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2021 Vol. 18, No. 34
Published: 2021-12-05
 
 
7 Visualization analysis on research of floating needle based on CiteSpace#br#
QIU Wencong1 WU Yuezhe1 SUN Jian2▲ CAO Xuewei3
Objective To analyze the cooperation network, development trend and research hotspots in the field of floating needle by bibliometric method. Methods The literatures related to floating needle research in CNKI and Wanfang database from January 1997 to December 2020 were searched. The co-occurrence analysis of research institutions, authors and keywords in the included literatures was carried out by CiteSpace software. The keywords were further analyzed by cluster analysis and emergence analysis, and the visual knowledge map was drawn. Results The number of articles published on floating needle was increasing year by year and was in the stage of rapid growth. Published institutions were mainly scientific research institutions and affiliated hospitals. The authors with Professor Fu Zhonghua as the core and Huang Yong and Sun Jian as the center published the most. Keywords emergent and cluster analysis showed that floating needle research mainly focused on clinical research of orthopedic diseases and pain. With the passage of time, more and more diseases were studied, and the discussion on basic theories became more and more extensive. Conclusion The number of floating needlerelated studies publications increases year by year, the types of diseases involved in the studies have been enriched, and the quality of the studies has been improving. The research and theoretical discussion centering on the tightened muscles and reperfusion approach are the hotspots of floating needle research in recent years.
2021 Vol. 18 (34): 7-11，22 [Abstract] ( 157 ) HTML (1 KB)  PDF (1675 KB)  ( 28 )
12 Visualization analysis of research hotspots and trends of poststroke depression in the field of traditional Chinese medicine based on CiteSpace#br#
MO Xueni FU Xiaohong WU Duo ZHANG Yue LAN Baixin LIU Jiao LIU Na MA Wei▲
Objective To explore the hotspots and trends of poststroke depression in the field of traditional Chinese medicine (TCM) based on CiteSpace software. Methods The literatures on poststroke depression in the field of the TCM collected from January 2002 to April 2021 was selected as the research subjects by CNKI database. The trend of the published articles, the cooperation status of authors, the institutions, the key words were analyzed respectively and the corresponding knowledge maps were drawn. Finally, visualization analysis results combined with manual retrieval were discussed in depth. Results A total of 1767 articles were included, and the annual number of published articles showed an upward trend. Through quantitative analysis, high-yield literature institutions and representative researchers and their teams were found. Research hotspots and trends were TCM emotional nursing, acupuncture and molecular biology, etc. The application of data mining technology in the field of TCM was also the mainstream of current research. Conclusion The maps initially and visually show the development trend of TCM, and reveal the research hotspots. They show the research overview of TCM on poststroke depression more intuitively, and form a general understanding of research hotspots and frontiers, and provide reference for determining the research direction.
2021 Vol. 18 (34): 12-17 [Abstract] ( 182 ) HTML (1 KB)  PDF (1761 KB)  ( 35 )
17 Visual analysis of diabetes mellitus yin deficiency syndrome researches based on CiteSpace#br#
LI Zhuang WANG Shidong ZHANG Hua LI Jiayue TANG Cheng ZHAO Boxu ZHANG Yaofu JIANG Li
Objective To analyze the hot spots and trends in the research field of diabetes mellitus yin deficiency syndrome visually based on CiteSpace, and to provide reference for future research in this field. Methods Literatures on diabetes mellitus yin deficiency syndrome in CNKI from January 2010 to December 2020 were selected. Based on the co-occurrence analysis function of CiteSpace, knowledge graphs were drawn for the analysis of annual publications, fund support, author cooperation network, distribution of literature research institutions, and research hotspots. Results Finally, 545 literatures were included, and the annual number of literatures presented a steady upward trend. The institutional cooperation network was mature and stable, with Beijing and Shanghai as the core regions, with typical regional characteristics. Syndrome of deficiency of both qi and yin, syndrome of yin deficiency of liver and kidney, diabetic nephropathy, and coronary artery heart disease were the important research contents and trends in this field. Conclusion At present, the research in the field of diabetes mellitus yin deficiency syndrome is developing continuously, gradually forming a balanced core team cooperation network, and combining with the research hotspots in multidisciplinary fields, and diseases such as coronary heart disease, diabetic nephropathy, etc., which to comprehensively build a more mature academic system.
2021 Vol. 18 (34): 17-22 [Abstract] ( 132 ) HTML (1 KB)  PDF (2033 KB)  ( 14 )
23 Mechanism of VEGFR-3 promoting proliferation of cerebrospinal fluid-contacting neurons through PI3K/AKT signaling pathway#br#
HU Qian YAN Haijian▲
Objective To investigate the effect of vascular endothelial growth factor receptor-3 (VEGFR-3) on the proliferation of cerebrospinal fluid-contacting neurons (CSF-CNs) through PI3K/AKT signaling pathway. Methods CSF-CNs were isolated from ten 3-day-old C57 newborn mice, and divided into four groups: normal control group, empty plasmid control group, VEGFR-3 plasmid group and inhibitor group. The normal control group was without special treatment, empty plasmid control group added empty plasmid, and VEGFR-3 plasmid dilution was added into VEGFR-3 plasmid group, PI3K/AKT inhibitor was added into transfected cells in inhibitor group. The number and diameter of neurospheres were detected after 24 h, and the expression of VEGFR-3, PI3K, AKT, and p-AKT were detected by Western blot. Results The expression of VEGFR-3 in VEGFR-3 plasmid group was higher than that in normal control group and empty plasmid control group (P ＜ 0.05), and the transfection efficiency was the highest after 48 h. Compared with empty plasmid group and inhibitor group, the number and diameter of neurospheres in VEGFR-3 plasmid group increased (P ＜ 0.05), and the expression of PI3K, AKT, and p-AKT in VEGFR-3 plasmid group were higher (P ＜ 0.05). Conclusion VEGFR-3 can promote the proliferation of CSF-CNs by regulating PI3K/AKT signaling pathway.
2021 Vol. 18 (34): 23-25,34 [Abstract] ( 192 ) HTML (1 KB)  PDF (866 KB)  ( 22 )
26 Effect of Ziyin Tongluo Decoction on bone metabolism and bone mineral density in ovariectomized osteoporosis rats#br#
SUN Kai1 CHEN Rongbin2 YANG Yingdong1 LI Yong2
Objective To investigate the effect of Ziyin Tongluo Decoction on bone metabolism and bone mineral density in ovariectomized osteoporosis rats. Methods Fifty SD female rats were selected to establish ovariectomized rat model, and another ten SD rats were selected as the sham operation group. The rats were divided into model group, Western medicine group (Alendronate Sodium [10.51 mg/kg] and Alfacalccitalol [0.075 μg/kg]), Ziyin Tongluo Decoction low-dose (1.34 g/kg), medium-dose (2.68 g/kg) and high-dose (4.02 g/kg) groups according to random number table method, with ten rats in each group. They were treated by gavage. After 12 weeks of treatment, bone mineral density(BMD), bone microstructure and serum contents of procollagen Ⅰ N-terminal propeptide (PⅠNP), N-terminal telopeptide of type Ⅰ collagen(NTX)， and C-telopeptide of type Ⅰ collagen (CTX-Ⅰ) were determined. Results Compared with sham operation group, BMD, bone volume fraction, bone trabecular number, bone trabecular thickness, and PⅠNP level were decreased in model group, and the differences were statistically significant (P ＜ 0.05). The trabecular separation, trabecular pattern factor, structural model index, NTX, and CTX-Ⅰ levels were increased in model group, and the differences were statistically significant (P ＜ 0.05). Compared with model group, BMD, bone volume fraction, bone trabecular number, bone trabecular thickness and PⅠNP level in Ziyin Tongluo Decoction groups were increased; the trabecular separation, trabecular pattern factor, structural model index, NTX, and CTX-Ⅰ levels were decreased, and the differences were statistically significant (P ＜ 0.05). There was no significant difference between groups with different doses of Ziyin Tongluo Decoction (P > 0.05). Conclusion Ziyin Tongluo Decoction can improve bone metabolism, increase bone density and improve bone microstructure of ovariectomized rats, and achieve the effect of postmenopausal osteoporosis treatment.
