used to summarize core drugs and summarize the rules of differentiation and treatment. Results A total of 273 prescriptions involving 162 Chinese medicines were included. There were ten Chinese medicines with use frequency > 100, and Persicae Semen and Carthami Flos were used 155 times. There were nine categories of drug efficacy use frequency > 100, and 34 groups of drug combinations ≥60; there were 31 drug combinations with the confidence of drug pair association coefficient ≥0.85. Conclusion Professor Cheng Weiping’s main principles for the treatment of this disease are “promoting blood circulation for removing blood stasis, dispelling wind and evil, purging phlegm and clearing collaterals, tonifying deficiency and invigorating spleen and permeating dampness”.
		2022 Vol. 19 (19): 29-33 [Abstract] ( 24 ) HTML (1 KB) PDF (1374 KB) ( 96 )

	34	Research progress of the role of phospholysine phosphohistidine inorganic pyrophosphate phosphatase in tumor
		TANG Xiang1 WANG Jingzhi2 LIU Na1 CHEN Deyu1
		Phospholysine phosphohistidine inorganic pyrophosphate phosphatase (LHPP) is one of the important enzyme regulating histidine dephosphorylation, mainly expressed in liver, brain and kidney, and the regulation of histidine residues together with histidine kinase phosphorylation and dephosphorylation. The deletion of LHPP can destroy the balance between phosphorylation and dephosphorylation of histidine residues, resulting in PI3K/Akt and Wnt/β-catenin which, leads to the abnormality of cyclin and apoptotic protein, and promotes the occurrence and development of tumor. LHPP is significant for early screening, early diagnosis, treatment and prognosis of tumor patients, and it is expected to become a new therapeutic target and prognostic index for individualized treatment of patients. Based on the previous literature research, this review summarizes the research progress of the role of LHPP in some tumors such as liver cancer, glioma, and kidney cancer, in order to provide reference for the future research direction and application of LHPP in tumors.
		2022 Vol. 19 (19): 34-40 [Abstract] ( 47 ) HTML (1 KB) PDF (784 KB) ( 286 )

	41	Research progress of adipokines in nonalcoholic fatty liver disease
		SHI Xiangtian1 XU Yanan2 WANG Meng1 QIAO Tongshan1 QIAO Shan1 WANG Mancang1 OUYANG Xiaohui2 SU Xiulan2
		With the increasing prevalence of obesity related metabolic diseases in the world, the proportion of nonalcoholic fatty liver disease (NAFLD) in liver diseases is gradually increasing, and the disease brings related disabilities. Complications have brought a heavy burden to patients suffering from the disease and social medical care. Non-alcoholic steatohepatitis is the body’s glucose and fat metabolism disorder, systemic low-grade inflammation. Then pro-inflammatory and anti-inflammatory adipokines, as a hormone of secretion, is secreted by adipose tissue (AT) that compose the AT-liver axis. But the adipokines have different functions between the processes of inflammation and pro-inflammatory. It will be effective in liver transport, fat breakdown ability and liver fat deposition, and regulating the development of NAFLD. This article focuses on the expression level and mechanism of adiponectin, leptin, resistin, visfatin, retinol binding protein 4, and other adipokines in the progression of NAFLD disease. With the improvement of adipokines research and the follow-up of clinical research, new strategies and new ideas are provided for the treatment of adipokines in NAFLD disease.
		2022 Vol. 19 (19): 41-44,65 [Abstract] ( 23 ) HTML (1 KB) PDF (1062 KB) ( 278 )

	45	Research progress in associated immunotherapy of memory CD8+ T cells in hepatocellular carcinoma
		ZHANG Xiaoyu XU Ximing
		Hepatocellular carcinoma (HCC), as the most common type of primary liver cancer, leads to heavy economic and health burdens to patients. With the progress of immunology research about HCC, the role of memory CD8+ T cells in HCC suppression is gradually recognized. This article reviewes exogenous and endogenous immunotherapy based on the specific distribution, surface molecules, and functions of memory CD8+ T cells subsets. The exogenous immunotherapy mainly contains adoptive immunotherapy carried by memory CD8+ T cells, while the endogenous mainly contains targeted therapies targeting immunosuppressive molecules. Memory CD8+ T cell-associated immunotherapy has shown good efficacy in both animal and human trials in HCC, and it is hopeful for a bright future to the treatment of HCC.
		2022 Vol. 19 (19): 45-48,69 [Abstract] ( 52 ) HTML (1 KB) PDF (493 KB) ( 157 )

	49	Research progress on the mechanism of general anesthesia on developing brain injury in children and related brain protection measures
		YU Yang YU Yonghao
		Receiving multiple or long-term general anesthesia in infants and young children may affect the brain development of children, thereby affecting their learning and memory functions in adulthood, but the mechanism has not been unified. At present, it includes dendritic spine remodeling, non-microtubule-binding Tau protein, apolipoprotein E toxic fragment, and related promoter DNA methylation. In this paper, the relevant evidence of the effect of general anesthesia on the developing brain of children and the more popular mechanisms and brain protection measures in recent years are sorted out, in order to provide new ideas for the research and clinical treatment of the mechanism of general anesthesia-induced developmental brain-related injury.
		2022 Vol. 19 (19): 49-52 [Abstract] ( 55 ) HTML (1 KB) PDF (460 KB) ( 215 )

	53	Research progress of enolase -α and C-MYC promoter binding protein-1 regulating the occurrence and progression of hepatocellular carcinoma based on PI3K/Akt pathway
		XU Weixin WANG Chunfang LUO Yanhong
		Enolase-α (ENO1) is a type of key glycolysis enzyme with tissue-specific expression, which participates in glycolysis and affects the process of glycolysis. C-MYC promoter binding protein-1 (MBP-1) can inhibit the expression of oncogene C-MYC. At present, it has been found that they are expressed by the same genetic encode, and there is a complex relationship between their expression regulation and the PI3K/Akt pathway. ENO1 and MBP-1 play an important role in the progression and inhibition of tumors such as hepatocellular carcinoma (HCC) by regulating the PI3K/Akt pathway. This paper briefly reviewes the function of ENO1 and MBP-1, their expression regulation, and their relationship with PI3K/Akt signal pathway as well as the mechanism of this pathway on HCC. Thus we can explore possible molecular mechanism for the occurrence and progression of HCC so as to provide a theoretical basis for molecular targets to regulate this mechanism. It aims to provide new ideas for the effective treatment of HCC in the future.
		2022 Vol. 19 (19): 53-56 [Abstract] ( 50 ) HTML (1 KB) PDF (635 KB) ( 71 )

	57	Research progress on molecular biomarkers of endometrial atypical hyperplasia
		LYU Mingyi1 SUN Huiting2 LIU Huijun2 WANG Linxiao3 LIU Sufen4
		Endometrium atypical hyperplasia (EAH) is the precancerous lesion of endometrial cancer, its incidence rate is increasing year by year. With the continuous updating of the screening methods, the detection methods of EAH lesions are constantly updated. At present, the most commonly used detection method in clinic is histopathological examination, but there is no specific molecular biomarker. This paper reviews the recent advances in molecular biomarkers for diagnosis of EAH, such as steroid hormone receptors (estrogen receptors, progesterone receptors), proto-oncogenes and tumor suppressor genes (B-lymphocytoma-2, phosphatase and tensin homologues, P53, and AT-rich domain protein 1A), microRNA and their research status was analyzed.
		2022 Vol. 19 (19): 57-60 [Abstract] ( 50 ) HTML (1 KB) PDF (446 KB) ( 26 )

