中国医药导报
      Home                                                                                    中文
中国医药导报
 
Forthcoming Articles
Current Issue
Archive
Advanced Search
Read Articles
Download Articles
Email Alert
 
Quick Search  
  Adv Search
2021 Vol. 18, No. 9
Published: 2021-03-25
 
 
4 Comparative analysis of Chinese and American guidelines for the diagnosis and treatment of cancer pain
LI Hui1 RAO Yuefeng2
Drug therapy is the most important and commonly used method for the treatment of cancer pain. Regular and effective drug therapy can relieve 80%-90% of the pain symptoms of cancer patients. For a long time, the Clinical Practice Guidelines for Adult Cancer Pain issued by the National comprehensive cancer network (NCCN) of the United States in January every year has been one of the important references for doctors around the world in the diagnosis and treatment of cancer pain. The former National Health and Family Planning Commission of China issued two versions of the Standards for the Diagnosis and Treatment of Cancer Pain in 2011 and 2018 respectively. The guidelines of the two countries are different in the suggestions of the aspects of pain assessment, pain grade, dose titration, maintenance medication, dose conversion, opioids reduction and the prevention and treatment of opioid adverse reactions. In this paper, from the perspective of clinical pharmacists, the classification and comparative interpretation of the diagnosis and treatment of cancer pain in China and the United States are carried out, hoping to provide pharmaceutical suggestions for clinicians in the diagnosis and treatment of cancer pain.
2021 Vol. 18 (9): 4-7 [Abstract] ( 252 ) HTML (1 KB)  PDF (561 KB)  ( 84 )
8 Regulatory effect of adipokines on miR-506 expression in human adipocytes
QIN Zhenying1 ZHONG Fengyu2 CHEN Yao2 LI Jing1 YANG Zi1 WEN Juan3 WANG Yumei4 HU Youfang1
Objective To investigate the regulatory effect of adipokines tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) on the expression of miR-506 in mature human adipocytes. Methods Real-time fluorescence quantitative polynucleotide chain reaction was used to detect the expression level of miR-506 in human precursor adipocytes and mature adipocytes. TNF-α and IL-6 were treated with 10, 30 ng/mL for 0, 4, 8 and 24 h, and the expression level of miR-506 was detected at each time point. Results The expression level of miR-506 in mature adipocytes was higher than that in precursor adipocytes, and the difference was highly statistically significant (P < 0.01). The expression of miR-506 in mature human adipocytes at 4, 8 and 24 h after treatment with 10 ng/mL TNF-α and IL-6 were not significantly differents from those at 0 h after treatment (P > 0.05). The expression level of miR-506 in mature human adipocytes after treatment with 30 ng/mL TNF-α and IL-6 at 24 h were higher than those after treatment at 0 h, and the differences were statistically significant (all P < 0.05). Conclusion miR-506 expression is regulated by adipokines, which provides theoretical basis for the study of the correlation between miR-506 and inflammatory responses and obesity-related insulin resistance.
2021 Vol. 18 (9): 8-11,16 [Abstract] ( 286 ) HTML (1 KB)  PDF (910 KB)  ( 145 )
12 Construction of lncRNA-miRNA-mRNA network and prediction of key genes in rheumatoid arthritis fibroblast-like synoviocytes
ZHOU Xinpeng1,2 JIN Yehua1,2 ZHANG Runrun1,2 HE Dongyi1,2
Objective To explore the long non-coding RNA (lncRNA) -microRNA (miRNA) -mRNA network and key lncRNA in rheumatoid arthritis (RA) fibroblast-like synoviocytes (FLS), and to reveal the role of lncRNA in RA. Methods Data sets GSE103578, GSE83147 and GSE128813 were obtained from Gene Expression Omnibus (GEO) of the National Center for Biotechnology Information in the United States. Each data set contained three synovium-isolated FLS from healthy people in the control group and three FLS from RA patients in the RA group. R language program, idmap3 package was used for probe annotation. Limma package was used to standardize the data, remove batch effect and analyze gene differential expression. LogFC > 1.0 and P < 0.05 were used as the criteria for differential expression. Correlation analysis was conducted for the differentially expressed lncRNA and mRNA. In the lncbase, starBase and miRcode databases, the miRNAs related to lncRNA were obtained, and the miRNAs related to mRNA were searched in the miRWalk and TargetScan databases. The intersection of the two was taken, and the lncRNA-miRNA-mRNA network was constructed by Cytoscape software, and the lncRNAs in the network were taken as the key lncRNA. Results After standardization of GEO data set, elimination of batch effect and annotation, 14 760 mRNAs and 5290 lncRNAs were finally obtained. Compared with the control group, there were 31 mRNA up-regulated and 56 mRNA down-regulated in RA group, and 9 up-regulated genes and 14 down-regulated genes in lncRNA. The Pearson correlation coefficient R > 0.85 and P < 0.05 were used as the criteria for the co-expression of lncRNA-mRNA genes, and 18 co-expressed lncRNAs and 51 mRNAs were obtained. There were 26 miRNAs that had binding sites with co-expressed lncRNA and mRNA. In the constructed lncRNA-miRNA-mRNA co-expression network, there were 13 lncRNAs, including lncRNA XIST, NR2F2-AS1, LINC01018, etc., 26 miRNAs and 46 mRNAs. Conclusion Thirteen lncRNAs, such as lncRNA XIST, NR2F2-AS1, LINC01018, are differentially expressed in RA-FLS, and the expression of miRNA and mRNA is regulated through the competitive endogenous RNA mechanism to form a regulatory network of lncRNA-miRNA-mRNA, which could be used as the target lncRNA for further verification.
2021 Vol. 18 (9): 12-16 [Abstract] ( 317 ) HTML (1 KB)  PDF (1727 KB)  ( 83 )
17 Study on quality standard of Muniziqisaifula Mixture
GUO Xin1 ZHANG Yuxin2 Li Zhijian2 HUO Shixia2
Objective To establish quality standards for Muniziqisaifula Mixture. Methods Thin layer chromatography (TLC) was used to identify Nymphaea candida Presl. and Cichorium intybus L. The conten of esculetin in mixture was determined by high performance liquid chromatography. The Inertsil ODS-SP (250 mm×4.6 mm, 5 μm) was used as the colum, the mobile phase was quercetin took methanol- acetonitrile-0.2% H3PO4 （9∶6∶85）, the flow rate was 1.0 mL/min, the sample size was 10 μL, the column temperature was 30℃ and the detection wavelength was set at 342 nm. Results Nymphaea candida Presl. and Cichorium intybus L. could be clearly detected by TLC. The esculetin had a good linear relationship between 5.09-163.04 μg/mL (r = 1.0000). The average recovery rates of esculetin was 100.99%. Conclusion This method is fast and can be used to control the quality of Muniziqisaifula Mixture.
2021 Vol. 18 (9): 17-19,29 [Abstract] ( 272 ) HTML (1 KB)  PDF (830 KB)  ( 26 )
20 Determination of residues of seven quinolones in Thyroid Tablets by high performance liquid chromatography-mass spectrometry / mass spectrometry
ZHAO Wenfa WANG Chunlei FENG Jialong
Objective To establish a high performance liquid chromatography-mass spectrometry / mass spectrometry (LC-MS/MS) method for the determination of seven quinolones residues in Thyroid Tablets. Methods The column was ACQUITY UPLC?誖BEH C18 (2.1 mm×100 mm, 1.7 μm). Acetonitrile was used as mobile phase A and 0.1% formic acid as mobile phase B for gradient elution. The flow rate was 0.3 mL/min, the column temperature was 40℃. LC-MS/MS method, electrospray ionization source, multiple reaction monitoring and positive ion scanning method were used for detection. Results Seven quinolones showed good linear relationship in the concentration range of 1-100 ng/mL. The average recoveries of seven kinds of quinolones were in the range of 85.0%-100.0%, and RSDs were all less than 3.5%. Conclusion The established method is sensitive, accurate, stable, with little interference from impurities and strong specificity. It can be used for the determination of quinolone residues in Thyroid Tablets.