2021 Vol. 18 (34): 26-29,38 [Abstract] ( 87 ) HTML (1 KB)  PDF (1186 KB)  ( 23 )
30 Correlation between histogram analysis parameters derived from DCE-MRI and the expression of PD-L1 in triple-negative breast cancer#br#
LI Ji PENG Fei WANG Shuo
Objective To explore the correlation between dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) multi-function histogram parameters (Ktrans, Kep, Ve) and the expression of programmed death ligand 1 (PD-L1) in triple-negative breast cancer. Methods A collection of 52 patients with triple-negative breast cancer who were pathologically confirmed in the Tangshan People’s Hospital, Hebei Province from December 2019 to June 2020. Before surgery or before puncture, DCE-MRI was performed to calculate the histogram parameters of the MRI multi-function parameters (Ktrans, Kep, Ve) of the patient’s lesions, and the positive expression of PD-L1 in each lesion was detected by immunohistochemistry. The expression of PD-L1 was detected by two scoring methods: tumor positive cell score (TPS) and immune cell score (IC). According to the expression of PD-L1, they were divided into negative group and positive group, and the significance of each histogram quantitative parameter and the positive expression of PD-L1 in breast cancer was evaluated. Results In the TPS scoring system for triple-negative breast cancer, the positive expression rate of PD-L1 was 21.15%, and in the IC scoring system, the positive expression rate of PD-L1 was 40.38%. In the IC score group, the mean Ktrans, Ktrans P50, and Ktrans P75 values of the PD-L1 positive group were higher than those of the negative group (P ＜ 0.05). The mean Kep, Kep P25, and Kep P50 values of the PD-L1 positive group were higher than those of the negative group (P ＜ 0.05). In the TPS scoring group, the PD-L1 scoring status was compared in various functional parameters of MRI, and the difference was not statistically significant (P ＞ 0.05). Conclusion In the IC score group, PD-L1 positive triple-negative breast cancer patients have higher Ktrans and Kep. Therefore, MRI multifunctional parameters may be an effective imaging index for pre-evaluating whether patients with triple-negative breast cancer can be immunotherapy.
2021 Vol. 18 (34): 30-34 [Abstract] ( 35 ) HTML (1 KB)  PDF (753 KB)  ( 107 )
35 Effects of Shencao Tongmai Formular on ANP, AngⅡ of myocardium and cAMP, PKA, and PKC of nephrogenic tissue of chronic heart failure rats#br#
LI Hai1 LIU Xiaolei1 WANG Yi1 ZHANG Yan2
Objective To observe the effects of Shencao Tongmai Formula on atrial natriuretic peptide (ANP), angiotensinⅡ (AngⅡ) of myocardium and cyclic adenosine monophosphate (cAMP), protein kinase A (PKA), and protein kinase C (PKC) of nephrogenic tissue of chronic heart failure (CHF) rats. Methods Sixty SPF 12-week-old male rats weighing 300-350 g were randomly selected as the normal group and the sham operation group (coronary artery ligation was released after five seconds), with eight rats in each group. After coronary artery ligation, the remaining rats were fed down and exhausted swimming for 28 days to construct CHF model. After successful modeling, the rats were divided into traditional Chinese medicine group, Western medicine group, and model group by random number table remainder method, with eight rats in each group. Traditional Chinese medicine group was given Shencao Tongmai Formular crude drug 7.2g/(kg·d), twice a day; Western medicine group was given Fosinopril 1.2 mg/kg for the first time and distilled water 1.5 ml for the second time everyday; normal group, model group, and sham operation group were given distilled water 1.5 ml intragastric administration, twice a day, intervention for 28 d in all five groups. The changes of ANP, AngⅡ of myocardium and cAMP, PKA, and PKC of nephrogenic tissue of five groups were observed. Results The levels of ANP and AngⅡ in model group were higher than those of normal group and sham operation group, while the levels of ANP and AngⅡ in traditional Chinese medicine group were lower than those in model group, the differences were statistically significant (P ＜ 0.05). The levels of cAMP and PKC in model group were higher than those of normal group and sham operation group, and PKA was lower than that of normal group and sham operation group. The levels of cAMP and PKC in traditional Chinese medicine group were lower than that of model group, and PKA was higher than that of model group, with statistical significance (P ＜ 0.05). Conclusion Shencao Tongmai Formular is efficient in CHF treatment, renal function improvement. It’s also efficient in reducing the adverse effects of renal decompensation on CHF treatment.
2021 Vol. 18 (34): 35-38 [Abstract] ( 95 ) HTML (1 KB)  PDF (417 KB)  ( 80 )
39 Research progress of transdermal and external treatment of traditional Chinese medicine for spinal conditioning technology
ZHU Tingyu ZHAO Zhupei LIU Meihan SHI Xueqin DANG Yingying AN Hong LIU Jianfeng QIN Peijie
Spinal conditioning technology is a experience summary that is derived from the folk and benefiting the people, it has a large number, wide varieties and significant advantages. And it is a summary of non-invasive external treatment technology with traditional Chinese medicine characteristics for regulating spine and related diseases. This paper focuses on the summary and analysis of clinical literature related to the transdermal and external treatment of traditional Chinese medicine commonly used in spinal conditioning technology, in order to understand the research progress and shortage of related treatment methods, this paper hopes to provide some reference for the diversification of clinical treatment, and promote the popularization of technology. The lack of high quality evidence of spinal conditioning technology and difficulty in realizing economic and social value should be considered and prospeced, it is expected to attract the attention of relevant workers at all levels, and it plays a role of casting a brick to attract jade at the same time.
2021 Vol. 18 (34): 39-42，81 [Abstract] ( 60 ) HTML (1 KB)  PDF (989 KB)  ( 67 )
43 Research progress on pathogenesis of sinoatrial node dysfunction and atrial fibrillation based on fibrosis#br#
ZHANG Yidan1 WANG He2 SI Chunying2 CAO Yingjie3 XIE Jinhong2
Sinoatrial node dysfunction and atrial fibrillation are common arrhythmias in clinic, and they often coexist and interact with each other. Cardiac fibrosis is a marker of a series of pathological conditions and a risk factor leading to cardiac dysfunction and poor prognosis. At present, many studies have shown that fibrosis is closely related to the occurrence and development of sinoatrial node dysfunction and atrial fibrillation. This paper reviews the pathogenesis and influencing factors of fibrosis in sinoatrial node dysfunction and atrial fibrillation, to understand the complex relationship between sinoatrial node disease and atrial fibrillation, and to provide new ideas for clinical treatment of sinoatrial node dysfunction and atrial fibrillation.
2021 Vol. 18 (34): 43-46 [Abstract] ( 77 ) HTML (1 KB)  PDF (573 KB)  ( 24 )
47 Resarch progress in the application of imaging in early screening of colorectal carcinoma#br#
CHEN Qiongling DU Yong▲ ZHENG Yongfa GE Wei
Colorectal carcinoma is one of the most common gastrointestinal tumors in clinic. Early screening and diagnosis of colorectal carcinoma is of great significance for reducing its morbidity and mortality. Imaging technology is the major method for early screening and diagnosis of colorectal carcinoma, which has been developing and improving in recent years. Advanced imaging techniques have improved the detection rate and coincidence rate of early screening and diagnosis of colorectal carcinoma. This paper introduces the pathogenesis of colorectal carcinoma, and summarizes the application of imaging techniques in the screening and diagnosis of early colorectal carcinoma, such as aer-barium double contrast radiography screening, electronic colonoscopy screening, multi-slice spiral CT scanning, magnetic resonance imaging, and identifies the advantages and disadvantages of different imaging techniques. Imaging technology should be comprehensively used according to the actual situation of the examination objects to improve the detection rate and accuracy in clinical practice, which is important to guide the treatment and prognosis of patients.
2021 Vol. 18 (34): 47-50 [Abstract] ( 28 ) HTML (1 KB)  PDF (529 KB)  ( 48 )
51 Research progress on the relationship between miR-150 and pulmonary diseases#br#
CAI Qian1 CHEN Sirui2 ZHU Yingqun1
With the aggravation of air pollution and the increase of harmful factors in the environment, the prevalence of respiratory diseases has been increasing year by year in recent years. Studies have shown that micrornas (miRNA) are involved in many pathophysiological processes of the body by regulating gene expression. miR-150 is a member of miRNA family, it has been proven to be associated with lung cancer, acute lung injury, pulmonary fibrosis, pulmonary hypertension, chronic obstructive pulmonary disease, pleural effusion and so on. Up-regulation or down-regulation of miR-150 can effectively regulate the biological process of these diseases, it is suggested that miR-150 is closely related to the occurrence, development and prognosis of the above-mentioned diseases, may provide new targets for the diagnosis and treatment of respiratory diseases. This paper will review the research progress on the relationship between miR-150 and lung diseases.
2021 Vol. 18 (34): 51-54 [Abstract] ( 79 ) HTML (1 KB)  PDF (530 KB)  ( 24 )
55 Visualization analysis of research hotspot and trend of traditional Chinese medicine education based on CiteSpace#br#
ZHANG Ruonan LI Xiang ZHENG Fanglin WANG Tianqi LI Yiqing HOU Shengtian
Objective To reveal the current research situation, hotspot and frontier of traditional Chinese medicine education through the visualization research. Methods Literatures related to traditional Chinese medicine education were retrieved from CNKI database from June 1958 to December 2020 and Web of Science Core Collection database from January 1979 to December 2020. CiteSpace was used for visualization to reveal the hotspot and trend in this field. Results At present, the research on traditional Chinese medicine education was in a rising trend, but the cooperation between scholars was relatively few, and the quality of academic research needed to be improved. “Chinese medicine”“higher education of Chinese medicine”“talent training”“Chinese medicine”“teaching reform”“acupuncture”“chemist”“flipped-classroom”“Chinese herbal medicine”“disease prevention” were hotspots of current research;“Chinese medicine culture”“talent training”“Chinese medicine”“traditional Chinese medicine”“acupuncture” were the forefront of future research. Conclusion Traditional Chinese medicine education is still in the weak area of Chinese education system, and its development can be promoted from three aspects with reform and innovation, talent training and cross-border communication.
