|
|
|
| Analysis of the medication rule of traditional Chinese medicine in treating anal sinusitis based on data mining#br# |
| YU Dayuan LIU Wei LI Xue LIU Renghai▲ |
| Department of Proctology, Dongfang Hospital of Beijing University of Chinese Medicine, Beijing 100078, China |
|
|
|
Abstract Objective To analyze the prescription rules of treating anal sinusitis with traditional Chinese medicine in periodical literature by using traditional Chinese medicine inheritance support system platform. Methods The literatures on traditional Chinese medicine treatment of anal sinusitis published in China National Knowledge Infrastructure, Chinese sci-tech Periodical Full-text Database and Wanfang Database from inception to February 2021 were screened, and the data were input into the traditional Chinese medicine inheritance support system platform. The data analysis module of the software was used to analyze the medication rule of traditional Chinese medicine in the treatment of anal sinusitis, including four nature of drugs, five flavours, channel tropism, drug use frequency, prescription rule and potential new prescription combination. Results A total of 49 prescriptions involving 118 traditional Chinese medicine were included. Drugs were mainly cold drugs (202 times), bitter drugs (263 times), sweet drugs (150 times), spicy drugs (109 times), mainly through the liver meridian (145 times), spleen meridian (132 times), stomach meridian (107 times), lung meridian (99 times). The six most frequently used herbs were amur cork-tree (26 times), liquorice root (21 times), golden thread (18 times), chinese angelica (14 times), garden burnet root (13 times) and lightyellow sophora root (13 times). The first six drug pairs were chinese angelica-unprocessed rehmannia root, liquorice root-orange fruit, chinese angelica-liquorice root , amur cork-tree-garden burnet root, liquorice root-golden thread, dandelion-wild chrysanthemum flower. A total of six core drug combinations for the new formula were excavated. Conclusion At present, the known traditional Chinese medicine prescriptions for the treatment of anal sinusitis are mainly to clear heat and remove diuresis, cool blood and detoxify, and also to soothe liver, promote blood circulation and relieve pain, etc. The core drug combinations and new prescriptions have certain reference value for the theoretical research, new drug development and clinical syndrome differentiation treatment of anal sinusitis.
|
|
|
|
|
|
[1] 杜媛芳.加味五味消毒饮保留灌肠治疗热毒型肛窦炎的临床疗效观察[D].成都：成都中医药大学，2020.
[2] 刘仍海.肛窦炎，肛门疾病的罪魁祸首[J].江苏卫生保健，2021（1）：13.
[3] 秦一翔，王增梅，李颖超.解毒化浊法对湿热下注型慢性肛窦炎患者免疫功能、氧化应激及炎性因子水平的影响[J].中医学报，2020，35(10):2252-2256.
[4] 钟赣生.中药学[M].北京：中国中医药出版社，2019：105-422.
[5] 李金元.加味苦参汤联合保留灌肠治疗肛窦炎的临床观察[J].江西中医药，2018，49（3）：49-51.
[6] 梁秋萍，谢翔宇.止痛如神汤口服及保留灌肠对肛窦炎患者炎症指标及疼痛程度的影响[J].中医临床研究，2021， 13（1）：114-116.
[7] 刘仍海，韩平，张健柏.肛肠疾病诊疗讲座[M].北京：人民军医出版社：64.
[8] 徐程.健脾疏肝方保留灌肠治疗脾虚肝郁型肛窦炎的疗效观察[D].北京：北京中医药大学，2019.
[9] 白垚，王少辉，张家墉，等.基于《中华医典》的溃疡性结肠炎药性、药理研究[J].西部中医药，2020，33（4）：74-78. DOI:10.12174/j.issn.1004-6852.2020.04.23.
[10] 高妍，周海芳，刘朵，等.黄柏化学成分分析及其药理作用研究进展[J].亚太传统医药，2019，15（4）：207-209. DOI:10.11954/ytctyy.201904068.
[11] 付琳，付强，李冀，等.黄连化学成分及药理作用研究进展[J].中医药学报，2021，49（2）：87-92.
[12] 陈红宇，沈洪.地榆活性成分及抗炎作用研究进展[J].中医药导报，2017，23（17）：110-113.
[13] 李冀，李想，曹明明，等.甘草药理作用及药对配伍比例研究进展[J].上海中医药杂志，2019，53（7）：83-87.
[14] 罗子宸，张雯，杨瑞，等.甘草“调和诸药”生物药剂学机制的研究进展[J].中草药，2021，52（1）：267-277.
[15] 赵静，夏晓培.当归的化学成分及药理作用研究现状[J].临床合理用药杂志，2020，13（6）：172-174.
[16] 任伟钰，郑宜鋆，张月梅，等.当归多糖药理作用的研究进展[J].时珍国医国药，2020，31（10）：2484-2487.
[17] 胡静，李科，李爱平，等.当归补血汤物质基础研究进展[J].中草药，2020，51（21）：5658-5663.
[18] 左风.防风中止痛成分的研究[J].国外医学：中医中药册，2001（6）：347-348.
[19] 张思旋，林茜，吴嘉瑞，等.基于网络药理学的“苍术-黄柏”药对治疗痛风作用机制研究[J].中国医院用药评价与分析，2019，19（8）：927-933.
[20] 周梦颖，钟琛聪.地榆活性成分及药理作用研究进展[J].现代养生，2018（4）：89-90.
[21] 谢骅.当归苦参丸联合他克莫司治疗脂溢性皮炎临床观察[J].皮肤病与性病，2018，40（3）：368-369.
[22] 王芳，孙秀梅，张兆旺.当归苦参丸方药5种提取方法的成分比较[J].科技资讯，2018，16（2）：208-209，211. |
|
|
|
