清肠汤联合美沙拉嗪治疗热盛血瘀型活动期溃疡性结肠炎患者的临床效果及其作用机制

Abstract
Figure/Table
References (27)
Related Citation (15)

Download: PDF (1469 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To research the clinical effect and mechanism of Qingchang Decoction combined with Mesalazine on ulcerative colitis patients with syndrome of blood stasis due to exuberant heat. Methods A total of 60 patients of active ulcerative colitis with syndrome of blood stasis exuberant from Zhangjiagang Hospital Affiliated to Nanjing University of Chinese Medicine were divided into treatment group (Qingchang Decoction and Mesalazine Sustained-release Granules) and control group (Mesalazine Sustained-release Granules) according to the random number table method, with 30 cases in each group. Three months after treatment, the clinical efficacy, traditional Chinese medicine symptom score, Mayo score, and endoscopic mucosal healing rate of each group were compared, immunohistochemical expression of tumor necrosis factor receptor-associated factor (TRAF) 6, nuclear transcription factor κB (NF-κB) and immunofluorescence staining of Toll-like receptors (TLR4) in mucosal tissues of two groups were analyzed. Results The clinical effect of the treatment group was better than that of the control group (P ＜ 0.05). After treatment, the single scores and total score of traditional Chinese medicine syndrome in both groups were lower than those before treatment, and those in the treatment group were lower than those in the control group (P ＜ 0.05). After treatment, Mayo scores in both groups were lower than those before treatment, and that in the treatment group was lower than that in the control group (P ＜ 0.05). After treatment, the mucosa healing rate in the treatment group was higher than that in the control group (P ＜ 0.05). After treatment, the expression of TRAF6 and NF-κB in both groups were lower than those before treatment, and the expression levels of TRAF6 and NF-κB in treatment group were lower than those in control group (P ＜ 0.05). After treatment, the expression of immunofluorescence TLR4 in both groups were lower than those before treatment, and that in the treatment group was lower than that in the control group (P ＜ 0.05). Conclusion Qingchang Decoction combined with Mesalazine can effectively improve the clinical symptoms, intestinal mucosal healing of active UC patients with syndrome of blood stasis due to exuberant heat. The anti-inflammatory effect of Qingchang Decoction may be achieved by inhibiting the TLR4/TRAF6/NF-κB signaling pathway.

Key words： Qingchang Decoction Ulcerative colitis Syndrome of blood stasis due to exuberant heat Clinical efficacy Toll-like receptors 4/tumor necrosis factor receptor-associated factor 6/nuclear transcription factor κB

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	WANG Xiaoyu MIAO Zhiwei ZHANG Yaohui ZHANG Chunyu XU Yan

Cite this article:

WANG Xiaoyu MIAO Zhiwei ZHANG Yaohui ZHANG Chunyu XU Yan. Clinical effect and mechanism of Qingchang Decoction combined with Mesalazine on ulcerative colitis patients with syndrome of blood stasis due to exuberant heat[J]. 中国医药导报, 2022, 19(19): 115-119.

URL:

https://www.yiyaodaobao.com.cn/EN/ OR https://www.yiyaodaobao.com.cn/EN/Y2022/V19/I19/115