2021 Vol. 18 (34): 55-60 [Abstract] ( 139 ) HTML (1 KB)  PDF (1545 KB)  ( 23 )
61 Current situation and reform strategy of infectious diseases teaching in China #br#
CHEN Zhangqian ZHANG Wei WANG Jiuping
Although infectious disease prevention and control work has achieved world-renowned achievements for decades in China, the teaching reform of infectious diseases has been stagnant for a long time. In the teaching of infectious diseases, there are some problems, such as backward teaching materials and contents, limited teaching conditions, single teaching forms and teaching methods, and insufficient teacher reserve, which can not meet the current training needs of medical talents, but also fundamentally restrict the further improvement of the prevention and treatment ability of infectious diseases in China. Combined with new emergent infectious diseases appear constantly, change traditional infectious disease, infectious subject to status quo of the development of severe infection, it is necessary to update the teaching contents, the organic integration of a variety of teaching forms and methods and teaching mode, fundamental transformation, but also need to constantly optimize the teaching team, to strengthen the construction of teaching conditions. To fundamentally change the teaching dilemma caused by the designated treatment of infectious diseases in infectious diseases hospitals and the limitations of hardware conditions, and devote to cultivating the holistic and systematic concept of infectious diseases among medical students.
2021 Vol. 18 (34): 61-64 [Abstract] ( 45 ) HTML (1 KB)  PDF (730 KB)  ( 38 )
65 Research on countermeasures for training international compound talents in Chinese medicine colleges under the background of “the belt and road”#br#
BAI Yu1 ZHOU Donglei2 LI Hewei3 YANG Yuhe1 YU Xiao4 CHE Zhiyuan5
“The belt and road” strategy has brought opportunities and challenges for Chinese medicine to enter the international arena. In order to meet the requirements of internationalization of Chinese medicine, Chinese medicine colleges and universities must change their thinking of talent training and actively adapt to the needs of international talents. At present, Chinese medicine colleges and universities grasp the development opportunity of “the belt and road” and vigorously promote international education, but there are still some problems such as weak international awareness, lagging cultural communication, and lack of curriculum teachers. Therefore, Chinese medicine colleges and universities need to carefully analyze the current international development situation, and study the effective countermeasures of cultivating compound talents of Chinese medicine internationalization from the aspects of values, international recognition, teachers’ strength, cooperation platform and media publicity, so as to provide reference for the internationalization of Chinese medicine education.
2021 Vol. 18 (34): 65-68 [Abstract] ( 144 ) HTML (1 KB)  PDF (679 KB)  ( 51 )
69 Application of morphology teaching in breast diseases teaching#br#
ZHANG Dongxiao FU Na DONG Hao HUANG Qiao ZHAO Wenjie
Morphological observation plays an important role in the diagnosis and treatment of breast diseases, which is not only conducive to the diagnosis and differential diagnosis of the disease, but also of great significance to the treatment and prognosis. Doing morphology teaching well in clinical teaching can improve the learning effect of interns, probationers, and refreshers, and promote the improvement of medical quality. It needs some methods to do well in morphology teaching. In this paper, five common methods of morphology teaching are analyzed, including the explanation of morphological observation methods, the elaboration of morphological changes, the application of micro morphology, the construction of morphological database, and the teaching of case discussion, examples are given for each method, in the construction of morphological database the clinical manifestation image database, auxiliary examination image database, case database, treatment database and other commonly used image data sets are introduced. To improve students’ ability of diagnosis and treatment, improve the quality of teaching by the comprehensive programs.
2021 Vol. 18 (34): 69-72 [Abstract] ( 26 ) HTML (1 KB)  PDF (679 KB)  ( 32 )
73 Application effect of new teaching mode in human anatomy teaching of medical imaging technology specialty#br#
ZHANG Xiaoli DU Juan LI Jiayi ZHU Changlin LIU Zhe
Objective To explore the application and effect of new teaching mode of human anatomy teaching of medical imaging technology specialty. Methods From March 2020 to February 2021, 160 vocational college students of medical imaging technology specialty of grade 2019 and grade 2020 in Beijing Health Vocational College were selected as the research objects. One class from each grade was selected, with a total of 80 students as the control group, and the remaining 80 students were in the experimental group. The control group adopted the traditional teaching method, and the experimental group adopted the new teaching method. The test scores of the two groups were compared; questionnaire survey was used to analyze the students’ professional cognition, learning participation, learning motivation, and learning satisfaction. Results The theoretical, experimental and total scores of the experimental group were higher than those of the control group (P < 0.05). The results of the questionnaire survey showed that the new teaching mode can improve students’ professional recognition, learning participation, learning motivation, and learning satisfaction. Conclusion The new teaching mode arouses students’ learning initiative and improves students’ academic performance.
2021 Vol. 18 (34): 73-76 [Abstract] ( 47 ) HTML (1 KB)  PDF (822 KB)  ( 56 )
77 Application effect of quantitative evaluation on clinical pathway teaching method in operation room nursing#br#
WU Aidi1 WANG Liying1 YU Danqing1 YE Xide2
Objective To investigate the effect of the quantitative evaluation on clinical pathway teaching method in operating room nursing and satisfaction analysis of teachers and students. Methods A total of 176 operating room nursing students in the First People’s Hospital of Yuhang District of Hangzhou from June 2018 to May 2019 were selected as the research objects, and they were divided into observation group and control group according to random number table method, with 88 cases in each group. The observation group used quantitative evaluation clinical pathway teaching method, and the control group used clinical pathway teaching method. After the teaching, the theoretical and practical performance of two groups were compared, questionnaire was used to investigate teaching satisfaction, learning satisfaction and cooperation satisfaction. Results The theoretical and practical performance of observation group were higher than those of control group (P < 0.01). The satisfaction of observation group was higher than that of control group (P < 0.05). The nursing students’ learing satisfaction of teacher in observation group was higher than that in control group (P < 0.05). The nursing students’ corrdination satisfaction degree of doctors in observation group was higher than that in control group (P < 0.05). Conclusion Quantitative evaluation of clinical pathway teaching mode can improve the teaching effect of nursing students and provide theoretical basis for the promotion of clinical nursing teaching mode in practice.
2021 Vol. 18 (34): 77-81 [Abstract] ( 70 ) HTML (1 KB)  PDF (689 KB)  ( 24 )
82 Research and practice of interdisciplinary curriculum on the training of undergraduate talents in acupuncture and massage major based on the humanistic core quality #br#
WANG Xingping1 LIAO Jing1 XU Ming1 WU Xiang1 XU Ying1,2,3 XU Weihui2
The humanistic core quality points to the students’ overall ideology and key ability, which can promote the construction and transcendence of students’ values, and should be the fundamental follow of the cultivation of humanistic core quality in schools. This paper combs the historical significance and realistic value of the humanistic core quality for acupuncture and massage education, explains the key concepts of the humanistic core quality and integrates them into the curriculum experience of interdisciplinary schools, digital curriculum experience, social and cultural practice curriculum experience, and realistic project curriculum experience. In addition, the interdisciplinary curriculum practice of acupuncture and massage specialty is carried out from the two fulcrum points of “humanities +” curriculum form formed by interdisciplinary fusion and the specific process of “sinking - rising”.
2021 Vol. 18 (34): 82-85,95 [Abstract] ( 84 ) HTML (1 KB)  PDF (1076 KB)  ( 202 )
86 Clinical efficacy of modified Bushen Shengsui Chenggan Preparation combined with pegylated interferon α-2b in the treatment of chronic hepatitis B and its influence on liver function and liver fibrosis#br#
HUANG Dawei1 LU Dingbo1 JIANG Shiyi1 LI Hanmin2
Objective To explore the clinical efficacy of modified Bushen Shengsui Chenggan Preparation combined with pegylated interferon α-2b in the treatment of chronic hepatitis B (CHB) and its influence on liver function and liver fibrosis. Methods A total of 70 CHB patients in Hubei Hospital of Traditional Chinese Medicine from September 2017 to December 2019 were divided into the observation group（35 cases） and the control group（35 cases）by random number table method, the control group was treated with pegylated interferon α-2b, and the observation group was treated with modified Bushen Shengsui Chenggan Preparation combined with pegylated interferon α-2b, the traditional Chinese medicine symptom score, liver function index (serum total bilirubin [TBil], alanine aminotransferase [ALT], asparagine aminotransferase [AST], serum albumin [ALB]), liver fibrosis index (type Ⅲ procollagen [PCⅢ], collagen typeⅣ[Ⅳ-C], layer mucins [LN], hyaluronidase [HA]), HBV markers (ALT normalization rate, hepatitis B virus [HBV]-DNA negative conversion rate and Hepatitis B E antigen [HbeAg] negative conversion rate) before and after treatment and adverse reactions were compared between the two groups. Results Before treatment, there were no significant differences in traditional Chinese medicine symptom scores between the two groups (P ＞ 0.05); after treatment, traditional Chinese medicine symptom scores of the two groups were lower than before treatment, and the observation group was lower than the control group (P ＜ 0.05). Before treatment, there were no significant differences in liver function indexes (TBil, ALT, AST, ALB) between two groups (P ＞ 0.05); after treatment, the ALB levels of the two groups were higher than those before treatment, while the TBil, ALT, AST levels were lower than before treatment, and the ALB levels of the observation group were higher than the control group, while the TBil, ALT, and AST levels were lower than the control group (P ＜ 0.05). Before treatment, there was no significant difference in liver fibrosis indexes (PCⅢ, Ⅳ-C, LN, and HA) between the two groups (P ＞ 0.05). After treatment, the levels of PCⅢ, Ⅳ-C, LN, and HA in the two groups were lower than those before treatment, and the observation group was lower than the control group (P ＜ 0.05). After six month follow-up, the HBeAg negative conversion rate of the observation group was significantly higher than those of the control group (P ＜ 0.05). There was no significant difference in the incidence of adverse reactions between two groups (P ＞ 0.05). Conclusion Modified Bushen Shengsui Chenggan Preparation combined with pegylated interferon α-2b in the treatment of CHB is helpful to improve liver function and liver fibrosis. It has significant curative effect and good safety, and is worthy of clinical application.