2021 Vol. 18 (9): 20-23 [Abstract] ( 117 ) HTML (1 KB)  PDF (750 KB)  ( 102 )
24 Study on Huoxiang Zhengqi Powder in the treatment of coronavirus disease 2019 with gastrointestinal symptoms based on network pharmacology
SHI Min LIU Fulin XIA Xuting ZHANG Ting LIAO Chenmin
Objective To analyze the mechanism of Huoxiang Zhengqi Powder in the treatment of coronavirus disease 2019 with gastrointestinal symptoms based on the method of network pharmacology. Methods The chemical components contained in Huoxiang Zhengqi Powder and target genes were searched by traditional Chinese medicine systems pharmacology database and analysis platform (TCMSP). The GeneCards database and online Mendelian inheritance in man (OMIM) were used for finding the target genes related to the treatment of coronavirus disease 2019 with gastrointestinal symptoms. Cytoscape 3.7.2 software were used to draw a network diagram of target genes-traditional Chinese medicine components. The protein-protein interaction network diagram of the target genes was constructed by String, and the enrichment analysis of GO and KEGG pathways of the target genes was performed in R language, and the molecular docking was performed by using the SwissDock online molecular docking tool. Results The 224 active ingredients of traditional Chinese medicine contained in Huoxiang Zhengqi Powder were associated with proto-oncogene (JUN), mitogenactivated protein kinase 8 (MAPK8), and MAPK14, bcl-2-like protein1 (BCL2L1), epidermal growth factor receptor, interleukin-6 (IL-6) and other 50 target genes related to coronavirus disease 2019 with gastrointestinal symptoms. GO enrichment analysis revealed 1579 related items, mainly related to the response to bacterial origin molecules, the response to oxidative stress, and MAPK signal pathways. KEGG pathway enrichment analysis screened 133 signal pathways, mainly related to tumor necrosis factors signal pathway, IL-17 signal pathway, etc. Molecular docking showed naringenin in Hnoxiang Zhengqi Powder and target gene IL-6 had strong affinity. Conclusion Huoxiang Zhengqi Powder can treat coronavirus disease 2019 with gastrointestinal symptoms through multiple targets and pathways.
2021 Vol. 18 (9): 24-29 [Abstract] ( 471 ) HTML (1 KB)  PDF (1464 KB)  ( 103 )
30 Exploration on the mechanism of Chaihu Shugan Powder in the treatment of chronic prostatitis based on network pharmacology
ZHU Xiaoyun1 BA Yuanming2
Objective To explore the mechanism of Chaihu Shugan Powder in the treatment of chronic prostatitis based on network pharmacology. Methods According to the drug-likeness and oral bioavailability, the predictive targets of effective active ingredients of Chaihu Shugan Powder in the treatment of chronic prostatitis were screened through the pharmacology database analysis platform of traditional Chinese medicine system and GeneCards. The network graph of active component of Chaihu Shugan Powder-target of chronic prostatitis was drawn by Cytoscape 3.7.2. The network analysis of target interaction was made by STRING database. Finally, the target, signal pathway and biological process were analyzed in the biological information annotation database. Results A total of 129 active components were screened out, among which, the number of Citri Reticulatae Pericarpium, Bupleuri Radix, Chuanxiong Rhizoma, Cyperi Rhizoma, Aurantii Fructus, Paeoniae Radix Alba, Glycyrrhizae Radix Et Rhizoma was 5, 14, 6, 17, 5, 11, 71 respectively. A total of 1121 targets of active ingredients were obtained, including IL-6, IL-2, SRC, EGFR, IGF1R, and so on. KEGG pathway enrichment analysis showed that chemokine signaling pathway, MAPK signaling pathway, T cell signaling pathway and others were mainly involved. Conclusion This study reveals the potential target and KEGG signaling pathway of Chaihu Shugan Powder in the treatment of chronic prostatitis, which can provide new ideas for the mechanism of its intervention in chronic prostatitis.
2021 Vol. 18 (9): 30-34,47 [Abstract] ( 501 ) HTML (1 KB)  PDF (2846 KB)  ( 101 )
35 Research progress of the diagnosis and treatment of combined periodontal-endodontic lesions
WANG Xinyuan ZHAO Xingshen LIU Jin YU Qing CHENG Xiaogang
Combined periodontal-endodontic lesions is a common oral disease among the middle-aged and elderly population, whose diagnosis and treatment are usually complicated. In this study, a total of 164 literatures directly related to combined periodontal-endodontic lesions in recent 15 years (2005—2020) were screened out through literature retrieval (PubMed and VIP full-text databases) and extensive reading. Then, an intensive reading, data summary and analysis of the selected literatures were done, and the research progress of the pathogenesis and risk factor, diagnose and differential diagnosis, classification, treatment, and prognosis associated with combined periodontal-endodontic lesions were reviewed, aiming at providing a guidance for its clinical diagnosis and treatment.
2021 Vol. 18 (9): 35-38 [Abstract] ( 615 ) HTML (1 KB)  PDF (681 KB)  ( 88 )
39 Research progress on skin toxicity related to radiotherapy of breast cancer
LIU Di1，2 ZHENG Zhewen1，2 ZHANG Shuyuan1，2 ZHU Chunmei1，2 ZHANG Hongyan2 ZHOU Yunfeng2
Radiation dermatitis is one of the most common complications of breast cancer patients after radiation therapy. It has the characteristics of long-term, persistent and progressive effects. The clinical manifestations of radioactive dermatitis include erythema, desquamation, ulceration, fibrosis and necrosis. These skin reactions not only affect beauty, but also reduce the quality of life, leading to the interruption of treatment, and seriously affect the overall efficacy. This paper reviews the research progress of skin toxicity during radiotherapy for breast cancer from the aspects of classification, mechanism, grading, influencing factors, prevention and treatment.
2021 Vol. 18 (9): 39-42 [Abstract] ( 589 ) HTML (1 KB)  PDF (612 KB)  ( 37 )
43 Diagnosis and individualized treatment options of cervical incompetence
WANG Xiaodan1 JIANG Haili2 LI Jinghua3 WANG Yu1
Cervical incompetence is one of the main causes of second trimester abortion and premature delivery, and it is also a difficult problem for Department of Obstetrics and Gynecology clinicians. Because of its complex etiology, the diagnosis lacks objective and unified criteria. In addition to conservative treatment, cervical cerclage is the most effective way. However, different surgical methods have their own advantages and disadvantages. Accurate selection of appropriate surgical methods is not only related to the success of pregnancy, but also can reduce the injury of pregnant women. Timely and accurate diagnosis of cervical incompetence and selection of individualized surgical methods according to different surgical indications are the key to a good outcome for pregnant women.
2021 Vol. 18 (9): 43-47 [Abstract] ( 231 ) HTML (1 KB)  PDF (619 KB)  ( 39 )
48 Clinical research progress of sodium fluorescein in high-grade glioma microsurgery
YANG Weiran1 WANG Zhong2 ZHANG Yisong2
This article reviews and analyzes the clinical research progress of sodium fluorescein guided high-grade glioma microsurgery in terms of its principle, application history, influence on tumor resection degree, adverse reactions, administration time and method, and comparison with five-aminolevulinic acid. Intracranial high-grade glioma has the characteristics of diffuse invasive growth. Fluorescence guided technology can realize the visualization of tumor boundary, enhance the recognition of tumor boundary, and improve the degree of tumor resection by intravenous injection of fluorescent drugs for real time intraoperative fluorescent labeling of tumor. It is cheap, easy to store, easy to control the dosage, good safety, and low incidence of adverse reactions caused by intraoperative application of fluorescein sodium. This article provides a reference for the clinical application of fluorescein sodium in the microsurgery of high-grade glioma.
2021 Vol. 18 (9): 48-51,55 [Abstract] ( 319 ) HTML (1 KB)  PDF (602 KB)  ( 43 )
52 Research progress on LncRNA MALAT1 and breast cancer
WANG Simin1 LI Na1 XIONG Haojun1 ZHANG Cuiwei2 CHAI Li2▲
Breast cancer is one of the most common female malignant tumors in China. In recent years, the occurrence and development of non-coding RNA in the breast cancer has attracted increasingly attention. MALAT1 is a long non-coding RNA closely related to the proliferation, invasion, metastasis and prognosis of breast cancer. However, its role in various stages of breast cancer is still controversial, and its molecular mechanism is still unclear. This paper summarizes the research progress of LncRNA MALAT1 in breast cancer, aiming to provide new ideas for the early detection and diagnosis of breast cancer, and to explore new drug targets.
