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2020 Vol. 17, No. 10
Published: 2020-04-05
 
 
4 Study of rmhTNF-α combined with anti-PD-1 in the treatment of Lewis lung cancer in mice
ZHU Liaoliao ZHANG Cun XU Ying LI Xiaoju GAO Yuan HAN Jun ZHANG Yingqi
Objective To study the therapeutic effect and mechanism of recombinant mutated human tumor necrosis factor-α (rmhTNF-α) combined with PD-1 monoclonal antibody (anti-PD-1) in Lewis lung cancer in mice. Methods A total of 24 female C57BL/6 mice aged 6 to 8 weeks were divided into 4 groups according to the random number table method, with 6 mice in each group: normal saline group, rmhTNF-group, anti-PD-1 group, and combined administration group. The tumor was measured with vernier caliper and observed by in vivo imaging. After 16 days, the mice were euthanized and the tumor was removed and weighed. The survival period of mice were observed. Immunohistochemical was used to detect tumor CD8+T cells. Results Compared with the normal saline group, the tumor volume and tumor weight in the rmhTNF-α group, anti-PD-1 group and the combined administration group all decreased, with highly statistically significant differences (P ＜ 0.01). The tumor volume of rmhTNF-α group was larger than that of the combined administration group, and the difference was statistically significant (P ＜ 0.05). However, there was no significant difference in tumor volume between the combined administration group and the anti-PD-1 group (P ＞ 0.05). There was no statistically significant difference in tumor weight between the combined administration group and the rmhTNF-α group and anti-PD-1 group (all P ＞ 0.05). Compared with the normal saline group, the survival of rmhTNF-α group, anti-PD-1 group and the combined administration group increased, and the differences were statistically significant (P ＜ 0.05 or P ＜ 0.01), while the survival of the combined administration group was not statistically significant compared with the rmhTNF-α group and anti-PD-1 group (all P ＞ 0.05). Compared with the normal saline group, the number of CD8+T cells increased in the rmhTNF-α group (P ＜ 0.05). Compared with the normal saline group, the number of CD8+T cells increased significantly in the anti-PD-1 group and combined administration group (P ＜ 0.01). The number of CD8+T cells in the combined administration group was less than that in the rmhTNF-α group (P ＜  0.01), while the number of CD8+T cells was not statistically significant compared with that in the anti-PD-1 group (P ＞ 0.05). Conclusion RmhTNF-α can inhibit lung cancer in mice, but it can not enhance the effect of anti-PD-1 to treat lung cancer.
2020 Vol. 17 (10): 4-7 [Abstract] ( 255 ) HTML (1 KB)  PDF (749 KB)  ( 75 )
8 Benzoylpaeoniflorin promote cholesterol efflux by enhancing ABCA1 expression
CHEN Xiaojia1 TANG Wanze2 MA Weilie1 DING Hang1 ZHANG Zhizhen1
Objective To investigate the effect of Benzoylpaeoniflorin (BP) on cholesterol efflux from THP-1 cells. Methods The experiment was divided into ac-LDL group, apoA-1 group and apoA-1+BP group. The model of foam cells was established by adding 160 nmol/L phorbol-1-myristate-13-acetate (PMA) for 24 h in THP-1 cells, followed by 50 μg/mL acetylated low-density lipoprotein (ac-LDL). The foam cells cholesterol efflux rate was determined using liquid scintillation counting, the contents of total cholesterol of foam cells were observed by enzymatic reaction method. adenosine triphosphate binding cassette transporter A1(ABCA1) mRNA expression was detected by quantitative polymerase chain reaction (qPCR). The expression of ABCA1, sterol regulated original binding proteins（SREBPs）and Liver X receptor alpha (LXRα) were analyzed by Western blot. Results THP-1 cell model was successfully established. Cholesterol efflux of foam cells in apoA-1+BP group was higher than that in apoA-1 group, and the difference was highly statistically significant (P < 0.01). The total cholesterol content of foam cells in apoA-1+BP group were lower than those in apoA-1 group, and difference was highly statistically significant (P < 0.01). The mRNA and protein levels of ABCA1 in apoA-1+BP group were higher than those in apoA-1 group, and the difference was statistically significant (P < 0.05 or P < 0.01). The expression levels of LXRα in apoA-1+BP group were higher than those in apoA-1 group, and the difference was highly statistically significant (P < 0.01). The SREBP1 and SREBP2 expression levels in apoA-1+BP group were lower than those in apoA-1 group, and the difference was highly statistically significant (P < 0.01). Conclusion BP can promote cholesterol efflux through the LXRα-ABCA1 pathway.
2020 Vol. 17 (10): 8-12 [Abstract] ( 187 ) HTML (1 KB)  PDF (842 KB)  ( 84 )
13 Experimental study on the effect of acupoint application of Jingyi Anshen Powder on neurotransmitters in rats with insomnia
HU Jinxia1 LU Jun2 WANG Hongxia1 JIANG Yu1 LIU Tao1 HU Xiaoling1
Objective To explore the effect of acupoint application of Jingyi Anshen Powder on neurotransmitters in rats with insomnia. Methods According to the random number table method, 64 male rats were divided into four groups: control group (n = 16), model group (n = 16), blank group (n = 16) and experimental group (n = 16). Control group was intraperitoneally injected with 0.9% Sodium Chloride Solution (1 mL/100 g) once a day for 2 days, and fed continuously for 7 days without any intervention. Model group, blank group and experimental group were all injected intraperitoneally with P-phenylalanine (PCPA) once a day for two consecutive days to create a sleep deprivation model. After molding, model group was fed for 7 days without any intervention. After molding, in blank group, blank film was applied to shenque and neiguan acupoints once a day, 30 minutes a time for 7 days. After molding, in experimental group, Jingyi Anshen Powder was applied to shénquē and nèigu?觀n acupoints once a day for 30 minutes for 7 days. On the 8th day of the experiment, the rats were decapitated, the brain tissues were taken out after craniotomy, the hypothalamus was separated, washed and chopped, and the supernatant was taken from the homogenate. Contents of 5-hydroxytryptamine (5-HT), 5-hydroxyindoleacetic acid (5-HIAA), dopamine (DA) and noradrenaline (NANE) were measured by enzyme-linked immunosorbent assay. Results The exhaustion time of model group, blank group and experimental group was shorter than that of control group, and the despair time of model group, blank group and experimental group was longer than that of control group, the differences were statistically significant (P < 0.01). The exhaustion time of blank group and experimental group was longer than that of model group, and the desperation time of blank group and experimental group was shorter than that of model group, the differences were highly statistically significant (P < 0.01). The contents of 5-HT in model group and blank group were lower than that in control group, the contents of 5-HT in experimental group was higher than that in model group and blank group, the differences were statistically significant (P < 0.05 or P < 0.01). The contents of 5-HIAA in model group and blank group were lower than that in control group, while the content of 5-HIAA in experimental group was higher than that in model group, the differences were highly statistically significant (P < 0.01). DA contents of hypothalamus in model group and blank group were higher than that in control group, DA content of hypothalamus in experimental group was lower than that in model group, the differences were highly statistically significant (P < 0.01). The contents of hypothalamic NANE in model group and blank group were higher than that in control group, the contents of hypothalamic NANE in experimental group were lower than that in model group and blank group, the differences were statistically significant (P < 0.05 or P < 0.01). Conclusion Jingyi Anshen Powder is applied to the acupoints of insomnia rats to improve sleep by affecting the changes of the level of neurotransmitters in the hypothalamus.