2021 Vol. 18 (34): 86-90 [Abstract] ( 156 ) HTML (1 KB)  PDF (565 KB)  ( 28 )
91 Bibliometrics and visual analysis in the field of quality of death based on Web of Science database#br#
WANG Zhen1 SU Mengyu1 ZHOU Ning2 ZHANG Yuxi3 WU Jinfeng4
Objective To explore the current research status, hotspots, and frontiers in the field of quality of death, and to provide direction for future research. Methods The retrieval time was from the database contruction to September 2020, and the data source was the Web of Science core collection. The annual number of documents was analysised by Excel 2019. CiteSpace 5.7 R2 software was used to draw national and institutional cooperation networks to explore the distribution of major research forces in this field. In order to reflect the research evolution process and hotspots information of this field, the time chart of keywords, surge keywords and highly cited literatures were comprehensively applied. Results A total of 290 papers in the field of quality of death were concluded. Four countries included United States, Netherlands, United Kingdom, and Belgium and their institutions were the leading forces of scientific research. Research hotspots in the field of quality of death were “quality of care” “end of life discussion” “awareness of terminal illness” “measurement tools” “comfortable care for patients with advanced dementia”, and “urgent referrals”. The leading edge topics in the future research of quality of dying were “survival” and “people”. Conclusion The research in quality of death is certainly increasing and the tremendous potential growing. In the future, researchers can explore the operation model of hospice care institutions suitable for China combining with local characteristics and promote sustainable development of hospice care.
2021 Vol. 18 (34): 91-95 [Abstract] ( 108 ) HTML (1 KB)  PDF (935 KB)  ( 124 )
96 Diagnostic value of serum cytokeratin 18 levels of M30 and M65 in non-alcoholic steatohepatitis: a meta-analysis#br#
CHE Yang WANG Yang WANG Jinming SHI Ying▲
Objective To evaluate the diagnostic value of cytokeratin 18 fragments M30 and M65 in non-alcoholic steatohepatitis (NASH). Methods Literatures from PubMed, EMbase, Cochrane online Library, CNKI and Wanfang database were systematically searched by computer. The retrieval time was from inception to October 2020. After sorting out the collected literature and evaluating its quality, Meta-Disc1.4 software and Stata 16.0 software were used for statistical analysis. Results This paper included 17 literatures, 15 literatures related to M30 and seven literatures related to M65, with a total sample size of 1301. The total sensitivity and specificity of M30 for NASH were 0.646 (95%CI:0.606-0.684) and 0.772 (95%CI: 0.736-0.806), respectively. The total sensitivity and specificity of M65 for NASH were 0.698 (95%CI: 0.639-0.752) and 0.756 (95%CI: 0.699-0.807), respectively. The area under curve of the summary receiver operator characteristic method (sROC) of M30 was 0.8264. The area under the sROC curve of M65 was 0.7899. Conclusion Cytokeratin 18 fragments M30 and M65 have certain significance for clinical diagnosis of NASH, but the effect of diagnosis alone or exclusion of NASH is moderate, and the diagnosis should be combined with other tests.
2021 Vol. 18 (34): 96-100 [Abstract] ( 150 ) HTML (1 KB)  PDF (1186 KB)  ( 37 )
101 Effect of continuous iliac fascial space block on perioperative analgesia, hemodynamics and postoperative delirium in advanced age patients undergoing hip surgery#br#
XU Tongsheng1 LIU Zhenqing1▲ CHEN Xiaodong1 ZHANG Shujun2
Objective To explore the effect of continuous iliac fascial space block on perioperative analgesia, hemodynamics, and postoperative delirium in advanced age patients undergoing hip surgery. Methods A total of 178 advanced age patients undergoing hip surgery admitted to the Wuxi Ninth People’s Hospital of Jiangsu Province from January 2019 to January 2021 were selected as objects, and they were divided into into control group and observation group according to the random number table method, with 89 cases in each group. The control group was treated with conventional preoperative treatment, and the observation group was given continuous iliac fascial space block. Intraoperative blood loss, surgery time and hospital stay of two groups were observed. Visual analogue scale (VAS) score, mean arterial pressure and heart rate were compared between two groups enter the operating room (T1), 30 min after block (T2), after surgery (T3) and 30 min after surgery (T4). The incidence and duration of delirium within 7 d after surgery were observed. The incidence of adverse reactions in  two groups were observed. Results There were no significant differences in intraoperative blood loss and surgery time between two groups (P > 0.05); the hospital stay of observation group was shorter than that of control group (P < 0.05). There were no significant differences in VAS score, mean arterial pressure, and heart rate between the two groups at T1 (P > 0.05). VAS score, mean arterial pressure, and heart rate at T2, T3, and T4 in observation group were lower than those in control group (P < 0.05). The incidence of delirium in observation group was lower than that in control group, and the duration of delirium was shorter than that in control group (P < 0.05). The incidence of adverse reactions in observation group was lower than that in control group (P < 0.05). Conclusion Continuous iliac fascial space block for advanced age patients with hip surgery can shorten the surgery time, reduce pain, stabilize blood pressure and heart rate, and reduce the incidence of delirium and adverse reactions.
2021 Vol. 18 (34): 101-104 [Abstract] ( 75 ) HTML (1 KB)  PDF (491 KB)  ( 20 )
105 Effect of electroacupuncture at zúsānlǐ point combined with Nalbuphine on abdominal pain of patients during mixed hemorrhoid surgery#br#
LU Yue1 HAN Xiaoyun1 JIAO Hao2
Objective To observe the effect of electroacupuncture at  zúsānlǐ point combined with Nalbuphine on patients with abdominal pain during mixed hemorrhoid surgery. Methods A total of 80 patients with mixed hemorrhoids admitted to Shijiazhuang Municipal Hospital of Traditional Chinese Medicine from September 2020 to January 2021 were selected, and they were divided into two groups according to the random number table method, with 40 cases in each group. The control group was treated with Nalbuphine intraoperatively, while the observation group was treated with electroacupuncture at zúsānlǐ point combined with Nalbuphine intraoperatively, electroacupuncture lasts 20 min. The incidence of abdominal pain was compared between two groups, and the pain degree of patients with abdominal pain was evaluated by visual analog scale (VAS). Systolic blood pressure (SBP), diastolic blood pressure (DBP), heart rate (HR),  blood oxygen saturation (SpO2), and electrogram (ECG) were compared between two groups before anesthesia, before surgery and immediately after surgery; the serum neurotransmitter levels (substance P [SP] and neurokinin 1[NK-1]) were compared between two groups before surgery, immediately after surgery, and 24 h after surgery; the incidence of adverse reactions in the two groups was recorded. Results The incidence of abdominal pain and VAS score in observation group was lower than that in the control group (P < 0.05). SBP, DBP, and HR of two groups before surgery were higher than those before anesthesia, SBP, DBP, and HR at immediately after surgery were lower than those before surgery (P < 0.05). There were no significant differences in SBP, DBP, HR, and SpO2 between two groups at different time points (P > 0.05). There was no abnormal change of ECG in both groups at different time points. The levels of SP and NK-1 at immediately after surgery and 24 h after surgery in both groups were higher than those before surgery (P < 0.05), and the levels of SP and NK-1 at 24 h after surgery were lower than those at immediately after surgery (P < 0.05). The levels of serum SP and NK-1 in observation group were lower than those in the control group at immediately after surgery and 24 h after surgery (P < 0.05). There was no significant difference in the incidences of adverse reactions between two groups (P > 0.05). Conclusion Electroacupuncture at zúsānlǐ point combined with Nalbuphine for patients with mixed hemorrhoid surgery can reduce the degree of abdominal pain, regulate the levels of serum neurotransmitters levels, and has good safety.
