烯醇化酶-α和C-MYC启动子结合蛋白-1基于PI3K/Akt通路调控肝细胞癌发生发展的研究进展

Abstract
Figure/Table
References (32)
Related Citation (15)

Download: PDF (635 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Enolase-α (ENO1) is a type of key glycolysis enzyme with tissue-specific expression, which participates in glycolysis and affects the process of glycolysis. C-MYC promoter binding protein-1 (MBP-1) can inhibit the expression of oncogene C-MYC. At present, it has been found that they are expressed by the same genetic encode, and there is a complex relationship between their expression regulation and the PI3K/Akt pathway. ENO1 and MBP-1 play an important role in the progression and inhibition of tumors such as hepatocellular carcinoma (HCC) by regulating the PI3K/Akt pathway. This paper briefly reviewes the function of ENO1 and MBP-1, their expression regulation, and their relationship with PI3K/Akt signal pathway as well as the mechanism of this pathway on HCC. Thus we can explore possible molecular mechanism for the occurrence and progression of HCC so as to provide a theoretical basis for molecular targets to regulate this mechanism. It aims to provide new ideas for the effective treatment of HCC in the future.

Key words： Enolase-α C-MYC promoter binding protein-1 PI3K/Akt pathway Hepatocellular carcinoma

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	XU Weixin WANG Chunfang LUO Yanhong

Cite this article:

XU Weixin WANG Chunfang LUO Yanhong. Research progress of enolase -α and C-MYC promoter binding protein-1 regulating the occurrence and progression of hepatocellular carcinoma based on PI3K/Akt pathway[J]. 中国医药导报, 2022, 19(19): 53-56.

URL:

https://www.yiyaodaobao.com.cn/EN/ OR https://www.yiyaodaobao.com.cn/EN/Y2022/V19/I19/53

