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| Research progress on LncRNA MALAT1 and breast cancer |
| WANG Simin1 LI Na1 XIONG Haojun1 ZHANG Cuiwei2 CHAI Li2▲ |
1.Clinical Medicine College, Southwest Medical University, Sichuan Province, Luzhou 646000, China;
2.Department of Pathology, the Affiliated Hospital of Southwest Medical University, Sichuan Province, Luzhou 646000, China |
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Abstract Breast cancer is one of the most common female malignant tumors in China. In recent years, the occurrence and development of non-coding RNA in the breast cancer has attracted increasingly attention. MALAT1 is a long non-coding RNA closely related to the proliferation, invasion, metastasis and prognosis of breast cancer. However, its role in various stages of breast cancer is still controversial, and its molecular mechanism is still unclear. This paper summarizes the research progress of LncRNA MALAT1 in breast cancer, aiming to provide new ideas for the early detection and diagnosis of breast cancer, and to explore new drug targets.
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[1] Qian X，Zhao J，Yeung PY，et al. Revealing lncRNA structures and interactions by sequencing-based approaches [J]. Trends Biochem Sci，2019，44（1）：33-52.
[2] Chen QJ，Zhu CJ，Jin YY. The oncogenic and tumor suppressive functions of the long noncoding RNA MALAT1：an emerging controversy [J]. Front Genet，2020，11：93.
[3] Ji P，Diederichs S，Wang W，et al. MALAT-1，a novel noncoding RNA，and thymosin beta4 predict metastasis and survival in early-stage non-small cell lung cancer [J]. Oncogene，2003，22（39）：8031-8041.
[4] 孙秀凤，周芬，吴婷.长链非编码RNA MALAT1对NSCLS增殖、侵袭迁移及凋亡的影响[J].中国肿瘤外科杂志，2020，12（2）：148-152，157.
[5] 韩志蓉，奉泽锦，韩亮，等.甲状腺微小乳头状癌中MALAT1和FGF2表达及临床意义[J].临床肿瘤学杂志，2019，24（9）：804-807.
[6] 彭浩，武玉东，李健，等.长链非编码RNA MALAT-1通过EZH2-β-catenin信号通路调控肾癌细胞的增殖、凋亡及侵袭[J].现代泌尿外科杂志，2020，25（1）：63-67.
[7] Chen RB，Liu Y，Zhuang H，et al. Quantitative proteomics reveals that long non-coding RNA MALAT1 interacts with DBC1 to regulate p53 acetylation [J]. Nucleic Acids Res，2017，45（17）：9947-9959.
[8] 王哲，张敬，陈怀安，等.长链非编码MALAT1对膀胱癌细胞迁移和侵袭影响机制探讨[J].中华肿瘤防治杂志，2019，26（18）：1342-1347.
[9] Arun G，Diemneier S，Akerman M，et al. Differentiation of mammary tumors and reduction in metastasis upon malatl lncRNA loss [J]. Genes Dev，2016，30（1）：34-51.
[10] Zhao ZY，Chen CJ，Liu Y，et al. 17β-Estradiol treatment inhibits breast cell proliferation, migration and invasion by decreasing MALAT-1 RNA level [J]. Biochem Biophys Res Commun，2014，445（2）：388-393.
[11] Guffanti A，Iacono M，Pelucchi P，et al. A transcriptional sketch of a primary human breast cancer by 454 deep sequencing [J]. BMC Genomics，2009，10：163.
[12] Xu SP，Sui SY，Zhang JF，et al. Downregulation of long noncoding RNA MALAT1 induces epithelial-to-mesenchymal transition via the PI3K-AKT pathway in breast cancer [J]. Int J Clin Exp Pathol，2015，8（5）：4881-4891.
[13] Sun Y，Wu J，Wu SH，et al. Expression profile of microRNAs in c-Myc induced mouse mammary tumors [J]. Breast Cancer Res Treat，2009，118（1）：185-196.
[14] Huang NS，Chi YY，Xue JY，et al. Long non-coding RNA metastasis associated in lung adenocarcinoma transcript 1 （MALAT1） interacts with estrogen receptor and predicted poor survival in breast cancer [J]. Oncotarget，2016，7（25）：37957-37965.
[15] Eastlack SC，Dong S，Mo YY，et al. Expression of long noncoding RNA MALAT1 correlates with increased levels of Nischarin and inhibits oncogenic cell functions in breast cancer [J]. PLoS One，2018，13（6）：e0198945.
[16] Zhang P，Zhou HX，Lu KF，et al. Exosome-mediated delivery of MALAT1 induces cell proliferation in breast cancer [J]. Onco Targets Ther，2018，11：291-299.