	61	Application progress of pharyngeal electrical stimulation in rehabilitation of patients with dysphagia after stroke
		JIANG Jianhua1 JIANG Qiaoli2 LI Caihong1 LIANG Juanming3 HU Qiongyan4
		Dysphagia after stroke seriously affects the prognosis and quality of life of patients, and poses a heavy burden on patients, families, and society. More effective rehabilitation methods are urgently needed in clinic. In recent years, as a new technique for the treatment of neurological dysphagia, pharyngeal electrical stimulation has shown good curative effect on the rehabilitation of patients with dysphagia after stroke, which can improve swallowing function, reduce aspiration, and promote the early removal of tracheotomy cannula, and has good tolerance and safety. In this paper, the mechanism, treatment parameters, application effect, and tolerance, effectiveness and safety of pharyngeal electrical stimulation are expounded in order to provide a new method for clinical rehabilitation intervention of patients with dysphagia after stroke.
		2022 Vol. 19 (19): 61-65 [Abstract] ( 19 ) HTML (1 KB) PDF (548 KB) ( 48 )

	66	Research progress on the effect and mechanism of extracorporeal shock wave on nonspecific low back pain
		FAN Yongfu1 SU Kaiqi1 YUAN Jie1 NIE Chenchen1 RUAN XiaoDi1 LIU Feilai2 FENG Xiaodong2
		Non-specific low back pain (NLBP) is a common degenerative disease in clinic, which has attracted wide attention due to its high incidence rate and disability rate. The pathogenesis of the disease is complicated, and there is no better treatment strategy at present. In recent years, extracorporeal shock wave therapy (ESWT) has been widely used to eliminate inflammation in tissues, promote blood circulation and improve central sensitization; it can significantly alleviate waist pain in patients with NLBP, improve muscle and joint function, is non-invasive and safe, and it has been recognized by the majority of patients, is worthy of clinical promotion. This article summarizes the clinical efficacy and mechanism research progress of ESWT in the treatment of NLBP, in order to provide reference for clinical application and research.
		2022 Vol. 19 (19): 66-69 [Abstract] ( 60 ) HTML (1 KB) PDF (517 KB) ( 71 )

	70	Exploration on the cultivation of ideological and political construction ability of medical professional teachers
		JIANG Rilei1 JIN Yong2 CHEN Xiaolei3 WU Zhongping1 LI Qian4 XIAO Bo5
		Based on nearly 10 years of practice and research, Shanghai University of Traditional Chinese Medicine has explored the connotation of curriculum ideological and political construction, analyzed the problems existing in teachers’ curriculum ideological and political construction ability, and gradually formed a series of measures to cultivate teachers’ curriculum ideological and political construction ability. It mainly includes: academic forums to improve theoretical level, multi-level project research to open up growth path, demonstration team to teach and build experience, thematic websites to promote cutting-edge learning, workshops to reserve talents, and teacher-student interaction to achieve full education. Through repeated exploration and practice, professional teachers have significantly improved their ability of ideological and political construction in curriculum, produced many teaching achievements and played a leading role in demonstration.
		2022 Vol. 19 (19): 70-73,102 [Abstract] ( 27 ) HTML (1 KB) PDF (759 KB) ( 55 )

	74	Application effect of situational simulation teaching method in undergraduate clinical nursing education in psychiatry department
		CAI Min SHI Yanru GUO Li QIAO Yuting WANG Huaning
		Objective To explore the application effect of situational simulation teaching method in undergraduate clinical nursing education in psychiatry department. Methods From December 2017 to December 2019, 90 full-time undergraduate students who received Psychiatry courses jointly undertaken by Department of of Psychiatry, the First Affiliated Hospital of Air Force Military Medical University and Department of Nursing, Air Force Medical University were selected as research objects. According to the random number table method, they were divided into experimental group and control group, with 45 students in each group. The experimental group was reveived situational simulation teaching method, while the control group was adopted with traditional teaching method. The theoretical knowledge and operational skills, teaching effect satisfaction, and comprehensive ability between two groups were compared. Results The scores of theoretical knowledge and operational skills of students in experimental group were higher than those in control group, and the differences were statistically significant (P < 0.05). The scores of overall teaching evaluation, learning interest, learning active and initiative, independent learning motivation, improve the ability to analyze and solve problems, interpersonal communication skills, teamwork spirit, help for future work, and total scores of students in experimental group were higher than those in control group, and the differences were statistically significant (P < 0.05). The scores of effective communication ability, emergency response ability, psychological adaptation ability, and critical thinking of students in experimental group were higher than those in control group, and the differences were statistically significant (P < 0.05). Conclusion Situational simulation teaching method can effectively improve the theoretical assessment score and practical operation ability of nursing students in psychiatry department, and more effectively develop students’ learning enthusiasm, which is worth promoting in the follow-up teaching activities.
		2022 Vol. 19 (19): 74-77 [Abstract] ( 30 ) HTML (1 KB) PDF (592 KB) ( 80 )

	78	Thinking on teaching and assessment system for standardized training of stomatological residents in general hospitals
		WU Xi1 TAN Yinghui2
		Standardized training of resident physicians is an important part of post-graduation medical education for medical students, which is very important to accelerate the training of qualified clinicians and improve the overall level of physicians. This article elaborates the teaching and assessment status of standardized training of stomatological residents in general hospitals, it also proposes the ways to build the hierarchical teaching and assessment system. Diagnostic evaluation is formed through admission examination, and advanced teaching plans are established in groups. Proper evaluation is formed in different levels of students by process assessment, which designs the grading assessment standard. Finally, summative evaluation will be assessed in the completion assessment. This full-cycle evaluation system is more systematic and comprehensive, and can get timely feedback in multiple evaluations, so as to further optimize the hierarchical teaching system and promote the continuous improvement of standardized teaching quality and the optimization of talent training mode for stomatological residents in general hospitals.
		2022 Vol. 19 (19): 78-81 [Abstract] ( 49 ) HTML (1 KB) PDF (763 KB) ( 40 )

	82	Exploration of independent learning practice in the whole process of special internship of pharmacy majors
		ZHU Haitao1 ZHAO Yonghen2 CHEN Lin1 CHEN Li1
		Independent learning ability is a necessary quality for innovative talents, and the cultivation of this ability should run through the whole process of education. In the process of internship for pharmacy students, traditional methods are still adopted at present, and no attention is paid to the improvement of independent learning ability. Exploring and improving students’ independent learning ability is an important topic facing pharmacy education at present. This study observes the learning behavior of students in the process of internship, analyzes the relationship between internship characteristics and independent learning, summarizes teaching experience, and then puts forward guidance strategies for independent learning, and carries out practical verification. After the whole process of independent learning and training, students have effectively changed their passive learning state, promoted the improvement of independent learning ability, and laid the foundation for future ability improvement.
		2022 Vol. 19 (19): 82-85 [Abstract] ( 16 ) HTML (1 KB) PDF (935 KB) ( 100 )

	86	Exploration of cultivation of cultural dissemination ability of chinese pharmacy students based on outcome-based foreign language teaching reform
		LI Yanwei1 BAO Lei2 ZHANG Lihong1 ZHU Hongbing1 QI Jiajia1
		With increasingly frequent international exchanges, the dissemination of traditional Chinese medicine is arduous. The concept of outcome-based education is introduced more and more in medical education to enhance the cultural communication ability of medical students, and inject continuous power for the revitalization and development of traditional Chinese medicine culture and the construction of healthy China. This paper starts with challenges faced by traditional Chinese medicine culture dissemination, reviews outcome-based education theoretical connotation, and discusses the foreign language teaching reform in Chinese pharmacy based on the outcome-based education concept as the core. Exploring and practicing the teaching objective centered on outcome-based education concept, enrich the teaching content, improve the teaching means and optimize the teaching evaluation, which aims to renew educational idea and teaching behavior. Based on the outcome-based education concept foreign language teaching reform will enhance Chinese pharmacy students’ subjective initiative of cultural dissemination, cultivate innovative traditional Chinese medicine culture dissemination talents, and provide certain reference significance for medical education in traditional Chinese medicine colleges and universities.
		2022 Vol. 19 (19): 86-89 [Abstract] ( 16 ) HTML (1 KB) PDF (584 KB) ( 238 )