2021 Vol. 18 (34): 105-108，112 [Abstract] ( 74 ) HTML (1 KB)  PDF (514 KB)  ( 31 )
109 Feasibility analysis of optimal PEEP level setting in patients undergoing laparoscopic radical resection of colorectal cancer with dynamic lung compliance combined with alveolar void volumetric guidance#br#
WANG Chuanguang ZHOU Jianwei HUANG Yan YAO Yinguang WU Zhenhua YE Yonggong
Objective To investigate the feasibility of dynamic lung compliance (Cdyn) combined with alveolar void volumetric (VD/VT) guided optimum positive end-expiratory pressure (PEEP) for improving intraoperative oxygenation in patients with laparoscopic radical resection of colorectal cancer. Methods From December 2018 to August 2020, 26 patients undergoing elective laparoscopic radical resection of colorectal cancer in Lishui Central Hospital of Zhejiang Province were selected as the research subjects. VT was set at 7 mL/kg, and volumetric increasing recruitment manoeuvre (RM) and PEEP titration were performed after the pneumopitoneum position was established. Starting from 14 cmH2O, each step decreased by 2 cmH2O and maintained for 10 min, and the end point of optimal PEEP was determined when it was reduced to 4 cmH2O. Cdyn, VD/VT, oxygenation index (OI), blood lactic acid (Lac), stroke volume variation (SVV) and other indicators in pneumoperitoneum was established for 10 min (T1) and corresponding PEEP level was established to control respiration for 20 min (T2), 30 min (T3), 40 min (T4), 50 min (T5), 60 min (T6), and 70 min (T7) were monitored. Results No significant hemodynamic fluctuations were observed in all patients undergoing PEEP titration (SVV < 13%). Compared with T1, Cdyn at T5 increased significantly (P < 0.01), and  it was at the peak of titration process; OI was significantly increased (P < 0.05); VD/VT was significantly decreased at T3 and T5 (P < 0.05). Conclusion The optimal PEEP titration after RM combined with the goal oriented setting of Cdyn and VD/VT can effectively improve the oxygenation of patients during laparoscopic radical resection of colorectal cancer.
2021 Vol. 18 (34): 109-112 [Abstract] ( 21 ) HTML (1 KB)  PDF (494 KB)  ( 86 )
113 Professor Wang Xiuxia’s view on “circular-motion of five phases” in treating ovarian cancer#br#
YU Yang1 SHEN Ying1 YANG Shuang1 HAN Fengjuan2
Based on the theory of “circular-motion of five phases”, Professor Wang Xiuxia believes that the movement of all things between heaven and earth is a big circle movement, while the movement of five internal organs within the human body is a small circle movement. If we want to understand the theory of yin and yang and five organs, we should first understand the way of “circular-motion of five phases”. Therefore, the etiology and pathogenesis of ovarian cancer are summarized as water losing warm malnutrition, wood losing free activity, and central axis losing movement. She proposes warming moisture, regulating wood qi, strengthening soil and drying dampness, so as to recover circular-motion, and takes self-made Lichong Shengsui Decoction to add and subtract treatment. At the time of clinical diagnosis, she emphasizes that loyal to the Chinese medicine and refer to the Western medicine, sinicizes the West. She also explores the role of this prescription in the treatment of ovarian cancer, and pays more attention to the emotional factors of patients, treats them both physically and mentally, and improves their life cycle and quality of life.
2021 Vol. 18 (34): 113-116 [Abstract] ( 25 ) HTML (1 KB)  PDF (655 KB)  ( 49 )
117 Study on the mechanism of Professor Dong Guirong’s “balance of yin and yang movement acupuncture” in the diagnosis and treatment of upper limb paralysis after stroke#br#
ZHOU Liang1 BAO Chunling1 SHI Cheng2 WU Dan1 LIU Yingchao1 FANG Meng1 ZHANG Siqi1 DONG Guirong1
Professor Dong Guirong is a famous expert of acupuncture and moxibustion in China. He is good at diagnosis and treatment of nervous system, respiratory system, gynecology and related difficult diseases. He has been engaged in the clinical and mechanism of stroke for a long time. He establishes methods of scalp point penetration needling, balance of yin yang regulating needling and balance of yin and yang movement acupuncture to treat apoplexy, with remarkable curative effect. Balance of yin and yang movement acupuncture is a combination of yin yang balance regulating needling with biomechanics and biofeedback, it has formed a complete pathway of “nerve-structure-joint-muscle-muscle tension-motor function” after stroke. This paper introduces Professor Dong Guirong’s balance of yin and yang movement acupuncture, mainly expounds the establishment background, operation method, acupoint selection, mechanism and manipulation characteristics.
2021 Vol. 18 (34): 117-120,134 [Abstract] ( 72 ) HTML (1 KB)  PDF (670 KB)  ( 14 )
121 Exploration on the mechanism of Astragali Radix and Codonopsis Radix couplet medicines in treating diabetic nephropathy based on network pharmacology#br#
LIU Zhengping1 CAO Po2 ZHONG Jian2 WEI Yu2 WANG Shidong2 SHI Yuexin1
Objective To explore the mechanism of Astragali Radix and Codonopsis Radix couplet medicines in treating diabetic nephropathy based on network pharmacology. Methods Traditional Chinese medicine systems pharmacology database and analysis platform was used to search for the effective components and related targets of Astragali Radix and Codonopsis Radix. The network diagram of drug effective components-target was plotted by using Cytoscape 3.8.1 software. OMIM, DisGeNET and GeneCards databases were used to obtain related targets of diabetic nephropathy. The intersections with drug targets were uploaded by using STRING 11.0 database to construct a protein protein interaction network. Metascape database was used for gene ontology and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis on the intersecting targets. Results A total of 34 effective components were obtained from Astragali Radix and Codonopsis Radix couplet medicines, and 15 core targets were obtained from the intersecting targets. KEGG analysis showed that its main pathways of intersection targets included signaling pathways of AGE-RAGE, IL-17, MAPK, NF-κB, VEGF, JAK-STAT, and so on. Conclusion Astragali Radix and Codonopsis Radix couplet medicines may have effect on diabetic nephropathy through the action of quercetin, kaempferol, luteolin and other components on multiple targets such as AKT1, IL-6, TNF, and the regulation of multiple signaling pathways such as AGE-RAGE, IL-17, and others.
2021 Vol. 18 (34): 121-125 [Abstract] ( 195 ) HTML (1 KB)  PDF (1881 KB)  ( 116 )
126 Analysis of the medication rule of traditional Chinese medicine in treating anal sinusitis based on data mining#br#
YU Dayuan LIU Wei LI Xue LIU Renghai▲
Objective To analyze the prescription rules of treating anal sinusitis with traditional Chinese medicine in periodical literature by using traditional Chinese medicine inheritance support system platform. Methods The literatures on traditional Chinese medicine treatment of anal sinusitis published in China National Knowledge Infrastructure, Chinese sci-tech Periodical Full-text Database and Wanfang Database from inception to February 2021 were screened, and the data were input into the traditional Chinese medicine inheritance support system platform. The data analysis module of the software was used to analyze the medication rule of traditional Chinese medicine in the treatment of anal sinusitis, including four nature of drugs, five flavours, channel tropism, drug use frequency, prescription rule and potential new prescription combination. Results A total of 49 prescriptions involving 118 traditional Chinese medicine were included. Drugs were mainly cold drugs (202 times), bitter drugs (263 times), sweet drugs (150 times), spicy drugs (109 times), mainly through the liver meridian (145 times), spleen meridian (132 times), stomach meridian (107 times), lung meridian (99 times). The six most frequently used herbs were amur cork-tree (26 times), liquorice root (21 times), golden thread (18 times), chinese angelica (14 times), garden burnet root (13 times) and lightyellow sophora root (13 times). The first six drug pairs were chinese angelica-unprocessed rehmannia root, liquorice root-orange fruit, chinese angelica-liquorice root , amur cork-tree-garden burnet root, liquorice root-golden thread, dandelion-wild chrysanthemum flower. A total of six core drug combinations for the new formula were excavated. Conclusion At present, the known traditional Chinese medicine prescriptions for the treatment of anal sinusitis are mainly to clear heat and remove diuresis, cool blood and detoxify, and also to soothe liver, promote blood circulation and relieve pain, etc. The core drug combinations and new prescriptions have certain reference value for the theoretical research, new drug development and clinical syndrome differentiation treatment of anal sinusitis.
2021 Vol. 18 (34): 126-130 [Abstract] ( 89 ) HTML (1 KB)  PDF (843 KB)  ( 29 )
131 Analysis on characteristics of medicine used by Liu Ziwei of Huaixuan Medical School#br#
GU Renzhuang1 YU Chen2 CUI Wencheng3
Liu Ziwei, a descendant of Huaixuan medical school, has been in charge of Huaixuan medical school for more than 20 years. The medical school has far-reaching influence and is regarded as the “ancestor of the God of fire”. Liu Ziwei’s medication features are distinct. Liu Ziwei often uses the method of yin and yang complementation in the treatment of the deficiency of five zang-viscera disorders. It is believed that people are born with wood before they have fire, and the method of making fire by supplementing wood is often used to treat the yang deficiency and yin excessiveness disorders. And the fire must not show its path, naturally shift or change in order to grow and sustain life, so the method of fire must be used to repair by the fire must be hidden. Liu Ziwei often used these three drug characteristics successively or simultaneously in the yang deficiency disorders. In view of the abnormal ascension and descent, the combination of deficiency and excess, and struggle between vital qi and pathogen disorders, there are the characteristics of the combination of ascension and descent, supplementing the deficiency and reducing the excess, the combination of convergence and dispersion, it is worth learning from. The characteristics of Liu Ziwei’s medication are described to highlight his thought.