2020 Vol. 17 (10): 13-17 [Abstract] ( 156 ) HTML (1 KB)  PDF (579 KB)  ( 140 )
18 Repair effect of placental mesenchymal stem cells on endometrial injury in rats
WANG Xiangxiang1,2 WANG Yan1,2 YANG Shaoshao1,2 ZHANG Junjun2
Objective To study the repair effect of placental mesenchymal stem cells on endometrial injury in rats. Methods From May to November 2019, a total of 60 female SD rats (Qinglongshan Animal Breeding Farm, Jiangning District, Nanjing) were constructed endometrial injury models by chemical damage method, and they were divided into control group, gel group and model group by simple random sampling, with 20 rats in each group. After three estrous cycles, 10 rats from each group were randomly sampled for HE staining, and the number of endometrial glands and endometrial thickness were measured, while the percentage of endometrial fibrosis were measured by Masson staining. The other 30 rats were caged with male rats. On the 10th day of conception, the number of uterine embryos in the rats was observed by laparotomy. Results Compared with the control group, the number of endometrial glands decreased, the thickness of the endometrium became thinner, the percentage of endometrial fibrosis increased, while the number of uterine embryos in pregnant rats decreased in the model group, and the differences were statistically significant (P ＜ 0.05). Compared with the model group, the number of endometrial glands increased, the thickness of the endometrium increased, the percentage of endometrial fibrosis area decreased, while the number of uterine embryos in pregnant rats increased in the gel group, and the differences were statistically significant (P ＜ 0.05). Compared with the control group, the number of endometrial glands and endometrial thickness had no significant changes in the gel group, and the differences were not statistically significant (P ＞ 0.05); while the percentage of endometrial fibrosis increased, the number of uterine embryos in pregnant rats decreased, and the differences were statistically significant (P ＜ 0.05). Conclusion Placental mesenchymal stem cells can repair damaged endometrium, increase the number of endometrial glands and endometrial thickness, reduce the percentage of endometrial fibrosis area, and improve embryo implantation rate.
2020 Vol. 17 (10): 18-21,41 [Abstract] ( 160 ) HTML (1 KB)  PDF (997 KB)  ( 43 )
22 Determination of Bortezomib in rat plasma by UHPLC-MS/MS method
LIU Jin1 LIU Ke2 JIANG Wei3 HUANG Cuiyun3 DENG Yi3 SHU Chang3 ZHANG Feng3
Objective To establish an ultra high performance liquid chromatography-tandem mass spectrometry method for the determination of Bortezomib in rat plasma. Methods Plasma sample preparation was treated by protein precipitation. ColumWaters XBridge?誖 BEH C18 (2.5 μm, 50 mm × 2.1 mm) was used as the column. Acetonitrile and 10 mmol/L ammonium formate solution was used as the mobile phase, with gradient elute, the volume flow rate was 0.3 mL/min, the column temperature was maintained at at 35℃. Multi-reaction detection positive ion mode was used to analysis. Results The Bortezomib in the range of 0.5-100 ng/mL showed a good liner, the standard linear regression equation was Y = 14.41X-0.4490 (r = 0.9974). The lower limit of quantification was 0.5 ng/mL, and the results of in-day, day-time precision and accuracy, extraction recovery, matrix effect and stability of quality control samples with low, medium and high 3 mass concentrations were all good. Conclusion The method is accurate, sensitive and reproducible, and can be used in the pharmacokinetic study of Bortezomib in rats.
2020 Vol. 17 (10): 22-25 [Abstract] ( 198 ) HTML (1 KB)  PDF (557 KB)  ( 45 )
26 Study on quality characteristics of specification grade of Radix Peucedani medicinal materials in different producing areas
LI Yunyun1 PAN Ya′nan1 GUO Tingting1 ZHANG Hong1 LIU Shoujin1 GAO Guangyin2
Objective To explore the differences in quality characteristics between the Radix Peucedani of the ancestral cultivars of different producing areas, and to provide a reference for the establishment of the standards of the classification of Peucedani Radix. Methods In January 2018, 20 batches of graded samples were collected from five production areas including Ningguo Zhongxi, Ningguo Nanshan, Ningguo Yunti, Anhui Chizhou, and Zhejiang Tuoling. A total of 10 individuals were selected to measure the diameter at 1/3 of the head and the total length of Tiaohu. The thin layer chromatography method was used to qualitatively identify the medicinal materials with the reference materials of Praeruptorin A, Praeruptorin B, qianhucoumarin E. The alcohol-soluble extracts were tested according to the requirements of the 2015 edition of the Chinese Pharmacopoeia; and the content of three coumarins was determined by high performance liquid chromatography. Results The data of different grades of medicinal materials from the same place of origin had crossover phenomenon, but the mean values of different grades of medicinal materials from different places of origin had little difference and fluctuated in a small range. The 20 batches of samples all showed the same color spots in the same position as the control. The contents of the extracts of different grades of crude drugs all meet the requirements of the 2015 edition of the Chinese Pharmacopoeia, with certain regularity. There were some differences in the content of coumarin among different grades. Conclusion The quality of medicinal materials from the five producing areas regions is consistent. There is no obvious regularity between the appearance and internal components of different grades of Radix Peucedani in the region, but there are some differences in quality, which can be further studied.
2020 Vol. 17 (10): 26-30 [Abstract] ( 148 ) HTML (1 KB)  PDF (661 KB)  ( 136 )
31 Progress of experimental research in the treatment of bronchial asthma with Chinese medicine based on NF-κB signaling pathway
WU Mingyun1,2 YU Jian′er1 BAI Li3 XUE Zheng1,3 JIANG Shenhua1,2 XU Wanchao1,2
This paper reviews the experiment research progress of Chinese medicine in the treatment of bronchial asthma via nuclear factor-κB (NF-κB) signaling pathway. NF-кB signaling pathway can regulate immune/inflammatory cells and airway structure cells, inducing the occurrence and development of bronchial asthma. In recent years, experimental studies have shown that a variety of traditional Chinese medicine compounds, traditional Chinese medicine single-drugs and their extracts and traditional Chinese medicine monomers can be passed inhibits NF-κB pathway, improves asthma symptoms, reduces airway inflammation and airway hyperresponsiveness, reverses airway remodeling, and achieves significant effects in preventing and treating bronchial asthma.
2020 Vol. 17 (10): 31-34 [Abstract] ( 170 ) HTML (1 KB)  PDF (665 KB)  ( 147 )
35 Status analysis of function evaluate methods in chronic heart failure
XU Qiuwen1 GUO Ziqiang2
The chronic heart failure (“HF”for short) is the severe stage and the end of various heart diseases, which has high incidence. HF is one of the most serious cardiovascular diseases. At present, the common methods of HF cardiac function evaluation are New York heart association classification, 6 minute walk test, the detection like natriuretic peptide, echocardiography and hemodynamic monitoring. This paper makes a detailed analysis of 5 methods for the cardiac function evaluation and prognosis of HF. It is a thought-provoking question about how to assess the functional capacity of chronic heart failure patients conveniently and precisely.