2021 Vol. 18 (9): 52-54 [Abstract] ( 344 ) HTML (1 KB)  PDF (576 KB)  ( 40 )
56 Analysis of the status quo and influencing factors of ICU nurses’ sense of coherence
FU Jing ZHOU Xinyi DING Ping▲
Objective Investigate the status quo of intensive care unit (ICU) nurses’ sense of coherence (SOC) and to analyze the influencing factors. Methods Convenient sampling was adopted, and a total of 255 ICU nurses from a third-class tertiary hospital in Anhui Province from November 2019 to May 2020 were selected as the research subjects. The general situation questionnaire, the psychological consistency scale, the general self-efficacy scale, and the organization support surveys and simple coping style questionnaires were used to conduct. Results The total score of ICU nurses’ SOC was (53.24±10.24) points. There was a statistically significant difference in the SOC scores of nurses with different working years in ICU and professional titles and perceived health (P ＜ 0.05). Self-efficacy, organizational support, and active coping scores were positively correlated with the total SOC score and scores of various dimensions (r ＞ 1, P ＜ 0.01). Multiple linear regression analysis showed that perceived health, self-efficacy, organizational support, and active coping were the main influencing factors of SOC (P ＜ 0.05). Conclusion ICU nurses’ SOC is at a low level and is related to perceived health, self-efficacy, organizational support, and active response, prompting nursing managers to formulate targeted intervention measures to take advantage of the important role of individual ICU nurses’ inherent potential and positive psychological qualities, improve their level of SOC.
2021 Vol. 18 (9): 56-59 [Abstract] ( 371 ) HTML (1 KB)  PDF (517 KB)  ( 49 )
60 Relationship between sedentary behavior and the level of physical activity of the elderly in the community and the constitution of traditional Chinese medicine
CUI Guanghui1 YIN Yongtian2 CHEN Lijun2 CHEN Lei1 LIU Xinyao3
Objective To explore the relationship between sedentary behavior, the level of physical activity and traditional Chinese medical constitution of the elderly in the community. Methods Using the traditional Chinese medical physique classification and judgment scale and the short international physical activity questionnaire, a total of 1091 elderly people were selected from Ji’nan City, Shandong Province to conduct a questionnaire survey in December 2019. Results There were statistically significant difference in the traditional Chinese medical constitution of the elderly with different ages, family economic levels, education levels, and chronic diseases (P ＜ 0.05). There was a statistically significant difference in the distribution of traditional Chinese medical constitution types among the elderly with different sedentary behavior and levels of physical activity (P ＜ 0.05). Logistic regression analysis showed that sedentary behavior was a risk factor for qi-deficiency (OR = 1.487，95%CI: 1.032-2.143), yang-deficiency (OR = 1.639，95%CI: 1.127-2.386), and idiosyncratic traits (OR = 2.063，95%CI: 1.019-4.178) in the elderly (P ＜ 0.05), while low-intensity physical activity was a risk factor for qi-deficiency (OR = 2.047，95%CI: 1.341-3.126), phlegm-dampness (OR = 2.563，95%CI: 1.304-5.041), and qi-stagnation (OR = 2.925，95%CI: 1.444-5.922) in the elderly (P ＜ 0.05). Conclusion The elderly should strengthen physical activity and reduce sedentary time to improve their biased constitution.
2021 Vol. 18 (9): 60-63 [Abstract] ( 418 ) HTML (1 KB)  PDF (509 KB)  ( 82 )
64 Investigation and analysis of the difference between the operation willingness of elderly cataract patients in urban and rural areas in Shanghai
LIU Chenjun1 JI Pei2 WANG Luan2▲
Objective To investigate the willingness of elderly cataract patients in Pudong New Area, Shanghai, and to compare the differences between the them, to provide reference for local eye disease prevention and control precision measures. Methods From June to July 2019, based on the free physical examination data of the local elderly, a random cluster sampling method after stratification was adopted to conduct a questionnaire survey on cataract patients over 60 years old in three communities in both urban and rural areas, and the patients’ cognition of cataracts, while indicators such as willingness to operate were compared and analyzed. Results Patients in urban areas were mainly males and elderly ≥80 years old, while rural patients are mainly females and patients less than 80 years old. In terms of gender, age, economic status, and living care of urban and rural patients, “Do you know that ‘the government provides free cataract surgery for the elderly from disadvantaged families every year’ ” “Are you willing to do cataract surgery” “It doesn’t matter if you don’t have an operation” (P ＜ 0.05). Conclusion Paying attention to the gap between urban and rural areas is the focus of precision measures for the prevention and treatment of eye diseases in the elderly in Pudong New Area.
2021 Vol. 18 (9): 64-67,72 [Abstract] ( 420 ) HTML (1 KB)  PDF (687 KB)  ( 59 )
68 Discussing the working process of medical device standard revision from the perspective of quality management
MAO Xin HAN Qianqian WANG Chunren
In order to further clarify the working process of medical device standard revision and improve the quality of the work, this paper applies the concept of continuous improvement in quality management to the whole process of medical device standard revision, and corresponds the main links in the working process of medical device standard revision to the elements in ISO/IEC 17025. The establishment, drafting, verification, request for comment, inspection, approval and issuing, implementation and evaluation, review and abolishment of medical device standards can be corresponded to contract review, internal audit, results and records control, purchasing services and supplies, ensuring the effectiveness of results, corrective actions and management reviews in the quality management system. The process of standard revision is similar to the operation of the quality management system. The methods to ensure the effectiveness of the quality management system can be extended to the process of standard revision, so as to achieve continuous improvement and improve the quality of standards.
2021 Vol. 18 (9): 68-72 [Abstract] ( 185 ) HTML (1 KB)  PDF (378 KB)  ( 86 )
73 Comparison of the effect of sternocleidomastoid muscle intermuscular approach and neck white thread approach in the treatment of unilateral thyroid nodule
CAI Baozhong
Objective To investigate the effect of sternocleidomastoid muscle intermuscular approach and neck white thread approach in the treatment of unilateral thyroid nodules. Methods Eighty patients with unilateral thyroid nodule who admitted to Xinhua Hospital of Xinhua Medical Group from June 2018 to April 2020 were selected as study objects. They were divided into observation group and control group according to the operation method, with 40 cases in each group. Control group was given the treatment through neck white thread approach, and observation group was given the treatment through sternocleidomastoid muscle intermuscular approach. The operation conditions were compared between the two groups, and the pain scores and incidence of complication three months after operation were compared between the two groups. Results There were no statistically significant differences in operation time, hospital stay and intraoperative blood loss between two groups (P > 0.05); the incision length of observation group was shorter than that of control group, and the difference was highly statistically significant (P < 0.01). The pain score of observation group was lower than that of control group, and the difference was highly statistically significant (P < 0.01). The total incidence of postoperative complications in observation group was lower than that in control group, and the difference was statistically significant (P < 0.05). Conclusion Sternocleidomastoid muscle intermuscular approach does not increase the risk of surgery and prolong the hospital stay, and it can reduce the patient’s pain. It has obvious advantages in protecting the function of the anterior neck area of patients, fewer complications, which is worthy of clinical promotion.
2021 Vol. 18 (9): 73-75,85 [Abstract] ( 264 ) HTML (1 KB)  PDF (663 KB)  ( 15 )
76 Meta-analysis of a randomized controlled trial of diode laser transurethral enucleation of the prostate in the treatment of prostatic hyperplasia
DU Yuelin YOU Chengyu WANG Hui WEI Tangqiang ZHANG Xiaojun WANG Anguo
Objective To systematically evaluate the safety and efficacy of diode laser transurethral enucleation of the prostate (DILEP) and transurethral plasma kinetic enucleation of the prostate (PKEP) in the treatment of prostatic hyperplasia. Methods Retrieved from Embase, Cochrane Library, PubMed, Web of Science, China Biological Literature Database, CNKI, Wanfang, WIP and other databases from January 2000 to October 2020. Randomized controlled studies of the two surgical procedures were compared, and meta-analysis was performed using RevMan 5.3 software. Results A total of five articles were included in the study, and a meta-analysis showed that the two surgical methods were associated with decreased hemoglobin levels (P < 0.000 01), postoperative bladder irrigation time (P = 0.03), postoperative catheter indwelling time (P = 0.003), incidence of irritation symptoms (P = 0.003) and the international prostate symptom score at six months after surgery (P = 0.04) had statistically significant differences. Conclusion Compared with PKEK, DILEP have less intraoperative bleeding, shorter postoperative bladder irrigation time and catheter indwelling time, and lower incidence of irritation symptoms. In addition, DILEP is comparable to PKEP in terms of early efficacy and have an advantage in terms of symptom relief.