2021 Vol. 18 (34): 131-134 [Abstract] ( 26 ) HTML (1 KB)  PDF (648 KB)  ( 28 )
135 Evaluation of myocardial work changes in early coronary heart disease patients by pressure-strain loop#br#
WU Qiuling LI Hua TANG Sha NIU Ming
Objective To evaluate the left ventricular myocardial work changes in early coronary heart disease by pressure-strain loop (PSL). Methods A total of 68 patients with suspected coronary heart disease admitted to the Fourth Clinical Medical College of Xinjiang Medical University (hereinafter referred to as “our hospital”) from June 2018 to September 2020 were selected. According to their coronary angiography results, they were divided into mild stenosis group (stenosis rate＜50%) (27 cases) and moderate stenosis group (50%≤stenosis rate＜75%) (41 cases). At the same time, 30 healthy subjects in our hospital were selected as control group. PSL was used to evaluate global longitudinal strain (GLS) and myocardial work parameters, including global work index (GWI), global constructive work (GCW), global wasted work (GWW), and global work efficiency (GWE). Pearson correlation coefficient was used to analyze the correlation between myocardial work parameters and left ventricular ejection fraction (LVEF) and GLS. The diagnostic value of myocardial work parameters in coronary heart disease was analyzed by using receiver operator characteristic curve and area under curve (AUC). Results The GLS and GWW of moderate stenosis group were higher than those of control group and mild stenosis group, while the GWI, GCW, and GWE of moderate stenosis group were lower than those of control group and mild stenosis group, the differences were statistically significant (P ＜ 0.05). GWI and GCW were positively correlated with LVEF (r ＞ 0, P ＜ 0.05), negatively correlated with GLS (r ＜ 0, P ＜ 0.05). All myocardial work parameters had diagnostic value for coronary heart disease (AUC ＞ 0.5, P ＜ 0.05). Conclusion PSL can accurately assess the changes of myocardial work in patients with coronary heart disease, providing a new diagnostic basis for early clinical evaluation of coronary heart disease.
2021 Vol. 18 (34): 135-138 [Abstract] ( 108 ) HTML (1 KB)  PDF (613 KB)  ( 24 )
139 Application value of endoscopic ultrasonography and CT in the diagnosis of esophageal submucosal masses#br#
LI Xiangyu GU Xuexiang GE Qianwen
Objective To study the application value of endoscopic ultrasonography and CT in the diagnosis of esophageal submucosal masses. Methods A total of 103 patients with esophageal submucosal masses detected by gastroscopy from January 2019 to December 2020 in the Affiliated Huaian NO.1 People’s Hospital of Nanjing Medical University were selected as the study subjects. All patients underwent endoscopic ultrasonography and CT examination, and were treated by surgery and diagnosed by pathology. The pathological results, endoscopic ultrasonography and CT findings of all patients were analyzed. The consistency between these two methods and pathological examination in judging benign and malignant tumors of different sizes of esophageal submucosa was compared. Results Pathological results of all patients showed that 8.74% were malignant tumors, all of which were malignant stromal tumors, and 91.26% were benign tumors. Endoscopic ultrasonography showed that the benign mass had clear boundary, smooth surface, and homogeneous or less homogeneous hypoechoic mass. The malignant mass was indistinct with mixed echogenic masses. CT showed that the benign mass had regular shape, oval solid mass, and clear boundary. The malignant mass had uneven density, fuzzy boundary, and uneven enhancement. Endoscopic ultrasonography was consistent with pathological examination (Kappa=0.797, P < 0.05), while CT was consistent with pathological examination (Kappa=0.415, P ＜ 0.05). The diagnostic coincidence rate of endoscopic ultrasound was higher than that of CT, and the difference was statistically significant (P ＜ 0.05). Endoscopic ultrasonography and CT had good consistency with pathological examination in ＞ 2 cm masses (Kappa=1.000, 0.800, P ＜ 0.05). In 1-2 cm masses, endoscopic ultrasonography had a general consistency with pathological examination (Kappa=0.470, P ＜ 0.05), while CT had a poor consistency with pathological examination (Kappa=0.356, P ＜ 0.05). In ＜ 1 cm masses, endoscopic ultrasonography had a general consistency with pathological examination (Kappa=0.642, P ＜ 0.05), while CT had no consistency with pathological examination (P > 0.05). Conclusion Endoscopic ultrasonography and CT have high consistency with pathological examination in the diagnosis of > 2 cm esophageal submucosal masses, which is worthy of promotion.
2021 Vol. 18 (34): 139-142,147 [Abstract] ( 36 ) HTML (1 KB)  PDF (896 KB)  ( 34 )
143 Effects of high frequency repetitive transcranial magnetic stimulation on cognitive function and white matter microstructure in mild cognitive impairment patients#br#
RAN Li1 GUO Zhiwei1 ZHOU Liang2 LI Zhongmei2 MU Qiwen1,2
Objective To study the effect of high-frequency repetitive transcranial magnetic stimulation (rTMS) on cognitive function and white matter microstructure in patients with mild cognitive impairment (MCI). Methods A total of 29 MCI patients enrolled in the community of Nanchong City, Sichuan Province from January to July 2019 were divided into true stimulation group and pseudo stimulation group according to the random number table method, with 17 cases and 12 cases respectively. The true stimulation group was given 10 Hz rTMS for 10 days to stimulate the right dorsolateral prefrontal lobe (DLPFC); the pseudo stimulation group was given a pseudo stimulation coil. All subjects underwent the mini-mental state examination (MMSE), Montreal cognitive assessment  (MoCA) and diffusion tensor imaging (DTI) at baseline and after treatment. The above cognitive score and diffusion fractional anisotropy (FA) were compared, and analyze the correlation between cognitive score and FA value were analyzed. Results After treatment, the MoCA and MMSE scores of the true stimulation group were higher than those before the treatment, while the MoCA scores of the pseudo-stimulation group were higher than those before the treatment, and the differences were statistically significant (P ＜ 0.05); there was no statistically significant difference in the scores between the two groups after the treatment (P ＞ 0.05). In the true stimulation group, the FA values of the bilateral superior frontal gyrus and the right precuneus were higher than before treatment, and the FA values of the bilateral superior frontal gyrus, the precuneus, the right middle frontal gyrus, and the right parieto-occipital lobe were higher than those before the treatment. In the stimulation group, the FA values of the left hippocampus, thalamus, lingual gyrus, and middle temporal gyrus were lower than those in the pseudo-stimulation group, and the difference was statistically significant (P ＜ 0.05). The MMSE score of the true stimulation group was negatively correlated with the FA values of the left occipital lobe and hippocampus (r = -0.590, P = 0.013; r = -0.518, P = 0.034). Conclusion High-frequency rTMS therapy may regulate the white matter microstructure integrity of partially damaged brain regions in patients with MCI, and lead to the corresponding improvement in cognitive function.
2021 Vol. 18 (34): 143-147 [Abstract] ( 29 ) HTML (1 KB)  PDF (580 KB)  ( 42 )
148 Clinical value of semi-quantitative grading of musculoskeletal ultrasound in the evaluation of joint activity in patients with rheumatoid arthritis#br#
WANG Chaoxin YANG Ling LI Wenhua WANG Chao XUE Xiaoxuan LU Zheng LIU Yan YUAN Shuqi
Objective To analyze the clinical value of musculoskeletal ultrasound semi-quantitative grading to evaluate joint mobility in patients with rheumatoid arthritis (RA). Methods A total of 80 RA patients admitted to Dongfang Hospital of Beijing University of Chinese Medicine from January 2019 to July 2021 were selected as the research objects. According to the disease activity score, they were divided into remission group, low, medium, and high activity group. Another 80 healthy volunteers in the same period were selected as the control group. The levels of joint ultrasound and serological indexes in each group were compared. Results Synovial hyperplasia, synovial blood flow signal, bone erosion, and joint effusion ultrasound semi-quantitative grading score, total score, and the levels of serum erythrocyte sedimentation rate (ESR), rheumatoid factor (RF), matrix metalloproteinase 3 (MMP-3), anti-cyclic citrulline antibody (anti-CCP), and anti-mutant citrulline vimentin antibody (anti-MCV) in each groups were compared, and the differences were statistically significant (P ＜ 0.05). Among them, the ultrasound semi-quantitative grading scores and total scores of synovial hyperplasia, synovial blood flow signals, bone erosion, and joint effusion in the high activity group were higher than those in the medium activity group, low activity group, remission group, and control group (P ＜ 0.05); and which in the medium activeity group was higher than those in the low activity group, remission group, and control group (P ＜ 0.05); the low activity group was higher than the remission group and the control group (P ＜ 0.05); the remission group was higher than the control group (P ＜ 0.05). The total score of musculoskeletal ultrasound semi-quantitative classification was positively correlated with serum ESR, RF, CRP, anti-CCP, and anti-MCV in RA patients (r = 0.651, 0.736, 0.720, 0.711, 0.749, P ＜ 0.05). Conclusion The semi-quantitative grading of musculoskeletal ultrasound is closely related to the serum indicators of RA patients. The use of semi-quantitative grading of musculoskeletal ultrasound can provide a reference for early evaluation of the patient’s disease progression.