2020 Vol. 17 (10): 35-37,49 [Abstract] ( 157 ) HTML (1 KB)  PDF (591 KB)  ( 90 )
38 Research progress of ginseng and ginsenoside in the treatment of rheumatic diseases
HAN Guangtao LI Haohuan
Inflammation protects the body from pathogens and danger signals caused by cellular changes. Although inflammation is a host defense mechanism, chronic inflammation is considered a major risk factor for the development of various inflammatory autoimmune diseases. Rheumatic diseases are systemic inflammatory and degenerative diseases, which mainly affect connective tissue and can lead to severe chronic connective tissue inflammation, ultimately leading to the degeneration of connective tissue. Ginseng and its ginsenoside have been proved to have anti-inflammatory activities and pharmacological effects on a variety of rheumatic diseases by inhibiting the expression and production of inflammatory mediators. This review gives a brief overview of ginseng and ginsenoside, and discusses recent studies on their pharmacological effects on the pathogenesis of rheumatic diseases. These insights may facilitate the development of ginseng and ginsenoside drugs to prevent and treat rheumatic diseases.
2020 Vol. 17 (10): 38-41 [Abstract] ( 214 ) HTML (1 KB)  PDF (543 KB)  ( 99 )
42 Research progress of Panax quinquefolium L. therapy for ischemic heart disease
LIU Yansong1 WANG Di1 HAO Zhenzhu1 GUO Huiwen1 PIAO Xinghu1 FANG Meishan2 WANG Bingmei1
Ischemic heart disease is the disease with the highest morbidity and death rate in the world, which seriously threatens people′s life and health. Panax quinquefolium L. has been widely used in the treatment of cardiovascular diseases. It has many effects such as anti-apoptosis of myocardial cells, arrhythmia, improvement of ventricular remodeling after infarction, and enhancement of antioxidant enzyme activity. There are many studies on the protective effect of main active components of Panax quinquefolium L. on ischemic heart disease, but the mechanism is still unclear. This article reviews the mechanism of the main active ingredients of Panax quinquefolium L. in the treatment of ischemic heart disease in recent years, and expounds from a variety of perspectives, such as inhibiting myocardial cell apoptosis, improving blood circulation, and inhibiting oxidative stress. Based on this, it also provides reference value for further multi-target, multi-level development and application of Panax quinquefolium L. and the organization.
2020 Vol. 17 (10): 42-45 [Abstract] ( 177 ) HTML (1 KB)  PDF (544 KB)  ( 135 )
46 The second- and third-line treatments and supporting evidence of polycystic ovary syndrome-related infertility
WANG Yaoyao1 HAO Songli2▲
In Clomiphene resistant anovulatory patients with polycystic ovary syndrome (PCOS) and no other infertility factors, either Metformin combined with Clomiphene citrate or Gonadotrophins could be used as a second-line pharmacological therapy, although Gonadotrophins are more effective. Gonadotrophins could also be used as a second-line pharmacological therapy in anovulatory patients with PCOS and Clomiphene failure. Laparoscopic ovarian surgery can also be used as a second-line therapy for ovulation induction in anovulatory patients with Clomiphene resistant PCOS and no other infertility factors. The usefulness of Letrozole as a second-line pharmacological treatment for ovulation induction in Clomiphene resistant women with PCOS requires further research. In terms of improving fertility, both pharmacological anti-obesity agents and bariatric surgery should be considered an experimental therapy in anovulatory women with PCOS and no other infertility factors. First-or second-line ovulation induction therapies have failed, in vitro fertilization (IVF)/intracytoplasmic single sperm injection (ICSI) could be offered as a third-line therapy in patients with PCOS in the absence of an absolute indication for IVF/ICSI. However, absolute indications for IVF/ICSI are lacking. For patients with PCOS undergoing IVF/ICSI treatment, the gonadotropin-releasing hormone antagonist protocol is preferred and an elective frozen embryo transfer strategy could be considered. In assisted conception units with sufficient expertise, in-vitro maturation of oocytes could be offered to women with PCOS.
2020 Vol. 17 (10): 46-49 [Abstract] ( 133 ) HTML (1 KB)  PDF (542 KB)  ( 102 )
50 Difficulties and countermeasures of academic research on traditional Chinese medicine culture
FU Wendi
It is the cornerstone and guarantee for the inheritance and development of traditional Chinese medicine and the implementation of the strategy of traditional Chinese medicine to carry out the cultural and scientific research of traditional Chinese medicine. At present, the research work of traditional Chinese medicine culture and science has not produced strategic research results that affect the overall situation in terms of top-level planning, core and key issues, team and institution building, and modernization and application of scientific research methods. Under the new situation, we should start from the height of cultural power building, from the respect and use of scientific research rules, clarify the focus and breakthrough of Chinese medicine culture research, strengthen team building and the application of new scientific and technological means. Carry out method reform, and give full play to the leading, supporting and serving role of Chinese medicine culture research.
2020 Vol. 17 (10): 50-53,69 [Abstract] ( 212 ) HTML (1 KB)  PDF (739 KB)  ( 113 )
54 Countermeasures of implementing pharmaceutical education reform in the environment of we-media
ZHANG Meng
With the development of information technology, we-media for information dissemination penetrates into people′s daily life and also affects pharmaceutical education. Integrating the we-media platform to participate in pharmaceutical education activities is of great significance to the cultivation and development of pharmaceutical talents. In view of this, this paper first combs the opportunities brought to pharmaceutical education by the characteristics of we-media, such as rapidity, flexibility, diversity and interactivity, and recognizes the challenges brought by information fragmentation and mixed information at the same time. Then it expounds the feasibility and necessity of implementing pharmaceutical education and teaching reform under the environment of self media. Finally, the ways of integrating we-media into pharmaceutical education are clarified from the aspects of pharmaceutical teaching, scientific research activities and pharmaceutical services, and the measures of pharmaceutical education reform are explored from changing the role of teachers, establishing the dominant position of students and establishing a mobile internet teaching platform, so as to make use of the advantages of we-media platform, penetrate and deeply integrate with pharmaceutical education, and promote development of pharmaceutical education.
2020 Vol. 17 (10): 54-57 [Abstract] ( 159 ) HTML (1 KB)  PDF (719 KB)  ( 56 )
58 Exploration and practice of good supply practice curriculum reform
SHI Kaiyun ZOU Xiaochuan HUI Junming LUO Jing REN Yanrong
Good supply practice (GSP) is an emerging pharmacy interdisciplinary and professional core course. In the teaching practice of GSP, it mainly aims at the problems of single teaching method, shortage of double-qualified teachers, poor practical skills of students and simple assessment method and so on, and firmly establishes the new concept of “drug quality by caring”. Based on students, students are taught in accordance with their aptitude. Situational simulation, university-enterprise cooperation and work-learning alternate modes are adopted, and the sequential progressive approach, modules of employable skills, project-based learning and small-class teaching method are comprehensively applied to carry out systematic reform and exploration on the traditional teaching mode, teaching methods, teaching means and assessment methods. It can fully mobilize the enthusiasm, initiative and creativity of students in learning, significantly improve the teaching quality, comprehensively enhance students′ GSP management ability, drug marketing skills and comprehensive business quality, and lay a good theoretical and practical foundation for students′ employment, career choice and entrepreneurship.