	90	Visual analysis of researches related to hypertension complicated with erectile dysfunction using CiteSpace software
		WANG Jisheng1 WANG Xian2 LI Haisong1 DENG Sheng1 LI Haiyan2 LI Yiming2
		Objective To analyze the domestic research status of hypertension complicated with erectile dysfunction. Methods Using CNKI database as the data source, the CiteSpace software was used to visualize and analyze the related researches on hypertension and erectile dysfunction in the period of more than 30 years from January 1990 to August 2021. The authors of relevant studies, the distribution of institutions were explored, and keywords were analyzed. Results A total of 144 Chinese literatures were included, and the annual publication volume was showed a trend of rising fluctuations; the core authors had formed a number of relatively stable research teams, but the cooperation between the teams was not close; keyword analysis found that there were multi-dimensional and multi-level research types involving clinical trials, basic experiments, and famous doctors’ experience. Conclusion This study provides a three-dimensional summary of the current research progress on the relationship between hypertension and erectile dysfunction, and provides potentially valuable information for researchers.
		2022 Vol. 19 (19): 90-93 [Abstract] ( 19 ) HTML (1 KB) PDF (1746 KB) ( 16 )

	94	Correlation between self-disclosure and social alienation, psychosocial adjustment in patients with psoriasis and its influencing factors analysis
		ZHANG Lianyun ZHU Beibei LIU Hongxia▲
		Objective To analyze the correlation of self-disclosure and social alienation, psychosocial adjustment in patients with psoriasis and influencing factors. Methods A total of 316 patients with psoriasis who visited the Department of Dermatology, Xinjiang Medical University Affiliated Hospital of Traditional Chinese Medicine from January 2019 to August 2021 were collected as research subjects. The levels of self-disclosure, social alienation, and psychosocial adaptation were assessed using the distress disclosure index (DDI), general alienation scale (GAS), and self-report psychosocial adjustment to illness scale (PAIS-SR). Pearson correlation was used to analyze the correlation between DDI total score and GAS total score and PAIS-SR total score, and the influencing factors of the level of self-disclosure in patients with psoriasis were analyzed. Results A total of 336 questionnaires were distributed in this survey, and 316 valid questionnaires were recovered, with an effective recovery rate of 94.05%. The total score of DDI in patients with psoriasis was (28.58±7.96) points, the total scores of GAS and PAIS-SR were (34.23±9.64) points and (31.90±9.55) points, respectively. There were significant differences in the total DDI scores of patients with different age, marital status, recurrent psoriasis, combined anxiety, and social support level (P ＜ 0.05). Pearson correlation analysis showed that the total score of DDI was negatively correlated with the total scores of GAS and PAIS-SR (r = -0.437, -0.505, P ＜ 0.01). Multiple linear regression analysis showed that age, marital status, recurrent psoriasis, combined anxiety, and social support were the influencing factors of self-disclosure level in patients with psoriasis (P ＜ 0.05). Conclusion The self-disclosure in patients with psoriasis is at a low level, and the lower the level of self-disclosure, the higher the level of social alienation, and the worse the level of psychosocial adaptation. Age, marital status, recurrent psoriasis, combined anxiety, and social support are the influencing factors of self-disclosure level in patients with psoriasis, and targeted intervention should be carried out to improve their self-disclosure level.
		2022 Vol. 19 (19): 94-97 [Abstract] ( 23 ) HTML (1 KB) PDF (757 KB) ( 42 )

	98	Effect of Liraglutide combined with Metformin on type 2 diabetes mellitus patients with coronary heart disease
		LIANG Huibin1 HAN Yi2
		Objective To observe the effect of Liraglutide combined with Metformin on patients with type 2 diabetes mellitus (T2DM) complicated with coronary heart disease. Methods The clinical data of 80 patients with type 2 diabetes mellitus and coronary heart disease admitted to the Department of Endocrinology of the Second Hospital of Shanxi Medical University from January to August 2021 were prospectively analyzed. According to the random number table method, they were divided into observation group and control group, with 40 cases in each group. The observation group was given Liraglutide and Metformin on the basis of the basic treatment of coronary heart disease, while the control group was given Metformin on the basis of the basic treatment of coronary heart disease. The changes in clinical efficacy, blood glucose, blood lipids, cardiac ultrasound, body mass index (BMI), nociceptin/orphanin FQ peptide (N/OFQ), and lipoprotein-associated phospholipase A2 (Lp-PLA2) before and after treatment were compared between the two groups. Results The clinical efficacy of the observation group was better than that of the control group, and the difference was statistically significant (P ＜ 0.05). After treatment, the fasting plasma glucose (FPG), 2 h postprandial blood glucose (2hPG), glycosylated hemoglobin (HbAlc), triglyceride (TG), total cholesterol (TC), high-density lipoprotein cholesterol (LDL-C), left ventricular end-diastolic diameter (LVEDD), BMI, N/OFQ, and Lp-PLA2 levels were lower than those before treatment, while high density lipoprotein cholesterol (HDL-C), left ventricular ejection fraction (LVEF), maximum peak velocity of early diastolic / maximum peak velocity of late diastolic (E/A) levels of the two groups were higher than those before treatment, and the differences were statistically significant (P ＜ 0.05). After treatment, the indexes of TG, TC, LDL-C, LVEDD, BMI, N/OFQ, and Lp-PLA2 in the observation group were lower than those in the control group, while the indexes of HDL-C, LVEF, and E/A were higher than those in the control group, and the differences were statistically significant (P ＜ 0.05). Conclusion Liraglutide combined with metformin can effectively regulate blood sugar, blood lipids, cardiac function, BMI, N/OFQ, and Lp-PLA2. The effect is better than Metformin alone, with fewer adverse reactions.
		2022 Vol. 19 (19): 98-102 [Abstract] ( 53 ) HTML (1 KB) PDF (649 KB) ( 65 )

	103	Meta-analysis of clinical efficacy and safety of stellate ganglion block in the treatment of postherpetic neuralgia
		MU Qiang1 CHAI Junlong1 LYU Honglin1 REN Da1 LIU Wenhua1 HUANG Yuanxin2 WANG Lin2
		Objective To evaluate the efficacy and safety of stellate ganglion block in the treatment of postherpetic neuralgia. Methods The randomized controlled trials of stellate ganglion block in the treatment of postherpetic neuralgia were searched in PubMed, The Cochrane Library, Embase, CNKI, CBM, VIP, and Wangfang Data from inception to April 2021. The selected literatures were evaluated according to the Cochrane bias risk assessment tool, and then the RevMan 5.4 version of the software was used for meta-analysis. Results A total of eight literatures were screened. Meta-analysis showed that the total effective rate of treatment in experimental group was higher than that in control group (OR = 4.50, 95%CI: 2.18 to 9.27, P < 0.0001), and the pain score after treatment in experimental group was lower than that in control group (MD = -0.66, 95%CI: -0.87 to -0.45, P ＜ 0.000 01). There was no significant difference in the incidence of adverse reactions between the two groups (OR = 0.58, 95%CI: 0.27 to 1.22, P = 0.15). Conclusion Stellate ganglion block is a safe and effective treatment for postherpetic neuralgia, which can obviously improve the total effective rate and relieve pain symptoms.
		2022 Vol. 19 (19): 103-106 [Abstract] ( 58 ) HTML (1 KB) PDF (1794 KB) ( 272 )