2021 Vol. 18 (9): 76-80 [Abstract] ( 342 ) HTML (1 KB)  PDF (711 KB)  ( 143 )
81 Effect of total laparoscopic nephroureterectomy and bladder sleeve resection in the treatment of urinary tract urothelial carcinoma
ZHANG Xiaolin LEI Ruru ZHANG Yanru CHEN Huai’an
Objective To analyze the effect of total laparoscopic nephroureterectomy and bladder sleeve resection in patients with urinary tract urothelial carcinoma. Methods A total of 80 patients with ureteral urothelial carcinoma who underwent surgical treatment in the First Affiliated Hospital of Hebei North University from March 2013 to March 2018 were selected as the subjects. According to different treatment methods, they were divided into conventional group (40 cases) and experimental group (40 cases). In the conventional group, laparoscopic nephreterectomy, bladder sleeve resection and distal ureteral open treatment were performed. The experimental group was treated with total laparoscopic nephroureterectomy and bladder sleeve resection. The amount of blood loss during operation, operative time, postoperative fasting time, catheter removal time, drainage tube removal time and postoperative hospitalization time were compared between the two groups. The pathological classification and pathological stages, recurrence rate and survival rate, prognosis of disease were compared between the two groups. Results The amount of blood loss during operation in the experimental group was lower than that in the conventional group, and the operative time, postoperative fasting time, catheter removal time, drainage tube removal time and postoperative hospital stay in the experimental group were all shorter than those in the conventional group, with statistical significance (P ＜ 0.05). There was no significant difference in the pathological grade and stage between the two groups (P ＞ 0.05). There was no significant difference in recurrence rate between the two groups (P ＞ 0.05). After 24 months of continuous follow-up, the survival rate of the experimental group was higher than that of the conventional group, and the difference was statistically significant (P ＜ 0.05). Conclusion Ureteral urothelial carcinoma using total laparoscopic renal length of ureteral resection and bladder cuff resection treatment, can reduce blood loss during operation, and promote the patients’ body recovery, shorter hospital stay, and thus improve disease-free survival rate of patients, at the same time during surgery patient position without transformation, to a certain extent, reduce the operation time, has high efficacy and safety, at the same time combined the corresponding nursing measures to further enhance the efficacy of treatment.
2021 Vol. 18 (9): 81-85 [Abstract] ( 324 ) HTML (1 KB)  PDF (543 KB)  ( 73 )
86 Application of Zhibitai Capsules for peritoneal dialysis
KONG Aili QIU Xiaoling
Objective To investigate the effect of Zhibitai Capsules on serum lipids, inflammatory factors and oxidation stress indexes in peritoneal dialysis patients. Methods A total of 85 patients with peritoneal dialysis admitted to Huludao Central Hospital of Liaoning Province from January 2018 to December 2019 were selected. According to random number table method, 42 cases were divided into control group and 43 cases were observed group, routine treatment was given to both groups, and Zhibitai Capsules was added to the observation group. After treatment for six months three, the acyl glycerin (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C) and inflammatory factor, interleukin 6 (IL-6) and IL-8, hypersensitive C-reactive protein (hs-CRP), and oxidative stress indicators superoxide dismutase (SOD), malondialdehyde (MDA) and glutathione (GSH) levels were compared between the two groups. Results In the control group, TG, TC, LDL-C, IL-6, IL-8, hs-CRP were higher than before treatment, and HDL-C was lower than before treatment; in the observation group, TG, TC, LDL-C, IL-6, IL-8, hs-CRP were lower than before treatment, and HDL-C was higher than before treatment. After treatment, TG, TC, LDL-C, IL-6, IL-8 and hs-CRP in observation group were lower than those in control group, and HDL-C was higher than those in control group (P ＜ 0.05). After treatment, SOD and GSH of the two groups were increased and MDA was decreased (P ＜ 0.05), SOD and GSH in observation group were higher than those in control group, and MDA in observation group was lower than that in control group (P ＜ 0.05). Conclusion Zhibitai Capsules could benefit from the regulation of blood lipid level of dialysis patients, and improve the level of inflammatory factors and oxidation stress indexes.
2021 Vol. 18 (9): 86-89 [Abstract] ( 564 ) HTML (1 KB)  PDF (483 KB)  ( 101 )
90 Meta-analysis of efficacy and safety of Tripterygium wilfordii extract combined with Leflunomide in treating rheumatoid arthritis
WANG Ziyang1 LI Weifeng2 JI Wei1
Objective To evaluate the efficacy and safety of Tripterygium wilfordii extract combined with Leflunomide in the treatment of rheumatoid arthritis. Methods The relevant clinical trials were collected from CNKI, VIP, WanFang, PubMed, Elsevier and Web of Science databases from the establishment of the database to February 2020. Two researchers independently screened the literature, extracted data and evaluated the quality of the included studies, and then conducted statistical analysis using RevMan 5.3 software. Results A total of ten clinical trials involving 696 patients were included. Meta-analysis results showed that in the experimental group, the total effective rate (OR = 3.80, 95%CI [2.34, 6.16], P < 0.000 01), the number of painful joints (MD = -1.56, 95%CI [-2.08, -1.05], P < 0.000 01), the number of painful joints (SMD = -0.92, 95%CI [-1.74, -0.09], P = 0.03), the number of erythrocytic sedimentation rate (SMD = -1.64, 95%CI [-2.26, -1.01], P ＜ 0.000 01), C-reactive protein (SMD = -1.98, 95%CI [-2.81, -1.14], P < 0.000 01), rheumatoid factor (SMD = -2.23, 95%CI [-3.27, -1.19], P < 0.0001) were better than the control group in terms of improvement. Conclusion Tripterygium wilfordii extract combined with Leflunomide was more effective in treating rheumatoid arthritis than Leflunomide alone.
2021 Vol. 18 (9): 90-94 [Abstract] ( 410 ) HTML (1 KB)  PDF (1639 KB)  ( 32 )
95 Effect of operation opportunity on prognosis of elderly hip fracture
ZHUO Zeming XING Shi WANG Hejie CHEN Lixi▲ WANG Yuan
Objective To study the effect of operation opportunity on the prognosis of elderly hip fracture. Methods A total of 112 elderly patients with hip fracture who were enrolled in Haikou Affiliated Hospital of Central South University Xiangya School of Medicine from March 2018 to April 2019 were selected as the observation objects and they were divided into study group and control group according to operation opportunity, with 56 patients in each group. The operation was performed within 48 hours after fracture in the study group, and the operation was performed within 48-72 hours after the fracture in the control group. The amount of blood loss, operation, hospitalization and fracture healing time were compared between the two groups, and the incidence of complications (vascular nerve injury, pulmonary infection, bone nonunion) were compared between the two groups. The flexion and abduction activity of hip joint were measured before and after operation and the visual analog scale (VAS), hip joint function (Harris) score, quality of life (QOL) score and clinical symptom score were investigated. Follow-up of one year, the mortality rate of the two groups was recorded and the operation results of the two groups were compared. Results There was no significant difference in the operation time between the two groups (P ＞ 0.05). The amount of blood loss in the study group were less than that in the control group, hospitalization and fracture healing time in the study group were lower than those in the control group, and the differences were statistically significant (all P ＜ 0.05). The total incidence of complications in the study group was lower than that in the control group, and the difference was statistically significant (P ＜ 0.05). There were no statistically significant differences in hip flexion, abduction activity, Harris score, VAS, QOL score and clinical symptom score between the two groups before operation (P ＞ 0.05). After operation, hip flexion, abduction activity, Harris score and QOL score in both groups were higher than before operation, while VAS and clinical symptom score were lower than before operation. In the study group, hip flexion, abduction activity, Harris score and QOL score were higher than those in the control group, while VAS and clinical symptom score were lower than those in the control group, and the differences were statistically significant (all P ＜ 0.05). The mortality rate of one year after operation in the study group was lower than that in the control group, the difference was statistically significant (P ＜ 0.05). Conclusion Early implementation of operation after hip fracture in elderly patients has more prominent effect, which can quickly improve the hip ability of patients, reduce the length of treatment, reduce the pain of patients, quickly relieve the corresponding symptoms, promote the recovery of mobility, prevent serious complications, and improve the quality of life.