2020 Vol. 17 (10): 58-61 [Abstract] ( 162 ) HTML (1 KB)  PDF (782 KB)  ( 132 )
62 Research on improving the effect of tertiary hospitals on the primary hospitals by teaching
WEI Hongling XING Yan
Objective To elucidate the role of teaching in the process of tertiary hospitals helping primary hospitals. Methods The relevant clinical and teaching indicators were collected before and after the tertiary hospitals helped the Huanxian People′s Hospital, Qingyang City, Gansu Province from January 2013 to December 2018. At the same time, the staff of Huanxian People′s Hospital, Qingyang City, Gansu Province were asked to evaluate the current teaching effect by questionnaire, and the collected objective and subjective data were statistically analyzed. Results Compared with the previous 3 years of help (from January 2013 to December 2015), the average annual outpatient volume and annual average hospitalization volume of Huanxian People′s Hospital, Qingyang City, Gansu Province increased after 3 years of help (from January 2016 to December 2018), with statistically significant differences (P ＜ 0.05). The results of the questionnaire showed that the autonomous teaching ability and consciousness of Huanxian People′s Hospital, Qingyang City, Gansu Province had been improved. The most expected form of teaching for grassroots medical staff to the superior help hospital was the case-based theoretical teaching, the most desired teaching purpose was to master new medical technology and establish clinical thinking, the most expected teaching time was the morning shift time, lasting 30 minutes to 1 hour. Conclusion With teaching as the starting point, tertiary hospitals can help grassroots hospitals, which can not only improve the clinical thinking ability of grassroots medical staff, but also, more importantly, improve their teaching ability. By digging out the teaching needs of grassroots medical staff to superior hospitals, it is convenient to carry out more targeted teaching work in the future, and effectively improve the assistance effect of superior hospitals.
2020 Vol. 17 (10): 62-65 [Abstract] ( 180 ) HTML (1 KB)  PDF (742 KB)  ( 41 )
66 Application of teaching supply-side-reform in the experimental teaching of pharmaceutics
CHEN Xin LIU Hongmei HUANG Yan TANG Yuan LI Xiaohui JIA Yi
With the development of economy, pharmaceutical industry in China is in the stage of strategic transformation from generic drugs to original drugs. As a result, the pharmaceutical industry put forward higher requirements for pharmacy talents. Traditional course of pharmaceutics experiment have been unable to meet the demand of high-level educational products for cultivating high-quality talents. Therefore, this study propose teaching reform from the perspective of teaching supply-side, and conduct appropriate structural adjustment from multiple dimensions such as teachers, teaching content and scientific research to improve the supply of effective resources in the training of pharmacy talents, to meet the needs of students for high-quality teaching resources and the needs of society for high-quality pharmacy talents. After the practice of teaching supply-side-reform, students′ innovation and solving problems ability have been significantly improved. At the same time, from the perspective of supply-side-reform, it explores the training strategy of innovative pharmacy talents, and provides a beneficial reference for the majority of pharmacy educators to explore more effective experimental curriculum reform.
2020 Vol. 17 (10): 66-69 [Abstract] ( 148 ) HTML (1 KB)  PDF (717 KB)  ( 82 )
70 Application of PBL teaching method in ablation training of refresher physicians for liver cancer refresher doctor
SUN Yu ZHANG Honghai LIU Bojun YUAN Chunwang CUI Shichang ZHANG Yonghong ZHENG Jiasheng
Objective To study the effect of the problem-based learning (PBL) in ablation training for liver cancer interventional students. Methods A total of 65 refresher physicians were selected as the study subjects who were taking advanced courses in the Minimally Invasive Interventional Center of Oncology and Liver Disease in Beijing You′an Hospital of Capital Medical University from March 2017 to February 2019, and they were divided into the experimental group and the control group by random number table method. Among them, thirty-three of the experimental group received the PBL teaching model, while thirty-two of the control group received the traditional teaching model. The training time was 6 months, and the teaching effect was evaluated by examination and questionnaire survey. Results The test scores of theory, skill and case analysis in the experimental group were significantly higher than those in the control group, and the differences were statistically significant (P ＜ 0.05). The questionnaire survey scores of learning initiative, literature retrieval ability, teamwork ability and teaching effect in the experimental group were significantly higher than those in the control group, and the differences were statistically significant (P ＜ 0.05). Conclusion The application of PBL teaching in the ablation training of refresher doctor has a significant effect. It mobilizes the learning enthusiasm of refresher doctors and is worth promoting and applying.
2020 Vol. 17 (10): 70-73 [Abstract] ( 229 ) HTML (1 KB)  PDF (721 KB)  ( 215 )
74 A cross sectional survey of teaching effect of clinical trial among different level students in military university
SAI Xiaoyong1 SHI Jinhao1 SONG Yujian1 MA Lizhi2 SUN Yuanyuan1
Objective To explore the effects of students at different levels on the teaching of clinical trial theory, and to provide evidence-based basis for effectively improving the teaching effects of clinical trial courses for students in military medical university. Methods From September 2016 to September 2017, a total of 922 students with doctor′s degree, master′s degree and upgraded degree from Medical School of Chinese PLA were selected by cluster sampling. According to the difference of educational background, they were divided into the doctor student group, the master student group and the upgraded student group. Before and after the teaching, a unified questionnaire was used for face-to-face investigation, including 10 questions of right and wrong judgment. The accuracy of each question was compared before and after, and at the same time, the basic knowledge and learning purpose of the upgraded students were investigated. Results A total of 1844 questionnaires were issued, of which 1644 were valid, including 828 for doctoral student group, 716 for master student group, and 100 for upgraded student group. The total scores of the master students group and the doctor students group were significantly higher after teaching than before, with statistically significant differences (all P ＜ 0.05). Meanwhile, the accuracy of each question increased, but the degree of improvement was different according to the questions. There was no statistically significant difference in the total score of the upgraded students before and after teaching (P ＞ 0.05). The total score of the doctor students group before teaching was higher than that of the master students group and the upgraded students group. After teaching, the total score of the master student group was higher than that of the doctor student group and the upgraded student group, and the differences were statistically significant (all P ＜ 0.05). According to the survey before class, most of the upgraded students had not contacted or understood of this course before teaching, and 71.0% of the upgraded students took this course for the purpose of helping to write and publish papers. Conclusion Students with different educational backgrounds have different degrees in mastering basic theory of clinical trials. Therefore, training should be conducted for students at different levels and teaching should be conducted according to the individual.