2021 Vol. 18 (34): 148-151 [Abstract] ( 110 ) HTML (1 KB)  PDF (551 KB)  ( 15 )
152 Informatization construction and management practice and problem analysis of Chinese cerebri glioma clinical sample database#br#
CHEN Yu1 WANG Di2 LI Guanzhang2，3 ZHAO Zheng3 LI Yiying1
In recent years, the construction and management of clinical sample database in China has gradually developed in the direction of standardization, informationization and systematization. In order to summarize and analyze the experience of information construction and management of Chinese clinical sample database, this paper takes the construction and management framework of Chinese cerebri glioma clinical biological sample database as an example, systematically analyzes the standardized construction process, sample collection standard, information management system, clinical follow-up data collection and database scientific research output of the sample database. It is found that the scientific research output and academic influence of the database are mainly affected by the level of informatization and standardization management of the sample database. With the continuous improvement of the information and standardization management system, the scientific research output and academic influence of the database are increasing. The result shows that informatization plays an important role in the construction and management of clinical biological sample database, and provides important reference value for the construction and management of other clinical biological sample database in our country. At the same time, in order to further improve the information management of clinical sample database and summarize the common problems in the information management of clinical sample database, this paper reviews the main problems in the construction and management of clinical biological sample database reported in the literatures at home and abroad, analyzes the underlying causes and puts forward corresponding solutions, in order to promote the continuous progress of the management mode of clinical biological sample database in our country.
2021 Vol. 18 (34): 152-155 [Abstract] ( 24 ) HTML (1 KB)  PDF (368 KB)  ( 136 )
156 Quantitative analysis of public hospital management policies at the national level based on policy tools#br#
SUN Dongyue SONG Linzi YANG Jing
Objective To study the relevant policy documents of operation and management of public hospitals at the national level based on policy tools, in order to provide a reference for the formulation of public hospital management policies. Methods The collected policy content was quantitatively analyzed by content analysis method, and the 341 selected management policies were coded, classified and fitted to construct a three-dimensional analysis model of policy tools. Results This study constructed a policy tool analysis model with three dimensions, included policy tools, public hospital management level, and time phases. The 341 policy texts were included in the analysis, capacity-building policy tools were used the most, accounting for 43.99%. Authoritative policy tools were used the second most, accounting for 40.18%. There were 42 symbolic and exhortation policy tools were used, accounting for 12.32%; only 12 incentive policy tools, accounting for 3.52%. In the dimension analysis of management level, there were 209 policy items corresponding to hospital internal management, accounting for 61.29%. Conclusion The application situation of policy tools in the field of public hospital management is good, but the balance of use is insufficient. In the subsequent policy formulation of public hospital management, the internal structure of policy tools should be optimized to form a policy synergy, and comprehensively use policy tools to promote the high-quality development of public hospitals.
2021 Vol. 18 (34): 156-159,171 [Abstract] ( 108 ) HTML (1 KB)  PDF (1076 KB)  ( 16 )
160 Application effect of informatization management system in device management of central sterile supply department#br#
CAO Xuemei ZHANG Chunli
Objective To explore the application effect of informatization management system in device management of central sterile supply department. Methods A total of 1000 medical devices recovered from Central Sterile Supply Department of Xuzhou Central Hospital, Jiangsu Province from December 2018 to November 2020 were selected as the research subjects. They were divided into control group and experimental group by random number table method, with 500 devices in each group. The control group adopted the traditional management mode, and the experimental group adopted the informatization management system. The indicators of device condition (qualified rate of cleaning, damage rate, qualified rate of packaging, qualified rate of distribution) and the indicators of management effect (recycling classification time, information registration time, warehouse-out inspection time) were compared between the two groups. Results The qualified rate of cleaning, packaging and distribution in the experimental group were higher than those in the control group, and the damage rate of equipment was lower than that in the control group (P < 0.05). The recycling classification time, information registration time and warehouse-out inspection time in the experimental group were lower than those in the control group (P < 0.05). Conclusion The application of the information management system in central sterile supply department can effectively improve the work quality and efficiency, and makes the operation of central sterile supply department more professional and standardized, which is worthy of clinical application and promotion.
2021 Vol. 18 (34): 160-162 [Abstract] ( 35 ) HTML (1 KB)  PDF (433 KB)  ( 26 )
163 Influence of case management combined with information continuous nursing on inflammatory bowel disease#br#
SUN Suya1 CHEN Yamei2 LIN Mengyue1 CHEN Weixian1 BO Jin1 LIU Xiaohong3
Objective To explore the effect of case management combined with information continuous nursing on inflammatory bowel disease. Methods A total of 82 patients with inflammatory bowel disease admitted to the Department of Gastroenterology, North Hospital of Huashan Hospital Affiliated to Fudan University from March 2019 to March 2020 were selected. The patients were divided into group A and group B by random number table method, with 41 cases in each group. Group A was given routine nursing, and group B was given case management combined with information continuing nursing on this basis. Quality of life, improvement effect and nursing satisfaction score were compared between the two groups. Results The overall analysis showed that there were statistically significant differences between groups, time points and interaction (P ＜ 0.05), further pairings and intra-group comparisons: the scores of all dimensions and total quality of life of group B at each time point after intervention were higher than those before intervention, the differences were statistically significant (P ＜ 0.05), the scores of emotional competence and social competence in group A at different time points were higher than those before intervention, the differences were statistically significant (P ＜ 0.05); and the scores of all dimensions and total quality of life in group B were significantly higher than those in group A at each time point after intervention, the different were highly statistically significant (P ＜ 0.01); after intervention, disease activity index scores of group were lower than before intervention, and group B was lower than group A, the differences were statistically significant (P ＜ 0.05 or P ＜ 0.01); the number of patients in remission stage in group B was significantly higher than that in group A, the difference was statistically significant (P ＜ 0.05); after intervention, nursing satisfaction of group B was higher than that of group A, the difference was statistically significant (P ＜ 0.05). Conclusion Case management combined with information continuous nursing can improve the quality of life of patients with inflammatory bowel disease, promote the rehabilitation of patients and improve the nursing satisfaction of patients.
2021 Vol. 18 (34): 163-167 [Abstract] ( 70 ) HTML (1 KB)  PDF (731 KB)  ( 33 )
168 Influence of problem-oriented holistic nursing intervention on compliance behavior and disease knowledge of elderly patients with coronary heart disease#br#
YANG Fang SHEN Fei WANG Yunle WU Jun▲
Objective To explore the influence of problem-oriented holistic nursing intervention on compliance behavior and disease knowledge of elderly patients with coronary heart disease. Methods A total of 100 elderly patients with coronary heart disease admitted to Wuxi People’s Hospital Affiliated to Nanjing Medical University from September 2019 to March 2020 were selected, the patients were divided into control group (routine nursing intervention) and observation group (problem-oriented holistic nursing intervention) by random number table method, with 50 cases in each group. Self-efficacy, compliance behavior and disease knowledge master degre were compared between the two groups. Results The general self efficacy scale scores of both groups after intervention were higher than those before intervention, and the observation group was higher than the control group, and the differences were statistically significant (P ＜ 0.05). The observation group had higher total compliance with the doctor and disease knowledge than the control group, and the differences were statistically significant (P ＜ 0.05). Conclusion Problem-oriented holistic nursing intervention can enhance the self-efficacy of elderly coronary heart disease, help patients better understand coronary heart disease and its treatment knowledge, and improve patients’ compliance behavior.
2021 Vol. 18 (34): 168-171 [Abstract] ( 85 ) HTML (1 KB)  PDF (672 KB)  ( 82 )
172 Application of cluster nursing intervention in the prevention and treatment of radioactive dermatitis in patients with nasopharyngeal carcinoma#br#
CHEN Zihong1 ZHONG Qiang2 CHEN Yonghong1 LIAO Ning1 WEI Cui1 LI Dongmei1
Objective To explore the application of cluster nursing intervention in the prevention and treatment of radioactive dermatitis in patients with nasopharyngeal carcinoma. Methods A total of 210 nasopharyngeal carcinoma patients who received the first radical radiotherapy in the Department of Oncology Wuzhou Red Cross Hospital, Guangxi Zhuang Autonomous Region from January 2019 to February 2021 were selected as the study subjects. A random number table was used to divide the patients into observation group and control group. During the study, two patients with poor compliance quit and two patients with disease change were transferred to the department. Finally, 206 patients with nasopharyngeal carcinoma were included as the research objects, including 105 cases in observation group and 101 cases in control group. The control group received routine nursing, and the observation group received evidence-based cluster nursing intervention on the basis of the control group. The incidence and time of dermatitis at all levels, the severity of dermatitis and the time of appearance of skin injury signs were observed and evaluated after radiotherapy. Results There was no significant difference in the incidence of dermatitis between the two groups (P ＞ 0.05). The time of appearance of skin injury signs in the observation group was longer than that in the control group, and the total dermatitis score was lower than that in the control group (P ＜ 0.05). Log-rank test analysis of the two groups showed that the time of grade 2 dermatitis in the observation group was longer than that in the control group (P ＜ 0.05). Conclusion Compared with conventional nursing, cluster nursing intervention can delay the occurrence of radiation dermatitis and reduce the severity of dermatitis.
