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| Clinical value of semi-quantitative grading of musculoskeletal ultrasound in the evaluation of joint activity in patients with rheumatoid arthritis#br# |
| WANG Chaoxin YANG Ling LI Wenhua WANG Chao XUE Xiaoxuan LU Zheng LIU Yan YUAN Shuqi |
| Department of Functional Inspection, Dongfang Hospital of Beijing University of Chinese Medicine, Beijing 100078, China |
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Abstract Objective To analyze the clinical value of musculoskeletal ultrasound semi-quantitative grading to evaluate joint mobility in patients with rheumatoid arthritis (RA). Methods A total of 80 RA patients admitted to Dongfang Hospital of Beijing University of Chinese Medicine from January 2019 to July 2021 were selected as the research objects. According to the disease activity score, they were divided into remission group, low, medium, and high activity group. Another 80 healthy volunteers in the same period were selected as the control group. The levels of joint ultrasound and serological indexes in each group were compared. Results Synovial hyperplasia, synovial blood flow signal, bone erosion, and joint effusion ultrasound semi-quantitative grading score, total score, and the levels of serum erythrocyte sedimentation rate (ESR), rheumatoid factor (RF), matrix metalloproteinase 3 (MMP-3), anti-cyclic citrulline antibody (anti-CCP), and anti-mutant citrulline vimentin antibody (anti-MCV) in each groups were compared, and the differences were statistically significant (P ＜ 0.05). Among them, the ultrasound semi-quantitative grading scores and total scores of synovial hyperplasia, synovial blood flow signals, bone erosion, and joint effusion in the high activity group were higher than those in the medium activity group, low activity group, remission group, and control group (P ＜ 0.05); and which in the medium activeity group was higher than those in the low activity group, remission group, and control group (P ＜ 0.05); the low activity group was higher than the remission group and the control group (P ＜ 0.05); the remission group was higher than the control group (P ＜ 0.05). The total score of musculoskeletal ultrasound semi-quantitative classification was positively correlated with serum ESR, RF, CRP, anti-CCP, and anti-MCV in RA patients (r = 0.651, 0.736, 0.720, 0.711, 0.749, P ＜ 0.05). Conclusion The semi-quantitative grading of musculoskeletal ultrasound is closely related to the serum indicators of RA patients. The use of semi-quantitative grading of musculoskeletal ultrasound can provide a reference for early evaluation of the patient’s disease progression.
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