	107	Effect of isokinetic strength training on knee muscle strength and fall risk in the elderly
		CHENG Wenchang1 HUO Shaochuan2 LIU-FU Yifei2 ZHANG Congyu2 YANG Junxing2
		Objective To explore the effect of isokinetic strength training on knee muscle strength and fall risk in the elderly. Methods A total of 44 elderly people from Shenzhen Hospital of Guangzhou University of Chinese Medicine (Futian) and surrounding communities from May 2020 to May 2021 were recruited. They were divided into experimental group and control group by random envelope method, with 22 elderly people in each group. The control group received fall prevention education and functional exercise. On the basis of the control group, the experimental group carried out functional training of quadriceps femoris with isokinetic strength training system both groups were trained for eight weeks. The peak torque (PT) of knee flexion and extensor, the score of Tinetti performance oriented mobility assessment (Tinetti POMA), and the time of timed “up and go” test (TUGT) were compared between the two groups before and after training. Results During the study, a total of four elderly people fell off, including two elderly people in the control group, and two elderly people in the experimental group. After training, PT of knee flexor and extensor muscle in both groups were higher than those before training when the angular velocity of test were 60°/s and 180°/s, and the experimental group was higher than the control group, the differences were statistically significant (P ＜ 0.05). After training, Tinetti POMA scores in both groups were higher than those before training, and the experimental group was higher than the control group, the differences were statistically significant (P ＜ 0.05). After training, the time of TUGT in both groups was shorter than that before training, and the experimental group was shorter than the control group, the differences were statistically significant (P ＜ 0.05). There was no significant difference in the total incidence of adverse reactions between the two groups (P ＞ 0.05). Conclusion The application of isokinetic strength training system for quadriceps femoris function training can significantly improve the maximum knee strength of the elderly, improve the muscle endurance of lower limbs, enhance the balance of energy, and reduce the risk of falls in daily life.
		2022 Vol. 19 (19): 107-110 [Abstract] ( 19 ) HTML (1 KB) PDF (561 KB) ( 270 )

	111	Effects of low-dose Esmketamine on postoperative recovery quality of patients undergoing thoracoscopic radical resection of lung cancer
		CHEN Yongwang TANG Ni XIAO Wanli DUAN Xiaoxia LIU Yulin
		Objective To evaluate the effects of low-dose Esketamine on postoperative recovery quality of patients undergoing thoracoscopic radical resection of lung cancer. Methods A total of 96 patients who underwent thoracoscopic radical resection of lung cancer in the Affiliated Hospital of Southwest Medical University from March to October 2021 were selected. They were divided into Esmketamine group (group E) and control group (group C) by using random number table method, with 48 cases in each group. The anesthesia induction protocol of two groups was the same, group E was injected with Esmketamine 0.2 mg/kg intravenously, and group C was injected with the same amount of normal saline intravenously. Anesthesia time, operation time, and extubation time were compared between two groups; the score of 40-items quality of recovery scale (QOR-40) between two groups were compared at one day before operation (T0), 24 hours after operation (T1) and 48 hours after operation (T2). The rate of remedial analgesia and complications such as delirium, nausea and vomiting, blurred vision, and headache at T1 were recorded; the incidence of insomnia at T2 was compared between two groups. Results There were no significant differences in anesthesia time, operation time, extubation time between two groups (P > 0.05). The rate of postoperative insomnia in group E was lower than that in group C (P < 0.05). Compared with T0, the total scores of QoR-40, and the scores of emotional state, physical comfort, self-care ability, psychological support, and pain feeling scores at T1 of two groups were decreased, and the total scores of QoR-40 and the score of pain feeling at T2 in group C were decreased (P < 0.01). Compared with group C, the total scores of QoR-40 and the score of emotional state at T2 in group E were increased, and the pain feeling scores at T1 and T2 in group E were increased (P < 0.01). The remedial analgesia rate in group E was lower than that in group C (P < 0.05); there was no significant difference in the total incidence of complications between two groups (P > 0.05). Conclusion Low-dose Esmketamine can relieve postoperative pain, improve emotional state and sleep quality of patients undergoing thoracoscopic radical resection of lung cancer.
		2022 Vol. 19 (19): 111-114 [Abstract] ( 19 ) HTML (1 KB) PDF (554 KB) ( 10 )

	115	Clinical effect and mechanism of Qingchang Decoction combined with Mesalazine on ulcerative colitis patients with syndrome of blood stasis due to exuberant heat
		WANG Xiaoyu MIAO Zhiwei ZHANG Yaohui ZHANG Chunyu XU Yan
		Objective To research the clinical effect and mechanism of Qingchang Decoction combined with Mesalazine on ulcerative colitis patients with syndrome of blood stasis due to exuberant heat. Methods A total of 60 patients of active ulcerative colitis with syndrome of blood stasis exuberant from Zhangjiagang Hospital Affiliated to Nanjing University of Chinese Medicine were divided into treatment group (Qingchang Decoction and Mesalazine Sustained-release Granules) and control group (Mesalazine Sustained-release Granules) according to the random number table method, with 30 cases in each group. Three months after treatment, the clinical efficacy, traditional Chinese medicine symptom score, Mayo score, and endoscopic mucosal healing rate of each group were compared, immunohistochemical expression of tumor necrosis factor receptor-associated factor (TRAF) 6, nuclear transcription factor κB (NF-κB) and immunofluorescence staining of Toll-like receptors (TLR4) in mucosal tissues of two groups were analyzed. Results The clinical effect of the treatment group was better than that of the control group (P ＜ 0.05). After treatment, the single scores and total score of traditional Chinese medicine syndrome in both groups were lower than those before treatment, and those in the treatment group were lower than those in the control group (P ＜ 0.05). After treatment, Mayo scores in both groups were lower than those before treatment, and that in the treatment group was lower than that in the control group (P ＜ 0.05). After treatment, the mucosa healing rate in the treatment group was higher than that in the control group (P ＜ 0.05). After treatment, the expression of TRAF6 and NF-κB in both groups were lower than those before treatment, and the expression levels of TRAF6 and NF-κB in treatment group were lower than those in control group (P ＜ 0.05). After treatment, the expression of immunofluorescence TLR4 in both groups were lower than those before treatment, and that in the treatment group was lower than that in the control group (P ＜ 0.05). Conclusion Qingchang Decoction combined with Mesalazine can effectively improve the clinical symptoms, intestinal mucosal healing of active UC patients with syndrome of blood stasis due to exuberant heat. The anti-inflammatory effect of Qingchang Decoction may be achieved by inhibiting the TLR4/TRAF6/NF-κB signaling pathway.
		2022 Vol. 19 (19): 115-119 [Abstract] ( 60 ) HTML (1 KB) PDF (1469 KB) ( 37 )

	120	Discussion the clinical experience of Professor Tan Feng’s “three early” therapy in the treatment of ischemic stroke based on data mining
		LIANG Yangui1 TAN Feng1 CHEN Jie2 WU Haike1 CHENG Nanfang1 CHEN Wenlin1
		Objective To explore Professor Tan Feng’s clinical experience of using “three early” therapy in the treatment of ischemic stroke based on data mining technology. Methods Chinese medicine prescriptions of ischemic stroke patients treated in the outpatients and inpatients of Professor Tan Feng in Foshan Hospital of Traditional Chinese Medicine Affiliated to Guangzhou University of Chinese Medicine from January 2018 to June 2021 were collected. The traditional Chinese Medicine Inheritance Assistance Platform (V2.5) software was used for data analysis and mining by frequency analysis, association rules, complex entropy clustering analysis, and other methods. Results A total of 236 Chinese medicine prescriptions were screened, involving 127 Chinese medicine ingredients. The top five drug use frequency were Atractylodis Macrocephalae Rhizoma, Chuanxiong Rhizoma, Astragali Radix, Pinelliae Rhizoma, and Angelicae Sinensis Radix. The most frequently used drugs were harmonizing qi and blood drugs. The drug properties were mainly warm and flat, the drug tastes were mainly sweet and pungent, and the channel tropisms were mainly liver, spleen, and heart channels. Eighteen pairs of common Chinese medicine combinations were obtained by association rule analysis, and five potential new prescriptions were mined based on entropy clustering. Conclusion Professor Tan Feng believes that blood stasis runs through the course of ischemic stroke, and puts forward the “three early” therapy of traditional Chinese medicine in the treatment of ischemic stroke. The clinical application of drugs promoting blood circulation for removing blood stasis is emphasized, supplemented by drugs supplementing qi and dissipating phlegm, resolving stagnation for tranquilization, and the use of insect drugs for patients with chronic illness, and it can provide reference for clinical practice.
		2022 Vol. 19 (19): 120-124 [Abstract] ( 53 ) HTML (1 KB) PDF (1126 KB) ( 34 )