[17] Huang XJ，Xia Y，He GF，et al. MALAT1 promotes angiogenesis of breast cancer [J]. Oncol Rep，2018，40（5）：2683-2689.
[18] Li XL，Chen NF，Zhou L，et al. Genome-wide target interactome profiling reveals a novel EEF1A1 epigenetic pathway for oncogenic lncRNA MALAT1 in breast cancer [J]. Am J Cancer Res，2019，9（4）：714-729.
[19] 徐曼丽，王畅，王楠，等.MALAT1通过竞争miR-124上调SMYD3并促进乳腺癌细胞增殖与迁移[J].中国药科大学学报，2019，50（3）：344-351.
[20] Feng T，Shao F，Wu Q，et al. MiR-124 downregulation leads to breast cancer progression via LncRNA-MALATl regulation and CDK4/E2F1 signal activation [J]. Oncotarget，2016，7（13）：16205-16216.
[21] Chou J，Wang B，Zheng T，et al. MALAT1 induced migration and invasion of human breast cancer cells by competitively binding miR-1 with cdc42 [J]. Biochem Biophys Res Commun，2016，472：262-269.
[22] Wang Y，Zhou Y，Yang Z，et al. MiR-204/ZEB2 axis functions as key mediator for MALAT1-induced epithelial-mesenchymal transition in breast cancer [J]. Tumour Biol，2017，39（7）：1010428317690998.
[23] Zeng LH，Cen Y，Chen JJ. Long non-coding RNA MALAT-1 contributes to maintenance of stem cell-like phenotypes in breast cancer cells [J]. Oncol Lett，2018，15（2）：2117-2122.
[24] Bamodu CA，Huang WC，Lee WH，et al. Aberrant KDM5B expression promotes aggressive breast cancer through MALATl overexpression and down regulation of hsa-miR-448 [J]. BMC Cancer，2016，16：160.
[25] Kim J，Piao HL，Kim BJ，et al. Long noncoding RNA MALAT1 suppresses breast cancer metastasis [J]. Nat Genet，2018，50：1705-1715.
[26] Wang Z，Katsaros D，Biglia N，et al. High expression of long non-coding RNA MALAT1 in breast cancer is asso-ciated with poor relapse-free survival [J]. Breast Cancer Res Treat，2018，171：261-271.
[27] Jin C，Yan B，Lu Q，et al. Reciprocal regulation of Hsa-miR-1 and long noncoding RNA MALAT1 promotes triple-negative breast cancer development [J]. Tumour Biol，2016，37（6）：7383-7394.
[28] 望晓波，胡以利，望妮娜.长链非编码RNA MALAT1表达与乳腺癌患者临床病理特征及预后关系的Meta分析[J].肿瘤学杂志，2018，24（10）：967-972.
[29] 赵倩，杨亮，朱丽萍.长链非编码RNA肺腺癌转移相关转录本1（MALAT1）与乳腺癌淋巴结转移的关系[J].新疆医科大学学报，2019，42（8）：1007-1010.
[30] Li G，Zou L，Xie W，et al. The effects of NONRATT021972 lncRNA siRNA on PC12 neuronal injury mediated by P2X7 receptor after exposure to oxygen-glucose deprivation [J]. Purinergic Signal，2016，12（3）：479-487.
[31] Meseure D，Vacher S，Lallemand F，et al. Prognostic value of a newly identified MALAT1 alternatively spliced transcript in breast cancer [J]. Br J Cancer，2016，114（12）：1395-1404.
[32] Wang YM，Xue D，Li YW，et al. The long noncoding RNA MALAT-1 is a novel biomarker in various cancers：a meta-analysis based on the GEO database and literature [J]. J Cancer，2016，7（8）：991-1001.
[33] 胡潺潺，李青山，刘兰芳，等.MALAT1靶向微小RNA-206对乳腺癌细胞三苯氧胺敏感性的影响[J].临床肿瘤学杂志，2020，25（4）：289-295.
[34] 朱逸慜，徐兵河.Her2阳性乳腺癌的精准治疗及研究进展[J].中国肿瘤外科杂志，2020，12（4）：294-300.
[35] Zhang XP，Chen B，Yang SF，et al. Roles of MALAT1 in development and migration of triple negative and Her-2 positive breast cancer [J]. Oncotarget，2017，9（2）：2255-2267.
[36] Miao YF，Fan RG，Chen LG，et al. Clinical significance of long non-coding RNA MALAT1 expression in tissue and serum of breast cancer [J]. Ann Clin Lab Sci，2016， 46（4）：418-424. |
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