2021 Vol. 18 (9): 95-98,103 [Abstract] ( 473 ) HTML (1 KB)  PDF (570 KB)  ( 21 )
99 Application effect of progressive resistance exercise training in elderly patients with intertrochanteric fracture after internal fixation
XU Xinxuan1 YANG Longfei2 JIANG Su1 REN Yongping1 HUANG Aibing2
Objective To investigate the effect of progressive resistance exercise training on hip joint function after internal fixation of intertrochanteric fracture in elderly patients. Methods A total of 98 elderly patients with intertrochanteric fracture treated in Jiangsu Taizhou People’s Hospital from January 2018 to January 2020 were selected as the research subjects. According to random number table method, they were divided into observation group and control group, with 49 cases in each group. Intertrochanteric fracture internal fixation was performed in both groups. The control group received routine rehabilitation training intervention, and the observation group received progressive resistance exercise training intervention. The operative recovery index, complication rate, Harris hip function score, hip muscle strength and quality of life score were statistically compared between the two groups. Results The time of getting out of bed, hospital stay and fracture healing time in the observation group were shorter than those in the control group, and the differences were statistically significant (all P ＜ 0.05). The total incidence of complications in the observation group was lower than that in the control group, and the difference was statistically significant (P ＜ 0.05). After intervention, the level of hip muscle strength, Harris hip function score and quality of life score in both groups were higher than before, and the observation group was higher than the control group, the differences were statistically significant (all P ＜ 0.05). Conclusion The application of progressive resistance exercise training after internal fixation of senile intertrochanteric fracture can obtain better rehabilitation effect, promote fracture healing, improve hip function, increase joint muscle strength and improve the quality of life of patients, which has high clinical application value.
2021 Vol. 18 (9): 99-103 [Abstract] ( 426 ) HTML (1 KB)  PDF (555 KB)  ( 57 )
104 Effects of controllable micromotion on postoperative pain control and functional recovery in patients with femoral fracture
JIANG Yang1 WANG Yan1 GUO Meifeng1 TAO Hongming2
Objective To explore and analyze the influence of controllable micromotion on postoperative pain control and functional recovery in patients with femoral fracture. Methods A total of 180 patients with femoral fracture treated in Changzhou Traditional Chinese Medicine Hospital, Jiangsu Province from June 2017 to June 2020 were selected and they were divided into control group and observation group according to random number table method, with 90 patients in each group. The control group was given routine postoperative intervention, and the observation group was additionally treated with controlled fine motion intervention on the basis of control group. The intervention lasted for three weeks in both groups. The degree of postoperative pain, Lysholm score and satisfaction were compared between the two groups. Results Overall visual analogue scale (VAS) analysis showed that there were statistically significant differences in comparison between groups, time point comparison and interaction (P ＜ 0.05). Comparison within groups: VAS at three weeks, one month and three months after intervention in both groups were lower than before intervention, and the differences were statistically significant (all P < 0.05). Comparison between groups: VAS in the observation group was significantly lower than that in the control group at three weeks, one month and three months after intervention, and the differences were statistically significant (all P < 0.05). After intervention, Lysholm scores in both groups were higher than before intervention, and the observation group was higher than the control group, the differences were statistically significant (all P ＜ 0.05). The satisfaction of the observation group was higher than that of the control group, and the difference was statistically significant (P ＜ 0.05). Conclusion On the basis of routine postoperative intervention, the use of controllable micromotion can significantly reduce the degree of pain, promote the recovery of daily function after femoral fracture, and improve the satisfaction of patients.
2021 Vol. 18 (9): 104-107 [Abstract] ( 480 ) HTML (1 KB)  PDF (543 KB)  ( 54 )
108 Effect of locking plate surgery via the Carlson posterolateral approach on posterolateral tibial plateau fracture and its effect on joint function
GUO Siyuan LI Huanru WU Shengxiang
Objective To investigate the effect of locking plate surgery via the Carlson posterolateral approach on posterolateral tibial plateau fracture and its effect on joint function. Methods A total of 60 patients with posterolateral tibial plateau fracture admitted to the Anhui Wanbei Coal and Power Group General Hospital from January 2017 to January 2020 were selected and they were divided into observation group and control group according to random number table method, with 30 cases in each group. The observation group received locking plate surgery via the Carlson posterolateral approach, while the control group received locking plate surgery via the traditional posterior median approach. Intraoperative blood loss, fracture exposure time, surgery time, healing time, time to full weight bearing, incidence of complications and Rasmussen score of knee function six months after surgery were compared between the two groups. The changes of posterior slope angle (PA) and tibial plateau angle (TPA) of knee joint were compared between the two groups immediately after surgery and six months after surgery. Results The amount of intraoperative blood loss in the observation group was significantly less than that in the control group, and the fracture exposure time was significantly shorter than that in the control group, and the differences were statistically significant (all P < 0.05). There were no significant differences in surgery time, healing time and time to full weight bearing between the two groups (P ＞ 0.05). After surgery, there were no complications such as foreign body rejection and incision nonunion in the two groups. The excellent and good rate of Rasmussen score in observation group was significantly higher than that in control group, and the difference was statistically significant (P < 0.05). There were no significant differences in PA and TPA between the two groups immediately after surgery and six months after surgery (P ＞ 0.05). Conclusion Locking plate surgery via the Carlson posterolateral approach can reduce intraoperative blood loss in patients with posterolateral tibial plateau fracture, shorten fracture exposure time, and significantly restore the knee function of patients, which is worthy of clinical promotion and application.
2021 Vol. 18 (9): 108-111 [Abstract] ( 225 ) HTML (1 KB)  PDF (545 KB)  ( 35 )
112 Analysis of laboratory examination results of 79 440 people of pre-pregnancy eugenics in Nanning City
RUAN Liming1 ZHONG Liuyu2 LIU Kun2 QIN Hong2
Objective To analyze the laboratory examination results of 79 440 people of pre-pregnancy eugenics in Nanning City, and to investigate the role of pre-pregnancy eugenics health examination in pre-pregnancy eugenics health care and birth defect prevention. Methods Retrospective analysis was conducted on the laboratory examination data of 79 440 people with couples of childbearing age and some women who received the national pre-pregnancy health examination from 2012 to 2015 in Nanning City. High risk factors of pregnancy for couples who received pre-pregnancy eugenics were screen. Results Three eugenics (cytomegalovirus, rubella virus, Toxoplasma gondii) and gynaecological reproductive tract infection were the main risk factors of the participating women. The top three abnormal detection rates of the items examined by the couple were blood routine, hepatitis B three-line and liver function test. Conclusion Pre-pregnancy eugenics health examination can find out all kinds of high-risk factors in time, and promote couples of childbearing age to understand their personal health situation before pregnancy, and actively prevent the occurrence of adverse pregnancy outcome and birth defect.
2021 Vol. 18 (9): 112-116 [Abstract] ( 113 ) HTML (1 KB)  PDF (948 KB)  ( 87 )
117 Analysis of growth and development and nutritional status of children with 3-14 years old in Xichang City
YANG Yuxiang ZHANG Yue
Objective To analyze the growth and development and nutritional status of children with 3-14 years old in Xichang City of Sichuan Province, and provide guidance for improving children’s health. Method The stratified cluster sampling method was used to select 1332 children from 19 schools in Xichang City of Sichuan Province from April to May 2018. Their height and weight were measured, body mass index (BMI) was calculated, and their nutritional status was evaluated according to the World Health Organization standard table of height and weight for children. Results The height of girls in 10-<11 years old group, 11-<12 years old group and 12-<13 years old group were significantly higher than those of boys, and the differences were statistically significant(all P < 0.05), and the height of boys in other groups were significantly higher than those of girls, and the differences were statistically significant (all P < 0.05). Weight and BMI of boys in all groups were significantly higher than those of girls, and the differences were statistically significant (all P < 0.05). The height of boys and girls before seven years old were lower than those of the national level, while the height of boys after 12 years old and girls after eight years old were higher than those of the national level. The weight of boys after six years old were higher than those of the national level, and the weight in each period of girls were higher than those of the national level. BMI of boys and girls in each period were higher than those of the national level. The rate of obesity and overweight in boy group were significantly higher than those in girl group, and the rate of emaciation and low body weight in boy group were significantly lower than those in girl group,  and the differences were statistically significant(all P < 0.05). There were no significant differences in growth retardation rate and malnutriton rate between two groups (P ＞ 0.05). There were statistically significant differences in the rates of obesity, overweight, emaciation, low body weight and growth retardation in the pre-school-age group, school-age group and adolescent group (P < 0.05); however, there was no statistical significance in the rate of malnutriton among three groups (P > 0.05). Conclusion The overall development of children with 3-14 years old in Xichang City of Sichuan Province is good, but the rate of obesity and overweight are high. Malnutrition is mainly manifested as emaciation. It is necessary to strengthen reasonable nutrition publicity and education, urge nutrition balance, develop good living habits, reduce long-time sit in and increase activity.