	125	Treatment of heart failure based on the theory of five zang viscera
		LIU Wenrui ZHOU Hua QU Huiyan YANG Tianshu WANG Tian TANG Qiaolin
		The holism is an important part of traditional Chinese medicine theory. Under the guidance of the holism, traditional Chinese medicine theory believes that heart failure is a systematic disease, which is not only related to the heart, but also closely related to lung, spleen, liver, and kidney. The location of the disease focuses on the heart and lung, it should purge lung for diuresis, and tonify the heart and lung; the location of the disease focuses on the heart and spleen, it should invigorate spleen for diuresis, and tonify the heart and spleen; the location of the disease focuses on the heart and liver, it should disperse the liver and activate qi, and nourish the heart and regulate the liver; the location of the disease focuses on the heart and kidney, it should warm yang for diuresis, and tonify the kidney and strengthen the heart. Clinical dialectic and treatment should be regarded as the change of disease location, the transformation of deficiency and excess, with the syndrome change prescription.
		2022 Vol. 19 (19): 125-128 [Abstract] ( 25 ) HTML (1 KB) PDF (614 KB) ( 290 )

	129	Visual analysis of traditional Chinese medicine in the treatment of hepatic fibrosis based on CiteSpace
		ZHANG Ya1 LYU Wenliang2
		Objective To analyze the research status, hotspots, and trends of traditional Chinese medicine in the treatment of hepatic fibrosis in the past 40 years. Methods Articles related to the treatment of hepatic fibrosis with traditional Chinese medicine collected from January 1980 to December 2021 were searched by China national knowledge infrastructure, Wanfang Data, and VIP databases, and CiteSpace 5.8.R3 analysis software was used to perform visual analysis on the trend of the number of published articles, authors, research institutions， and keywords of the retrieved articles. Results A total of 4469 articles from core journals were included, it was in the initial stage before 1997, the number of articles published began to grow rapidly from 1998 to 2004, fell slightly from 2005 to 2007, remained at a high level from 2008 to 2012, fell slightly from 2013 to 2015, and rose briefly from 2016 to 2017. There was a slight decrease from 2018 to 2021. There were 95 core authors whose publications were ≥9, mainly Liu Ping, Liu Chenghai, Liu Cheng, Xu Liming, Lü Zhiping, etc. The main research institutions were medical colleges and affiliated hospitals, among Guangxi University of Chinese medicine, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese medicine, and Shanghai University of Traditional Chinese Medicine were the main research institutions. The top three key words in frequency were rats, hematopoietic stem cells, and cirrhosis. Key words clustering could be divided into three categories: mechanism research, experimental research, and clinical research. The key words with the highest burst intensity were experimental research. Conclusion Traditional Chinese medicine in the treatment of hepatic fibrosis has realized the cross-regional, interagency cooperation, the research focus in the future will focus on traditional Chinese medicine monomer and oxidative stress, anti-oxidation, metabolomics, and other mechanisms, in order to better promote the development of liver fibrosis area.
		2022 Vol. 19 (19): 129-132,137 [Abstract] ( 27 ) HTML (1 KB) PDF (2126 KB) ( 22 )

	133	Discussion on the relationship between traditional Chinese medicine knowledge protection and intangible cultural heritage
		SHI Xueqin LIU Qian WANG Liuqing QIN Peijie AN Hong ZHANG Fengxia ZHAO Zhupei LIU Jianfeng
		Traditional Chinese medicine knowledge protection and intangible cultural heritage are two different tasks supervised by the State Administration of Traditional Chinese Medicine and the Ministry of Culture respectively, and both have relation, also have difference. Both contain traditional medicine, but their basic connotations, legal guarantees, and significance to the Chinese medicine industry are quite different. Intangible cultural heritage covers a wide range, focuses on the “cultural” attribute, and has relatively deep legal protection, but it is difficult to obtain effective protection for traditional medicine; while traditional Chinese medicine knowledge protection is to deeply excavate, protect, and promote the application of traditional knowledge of traditional Chinese medicine, to confirm and protect the intellectual property rights of traditional knowledge of traditional Chinese medicine, to solve the “not spread on pain” of traditional Chinese medicine, focus on the value of “real application”, under the constantly improving laws and regulations on traditional Chinese medicine knowledge protection, the rights and interests of knowledge holders can be protected, which is conducive to improve the service capacity of the traditional Chinese medicine industry.
		2022 Vol. 19 (19): 133-137 [Abstract] ( 17 ) HTML (1 KB) PDF (728 KB) ( 220 )

	138	Exploration the significance of the traditional Chinese medicine external treatment of hyperlipidemia based on “yang transforming qi, yin constituting body” theory
		XU Yun1 CHEN Xingjuan2 HOU Chengzhi1 HU Mu2 WAN Jiajie2 FENG Ling2
		From the perspective of “yang transforming qi，yin constituting body” in traditional Chinese medicine, combined with the changes of modern dietary habits, overeating fat and sweet taste, good rest and less movement, etc., this paper analyzes that the pathogenesis of hyperlipidemia is the deficiency of yang qi transformation and the formation of yin pathogen, and expounds the pathogenic process and characteristics of its pathological products phlegm, blood stasis, turbid fat and the pathological changes of deficiency of yang qi in the human body. Therefore, the treatment should take “yang transforming qi, yin constituting body” as the theoretical guiding principle, throughout the treatment of the disease, in order to reinforce yang and unblock yang, resolve and expel yin pathogen, while supplementing yang qi deficiency, yin constituting body too much to be corrected, removing phlegm and blood stasis, dysfunction of yang qi in transportation, in order to dissipate turbid fat, and ultimately make the human body to achieve the “yin-yang be achieved in the end, and the spirit can be cured”. In recent years, the effect of external treatment of traditional Chinese medicine in the treatment of hyperlipidemia is significant and outstanding, this article explores the mechanism of external treatment of traditional Chinese medicine in the treatment of hyperlipidemia, that is, the use of acupuncture and traditional Chinese medicine vaporization lipid regulation method to achieve the purpose of stimulating the human body yang qi, eliminating phlegm, blood stasis, and turbid fat, unblocking triple energizer qi and blood, while elucidating the advantages and innovations of external treatment of traditional Chinese medicine in the treatment of hyperlipidemia not only has a good clinical effect, but also can avoid drug toxic side effects, help to protect the people’s life and health.
		2022 Vol. 19 (19): 138-141 [Abstract] ( 25 ) HTML (1 KB) PDF (604 KB) ( 18 )

	142	Research on the rules of measles epidemic disease diagnosis and treatment based on data mining
		LIN Xueyu LI Jian MA Yuan ZHANG Wenfeng
		Objective To explore the cases related to measles epidemic disease recorded in ancient medical books of the Qing Dynasty based on association and clustering rules, and to provide diagnosis and treatment ideas for clinical prevention and treatment of acute infectious diseases. Methods “Measles” related medical cases Chinese Medical Canon in the Qing Dynasty were retrieved, and the cases were screened according to inclusion and exclusion criteria. A database was established via Excel to perform data collation, induction, and statistical analysis for frequency. SPSS software was used to conduct correlation and cluster analysis for high-frequency drugs. Results High-frequency drugs were Linderae Radix, Citri Reticulatae Pericarpium Viride, Asari Radix Et Rhizoma, and so on. In the aspect of four qi, the occurrence frequency of cold drugs and the usage frequency of warm drugs were the highest; in the aspect of five tastes, occurrence frequency of drugs in bitter, sweet, and spicy were high, while the most usage frequency of drugs in bitter and spicy were high; in the aspect of meridian passage, the occurrence frequency of drugs in lung, stomach, and liver meridian was high; the usage frequency of drugs in liver, lung, and spleen was high. High frequency of symptoms had fever, abdominal pain, dizziness, and so on. The drugs were divided into six groups according to the distance between the groups and the efficacy of the drugs. Conclusion Measles epidemic disease is often accompanied by fever, abdominal pain, dizziness, and other symptoms, treatment should eliminate stasis and promote measles drainage, disperse with pungent medicinals and descend with bitter medicinals. The analysis of the basic prescriptions in different stages of ancient books of the Qing Dynasty can provide effective diagnosis and treatment ideas for the prevention and treatment of traditional Chinese medicine epidemic diseases.
		2022 Vol. 19 (19): 142-145 [Abstract] ( 22 ) HTML (1 KB) PDF (966 KB) ( 38 )

