压力-应变环对早期冠心病心肌做功改变的定量评估

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Abstract Objective To evaluate the left ventricular myocardial work changes in early coronary heart disease by pressure-strain loop (PSL). Methods A total of 68 patients with suspected coronary heart disease admitted to the Fourth Clinical Medical College of Xinjiang Medical University (hereinafter referred to as “our hospital”) from June 2018 to September 2020 were selected. According to their coronary angiography results, they were divided into mild stenosis group (stenosis rate＜50%) (27 cases) and moderate stenosis group (50%≤stenosis rate＜75%) (41 cases). At the same time, 30 healthy subjects in our hospital were selected as control group. PSL was used to evaluate global longitudinal strain (GLS) and myocardial work parameters, including global work index (GWI), global constructive work (GCW), global wasted work (GWW), and global work efficiency (GWE). Pearson correlation coefficient was used to analyze the correlation between myocardial work parameters and left ventricular ejection fraction (LVEF) and GLS. The diagnostic value of myocardial work parameters in coronary heart disease was analyzed by using receiver operator characteristic curve and area under curve (AUC). Results The GLS and GWW of moderate stenosis group were higher than those of control group and mild stenosis group, while the GWI, GCW, and GWE of moderate stenosis group were lower than those of control group and mild stenosis group, the differences were statistically significant (P ＜ 0.05). GWI and GCW were positively correlated with LVEF (r ＞ 0, P ＜ 0.05), negatively correlated with GLS (r ＜ 0, P ＜ 0.05). All myocardial work parameters had diagnostic value for coronary heart disease (AUC ＞ 0.5, P ＜ 0.05). Conclusion PSL can accurately assess the changes of myocardial work in patients with coronary heart disease, providing a new diagnostic basis for early clinical evaluation of coronary heart disease.

Key words： Coronary heart disease Pressure-strain loop Left ventricular Myocardial work

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	WU Qiuling LI Hua TANG Sha NIU Ming

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WU Qiuling LI Hua TANG Sha NIU Ming. Evaluation of myocardial work changes in early coronary heart disease patients by pressure-strain loop#br#[J]. 中国医药导报, 2021, 18(34): 135-138.

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https://www.yiyaodaobao.com.cn/EN/ OR https://www.yiyaodaobao.com.cn/EN/Y2021/V18/I34/135

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