2021 Vol. 18 (9): 117-121 [Abstract] ( 348 ) HTML (1 KB)  PDF (706 KB)  ( 77 )
122 Correlation between self perceived burden and family function in child patients with bronchial asthma
JIANG Yanyan1 LI Xiaoqiong2 SUN Shiyu3▲
Objective To analyze the relationship between self perceived burden (SPB) and family function in children with bronchial asthma (BA). Methods A total of 100 patients with BA who treated in the Third Clinical Medical College of China Three Gorges University from June 2018 to May 2020 were selected, all children received two weeks routine treatment for BA and they were  followed up for one month. Before treatment, two weeks of treatment, and at the end of follow-up, SPB was assessed by self-perceived burden scale (SPBS), and family function was assessed by family assessment device (FAD). The relationship between the scores and total scores of SPBS and FAD were analyzed. Results The differences in SPBS scores of BA child patients at different time points were highly statistically significant (all P < 0.01). The differences in FAD scores of BA child patients at different time points were highly statistically significant (all P < 0.01). The scores and total scores of SPBS were positively correlated with the scores and total scores of FAD in BA child patients (r > 0, P < 0.05). Conclusion Children with BA have different degrees of SPB, with the control of the disease, the degree of SPB in children is decreased, and with the improvement of family function, the degree of SPB in children is gradually decreased, family function should be taken into consideration for intervention clinically in the future, to reduce SPB degree in BA children.
2021 Vol. 18 (9): 122-125 [Abstract] ( 493 ) HTML (1 KB)  PDF (572 KB)  ( 26 )
126 Effect of laparoscopic salpingectomy on serum β-HCG, blood routine and C-reactive protein levels and reproductive outcome in patients with ectopic pregnancy
XIE Wei YU Min▲
Objective To study the effect of laparoscopic salpingectomy on serum β-human chorionic gonadotropin (β-HCG), blood routine and C-reactive protein levels and reproductive outcome in patients with ectopic pregnancy. Methods A total of 110 cases of ectopic pregnancy admitted by the 901 Hospital of the Joint Logistic Support Force of the People’s Liberation Army from September 2017 to September 2020 were selected as study objects. According to the random number table method, they were divided into study group and control group, with 55 cases in each group. Study group was treated with laparoscopic salpingectomy, and control group was treated with ectopic pregnancy drug embryo killing conservative treatment. The serum β-HCG level, the decreasing extent of serum β-HCG level, the time taken for serum β-HCG level to return to normal level, hospital stay, reproductive outcome (ovulation rate, pregnancy rate, ectopic pregnancy rate), blood routine and C-reactive protein were compared between two groups. Results Before treatment, there was no significant difference in serum β-HCG level between two groups (P > 0.05). After 72 h of treatment, serum β-HCG level in both groups were lower than those before treatment, and study group was lower than control group, and the differences were all highly statistically significant (all P < 0.01). After 72 h of treatment, the decreasing extent of serum β-HCG level in study group was greater than that in control group, and the time taken for serum β-HCG level to return to normal level was shorter than that in control group; hospital stay of study group was shorter than that of control group, and the differences were highly statistically significant (all P < 0.01). There were no significant differences in ovulation rate and ectopic pregnancy rate between two groups after treatment (P > 0.05). The pregnancy rate in study group was higher than that in control group, and the difference was statistically significant (P < 0.05). There were no significant differences in blood routine and C-reactive protein between two groups (P > 0.05). Conclusion Laparoscopic salpingectomy in the treatment of ectopic pregnancy has significant curative effect, which is conducive to the recovery of serum β-HCG level, improving postoperative pregnancy rate of patients, shortening the hospital stay, no infection after operation, good recovery and high safety. It has clinical application value and is worthy of promotion.
2021 Vol. 18 (9): 126-129 [Abstract] ( 218 ) HTML (1 KB)  PDF (538 KB)  ( 69 )
130 Research on equity of health resource allocation in community health service institutions in western China
MA Yiwen1 ZHANG Qiqi1 ZHUANG Taifeng2▲
Objective To analyze the health resource allocation and equity of community health service institutions in western China from 2013 to 2018, and find out the influencing factors, provide the basis for optimizing the allocation of health resources allocation. Methods Gini index and agglomeration degree were used to evaluate the equity of health resources, and the differences were analyzed. Cluster analysis was used to find out the main factors of unbalanced resource allocation. Results During the 13th Five-Year Plan period, the equity of community health resources in western China tended to be better year by year, but there were still great differences among regions. The equity of health resources according to population distribution was higher than that according to geographical area distribution, and economic development was the main reason that affected the uneven distribution of resources in geographical distribution. Conclusion In terms of the allocation of community health resources in western China, geographical, population, economic and population mobility conditions should be considered comprehensively, and fairness and efficiency should be taken into account. In the regions with large population density and small land area, the accessibility of health resources to the population distribution should be enhanced; in the regions with small population density and large land area, the accessibility of health resources to the land area distribution should be enhanced to enhance the fairness of resource allocation among different regions within the region.
2021 Vol. 18 (9): 130-134 [Abstract] ( 261 ) HTML (1 KB)  PDF (549 KB)  ( 113 )
135 The experience of public health emergency management training in major developed countries abroad
ZHU Yu1 YIN Yanhong2 XU Peihai1 Nurlanbek·Hasenbek1 JIA Xiaoting1 WU Wei1 DONG Zeyu3 ZHU Qing1
There are still some problems in the capacity building of public health emergency management in China, such as lack of scientific guidance and specialization, lack of professional training of emergency management for cadres. By studying abroad to perfect the training system, action oriented training method, the modular design of the training content and the way of the whole system training and other advanced practice and experience of emergency management training to explore our country public health emergency management system of cadres training method and way, thus improve the cadres emergency management ability, promote the emergency management ability of modern construction.

 
2021 Vol. 18 (9): 135-139 [Abstract] ( 278 ) HTML (1 KB)  PDF (1243 KB)  ( 75 )
140 Systematic evaluation and pharmacoeconomic analysis of Paroxetine versus Duloxetine in treatment of depression
CHEN Xing WANG Xiaoli
Objective To provide evidence-based evidence for the choice of drugs for clinical treatment of depression and to evaluate the economics. Methods CNKI, WanFang, VIP, PubMed, EMBase, Cochrane library and SinoMed were all searched. Randomized controlled trials of Paroxetine and Duloxetine in the treatment of depression were screened, the retrieval time was set up until March 2020. Meta-analysis and pharmacoeconomic analysis were performed using RevMan 5.3 software and cost-effectiveness ratio. Results A total of 12 RCT articles, 1722 patients were included in the analysis. Meta-analysis results showed that there was no significant difference in the total effective rate between the two groups in treating depression (RR = 1.01, 95%CI [0.96, 1.07], P = 0.65), after treatment, there was a statistically significant difference in the score of hamilton depression scale between the two groups (MD = 0.71, 95%CI [0.25, 1.17], P = 0.003), and there was a statistically significant difference in the adverse reactions between the two groups (RR = 1.11, 95%CI [1.01, 1.21], P = 0.02), and both groups were well tolerated. In terms of pharmacoeconomics, the cost-effectiveness ratio of paroxetine was 371.21 and the duloxetine was 536.11, incremental cost-effectiveness ratio was -28 431.03. Conclusion Paroxetine and Duloxetine have similar clinical effects in the treatment of depression, and paroxetine is more prone to adverse reactions, and paroxetine has economic advantages.
2021 Vol. 18 (9): 140-144 [Abstract] ( 580 ) HTML (1 KB)  PDF (1165 KB)  ( 46 )
145 Examples on common couplet medicines of Chai Kequn’s in treating lung cancer
SUN Shuihua1 YU Zhihong1 LI Mingqian1 HE Haidong2 JIA Xiang3 CHEN Jiabin1 CHAI Kequn1▲
Professor Chai Kequn summarizes and creates four methods of traditional Chinese medicine cancer prevention and treatment, which are “strengthening spleen and tonifying kidney to strengen vital qi” “resolving dissipating phlegm and removing toxicity to dissipate cancer” “soothing liver and relieving depression to regulate emotion” “warming yang and unblocking collaterals to disperse cold and prevent changes”. In this paper, the connotation of Chai’s four methods of cancer prevention and treatment and their application in lung cancer are expounded, 12 pairs of commonly used couplet medicines are summarized, such as Dioscoreae Rhizoma-Euryales Semen, Coicis Semen-Lycii Fructus, Pseudostellariae Radix-Schisandrae Chinensis Fructus, Pinelliae Rhizoma-Scutellariae Radix, Taraxaci Herba-Forsythiae Fructus, Fagopyri Dibotryis Rhizoma-Bombyx Batryticatus, Bupleuri Radix-Paeoniae Radix Alba, Citri Reticulatae Pericarpium Viride-Citri Reticulatae Pericarpium, Aurantii Fructus-Curcumae Radix, Cinnamomi Ramulus-Angelicae Sinensis Radix, Cuscutae Semen-Morindae Officinalis Radix, Curculiginis Rhizoma-Epimedii Folium. This paper summarizes Professor Chai Kequn’s four methods of Chinese medicine syndrome differentiation and treatment of lung cancer, including the characteristics of couplet medicines compatibility and common dosage, and discusses its mechanism.