	146	Research on the potential molecular mechanism of Rupi Sanjie Capsules in the treatment of plasma cell mastitis based on network pharmacology and molecular docking technology
		XU Zhengjie FANG Kun▲ JIANG Suxiao DUAN Lijuan MAO Chunhua ZHANG Ping
		Objective To explore the potential mechanism of Rupi Sanjie Capsules in the treatment of plasma cell mastitis (PCM) by network pharmacology and molecular docking technology. Methods Active ingredients of Rupi Sanjie Capsules and corresponding targets were retrieved by traditional Chinese medicine systems pharmacology database and analysis platform, bioinformatics analysis tool for molecular mechanism of traditional Chinese medicine, and universal protein database, and combined with PCM targets collected from the GeneCards website, potential targets of Rupi Sanjie Capsules for PCM were screened. A drug-ingredient-target-disease network picture was constructed and analyzed for key ingredients, the protein-protein interaction network was built and studied for key targets. Furthermore, key targets and enrichment pathways were studied by gene ontology (GO) and Kyoto database of genes and genomes pathway enrichment analysis. The main components and targets were studied by molecular docking. Results Rupi Sanjie Capsules had 36 potential targets for PCM, protein-protein interaction network suggested that interleukin (IL)-6, epidermal growth factor receptor, albumin, IL-1B, B-cell lymphoma-2L1, chemokine（C-C motif） ligand 2, and catalase were the core targets, related to nuclear factor κB, IL-17, Toll-like receptor signaling pathway, T helper cells 17, mitogen-activated protein kinase signaling pathways, etc., which may regulated cytokine activity, antioxidant activity, and protein phosphatase binding, transmembrane receptor protein kinase activity, cytokine receptor binding and other functions to play roles in the treatment of PCM. Molecular docking suggested that Rupi Sanjie Capsules may improve PCM by affecting apoptosis signals and progesterone secretion. Conclusion Rupi Sanjie Capsules has the comprehensive mechanism of multiple components, multiple targets, and multiple pathways, which may be used in the treatment of PCM.
		2022 Vol. 19 (19): 146-150,168 [Abstract] ( 19 ) HTML (1 KB) PDF (3226 KB) ( 29 )

	151	Evaluation research of right ventricular function in patients with atrial fibrillation by real-time three-dimensional echocardiography and speckle tracking imaging #br#
		WU Zhisheng XUE Jian MU Yuming Asimuguli Maimaiti
		Objective To evaluate the changes of right ventricular morphology and function in patients with atrial fibrillation by using real-time three-dimensional echocardiography and speckle tracking imaging. Methods A total of 45 patients with paroxysmal atrial fibrillation clinically diagnosed in the First Affiliated Hospital of Xinjiang Medical University (hereinafter referred to as “our hospital”) from September 2017 to April 2020 were selected as the atrial fibrillation group, at the same time, 45 healthy patients with normal heart were selected as the control group. The relevant parameters of right ventricular structure and function were obtained by two-dimensional ultrasound, real-time three-dimensional echocardiography, and speckle tracking imaging. Results Left atrium anterior-posterior diameter, left ventricular end diastolic volume, left ventricular end systolic volume, right ventricular end diastolic volume, and right ventricular end systolic volume in the atrial fibrillation group were higher than those in control group, and left ventricular ejection fraction, right ventricular ejection fraction, right ventricular fractional area change, and tricuspid annular plane systolic excursion were lower than those in the control group (P < 0.05); there were no significant differences in left ventricular stroke volume, right atrial left-right diameter, right ventricular dimension, and right ventricular stroke volume between the two groups (P > 0.05). Right ventricular longitudinal strain of free-wall, right ventricular longitudinal strain of septum, basal segment of right ventricular free-wall systolic peak strain, middle segment of right ventricular free-wall systolic peak strain, basal segment of right ventricular septum systolic peak strain, middle segment of right ventricular septum systolic peak strain, and right ventricular global longitudinal strain in the atrial fibrillation group were lower than those in the control group (P < 0.05); there were no significant differences in apical segment of right ventricular free-wall systolic peak strain and apical segment of right ventricular septum systolic peak strain between the two groups (P > 0.05). Conclusion The myocardial contraction of right ventricle in patients with atrial fibrillation is weaker, and the reduction of right ventricular inflow tract is more obvious. Real-time three-dimensional echocardiography and speckle tracking imaging assessment can provide diagnostic information for evaluating changes in right ventricular function in patients with atrial fibrillation.
		2022 Vol. 19 (19): 151-155 [Abstract] ( 20 ) HTML (1 KB) PDF (770 KB) ( 156 )

	156	Application value of retrospective ECG-gated CTPA in pulmonary artery elasticity and cardiac function in patients with pulmonary hypertension
		WANG Dawei1 YANG Fei2▲ YANG Zhixiang3 ZHU Xiaolong2 ZHU Yuexiang2 CUI Shujun2 LIU Lan2 ZHANG Zhenming1
		Objective To investigate the application value of retrospective ECG-gated CT pulmonary angiography (CTPA) in pulmonary artery elasticity and cardiac function in pulmonary hypertension(PH) patients. Methods From March 2016 to January 2020, patients with PH diagnosed by clinical manifestations and echocardiography in the First Affiliated Hospital of Hebei North University and who received retrospective ECG-gated CTPA were included in PH group(30 cases). At the same time, the patients without pulmonary artery disease by retrospective ECG-gated CTPA and normal pulmonary artery pressure by echocardiography were collected as control group (30 cases). Arterial dilation (AD) and cardiac function parameters were compared between two groups. Results AD value of PH group was lower than that of control group, and the difference was statistical significant (P < 0.05). The right ventricular end systolic volume, right ventricular end diastolic volume, right ventricular end diastolic volume/left ventricular end diastolic volume, and right ventricular end systolic volume/left ventricular end systolic volume of PH group were higher than those of control group, right ventricular ejection fraction was lower than that of control group, and the differences were statistical significant (P < 0.05). Conclusion Retrospective ECG-gated CTPA can noninvasively assess pulmonary artery elasticity and right cardiac function in PH patients, so as to provide a forceful imaging basis for the diagnosis and treatment of PH patients.
		2022 Vol. 19 (19): 156-159 [Abstract] ( 22 ) HTML (1 KB) PDF (929 KB) ( 102 )