2020 Vol. 17 (10): 74-77 [Abstract] ( 153 ) HTML (1 KB)  PDF (698 KB)  ( 77 )
78 Changes and significance of serum 25-hydroxivitamin D, IL-10 and left atrial diameter in patients with atrial fibrillation
CAO Wenzhai1 ZHANG Ting2 ZENG Rui3
Objective To observe the changes of serum 25-hydroxivitamin D [25(OH)D], interleukin-10 (IL-10) and left atrial diameter (LAD) in patients with atrial fibrillation, and to explore their relationship with atrial fibrillation. Methods A total of 111 patients with atrial fibrillation admitted to the Department of Cardiovascular Medicine, Zigong First People′s Hospital (hereinafter referred to as “our hospital”) from December 2011 to December 2012 were selected as the research group, including 20 patients with paroxysmal atrial fibrillation, 40 patients with persistent atrial fibrillation and 51 patients with permanent atrial fibrillation. Another 109 cases of non-atrial fibrillation patients hospitalized in the Department of Cardiovascular Medicine of our hospital at the same time were selected as the control group. Serum 25(OH)D and IL-10 were detected by ELISA, LAD was measured by echocardiography and they were compared. Results The levels of 25(OH)D and IL-10 in the study group were significantly lower than those in the control group, and the LAD was higher than that in the control group, with statistically significant differences (all P ＜ 0.05). Serum 25(OH)D and IL-10 levels and LAD of patients with different atrial fibrillation types in the study group showed statistically significant differences (all P ＜ 0.05). Compared with the persistent atrial fibrillation group, 25(OH)D and IL-10 levels decreased and LAD increased in the permanent atrial fibrillation group, with statistically significant differences (all P ＜ 0.05). Compared with the paroxysms atrial fibrillation group, 25(OH)D and IL-10 levels decreased and LAD increased in the persistent atrial fibrillation group and permanent atrial fibrillation group, with statistically significant differences (all P ＜ 0.05). Conclusion In patients with atrial fibrillation, 25(OH)D, IL-10, and LAD are closely related to the occurrence and development of atrial fibrillation.
2020 Vol. 17 (10): 78-81 [Abstract] ( 186 ) HTML (1 KB)  PDF (661 KB)  ( 134 )
82 Clinical study of puerarin combined with α-lipoic acid in the treatment of diabetes mellitus with carotid atherosclerosis
HE Guixiang1 MA Yunhui2 LIU Haiyan1 ZHONG Yi3
Objective To investigate the clinical effect of puerarin combined with α-lipoic acid in the treatment of diabetes mellitus with carotid atherosclerosis. Methods A total of 122 patients with diabetes mellitus complicated with carotid atherosclerosis admitted to Ansteel Group Hospital from January 2015 to January 2019 were selected and they were divided into the control group and the study group according to the random number table method, with 61 cases in each group. The control group was treated with α-lipoic acid on the basis of routine treatment, and the study group was treated with α-lipoic acid on the basis of the control group. The clinical efficacy, glucose and lipid metabolism indexes and oxidative stress indexes of the two groups were compared, and the occurrence of adverse reactions of the two groups during treatment was recorded. Results After one month of treatment, the total clinical effective rate of the study group was higher than that of the control group, and the difference was statistically significant (P ＜ 0.05). Before treatment, there was no statistically significant difference between the two groups in glycosylated hemoglobin (HbA1c), total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL) and high-density lipoprotein (HDL) (P ＞ 0.05). After one month of treatment, there was no significant difference in HbA1c between the two groups (P ＞ 0.05). In both groups, TC, TG and LDL decreased and HDL increased compared with that before treatment, and TC, TG and LDL in the study group were lower than those in the control group and HDL was higher than those in the control group, with statistically significant differences (all P ＜ 0.05). There was no statistically significant difference in serum superoxide dismutases (SOD) and malondialdehyde (MDA) levels between the two groups before treatment (P ＞ 0.05). After one month of treatment, SOD increased and MDA decreased in the two groups, and SOD in the study group was higher than that in the control group, while MDA was lower than that in the control group, with statistically significant differences (all P ＜ 0.05). There was no statistically significant difference in the incidence of adverse reactions between the two groups (P ＞ 0.05). Conclusion Puerarin combined with α-lipoic acid in the treatment of diabetes mellitus with carotid atherosclerosis has a significant effect, and can effectively improve the level of blood lipid and oxidative stress index in patients, with a good safety and high clinical application value.
2020 Vol. 17 (10): 82-85 [Abstract] ( 235 ) HTML (1 KB)  PDF (662 KB)  ( 85 )
86 Effect of transcranial direct current stimulation combined with staging acupuncture on upper limb motor function in stroke patients with hemiplegia
ZHENG Su1 PENG Li2 MU Jingping1
Objective To investigate the effect of transcranial direct current stimulation combined with staging acupuncture on upper limb motor function in patients with stroke. Methods A total of 120 patients with hemiplegia caused by stroke in Department of Medical, Shiyan Taihe Hospital of Hubei Province from January 2016 to December 2018 were selected. They were divided into transcranial direct current stimulation group (tDCS), staging acupuncture group, combined group, with 40 patients in each group. tDCS group was treated with transcranial direct current stimulation. Staging acupuncture group was treated with staging acupuncture. Combined group was treated with transcranial direct current stimulation combined with staging acupuncture. After 6 courses of treatment, the clinical effect was evaluated. Fugl-meyer rating scale (FMA), modified Barthel index (MBI), and modified Ashworth scale (MAS) were used for evaluation. The distribution of clinical stages before and after treatment were observed and compared. Results The total effective rate of combined group was significantly higher than that of tDCS group and staging acupuncture group, and the difference was statistically significant (P < 0.05). There was no significant difference in FMA score, MBI and MAS score between three groups before treatment (all P > 0.05). After treatment, FMA score, MBI and MAS score of combined group were higher than those of staging acupuncture group and tDCS group, with statistically significant differences (all P < 0.05). Moreover, FMA score, MBI and MAS score of staging acupuncture group were higher than those of tDCS group, with statistically significant differences (all P < 0.05). The clinical staging of combined group was better than that of staging acupuncture group and tDCS group, and the difference was statistically significant (P < 0.05). Conclusion tDCS combined with staging acupuncture can improve FMA score, MBI and MAS scores of upper limb in hemiplegia after stroke, improve the recovery of upper limb motor function and muscle tension, improve patients′ ability to live and improve clinical efficacy.
