IVIM-MRI在宫颈癌根治性同步放化疗效果评价中的应用价值

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Abstract Objective To investigate the application value of introvoxel incoherent motion (IVIM)-MRI in evaluation of curative effect of radical concurrent chemoradiotherapy for cervical cancer. Methods A total of 67 patients with middle and advanced cervical cancer diagnosed and treated in the Affiliated Hospital of North China University of Science and Technology from February 2019 to June 2021 were collected, all subjects received concurrent chemoradiotherapy. Routine MRI, diffusion weighted imaging (DWI) and IVIM were performed within three days before treatment (before treatment), treatment for three weeks (in the treatment), and three days after treatment (after treatment). Patients whose tumor volume decreased by more than 1/3 after treatment compared with before treatment were included in the treatment sensitive group, and the rest were treatment non-sensitive group. The tumor regression rate was calculated; image parameters and parameter change rate at different time points were compared between two groups; the correlation between imaging parameters and tumor regression rate was analyzed. Results Before treatment, the apparent diffusion coefficient (ADC) value, diffusion coefficient (D) value and false diffusion coefficient (D*) value of treatment sensitive group were higher than those of treatment non-sensitive group (P < 0.05); in the treatment, ADC value, D value, D* value, and perfusion score (f) value in treatment sensitive group were higher than those in treatment non-sensitive group (P < 0.05); after treatment, ADC value, D value, and f value in treatment sensitive group were higher than those in treatment non-sensitive group (P < 0.05). In the treatment and after treatment, the change rate of ADC value, D value, and f value in treatment sensitive group was higher than those in treatment non-sensitive group (P < 0.05). The tumor regression rate of 67 patients was (66.3±24.8)%. Before treatment, ADC value and f value were positively correlated with tumor regression rate (r > 0, P < 0.05); in the treatment, the change rate of ADC value and D value were positively correlated with tumor regression rate (r > 0, P < 0.05); after treatment, the change rate of ADC value and D value were positively correlated with tumor regression rate (r > 0, P < 0.05). Conclusion IVIM parameters and their change rate have certain guiding significance for evaluating the effect of radical concurrent chemoradiotherapy for middle and advanced cervical cancer.

Key words： Middle and advanced cervical cancer Magnetic resonance imaging Introvoxel incoherent motion Concurrent chemoradiotherapy Efficacy evaluation

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	LI Weilan XIE Zongyuan WANG Yajing LI Hui CHEN Weibin WANG Zhiqiang ZHANG Huiying

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LI Weilan XIE Zongyuan WANG Yajing LI Hui CHEN Weibin WANG Zhiqiang ZHANG Huiying. Application value of IVIM-MRI in evaluation of curative effect of radical concurrent chemoradiotherapy for cervical cancer[J]. 中国医药导报, 2022, 19(19): 160-163.

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https://www.yiyaodaobao.com.cn/EN/ OR https://www.yiyaodaobao.com.cn/EN/Y2022/V19/I19/160

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