	160	Application value of IVIM-MRI in evaluation of curative effect of radical concurrent chemoradiotherapy for cervical cancer
		LI Weilan XIE Zongyuan WANG Yajing LI Hui CHEN Weibin WANG Zhiqiang ZHANG Huiying
		Objective To investigate the application value of introvoxel incoherent motion (IVIM)-MRI in evaluation of curative effect of radical concurrent chemoradiotherapy for cervical cancer. Methods A total of 67 patients with middle and advanced cervical cancer diagnosed and treated in the Affiliated Hospital of North China University of Science and Technology from February 2019 to June 2021 were collected, all subjects received concurrent chemoradiotherapy. Routine MRI, diffusion weighted imaging (DWI) and IVIM were performed within three days before treatment (before treatment), treatment for three weeks (in the treatment), and three days after treatment (after treatment). Patients whose tumor volume decreased by more than 1/3 after treatment compared with before treatment were included in the treatment sensitive group, and the rest were treatment non-sensitive group. The tumor regression rate was calculated; image parameters and parameter change rate at different time points were compared between two groups; the correlation between imaging parameters and tumor regression rate was analyzed. Results Before treatment, the apparent diffusion coefficient (ADC) value, diffusion coefficient (D) value and false diffusion coefficient (D) value of treatment sensitive group were higher than those of treatment non-sensitive group (P < 0.05); in the treatment, ADC value, D value, D value, and perfusion score (f) value in treatment sensitive group were higher than those in treatment non-sensitive group (P < 0.05); after treatment, ADC value, D value, and f value in treatment sensitive group were higher than those in treatment non-sensitive group (P < 0.05). In the treatment and after treatment, the change rate of ADC value, D value, and f value in treatment sensitive group was higher than those in treatment non-sensitive group (P < 0.05). The tumor regression rate of 67 patients was (66.3±24.8)%. Before treatment, ADC value and f value were positively correlated with tumor regression rate (r > 0, P < 0.05); in the treatment, the change rate of ADC value and D value were positively correlated with tumor regression rate (r > 0, P < 0.05); after treatment, the change rate of ADC value and D value were positively correlated with tumor regression rate (r > 0, P < 0.05). Conclusion IVIM parameters and their change rate have certain guiding significance for evaluating the effect of radical concurrent chemoradiotherapy for middle and advanced cervical cancer.
		2022 Vol. 19 (19): 160-163 [Abstract] ( 55 ) HTML (1 KB) PDF (538 KB) ( 34 )

	164	Bibliometric analysis of nursing research on heart valve replacement in China
		DING Nana1 WANG Xiaohua2 JIANG Hu3 DING Chengbing4 ZHANG Fang1
		[Abstract] Objective To take the bibliometric analysis of nursing research literature on heart valve replacement in China from 2010 to 2020, and to provide reference for relevant studies. Methods The data of CNKI, Wanfang and SinoMed Database were searched, and the bibliometrics method was used to analyze the domestic studies on nursing care of heart valve replacement from 2010 to 2020. Results A total of 1485 studies related to nursing research of heart valve replacement published in China were included, and the number of published literature showed an overall increasing trend, and Chinese General Practice Nursing had the largest number of articles, with 51 articles. There were 110 research papers had received funds support. Zhengzhou Seventh People’s Hospital published the most papers, with a total of 48, it involved 31 provinces, cities, and autmomous regions, and Henan Province published the most articles with 177, and the literature cooperation degree was 2.34, and the co-authorship rate was 56.63%. The research focuses on perioperative nursing, continuity nursing, rehabilitation nursing, and so on. Conclusion The research level of heart valve replacement nursing in China is relatively low, so it is necessary to increase the level of evidence and increase the support of scientific research funds, promote inter-institutional and inter-regional cooperation and exchange, fully grasp the research hotspots, and improve the level of scientific research.
		2022 Vol. 19 (19): 164-168 [Abstract] ( 51 ) HTML (1 KB) PDF (1617 KB) ( 32 )

	169	Effects of Dexmedetomidine combined with intraoperative warming on hypoxic brain injury and cellular immunity in patients undergoing radical resection of colorectal cancer
		SONG Xiaotao1 LI Minghui2 FENG Haihong2 GUO Fei2 YAO Jie3 WU Xueliang2
		[Abstract] Objective To explore the effect of comprehensive intraoperative warming nursing on hypoxic brain injury and cellular immunity in patients undergoing radical resection of colorectal cancer. Methods A total of 100 patients who undergoing radical resection of rectal cancer in the First Affiliated Hospital of Hebei North University from March 2019 to March 2020 were selected as the research subjects. The patients were divided into two groups by random number table method, with 50 cases in each group. The control group was given Dexmedetomidine, and the observation group was given Dexmedetomidine combined with comprehensive intraoperative warming nursing intervention. The scores of mini-mental state scale (MMSE), cellular immune function, interleukin-6 (IL-6), C-reactive protein (CRP), the change of tumor necrosis factor-α (TNF-α), the post-operative cognitive dysfunction (POCD), and complications of the two groups were counted. Results Before surgery, there was no significant difference in MMSE score between the two groups (P ＞ 0.05). The MMSE scores of the control group one and three days after operation were lower than those before operation, and the differences were statistically significant (P ＜ 0.05). MMSE scores of observation group were higher than control group one and three days after operation, the differences were statistically significant (P ＜ 0.05). Before surgery, there were no significant differences in CD4+, CD8+, CD4+/CD8+ between the two groups (P ＞ 0.05). One and threee days after operation, CD4+, CD8+, and CD4+/CD8+ were lower than those before operation, the differences were statistically significant (P ＜ 0.05). One and three days after operation, CD4+, CD8+, and CD4+/CD8+ in the observation group were higher than those in the control group, the differences were statistically significant (P ＜ 0.05). Before operation, there were no significant differences in IL-6, TNF-α, and CRP between the two groups (P ＞ 0.05). One and three days after operation, IL-6, TNF-α, and CRP in two groups were significantly higher than those before operation (P ＜ 0.05). One and threee days after operation, IL-6, TNF-α, and CRP in the observation group were lower than those in the control group, the differences were statistically significant (P ＜ 0.05). One and threee days after operation, the incidence of POCD in the observation group was lower than that in the control group, the difference was statistically significant (P ＜ 0.05). The total incidence of complications in the observation group was lower than that in the control group, the difference was statistically significant (P ＜ 0.05). Conclusion Comprehensive intraoperative warming nursing intervention for patients undergoing radical resection of colorectal cancer has an ideal effect. It can promote the recovery of patients’ cognitive function, reduce the patient’s cellular immune suppression state and the secretion of inflammatory factors, thereby reducing the incidence of POCD and complications.
		2022 Vol. 19 (19): 169-173 [Abstract] ( 52 ) HTML (1 KB) PDF (700 KB) ( 50 )

	174	Effect of oral nutritional supplements combined with resistance exercise on nutritional statu of patients with head and neck tumor radiotherapy
		YANG Can ZHU Yunxia FEI Zhenzhen LIU Na
		Objective To explore the effect of oral nutrition supplements combined with resistance exercise nutritional statu of patients with head and neck tumor radiotherapy. Methods A total of 80 patients with head and neck tumor radiotherapy treated in Zhejiang Cancer Hospital from January 2020 to March 2021 were selected, and divided into control group and observation group by random number table method, with 40 cases in each group. The control group was given oral nutrition supplements from the begining of radiotherapy, and the observation group was given oral nutritional supplements combined with resistance exercise from the begining of radiotherapy. Nutritional statu assessment and hematological indexes of two groups were compared after radiotherapy. Results After radiotherapy, the incidence rate of nutritional risk in observation group was lower than that in control group (P ＜ 0.05). After radiotherapy, the degree of malnutrition in observation group was lighter than that in control group (P ＜ 0.05). After radiotherapy, the levels of hemoglobin and lymphocytes in observation group were higher than those in control group (P ＜ 0.05). There were no significant differences in the levels of total protein, albumin, and prealbumin between two groups after radiotherapy (P ＞ 0.05). Conclusion Oral nutrition supplements combined with resistance exercise can reduce nutritional risk, reduce the degree of malnutrition, lower the decline index of hemoglobin and lymphocytes, so as to improve the nutritional statu of patients.
		2022 Vol. 19 (19): 174-177,185 [Abstract] ( 18 ) HTML (1 KB) PDF (701 KB) ( 124 )