2020 Vol. 17 (10): 86-89 [Abstract] ( 244 ) HTML (1 KB)  PDF (661 KB)  ( 132 )
90 Effect of electroacupuncture combined with bladder control training on urinary function in patients after thoracolumber fracture with hypotonic bladder
LIU Xifang1,2 JI Xiaoyan2 ZHANG Qian3 LI Hanxiao2 YANG Minyi1
Objective To investigate the effects of electroacuncture combined with bladder control training on urinary function in patients after thoracolumber fracture with hypotonic bladder. Methods From March 2016 to March 2018, 43 cases with thoracolumber fracture with hypotonic bladder who treated in Honghui Hospital, Xi′an Jiaotong University were selected. They were divided into treatment group (n = 22) and control group (n = 21), according to the treatment methods. Treatment group was treated with electroacupuncture combined with bladder control training, and control group was treated with electroacupuncture. The treatment lasted for 8 weeks and clinical effect was evaluated. Bladder capacity, residual urine volume, urination frequency and quality of life questionnai-core 30 (QOL-C30) scores were compared. Results After 8 weeks of treatment, the total effective rate of treatment group was higher than that of control group, and the difference was statistically significant (P < 0.05). The reduction rate of residual urine volume in treatment group was higher than that in control group, and the increase rate of the number of independent and assisted urination was higher than that in control group, with statistically significant differences (all P < 0.05). Before treatment, there was no statistically significant difference between two groups in each urination volume, maximum urination volume, maximum bladder volume and bladder urination pressure (P > 0.05). After treatment, each urinary volume, maximum urination volume, maximum bladder volume and bladder urination pressure of two groups were higher than those before treatment, and treatment group was higher than control group, with statistically significant differences (all P < 0.05). There was no significant difference in scores of somatic symptoms, social symptoms, psychological symptoms and physical symptoms before treatment. After 8 weeks of treatment, scores of somatic symptoms, social symptoms, psychological symptoms and physical symptoms in two groups were higher than those before treatment, and treatment group was higher than control group, with statistically significant differences (all P < 0.05). Comclusion Electroacupuncture combined with bladder contol training can effectively improve urinary function in patients after thoracolumberfracture with hypotonic bladder, prevent long-term complications and improve quality of life.
2020 Vol. 17 (10): 90-93 [Abstract] ( 153 ) HTML (1 KB)  PDF (659 KB)  ( 80 )
94 Application of PDCA cyclic model in nursing management of cancer pain drugs for cancer patients
SONG Shuang1 LIU Bao1 ZHANG Huan2▲
Objective To explore the effect of PDCA cyclic model in nursing management of cancer pain drugs for cancer patients. Methods A total of 146 cases with cancer pain in the Department of Internal Medicine, Harbin Medical University Cancer Hospital were selected as the research subjects. In chronological order, patients who enrolled from January to June 2018 were set as the control group (75 cases), and  patients who enrolled from September 2018 to February 2019 were set as the test group (71 cases). The control group received routine care, and the test group  received PDCA cycle model care. The pain control outcomes of the two groups were compared. Results There was no statistically significant difference between the two groups in the the scores of pain degree and the impact of pain on activity (P > 0.05). The pain control satisfaction scores of the test group were higher than thoes of the control group, and the pain belief scores were lower than those of the control group, with statistically significant differences (all P < 0.05). Conclusion PDCA can improve pain control satisfaction and pain belief of cancer patients, and improve the quality of pain nursing and treatment effect.
2020 Vol. 17 (10): 94-97 [Abstract] ( 246 ) HTML (1 KB)  PDF (697 KB)  ( 74 )
98 A study on the status and influencing factors of stigma for digestive system tumor patients after operation
FU Min1，2 HU Shaohua3 WANG Weili4 LUAN Beibei5 WANG Ting1，2
Objective To understand the current status and influencing factors of stigma in patients with digestive system tumors. Methods A total of 300 patients with digestive system tumors who were diagnosed in the gastrointestinal ward area of general surgery in a top three hospital in Anhui Province from July 2017 to December 2018 were selected by the convenience sampling method. The general information questionnaire, social impact scale, and social support scale were used to investigate patients′ general information, stigma, and social support status, while the relationship between stigma and social support and general information were analyzed. Results There were 294 valid questionnaires, and the effective recovery rate was 98%. The total score of 294 patients were (59.50±9.85) points, which was at a medium level. There were statistically significant differences in the scores of stigma among patients of different genders, places of residence, education, religion, marital status, and whether living with their children in the past month (P ＜ 0.05). There was a negative correlation between social support and stigma scores (P ＜ 0.01). Gender, marital status, religious beliefs, and awareness of social support levels were the influencing factors of the stigma score of patients with digestive system tumors (P ＜ 0.01). Conclusion Patients with gastrointestinal cancer have a high score of stigma. Medical staff need to strengthen their social support level to reduce the level of stigma.
2020 Vol. 17 (10): 98-101 [Abstract] ( 154 ) HTML (1 KB)  PDF (697 KB)  ( 43 )
102 Analysis of high risk factors of pulmonary infection in patients with pulmonary tuberculosis during hospitalization
LI Shunli1 LIU Yang2
Objective To analysis the high risk factors of pulmonary infection in patients with pulmonary tuberculosis during hospitalization. Methods The clinical data of 400 patients with pulmonary tuberculosis confirmed in Beijing Chao-yang Hospital, Capital Medical University from January 2015 to December 2018 were analyzed retrospectively. According to whether pulmonary infection occurred, they were divided into control group (uninfected, 328 cases) and study group (infected, 72 cases). The high risk factors of pulmonary infection caused by pulmonary tuberculosis complications were screened. Results The age ≥60 years, course ≥5 years, smoking history, diabetes history, cavitary tuberculosis, number of lung fields involved ≥3, retreatment of tuberculosis, hemoptysis, anemia, long-term use history of glucocorticoids, long-term use history of broad-spectrum antibiotics and invasive operation in the study group were significantly higher than those in the control group, and the differences were statistically significant (P ＜ 0.05). The retreatment of pulmonary tuberculosis, cavitary tuberculosis, diabetes history, long-term use history of glucocorticoids and long-term use history of broad-spectrum antibiotics were all high risk factors of pulmonary tuberculosis complicated with pulmonary infection (OR ＞ 1, P ＜ 0.05). Conclusion Pulmonary tuberculosis patients are more likely to be complicated with pulmonary infection. Retreatment of pulmonary tuberculosis, cavitary pulmonary tuberculosis, diabetes mellitus, long-term use of glucocorticoids and broad-spectrum antibiotics are the high risk factors of pulmonary tuberculosis complicated with pulmonary infection. Clinical intervention measures should be taken to reduce the incidence of pulmonary infection.
2020 Vol. 17 (10): 102-104,133 [Abstract] ( 118 ) HTML (1 KB)  PDF (1143 KB)  ( 176 )
105 Impact of whole-process closed-loop intelligent pathway real-time control on clinical transfusion safety
CHEN Hongxia1 NI Wei2,3 WU Changlin4
Objective To explore the impact of whole-process closed-loop intelligent pathway real-time control on clinical transfusion safety. Methods A total of 3548 patients with blood transfusion in Xianning Central Hospital, the First Affiliated Hospital of Hubei University of Science and Technology from June 2016 to June 2018 were selected, and the patients were divided into 2016 group (1545 cases) and 2018 group (2003 cases) according to chronological order. The 2016 group adopted the conventional blood transfusion safety management method, and the 2018 group adopted the full closed-loop intelligent routing real-time control. The effects of real-time control of intelligent routing of blood specimens, the status of blood transfusion, the average operating time and quality of blood preparation and transfusion, and the effect of blood transfusion safety control of two groups were compared. Results The pre-transfusion detection rate, post-transfusion efficacy evaluation detection rate, and cross-matching test blood specimen time compliance rate in the 2018 group were significantly higher than those in the 2016 group (P < 0.05). The infusion rate within 30 minutes and infusion completion rate within 4 hours after blood retrieval in the 2018 group were significantly higher than those in the 2016 group (P < 0.05). The operation time of blood preparation and blood transfusion in the 2018 group were longer than those in the 2016 group, while the quality were higher than those in the 2016 group (P < 0.05). The number of blood sample errors or unqualified cases, the initial blood group test or the number of single blood group application errors in the 2018 group were significantly lower than those of the 2016 group, and the differences were all statistically significant (all P ＜ 0.05). Conclusion The whole-process closed-loop intelligent pathway real-time control on clinical blood transfusion can effectively control the safety and quality of blood transfusion, while avoid the occurrence of adverse events of clinical blood transfusion, and significantly improve the level of scientific safe blood transfusion.