2021 Vol. 18 (9): 145-148 [Abstract] ( 223 ) HTML (1 KB)  PDF (696 KB)  ( 151 )
149 Discussion on paracentral acute middle maculopathy from “collateral theory”
SUN Mei1,2 HAO Xiaofeng2 XIE Like2 JIN Qi1,2
Paracentral acute middle maculopathy (PAMM) is a rare disease caused by ischemia of the middle and deep capillaries of the retina. Retinal blood vessels are tiny, belonging to collaterals, collaterals and eyes have a close relationship. This article discusses the relationship between the collaterals and the PAMM through the elaboration of the relationship between the collaterals and the eyes physiology and pathology, starting with the collateral theory. Deficiency of positive qi is the basis of PAMM, and eye collaterals stasis is the core of PAMM. PAMM pathogenes is features are comprised of being easy to block and choke, easy to enter but difficult to come out, and easy to form a visible lesion. In clinical practice, we should pay attention to the use of pungent drugs, insect drugs, rattan drugs and tonic drugs, treat both manifestation and root cause of disease, strengthen vital qi to eliminate pathogenic factor in the treatment of PAMM.
2021 Vol. 18 (9): 149-151,167 [Abstract] ( 319 ) HTML (1 KB)  PDF (766 KB)  ( 72 )
152 Analysis on the characteristics of the core academic thoughts of Lingnan dermatology school of traditional Chinese medicine
WANG Wuhao LI Hongyi DANG Ruonan CHEN Qiumei MO Junxi WU Yuansheng
Lingnan dermatology school of traditional Chinese medicine is rooted in the soil of Lingnan medicine, which is an important branch of Lingnan medicine school. Analyzing and summarizing its core academic thoughts is conducive to the inheritance and innovation of the theoretical system of traditional Chinese medicine, which also can enrich the academic connotation of Lingnan medicine. The core academic thought of Lingnan dermatology school of traditional Chinese medicine is born by Xuan Guowei, a master of traditional Chinese medicine, based on inheriting the classical theory of traditional Chinese medicine, combining the characteristics of Lingnan region and clinical experience of more than 50 years. The specific ideological connotation includes: attaching importance to five kinds of clinical thinking of traditional Chinese medicine; it is advocated that regulating yin and yang is the school of curing diseases, and it is emphasized that the treatment of refractory and intractable skin diseases can be based on the principles of “kidney” and “poison”; the prescription of skin diseases should be combined with Chinese and Western medicine, internal and external medicine, and three factors should be taken into consideration; paying attention to the diagnosis and treatment from multiple perspectives, and emphasizing the influence of social and psychological factors on the prevention and treatment of skin diseases.
2021 Vol. 18 (9): 152-155 [Abstract] ( 271 ) HTML (1 KB)  PDF (693 KB)  ( 98 )
156 Experience of Professor Wan Donggui in treating triple negative breast cancer from phlegm
ZHANG Jing1 LUO Chufan1 ZHOU Xin1 WAN Donggui2▲
Triple-negative breast cancer is a difficult and hot spot in clinical research. At present, Western medicine lacks targeted treatment methods, and traditional Chinese medicine has certain characteristics and advantages. Professor Wan Donggui has been practicing medicine for more than 30 years, and has opened a special disease clinic for triple-negative breast cancer for 8 years. She has accumulated rich clinical experience, and is good at treating triple-negative breast cancer from phlegm. She has created a special disease prescription for the prevention and treatment of recurrence and metastasis of triple-negative breast cancer, “Louci Sanjie Fang”, which has been applied in clinical practice for many years and has achieved satisfactory results. Professor Wan Donggui thinks that endogenous phlegm-turbidity is an important part of the occurrence and development of triple-negative breast cancer, phlegm-dampness is a common constitution of triple-negative breast cancer, phlegm-turbid coagulation is the main cause of recurrence and metastasis of triple-negative breast cancer, so the main therapeutic principle is dissipating phlegm to remove mass, treating form depression and deficiency, dispersing the stagnated liver-energy and invigorating the spleen, regulating qi-flowing for eliminating phlegm. Meanwhile, she pays attention to guiding medicinal herb, makes good use of the drugs for dredging mammary collaterals, ventilating lung qi for dissipating phlegm, dispelling wind and dredging channel, in order to eliminate the source of phlegm, improve biased physique constitution, and prevent development and transmission.
2021 Vol. 18 (9): 156-159 [Abstract] ( 347 ) HTML (1 KB)  PDF (744 KB)  ( 271 )
160 Director Lei Genping’s experience in treating edema based on syndrome differentiation of six channels theory
CUI Jiaojiao1 LEI Genping2 DONG Sheng2
This article mainly summarizes the academic thought and clinical experience of Director Lei Genping in treating edema disease from syndrome differentiation of six channels theory. According to the pathogenic characteristics and pathogenesis of the six meridians, Director Lei Genping put forward six aspects to treat edema: regulating taiyang meridian, unblocking yangming meridian, reconciling shaoyang meridian, warming and tonifying taiyin meridian, clearing and tonifying shaoyin meridian, and taking care of jueyin meridian. Clinical effect is remarkable. Therefore, this article will systematically describe Lei Genping’s academic thought and experience of syndrome differentiation and treatment of edema disease from six aspects of taiyang meridian, yangming meridian, shaoyang meridian, taiyin meridian, shaoyin meridian and jueyin meridian, so as to provide new diagnosis and treatment ideas for clinical treatment of edema disease and improve clinical efficacy.
2021 Vol. 18 (9): 160-163 [Abstract] ( 242 ) HTML (1 KB)  PDF (695 KB)  ( 115 )
164 Drug characteristics, regularity and application of Shennong’s Classic of Materia Medica in the treatment of cough with dyspnea
WANG Yue1 SU Xin2
Shennong’s Classic of Materia Medica has mentioned 41 kinds of herbs with therapeutic effect of cough with dyspnea. This paper makes statistics and analysis from the aspects about the distribution of drugs, nature and flavour, meridian tropism, the classification of efficacy, and the trend of action, so as to explore the characteristics and regularity of herbs in Shennong’s Classic of Materia Medica for treating cough with dyspnea, in order to provide reference for clinical treatment and new drug research and development of cough. The results show that the distribution of drugs are mainly the following products and plant drugs; most of the flavor is pungent and mild; thirty-one drugs can be found and meridian, cough is closely related to lung, kidney and heart; up to now, there are 26 flavors, involving 13 kinds of efficacy, most of which are warming interior formula, antitussive and antiasthmatic medicine and heat-clearing medicine; the tend of drugs effect is sinking and descending more than ascending and floating; it can play a role by eliminating pathogenic factors, nourishing vital qi and special effects.
2021 Vol. 18 (9): 164-167 [Abstract] ( 127 ) HTML (1 KB)  PDF (755 KB)  ( 151 )
168 Clinical efficacy of ultrasound-guided akupotomye in the treatment of thoracolumbar fascitis
WANG Cheng LYU Ya’nan DENG Xiangqiang LIANG Shufeng Gao Xin
Objective To compare the clinical efficacy of ultrasound-guided akupotomye with ordinary acupuncture in the treatment of thoracolumbar fascitis. Methods A total of 60 patients with thoracolumbar fascitis admitted to the outpatient department of Rehabilitation Treatment Center, Guangxi Zhuang Autonomous Region People’s Hospital from March 2018 to March 2019 were collected. According to the random number table method, they were divided into control group (30 cases) and treatment group (30 cases). The control group was treated with ordinary acupuncture and the treatment group was treated with ultrasound-guided akupotomye. After three courses of treatment, the scores of simplify McGill scale (visual analogue score [VAS], pain grading index [PRI] score and present pain intensity [PPI] score), body impairment index (PII) rating scale before and after treatment and clinical efficacy in two groups were compared. Results After treatment, VAS, PRI scores, PPI scores and PII scores of two groups were lower than those before the treatment, and scores of each item in the treatment group were lower than those in the control group, with statistical significant differences (all P ＜ 0.05). The clinical efficacy of the treatment group was better than that of the control group, with statistical significance (P ＜ 0.05). Conclusion Both treatments can effectively reduce the pain and restore the function of the lumbar and leg in patients with lsodorsal myofasciitis, thus improving the quality of life. Ultrasound-guided akupotomye treatment of thoracolumbar fascitis is more effective than ordinary acupuncture in improving the clinical symptoms, which is worthy of further clinical application.