[1] Ji H，Wang J，Guo J，et al. Progress in the biological function of alpha-enolase [J]. Anim Nutr，2016，2（1）：12-17.
[2] Subramanian A，Miller DM. Structural analysis of α-enolase：mapping the functional domains involved in down-regulation of the c-myc protooncogene [J]. J Biol Chem，2000，275（8）：5958-5965.
[3] Trojanowicz B，Hoang-Vu C，Sekulla C. ENO1（Enolase 1，（alpha））[J]. Atlas Genet Cytogenet Oncol Haematol，2010，14（7）：635-640.
[4] Osthus RC，Shim H，Kim S，et al. Deregulation of glucose transporter 1 and glycolytic gene expression by c-Myc [J]. J Biol Chem，2000，275（29）：21797-21800.
[5] Shi M，Dai WQ，Jia RR，et al. APCCDC20-mediated degradation of PHD3 stabilizes HIF-1a and promotes tumorigenesis in hepatocellular carcinoma [J]. Cancer Lett，2021， 496：144-155.
[6] Zhu X，Yu H，Li B，et al. Targetting an LncRNA P5848-ENO1 axis inhibits tumor growth in hepatocellular carcinoma [J]. Biosci Rep，2019，39（11）：1-8.
[7] Li L，Wang F，Zhang J，et al. Typical phthalic acid esters induce apoptosis by regulating the PI3K/Akt/Bcl-2 signaling pathway in rat insulinoma cells [J]. Ecotoxicol Environ Saf，2021，208：111461.
[8] D?觟rng P，Calvis DF，Dombrowski F. Nuclear ErbB2 expression in hepatocytes in liver disease [J]. Virchows Arch，2021，478（2）：309-318.
[9] Qiao G，Wu A，Chen X，et al. Enolase 1，a Moonlighting Protein，as a Potential Target for Cancer Treatment [J]. Int J Biol Sci，2021，17（14）：3981.
[10] Yang X，Sun J，Sun H，et al. MicroRNA-30a-3p acts as a tumor suppressor in MHCC-97H hepatocellular carcinoma cells by targeting COX-2 [J]. J Cancer，2021，12（13）：3945.
[11] Cheng R，Wang B，Cai X，et al. CD276 promotes vasculogenic mimicry formation in hepatocellular carcinoma via the PI3K/AKT/MMPs pathway [J]. Onco Targets Ther，2020，13：11485.
[12] Wang J，Han Y，Wang M，et al. Natural triterpenoid saponin Momordin Ic suppresses HepG2 cell invasion via COX-2 inhibition and PPARγ activation [J]. Toxicol In Vitro，2020，65：104784.
[13] Guo C，Gao C，Lv X，et al. CRKL promotes hepatocarcinoma through enhancing glucose metabolism of cancer cells via activating PI3K/Akt [J]. J Cell Mol Med，2021， 25（5）：2714-2724.
[14] Teng C，Hsieh W，Wu H，et al. Hepatitis B virus pre-S2 mutant induces aerobic glycolysis through mammalian target of rapamycin signal cascade [J]. PLoS One，2015， 10（4）：e122373.
[15] Mirabilii S，Ricciardi MR，Tafuri A. mTOR Regulation of Metabolism in Hematologic Malignancies [J]. Cells，2020， 9（2）：404.
[16] Sun L，Lu T，Tian K，et al. Alpha-enolase promotes gastric cancer cell proliferation and metastasis via regulating AKT signaling pathway [J]. Eur J Pharmacol，2019， 845：8-15.
[17] Dimri M，Humphries A，Laknaur A，et al. Nqo1 ablation inhibits activation of the PI3K/Akt and MAPK/ERK pathways and blocks metabolic adaptation in hepatocellular carcinoma [J]. Hepatology，2020，71（2）：549.
[18] Ni F，Huang X，Chen Z，et al. Shikonin exerts antitumor activity in Burkitt’s lymphoma by inhibiting C-MYC and PI3K/AKT/mTOR pathway and acts synergistically with doxorubicin [J]. Sci Rep，2018，8（1）：1-10.
[19] Ahn H，Im E，Lee D Y，et al. Antitumor effect of pyrogallol via miR-134 mediated S phase arrest and inhibition of PI3K/AKT/Skp2/cMyc signaling in hepatocellular carcinoma [J]. Int J Mol Sci，2019，20（16）：3985.
[20] Zhang M，Liu S，Chua M，et al. SOCS5 inhibition induces autophagy to impair metastasis in hepatocellular carcinoma cells via the PI3K/Akt/mTOR pathway [J]. Cell Death Dis，2019，10（8）：1-15.
[21] Zheng H，Yang Y，Hong YG，et al. Tropomodulin 3 modulates EGFR-PI3K-AKT signaling to drive hepatocellular carcinoma metastasis [J]. Mol Carcinog，2019，58（10）：1897-1907.
[22] Tan W，Zhu S，Cao J，et al. Inhibition of MMP-2 expression enhances the antitumor effect of sorafenib in hepatocellular carcinoma by suppressing the PI3K/AKT/mTOR pathway [J]. Oncol Res，2017，25（9）：1543-1553.
[23] Ren F，Wu K，Yang Y，et al. Dandelion Polysaccharide Exerts Anti-Angiogenesis Effect on Hepatocellular Carcinoma by Regulating VEGF/HIF-1α Expression [J]. Front Pharmacol，2020，11：460.
[24] Wang L，Liu W，Huang X. MicroRNA-199a-3p inhibits angiogenesis by targeting the VEGF/PI3K/AKT signalling pathway in an in vitro model of diabetic retinopathy [J]. Exp Mol Pathol，2020，116：104488.
[25] Feng J，Li J，Wu L，et al. Emerging roles and the regulation of aerobic glycolysis in hepatocellular carcinoma [J]. J Exp Clin Cancer Res，2020，39（1）：1-19.
[26] Panasyuk G，Espeillac C，Chvin C，et al. PPARγ contributes to PKM2 and HK2 expression in fatty liver [J]. Nat Commun，2012，3（1）：1-9.
[27] Chen J，Chen J，Huang J，et al. HIF-2α upregulation mediated by hypoxia promotes NAFLD-HCC progression by activating lipid synthesis via the PI3K-AKT-mTOR pathway [J]. Aging（Albany NY），2019，11（23）：10839.
[28] Maranto C，Perconti G，Contino F，et al. Cellular stress induces cap-independent alpha-enolase/MBP-1 translation [J]. FEBS Lett，2015，589（16）：2110-2116.
[29] Czogalla B，Partenheimer A，Badmann S，et al. Nuclear Enolase-1/MBP-1 expression and its association with the Wnt signaling in epithelial ovarian cancer [J]. Transl Oncol，2021，14（1）：100910.
[30] Varone E，Decio A，Chernorudskiy A，et al. The ER stress response mediator ERO1 triggers cancer metastasis by favoring the angiogenic switch in hypoxic conditions [J]. Oncogene，2021，40（9）：1721-1736.
[31] Novais EJ，Choi H，Madhu V，et al. Hypoxia and Hypoxia-Inducible Factor-1α Regulate Endoplasmic Reticulum Stress in Nucleus Pulposus Cells：Implications of Endoplasmic Reticulum Stress for Extracellular Matrix Secretion [J]. Am J Pathol，2021，191（3）：487-502.
[32] Liu Y，Liao L，An C，et al. α-Enolase lies downstream of mTOR/HIF1α and promotes thyroid carcinoma progression by regulating CST1 [J]. Front Cell Dev Biol，2021， 9：670019.