2020 Vol. 17 (10): 105-108 [Abstract] ( 142 ) HTML (1 KB)  PDF (847 KB)  ( 39 )
109 Effect of different analgesic methods on postoperative rehabilitation of patients undergoing transabdominal myomectomy in enhanced recovery after surgery mode
HAN Xudong DU Lifang PING Chunzhi ZHANG Xiaolan
Objective To evaluate the effect of different analgesic methods on postoperative rehabilitation of patients undergoing transabdominal myomectomy in enhanced recovery after surgery（ERAS） mode. Methods A total of 50 patients with uterine fibroids, scheduled transabdominal myomectomy in Gansu Provincial Maternity and Child Care Hospital from March to October 2019 were divided into group M and group C by random number table method, with 25 cases in each group. Group M were treated with acetaminophen 500 mg and Ibuprofen 600 mg oral administration in preoperative, 0.25% Ropivacaine 20 mL infiltration at incision before the end of the operation and taken Tramadol 100 mg postoperative three times a day for three days. Group C were treated with intravenous patient controlled analgesia for 48 h. The visual analogue score (VAS) of the two groups were recorded at 3 h (T1), 6 h (T2),12 h (T3) and 24 h (T4) after operationin. The time of anal exhaust in postoperative, hospital stay, hospitalization cost and the rate of pruritus, nausea and vomiting, urinary retention, SpO2＜94% and rescue analgesia were recorded in the two groups. A total of 3 mL of venous blood were taken at 2 h (T0) and T4 before surgery and interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) were detected by enzyme-linked immune assay. Results There was difference in VAS score between different time points (P ＜ 0.05), the difference of VAS scores between groups was statistically significant (P ＜ 0.05). there was interaction between different time points and the two groups (P ＜ 0.05), The VAS score of group M at T1 was lower than that of group C (P ＜ 0.05). Compared with T1, the VAS score of group M increased at T2-T4 (P ＜ 0.05), while VAS score of group C decreased at T2-T4 (P ＜ 0.05). Compared with T2, the VAS score of group M increased at T4 (P ＜ 0.05). The anal exhaust time of group M was earlier than that of group C (P ＜ 0.05). There was no significant difference between two groups in hospital stay and hospitalization cost（P ＞ 0.05）. The number of patients with skin pruritus, nausea and vomiting and rescueanalgesia in group M were less than those in group C (P ＜ 0.05). There was no significant difference in the number of urinary retention and SpO2＜94% between the two groups (P ＞ 0.05). Compared with T0, the concentrations of IL-6 and TNF-α in the two groups were increased at T4 (P ＜ 0.05). Compared with group C, the concentrations of IL-6 and TNF-α in group M were decreased at T4 (P ＜ 0.01). Conclusion Under the ERAS mode, the multi-mode analgesic mode of nsaids combined with central analgesics and local anesthetics in the perioperative period of gynecological open surgery can effectively reduce the pain and inflammatory response of patients and promote the early rehabilitation of patients.
2020 Vol. 17 (10): 109-112 [Abstract] ( 144 ) HTML (1 KB)  PDF (435 KB)  ( 155 )
113 Intraperitoneal local anesthetic with Dexmedetomidine for postoperative analgesia after laparoscopic surgery: a systematic review  
DENG Minjia1 HU Lihui1 HUANG Xiaofang1 LIU Yuling1 WU Youping2
Objective To assess the efficacy and safety of intraperitoneal local anesthetic with Dexmedetomidine (DEX) for postoperative analgesia after laparoscopic surgery. Methods The PubMed, EMbase, Cochrane Library, CBM, Wanfang Database, China National Knowledge Infrastructure and VIP for all randomized controlled trials about intraperitoneal local anesthetic alone (group L) or with DEX (group LD) in laparoscopic surgery were searched. The retrieval period was from the establishment of the database to August 2019. Information was extracted and the research of risk of bias was evaluated, data was analyzed by RevMan5.3 software. Results Seven RCTs involving 422 patients were included. The results showed that compared with group L, group LD first use remedy postoperative analgesia drug prolonged [MD = 58.78, 95%CI: (23.72, 93.83), P = 0.001], 24 h remedial reduction total [Diclofenac: MD = -86.27, 95%CI: (-127.95,-44.58), P ＜ 0.0001], the incidence of postoperative shoulder pain reduce [OR = 0.16, 95%CI: (0.08, 0.31), P ＜ 0.000 01]. There was no significant difference in the incidence of adverse reactions such as nausea [OR = 0.71, 95%CI: (0.34, 1.47), P = 0.36], vomiting [OR = 0.40, 95%CI: (0.16,1.01), P = 0.05] between the two groups. Conclusion Intraperitoneal local anesthetic combines with DEX can improve the analgesia effect after laparoscopic surgery without increasing the occurrence of adverse reaction.
2020 Vol. 17 (10): 113-117 [Abstract] ( 235 ) HTML (1 KB)  PDF (1029 KB)  ( 113 )
118 Study on relationship between homocysteine and traditional Chinese medicine syndrome of type 2 diabetes mellitus
LU Cong1 ZHAO Jinxi2 HUANG Weijun3 ZHANG Xiuyuan1▲
Objective To study the relationship between homocysteine (Hcy) and traditional Chinese medicine syndrome of type 2 diabetes mellitus. Methods Two hundred patients with type 2 diabetes mellitus combined with hyperhomocysteinemia received treatment in Department of Endocrinology of Shunyi Hospital, Beijing Hospital of Traditional Chinese Medicine from January 2017 to June 2018 were selected as research subjects. All patients were divided into syndrome of spleen deficiency and stomach heat (96 cases), syndrome of deficiency of both qi and yin (38 cases), syndrome of yin deficiency of liver and kidney (36 cases), syndrome of deficiency of both yin and yang (30 cases) according to principal syndrome differentiation. In addition, they were divided into syndrome of turbidity (30 cases), syndrome of phlegm (33 cases), syndrome of dampness (59 cases), syndrome of stasis (78 cases) according to incidental symptom differentiation. The fully automatic biochemical analyser was used to determine the levels of Hcy. Results Hcy levels of patients with different traditional Chinese medicine main syndromes were significantly different (P < 0.05). There was significant difference in Hcy level between two types of traditional Chinese medicine main syndromes (P < 0.05), which was manifested as syndrome of deficiency of both yin and yang, syndrome of yin deficiency of liver and kidney, syndrome of deficiency of both qi and yin, syndrome of spleen deficiency and stomach heat. There was significant difference in Hcy level among different traditional Chinese medicine syndromes (P < 0.05). There was significant difference in Hcy level between two types of traditional Chinese medicine accompanying symptoms (P < 0.05), which was manifested as syndrome of stasis, syndrome of dampness, syndrome of phlegm, syndrome of turbidity. Conclusion Hcy may be the important factor in the development of diabetes mellitus. There is a certain correlation between Hcy level and different traditional Chinese medicine syndrome types of type 2 diabetes mellitus, which can provide some reference for the standardization and standardization of traditional Chinese medicine syndrome differentiation of type 2 diabetes mellitus.