2021 Vol. 18 (9): 168-171 [Abstract] ( 511 ) HTML (1 KB)  PDF (487 KB)  ( 62 )
172 Effect of Bining Decoction combined with akupotomye treating gouty nephropathy arthritis with syndrome of accumulation and binding of damp-heat
TONG Ying1 HU Rongxue2 TAN Jiahui2 ZHANG Shujun3 LI Zeguang1 ZHANG Weiping2 SHAO Zhonglin2 YANG Junchao2
Objective To explore the effect of Bining Decoction combined with akupotomye in the treatment of gouty nephropathy (GN) arthritis with syndrome of accumulation and binding of damp-heat. Methods Sixty patients with GN with syndrome of accumulation and binding of damp-heat admitted to Department of Rheumatology, the First Affiliated Hospital of Heilongjiang University of Chinese Medicine from December 2018 to December 2019 were collected. Through the random number table method, they were divided into treatment group and control group (30 cases in each group). The patients in the treatment group were treated by Bining Decoction combined with akupotomye. The patients in the control group were treated by Febuxostat Tablets. The treatment course for both groups was seven days. After treatment, blood uric acid (BUA), C-reactive protein (CRP), 24 h urine protein, visual analog scale (VAS), and joint activity score were used as the indicators of efficacy observation in the two groups. Results After treatment, the quantitative levels of BUA, CRP, 24 h urine protein, VAS and joint activity score in both groups were lower than those before the treatment, and the quantitative levels of BUA, CRP, 24 h urine protein, VAS and joint activity scores in the treatment group were lower than those in the control group, with statistical significant differences (P ＜ 0.05). Conclusion Bining Decoction combined with akupotomye in the treatment of GN with syndrome of accumulation and binding of damp-heat can effectively reduce BUA, CRP 24 h urine protein, relieve pain and improve joint function.
2021 Vol. 18 (9): 172-175 [Abstract] ( 353 ) HTML (1 KB)  PDF (491 KB)  ( 65 )
176 A case of reduced-dose decitabine in the treatment of myelodysplastic syndrome and a review of the literature
MA Dongsheng1 YE Fang2 XU Yuxiu1 WANG Meng1 GUO Li1
Myelodysplastic syndrome (MDS), also known as refractory anemia, depends on blood transfusion and has a high risk of transformation to acute leukemia, which seriously affects the quality of life and survival cycle of patients. Therefore, it is very important to make a definite diagnosis as early as possible through bone marrow morphology, immunology, cytogenetics, molecular biology and other examinations, and to stratify precise prognosis and standardize treatment. In this paper, a case of MDS (high-risk group) was reviewed, and different doses of demitabine were applied in the treatment of MDS patients and relevant literature was reviewed to explore the efficacy and safety of reduced dose of demitabine in the treatment of MDS patients.
2021 Vol. 18 (9): 176-178,184 [Abstract] ( 264 ) HTML (1 KB)  PDF (804 KB)  ( 105 )
179 Comprehensive study of the qualitative experience of patients with chronic low back pain based on the framework of outcome indicators
ZHANG Ying1* CHEN Hong2* CHEN Qianji1 WAN Ying1 LIU Wenke1 WANG Yue1 YU Changhe2
Objective To provide a wider perspective for the evaluation of chronic back pain (CBP) outcome from the point of view of patients’ values based on the theme of the outcome indicators framework, comprehensive research on the life experience and expectations of patients with chronic low back pain (CBP). Methods Electronic retrieval databases PubMed, EMbase, CINAHL, PsyclNFO, Web of Science, SinoMed, China national Rnowledge infrastructure (CNKI), VIP Chinese Science and Technology Journal Database (VIP), WanFang Data, the time was from the establishment of the database until 2020 in March, after using the quality evaluation standards of the Australian JBI evidence-based health care center to evaluate the quality of the literature, the thematic comprehensive method was used to analyze the research results, while the results were classified according to the conceptual framework of the outcome indicators recommended by the COMET website. Results Based on the 23 included studies, 4 themes and 14 sub-themes were identified: physiological or clinical (musculoskeletal and connective tissue outcome, general outcome), life impact (physical function, social function, role function, emotional function, recognition function, overall quality of life, nursing provision), resource utilization (economic efficiency, need for further intervention, social/nursing staff burden), adverse events (drug side effects, surgical effectiveness and safety). Conclusion Chronic low back pain has a negative impact on the patient’s physical, psychological, and social levels. It is necessary to fully consider the patient’s true expectations in the field of outcome measurement and CBP management.
2021 Vol. 18 (9): 179-184 [Abstract] ( 168 ) HTML (1 KB)  PDF (792 KB)  ( 80 )
185 Research on university laboratory safety management based on track intersecting theory
YANG Licheng* CHEN Yanjun* CUI Changhuan TAI Hongxiang
With the increasing number and scale expansion of laboratory construction at all levels ofcolleges and universities, laboratory safety has been becoming the top priority of campus security management. In order to implement effective accident prevention in university laboratories, the model of accident trajectory cross is designed for the present study based on rationale of trace intersecting theory, which aims to analyze the reasons for laboratory accidents resulting from the three factors of person, material and management defects. In accordance with the results, the three preventive measures are put forward, including the prevention of personal unsafe behavior, controlling the insecurity condition ofmaterial and object, and improvement of management. Furthermore, the feasibility study of trace intersecting theory is proved in the prevention of university laboratory accidents, which provides a theoretical reference for the improvement of university laboratory safety management.
2021 Vol. 18 (9): 185-188 [Abstract] ( 142 ) HTML (1 KB)  PDF (783 KB)  ( 48 )
189 Summaries and countermeasures of national female rugby medical work service
DING Jie1,2 CHEN Gen1,2 CUI Tongqing3 LI Wei2,4 GUI Chao2,4 WANG Zhibin1,2 FENG Xuehui1,2 XIE Qiang1,2
Objective To summarize the medical service work of national female rugby team and to discusses the countermeasures. Methods A total of 82 person-time of female rugby players who participated in the national team training camp from January 2017 to July 2020 were selected. Questionnaire surveys and clinical examinations were used to analyze and summarize common sports injuries. Results Through questionnaire survey and physical examination, 566 times of sports injury were found, including 374 times of acute injury, accounted for 66.08%; 192 times of chronic injury (33.92%). The top three common injury sites were ankle (28.98%), knee (25.80%) and waist (13.25%). Muscle (42.58%), ligament (22.79%) and tendon (20.67%) were the top three damaged tissue. The top three common diseases were ankle sprain (21.38%), lumbar muscle strain (13.25%) and lower limb muscle strain (12.54%). Conclusion According to the common sports injury diseases and injury types, in the future training, through strengthening physical training and nutrition supply, timely detection of sports injury, pay attention to fatigue recovery, mental health and menstrual cycle on the influence of women, reduce the occurrence of sports injury.
2021 Vol. 18 (9): 189-192 [Abstract] ( 186 ) HTML (1 KB)  PDF (658 KB)  ( 79 )
193 Practice and thinking of discipline inspection and supervision in public hospitals under the mode of combining peacetime with wartime
REN Jing
In the face of infectious public health emergencies, scientific medical treatment and strong political supervision are important guarantees for a comprehensive and effective response to them. Based on the research results of hospital party conduct and clean government construction inspections, bidding and procurement supervision and management, etc., this paper trigger thoughts on political supervision of public health emergencies. This paper analyzes the problems existing in the discipline inspection and supervision in peacetime and “wartime”, and puts forward the supervision countermeasures to improve the supervision efficiency. Based on the case study of the prevention and control supervision of infection in hospitals, cause to think，the discipline inspection supervision mechanism is established under the mode of combining peacetime with “wartime”.
2021 Vol. 18 (9): 193-196 [Abstract] ( 275 ) HTML (1 KB)  PDF (653 KB)  ( 112 )
Copyright © Editorial Board of 中国医药导报
Supported by:Beijing Magtech