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| Research progress of the role of phospholysine phosphohistidine inorganic pyrophosphate phosphatase in tumor |
| TANG Xiang1 WANG Jingzhi2 LIU Na1 CHEN Deyu1#br# |
1.Department of Oncology, Affiliated Hospital of Jiangsu University, Jiangsu Province, Zhenjiang 212001, China;
2.Department of Radiotherapy, Yancheng First People’s Hospital, Jiangsu Province, Yancheng 224001, China
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Abstract Phospholysine phosphohistidine inorganic pyrophosphate phosphatase (LHPP) is one of the important enzyme regulating histidine dephosphorylation, mainly expressed in liver, brain and kidney, and the regulation of histidine residues together with histidine kinase phosphorylation and dephosphorylation. The deletion of LHPP can destroy the balance between phosphorylation and dephosphorylation of histidine residues, resulting in PI3K/Akt and Wnt/β-catenin which, leads to the abnormality of cyclin and apoptotic protein, and promotes the occurrence and development of tumor. LHPP is significant for early screening, early diagnosis, treatment and prognosis of tumor patients, and it is expected to become a new therapeutic target and prognostic index for individualized treatment of patients. Based on the previous literature research, this review summarizes the research progress of the role of LHPP in some tumors such as liver cancer, glioma, and kidney cancer, in order to provide reference for the future research direction and application of LHPP in tumors.
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