	178	Bibliometric analysis of geriatric nurse specialists in China
		LIU Li ZHANG Shuai HU Xiuying
		Objective To systematically understand the current situation and existing problems of the training of geriatric nurse specialists and to provide references for the training of geriatric nursing staff in China. Methods The relevant studies published by CNKI, Wanfang, VIP, and SinoMed Database from inception to February 2021 were searched, with the subject terms of “geriatric nurse specialist”, “older adult”, “specialized nurse”, “advanced practice nurse”, “training” “specialized nurse training”, and “CNS”. The information on the publication year, journal, region, foundation, co-author rate, cooperation degree, and research content were analyzed by bibliometric analysis. Results A total of 131 literatures were included in this study, with an increasing trend of annual publication numbers in recent decades. Seventy-four articles were published in core journals, accounting for 63.2% of the included articles. Nursing Research and Journal of Nursing published the most relevant literatures, are all nine. The top three provinces and cities which published the most related studies were Guangdong Province, Beijing, and Sichuan Province. Thirty-eight articles were supported by at least one foundation. The degree of collaboration was 3.23, and the co-authoring rate was 75.6%. There were 51 articles on geriatric nurse training. Conclusion The research on geriatric nurse specialists has increased over the years, and the research mainly focuses on exploring the training strategies of geriatric nurse specialists. Further studies on professional career development, service evaluation, and clinical use are needed.
		2022 Vol. 19 (19): 178-181 [Abstract] ( 57 ) HTML (1 KB) PDF (694 KB) ( 11 )

	182	Influence of knowledge, faith and action health education mode on disease cognition and health behavior of elderly patients with hip fracture
		XI Gaoqin1 FANG Bin2 KANG Zhimin1
		Objective To explore the influence of knowledge, faith and action health education mode on disease cognition level and health behavior of elderly patients with hip fracture. Methods From January 2020 to January 2021, 105 patients with femoral neck fracture and femoral head necrosis in Shaoxing Central Hospital, General Hospital of Medical Community, Zhejiang Province, were selected as the research subjects. They were divided into observation group (53 cases) and control group (52 cases) according to random number table method. The observation group was given knowledge, faith and action health education mode intervention, and the control group was given routine rehabilitation education intervention. The cognitive level, health behavior, psychological state of the two groups were compared before intervention and six months after follow-up. Results After six months follow-up, the scores of disease cognition in both groups were higher than that before nursing, and the observation group was higher than control group (P ＜ 0.05). Health behavior scores of the two groups were significantly higher than before nursing, and observation group was higher than control group (P ＜ 0.05). The joint function scores of the two groups six months after follow-up were higher than those befor nursing, and the observation group was higher than the control group (P ＜ 0.05). After intervention, the psychological status scores of the two groups were lower than before intervention, and the observation group was lower than the control group (P ＜ 0.05). Conclusion In the elderly patients with hip fracture, the application of health education mode can improve the body function of patients, strengthen the attention of patients to the disease, improve the nursing effect, clinical value is significant.
		2022 Vol. 19 (19): 182-185 [Abstract] ( 47 ) HTML (1 KB) PDF (509 KB) ( 156 )

	186	Nursing effect of moxibustion combined with finger point on elderly patients with chronic urinary tract infection
		HU Dan WANG Lixia ZENG Xianghong ZHANG Li
		Objective To observe the nursing effect of moxibustion combined with finger point on elderly patients with chronic urinary tract infection. Methods A total of 80 elderly patients with chronic urinary tract infection hospitalized in the Department of Acupuncture and Moxibustion of Beijing Hospital of Integrated Traditional Chinese and Western Medicine from January 2018 to December 2020. They were divided into treatment group and control group by random number table method, with 40 cases in each group. Control group was adopted Traditional Chinese and Western medicine nursing intervention syndrome, On this basis of control group, the treatment group was treated with moxibustion and finger point treatment, the treatment lasted for three weeks. Clinical symptom grading standard table total score, frequent urination, urination urgency, dysuria, lumbago and fever, white blood cell count and bacteria count in urine, therapeutic effect and adverse reactions of the two groups were compared before and after treatment. Results After treatment, the total score of clinical symptom grading standard table of the two groups was lower than before treatment, and the treatment group was lower than the control group (P ＜ 0.05); the scores of frequent urination, urination urgency, urination pain, fever, and lumbago in both groups were lower than those before treatment, and urination urgency, urination pain and fever in treatment group were lower than those in control group (P ＜ 0.05); there was no significant difference in urine pain scores between the two groups (P ＞ 0.05); the number of white blood cells and bacteria in urine of the two groups were lower than before treatment, and the number of white blood cells in urine of the treatment group was lower than that of the control group (P ＜ 0.05); there was no significant difference in the number of urine bacteria between the two groups (P ＞ 0.05). The clinical effect of treatment group was better than control group (P ＜ 0.05). There were no adverse reactions and adverse events in two groups. Conclusion Moxibustion combined with finger point has a good effect on the improvement of many aspects of clinical symptoms and urinary white blood cell count in elderly patients with chronic urinary tract infection, and no obvious adverse reactions, simple operation, suitable for clinical promotion.
		2022 Vol. 19 (19): 186-189,193 [Abstract] ( 31 ) HTML (1 KB) PDF (721 KB) ( 77 )

	190	Effects of combined traditional Chinese and Western medicine intervention on anxiety and bleeding symptoms in patients with threatened abortion
		LIAO Linzhu1 ZHENG Yanwen2▲
		Objective To explore the clinical application value of combined traditional Chinese and Western medicine intervention in patients with threatened abortion. Methods A total of 112 patients with threatened abortion who were admitted to Wenzhou Hospital of Integrated Traditional Chinese and Western Medicine from March 2020 to April 2021 were selected as the research objects, and they were divided into study group and control group according to the random number table method, with 56 cases in each group. The control group was given routine nursing intervention, while the study group was given routine nursing intervention combined with acupoint sticking. The psychological status scores, clinical symptoms improvement, and nursing satisfaction were compared between the two groups before and after the intervention. Results After the intervention, the depression and anxiety self-rating scale scores in the two groups were lower than those before the intervention, while those of the study group were lower than those of the control group, and the differences were statistically significant (P ＜ 0.05). The time required for bleeding cessation, abdominal pain and low back pain relief in the study group were shorter than those in the control group, and the differences were statistically significant (P ＜ 0.05). After the intervention, the nursing satisfaction of the study group was higher than that of the control group, and the difference was statistically significant (P ＜ 0.05). Conclusion Combining traditional Chinese and Western medicine intervention for threatened abortion patients has a good effect, can significantly improve the patient’s anxiety, relieve their clinical symptoms, and is worthy of popularization and application.
		2022 Vol. 19 (19): 190-193 [Abstract] ( 24 ) HTML (1 KB) PDF (604 KB) ( 34 )

	194	Influence of “Internet +” volunteer service model on postoperative mood and quality of life of breast cancer patients
		YANG Yan SUN Meng LI Yanjing LIU Geng ZHU Xuedan YUAN Zhu▲
		Objective To explore the influence of “Internet +” volunteer service model on postoperative mood and quality of life of breast cancer patients. Methods A total of 80 inpatients undergoing radical breast cancer surgery in Beijing Friendship Hospital Affiliated to Capital Medical University (hereinafter referred to as “our hospital”) from June to December 2019 were selected as the control group, accepted face-to-face volunteer programs; a total of 80 inpatients undergoing radical breast cancer surgery in our hospital from January to October 2020 were selected as the experimental group, accepted the “Internet +” volunteer service program. Self-rated anxiety scale (SAS), self-rated depression scale (SDS) and Chinese version of cancer patients’ quality of life core questionnaire (QLQ-C30) were used to compare the levels of anxiety and depression between the two groups before and four months after operation, and the quality of life of patients were evaluated. Results Four months after operation SAS and SDS in the two groups were lower than those before the operation, and SDS in the experimental group was lower than that in the control group (P ＜ 0.05); four months after operation, there was no significant difference except for the cognitive function score of the control group compared with that preoperative (P > 0.05). The physical function score of the two groups was lower than that preoperative, while the emotional function, cognitive function, social function, role function and overall quality of life score were higher than that preoperative, the scores of physical function, cognitive function, role function, and overall quality of life in the experimental group were higher than those in the control group (P < 0.05). Conclusion “Internet +” volunteer service is better than the face-to-face volunteer service at this stage, which has a significant effect on the improvement of depression and quality of life of patients, and it can benefit more breast cancer patients.
		2022 Vol. 19 (19): 194-封三 [Abstract] ( 56 ) HTML (1 KB) PDF (558 KB) ( 45 )

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