2021 Vol. 18 (34): 172-175,184 [Abstract] ( 66 ) HTML (1 KB)  PDF (797 KB)  ( 25 )
176 Study on the application of characteristic traditional Chinese medicine continuing nursing mode in patients with ischemic stroke after treatment#br#
MA Jing1 ZHU Weiwei2▲ CHEN Jinbai3
Objective To analyze the application effect of charalteristic traditional Chinese medicine continuing nursing mode in patients with ischemic stroke after treatment. Methods A total of 100 patients with ischemic stroke in Shaoxing Hospital of Traditional Chinese Medicine of Zhejiang Province from January 2020 to January 2021 were selected as the reseach subjects, using double-blind method, they were numbered according to the time of admission and divided into control group 50 cases, conventional traditional Chinese medicine nursing were used; observation group 50 cases, based on the control group, traditional Chinese medicine continuing nursing were used; Barthel index (BI index), limb motor function, China seroke score (CSS), stroke specific quality of life scale (SS-QOL), anxiety and depression were compared between the two groups after three months of continuous intervention after discharge. Results After three months of intervention, the BI index, limb motor function, and SS-QOL scores of the two groups were higher than those before intervention, and the CSS scores were lower than those before intervention (P ＜ 0.05). BI index, limb motor function, and SS-QOL score in the observation group were higher than those in the control group, while CSS score and anxiety and depression score were lower than those in the control group (P ＜ 0.05). Conclusion Characteristic traditional Chinese medicine continuing nursing can improve the daily life ability of patients after ischemic stroke treatment and improve their quality of life.
2021 Vol. 18 (34): 176-179 [Abstract] ( 116 ) HTML (1 KB)  PDF (674 KB)  ( 13 )
180 Effect of individualized nutrition intervention on the control of blood glucose and inflammation with gestational diabetes mellitus patients #br#
SHI Huifang
Objective To explore the effect of individualized nutrition intervention on the control of blood glucose and inflammation in patients with gestational diabetes mellitus (GDM) patients. Methods A total of 120 patients with GDM who were admitted to the Department of Obstetrics, the Second Affiliated Hospital of Xingtai Medical College from January to December 2019 were selected as the research objects, and they were divided into study group and control group according to the random number table method, with 60 cases in each group. The control group took regular dietary guidance, and the study group took individualized nutritional intervention on the basis of the control group. The intervention was performed until the patient had a threatened cessation of childbirth. The blood glucose levels before and after the intervention (fasting blood glucose [FBG], two hours fasting blood glucose [2hFBG]), C-reactive protein (CRP) were compared, while the short form 36-item health survey score, nursing satisfaction, and perinatal outcome after the intervention were evaluated. Results After the intervention, FBG, 2hFBG, and CRP of two groups were lower than those before the intervention, while the study group was lower than the control group, and the differences were statistically significant (P ＜ 0.05). The total incidence of perinatal complications in the study group was lower than that in the control group, and the difference was statistically significant (P ＜ 0.05). The total incidence of adverse pregnancy outcomes in the study group was lower than that in the control group, and the difference was statistically significant (P ＜ 0.05). The scores of health feeling, physical sensation, sleep state, life satisfaction, and cognitive function in the quality of life score of the study group were higher than those of the control group, and the differences were statistically significant (P ＜ 0.05). The nursing satisfaction of the study group was higher than that of the control group, and the difference was statistically significant (P ＜ 0.05). Conclusion Individualized nutrition intervention can effectively regulate the blood glucose level of patients with GDM, reduce the inflammatory response of the patients, improve the perinatal outcome of mothers and infants, and can also improve the quality of life and nursing satisfaction of patients. It is worthy of clinical application.
2021 Vol. 18 (34): 180-184 [Abstract] ( 176 ) HTML (1 KB)  PDF (722 KB)  ( 34 )
185 Effect of WeChat continuous nutritional intervention on the level of hope, quality of life, and nutritional status of patients after gastric cancer surgery outside the hospital#br#
WANG Litan1 WENG Shaowen2 WANG Yuna3 LIU Qian4
Objective To explore the influence of WeChat continuous nutritional intervention on the hope level, quality of life, and nutritional status of patients with external gastric cancer after surgery. Methods A total of 85 patients undergoing gastric cancer surgery collected from Hainan General Hospital from January 2017 to January 2020 were included in the survey, and they were divided into control group (42 cases) and observation group (43 cases) by computer-digital randomization. The control group used routine nursing care, which included discharge guidance and follow-up records, while the observation group used WeChat continuous nutrition intervention nursing on the basis of the former. The Herth hope index and the short form 36-item health survey were used to evaluate the hope level, quality of life, and complication rate of the two groups at discharge and three months after discharge. Results The positive attitude, intimacy, positive action, and total scores of the two groups were higher than those three months after discharge, while the observation group was higher than the control group, and the differences were statistically significant (P ＜ 0.05). The health feeling, physical sensation, social integration, and sleep quality of two groups were higher than those three months after discharge, while the observation group was higher than the control group, and the differences were statistically significant (P ＜ 0.05). The total incidence of complications in the observation group was lower than that in the control group, and the difference was statistically significant (P ＜ 0.05). Conclusion WeChat continuous nutritional intervention can gradually promote the return of patients to life and society under the gradual restoration of gastrointestinal function, enhance the quality of life of patients, and also have certain help for the treatment effect of patients.
2021 Vol. 18 (34): 185-188 [Abstract] ( 132 ) HTML (1 KB)  PDF (709 KB)  ( 24 )
189 Application of clustering nursing in skin care of lymphatic tuberculosis refractory wound suface#br#
JI Wenqiu WANG Yuling▲ HUANG Zihui ZHANG Aifang WANG Hui WANG Lili
Objective To explore the application effect of cluster nursing on skin care of lymphatic tuberculosis refractory wound surface. Methods A total of 100 patients with refractory lymphoid tuberculosis wounds admitted to Nanjing Integrated Traditionnal Chinese and Western Medicine Hospital from February 2019 to March 2021 were selected and divided into control group and experimental group by random number table method, with 50 patients in each group. The control group was carried out routine nursing measures, while the experimental group was carried out cluster nursing measures on the basis of routine nursing measures. After 15 days of intervention, the cure rate, nursing satisfaction, and negative mood between the two groups were compared. Results The wound healing rate of the experimental group was higher than that of the control group, and the difference was, and the differences were(P ＜ 0.05). The total satisfaction degree of the experimental group was higher than that of the control group, and the difference was statistically significant (P ＜ 0.05). After the intervention, the anxiety and depression scores of the experimental group were lower than those before the intervention, while the experimental group was lower than the control group, and the differences were statistically significant(P ＜ 0.05). There were no significant differences in the scores of anxiety and depression in the control group before and after intervention (P ＞ 0.05). Conclusion Cluster nursing has a good effect in the management of refractory lymphatic tuberculosis wound and is worthy of clinical promotion.
2021 Vol. 18 (34): 189-192 [Abstract] ( 111 ) HTML (1 KB)  PDF (668 KB)  ( 30 )
193 Application of dietary intervention combined with continuous information support in the care of patients with high risk of ovarian hyperstimulation syndrome#br#
ZHANG Xi WANG Zirui YANG Rui SONG Donghong▲
Objective To explore the application of dietary intervention combined with continue information support in the care of patients with high risk of ovarian hyperstimulation syndrome (OHSS). Methods A total of 400 high-risk patients with OHSS who were preparing for egg retrieval in Reproductive Medicine Center, Peking University Third Hospital were divided into two groups based on the time of admission. Among them, patients admitted from June to July 2019 were the control group, with a total of 200 cases; patients admitted from August to October 2019 were the intervention group, with a total of 200 cases. In the control group, patients regular health education and dietary guidance after egg retrieval were given by nurses; while in the intervention group, except for routine nursing health education, patients were followed up every day from the day of egg retrieval to the 10th day after egg retrieval. During the period, the urine output, intake, and weight of patients were recorded. The number of hospitalizations due to severe OHSS and the change trend of urine output, intake, weight, and abdominal distension were compared between the two groups. Results The incidence of OHSS symptoms such as abdominal distension, nausea, vomiting, and decreased urine output in the intervention group were lower than those in the control group, and the differences were statistically significant (P ＜ 0.05); the comparison of hospitalization rates due to OHSS between the two groups was not statistically significant (P ＞ 0.05). Conclusion Dietary intervention, enhanced follow-up and information support for high-risk patients with OHSS can reduce uncomfortable signs and achieve better preventive effect of ovarian hyperstimulation.
2021 Vol. 18 (34): 193-196 [Abstract] ( 30 ) HTML (1 KB)  PDF (714 KB)  ( 50 )
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