[1] Martin M，Rene L，Lubos A，et al. Phages and Their Role in Gastrointestinal Disease：Focus on Inflammatory Bowel Disease [J]. Cell，2020，9（4）：1013.
[2] Flynn S，Eisenstein MDS. Inflammatory Bowel Disease Presentation and Diagnosis [J]. Surg Clin North Am，2019， 99（6）：1051-1062.
[3] Kaplan GG. The global burden of IBD：from 2015 to 2025 [J]. Nat Rev Gastroenterol Hepatol，2015，12（12）：720-727.
[4] Burisch J，Munkholm P. The epidemiology of inflammatory bowel disease [J]. Scand J Gastroenterol，2015， 50（8）：942-951.
[5] Kaplan GG，Ng SC. Understanding and Preventing the Global Increase of Inflammatory Bowel Disease [J]. Gastroenterology，2017，152（2）：313-321.e2.
[6] 钟宇，郑学宝，叶华，等.白头翁汤对溃疡性结肠炎大鼠的疗效及免疫机制的影响[J].中国实验方剂学杂志，2019， 25（12）：15-21.
[7] 钟宇，郑学宝，叶华，等.芍药汤对溃疡性结肠炎大鼠TLR4/NF-κB通路的影响[J].中国中药杂志，2019，44（7）：1450-1456.
[8] 闫曙光，惠毅，周永学.乌梅丸拆方对溃疡性结肠炎大鼠结肠TLR4/NF-κB 信号通路的影响[J].时珍国医国药，2013，24（6）：1386-1388．
[9] 王晓瑜，缪志伟，徐艳.清肠汤对热盛血瘀型溃疡性结肠炎患者的临床疗效及其对HGF/c-MET表达的影响[J].中国中西医结合消化杂志，2020，28（6）：444-448，453.
[10] 张国华，王晓瑜.血竭、三七、白芨灌肠治疗远端型溃疡性结肠炎的临床疗效观察[J].中国中西医结合消化杂志，2015，23（2）：140-142.
[11] 中华医学会消化病学分会炎症性肠病学组.炎症性肠病诊断与治疗的共识意见（2018年·北京）[J].中国实用内科杂志，2018，38（9）：796-813.
[12] 郑筱萸.中药新药临床研究指导原则[M].北京：中国医药科技出版社，2002：139-143.
[13] 张声生，沈洪，郑凯，等.溃疡性结肠炎中医诊疗专家共识意见（2017）[J].中华中医药杂志，2017，32（8）：3585-3589．
[14] Guyatt G，Mitchell A，Irvine EJ. A new measure of health status for clinical trials in inflammatory bowel disease [J]. Gastroenterology，1989，96（3）：804-810.
[15] Ye X，Wu H，Sheng L，et al. Oncogenic potential of truncated RXRα during colitis-associated colorectal tumorigenesis by promoting IL-6-STAT3 signaling [J]. Nat Commun，2019，10（1）：1463-1477.
[16] Covert MW，Leung TH，Gaston JE，et a1. Achieving stability of 1ipopolysaccharide-induced NF-kappaB activation [J]. Science，2005，309（5742）：1854-1857.
[17] Wu H，Fan H，Xing Z，et al. Shou1 Extracellular vesicles containing miR-146a attenuate experimental colitis by targeting TRAF6 and IRAK1 [J]. Int Immunopharmacol，2019，68：204-212.
[18] Lee JW，Lee SM，Chun J，et al. Novel Histone Deacetylase 6 Inhibitor CKD-506 Inhibits NF-κB Signaling in Intestinal Epithelial Cells and Macrophages and Ameliorates Acute and Chronic Murine Colitis [J]. Inflamm Bowel Dis，2020，26（1）：izz317.
[19] 郭玲珑，姜小艳，李娟娟，等.溃疡性结肠炎的中医药治疗研究进展[J].中国当代医药，2020，27（34）：26-30.
[20] 沈照峰，吴红辉，朱磊，等.基于PRIO-harms的中医药治疗溃疡性结肠炎系统评价再评价[J].中国中药杂志，2020，45（3）：9.
[21] 亢秀红，张立宏，王颖超，等.从健脾清化祛瘀论治溃疡性结肠炎[J].中国医药科学，2021，11（21）：100-103，107.
[22] 陈艺，王伟，曹志群.自拟芪仙苡酱汤联合中药灌肠治疗溃疡性结肠炎的临床观察[J].疑难病杂志，2022，21（1）：41-45.
[23] 宁丽琴.徐景藩教授治疗溃疡性结肠炎的临床疗效及数据挖掘研究[D].南京：南京中医药大学，2018.
[24] 张良宇，陆为民.徐景藩治疗溃疡性结肠炎经验[J].中医杂志，2018，59（23）：1993-1995.
[25] 王琦，沈洪.沈洪运用凉血化瘀法治疗溃疡性结肠炎经验撷粹[J].江苏中医药，2019，51（5）：17-19.
[26] 邢海伦，劳绍贤.劳绍贤教授诊治溃疡性结肠炎经验介绍[J].新中医，2014，46（8）：21-23.
[27] 张旭，周强，吴兵，等.张声生从“寒热”“气血”论治溃疡性结肠炎[J].中华中医药杂志，2018，33（7）：2885-2887.