高频重复经颅磁刺激对轻度认知障碍患者认知功能及白质微结构的影响

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Abstract Objective To study the effect of high-frequency repetitive transcranial magnetic stimulation (rTMS) on cognitive function and white matter microstructure in patients with mild cognitive impairment (MCI). Methods A total of 29 MCI patients enrolled in the community of Nanchong City, Sichuan Province from January to July 2019 were divided into true stimulation group and pseudo stimulation group according to the random number table method, with 17 cases and 12 cases respectively. The true stimulation group was given 10 Hz rTMS for 10 days to stimulate the right dorsolateral prefrontal lobe (DLPFC); the pseudo stimulation group was given a pseudo stimulation coil. All subjects underwent the mini-mental state examination (MMSE), Montreal cognitive assessment (MoCA) and diffusion tensor imaging (DTI) at baseline and after treatment. The above cognitive score and diffusion fractional anisotropy (FA) were compared, and analyze the correlation between cognitive score and FA value were analyzed. Results After treatment, the MoCA and MMSE scores of the true stimulation group were higher than those before the treatment, while the MoCA scores of the pseudo-stimulation group were higher than those before the treatment, and the differences were statistically significant (P ＜ 0.05); there was no statistically significant difference in the scores between the two groups after the treatment (P ＞ 0.05). In the true stimulation group, the FA values of the bilateral superior frontal gyrus and the right precuneus were higher than before treatment, and the FA values of the bilateral superior frontal gyrus, the precuneus, the right middle frontal gyrus, and the right parieto-occipital lobe were higher than those before the treatment. In the stimulation group, the FA values of the left hippocampus, thalamus, lingual gyrus, and middle temporal gyrus were lower than those in the pseudo-stimulation group, and the difference was statistically significant (P ＜ 0.05). The MMSE score of the true stimulation group was negatively correlated with the FA values of the left occipital lobe and hippocampus (r = -0.590, P = 0.013; r = -0.518, P = 0.034). Conclusion High-frequency rTMS therapy may regulate the white matter microstructure integrity of partially damaged brain regions in patients with MCI, and lead to the corresponding improvement in cognitive function.

Key words： Repetitive transcranial magnetic stimulation Cognitive impairment Diffusion tensor imaging Microstructure

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	RAN Li1 GUO Zhiwei1 ZHOU Liang2 LI Zhongmei2 MU Qiwen1
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RAN Li1 GUO Zhiwei1 ZHOU Liang2 LI Zhongmei2 MU Qiwen1,2. Effects of high frequency repetitive transcranial magnetic stimulation on cognitive function and white matter microstructure in mild cognitive impairment patients#br#[J]. 中国医药导报, 2021, 18(34): 143-147.

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https://www.yiyaodaobao.com.cn/EN/ OR https://www.yiyaodaobao.com.cn/EN/Y2021/V18/I34/143

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