2020 Vol. 17 (10): 118-121 [Abstract] ( 196 ) HTML (1 KB)  PDF (765 KB)  ( 113 )
122 Disease of “pharynx and upper esophageal opening” in Huangdi Neijing
MENG Fanqi ZHANG He CHEN Xiuhua
Huangdi Neijing is the foundation work of traditional Chinese medicine. This thesis systematically organizes the discussions about “pharynx and upper esophageal opening”, pointes out the differences between “pharynx” and “throat”: “pharynx” belongs to the digestive tract, and “throat” belongs to the respiratory tract. It analyzes the positions, functions and characteristics of “pharynx” and “throat”. In modern medicine, “pharynx” is equivalent to the esophagus and “throat” is equivalent to the upper opening of the esophagus. “Pharynx and upper esophageal opening” is the way of essential transporting up and down, and is nourished by the essential, and also is the outward manifestation of hepar and gallbladder. Moreover, it has also pointed out that, there are 11 meridians and collaterals related to the “pharynx and upper esophageal opening”, and the diseases of “pharynx and upper esophageal opening” are closely related to the abnormal meridians and collaterals. The diseases of “pharynx and upper esophageal opening” can be divided into two categories in the Huangdi Neijing: first, the local pathological changes in “pharynx and upper esophageal opening”, including the dry, swollen and pain, and abnormal sensation; second, the abnormal conduction function of “pharynx and upper esophageal opening”, including the obstructed diaphragm and pharynx, and emesis after swallowing. In the treatment, the principle of over all is to return abnormal meridians and collaterals to normal, by choosing corresponding acupoints in abnormal meridians and collaterals according to heat or cold, deficiency or excess.
2020 Vol. 17 (10): 122-125 [Abstract] ( 195 ) HTML (1 KB)  PDF (789 KB)  ( 111 )
126 Teaching practice and reflection of Shaolin internal power teaching module of Tuina exercise
YAO Fei1 AN Guanghui1 FANG Min1，2
According to the characteristics of massage, we should cultivate morality, stress students′ main body, pay attention to humanistic care, and study the new model of Shaolin′s internal skill teaching. In the process of teaching, we should skillfully deal with the relations of training form, nourishing spirit, giving consideration to both movement and stillness, combining virtual and actual, and complementing teaching and practicing, fully embody the characteristics of the traditional methods, enrich the teaching theory and practice of the traditional methods of fitness, which is conducive to the cultivation of professional talents and the promotion of our national fitness culture.
2020 Vol. 17 (10): 126-129,141 [Abstract] ( 182 ) HTML (1 KB)  PDF (730 KB)  ( 209 )
130 Effect of nourishing yin and removing pathogenic factors in the treatment of xerostomia after radiotherapy of nasopharyngeal carcinoma
CHEN Hong WANG Wei LI Peifu LI Fangfei
Objective To investigate clinical efficacy of nourishing yin and removing pathogenic factors in treating patients with xerostomia after radiotherapy for nasopharyngeal carcinoma. Methods From October 2016 to October 2018, 84 patients with xerostomia after radiotherapy for nasopharyngeal carcinoma were selected from Chongqing University Cancer Hospital. According to the random number table method, they were divided into control group and treatment group, with 42 cases in each group. Total dose of nasopharynx was 68-76 Gy + 10 mL of Kangfuxin Solution, three times a day was in control group. On the basis of control group, treatment group was added with traditional Chinese medicine for nourishing yin and eliminating pathogenic factors. Two groups were treated with one month as a course of treatment, a total of three courses of treatment. The dry mouth score, stimulated salivary flow and parotid flow (PSV, EDV, RI, D) between two groups were observed before and after treatment. Results After treatment, the score of dry mouth degree in two groups was lower than that before treatment, and stimulating saliva flow was more than that before treatment, and the improvement in treatment group was more significant than that in control group (P < 0.05 or P < 0.01). The PSV, EDV and D at the first month after radiotherapy in treatment group were lower than those at the third week after radiotherapy, there were significant differences (P < 0.05). The PSV, EDV and D at the first month after radiotherapy in the treatment group were lower than those of control group, there were significant differences (P < 0.05). Conclusion The method of nourishing yin and removing pathogenic factors can obviously improve the symptoms of xerostomia of nasopharyngeal carcinoma patients after radiotherapy, and has a better protective effect on salivary gland.
2020 Vol. 17 (10): 130-133 [Abstract] ( 135 ) HTML (1 KB)  PDF (768 KB)  ( 84 )
134 The characteristics of fluid retention in chronic heart failure and its treatment based on sanjiao theory
WU Yuehua
Fluid retention is the symptom of chronic heart failure and the variable factor in the course of the disease. Because the basic etiology and clinical stage of heart failure are different, its clinical symptoms and syndrome characteristics are different, which has become a difficult point in the treatment of chronic heart failure. According to the basic theory of traditional Chinese medicine, this paper expounds the formation mechanism and evolvement rule of fluid retention in the chronic heart failure, analyzes the characteristics of fluid retention in the different causes of heart failure and the syndrome characteristics of sanjiao of fluid retention in different clinical stages, discusses the basic treatment of fluid retention in chronic heart failure, and put forward the treatment principle of sanjiao and the choosing points of representative prescriptions, which has a positive theoretical significance and clinical practical value for the treatment based on syndrome differentiation of fluid retention in chronic heart failure.
2020 Vol. 17 (10): 134-137 [Abstract] ( 171 ) HTML (1 KB)  PDF (765 KB)  ( 150 )
138 Study on the rule of traditional Chinese medicine in the treatment of hot flashes related to endocrine therapy of breast cancer
ZHANG Ying1 LIU Qing2 ZHOU Xin1 LYU Lingyan1 WAN Donggui2
Objective To explore the rules of traditional Chinese medicine on hot flashes related to endocrine therapy of breast cancer. Methods Clinical researches about hot flashes related to endocrine therapy were collected by using CNKI, Wanfang and VIP from the time of the database established to July 2019, with the terms “traditional Chinese medicine, breast cancer, endocrine therapy, hot flashesl”. The medication frequency of efficacy, four qi, five flavors and meridian entry were analyzed. The association rules and cluster analysis were used to find the drug pairs and the new formulas. Results Sixty-two articles were included, involving 114 medicines. The most used ones were Radix Paeoniae Alba. The most frequently used were tonifying and heat-clearing medicines. The medicines those were sweet and cold were widely used and the meridians of traditional Chinese medicine were mainly liver and kidney. 10 drug pairs and 4 new formulas were found by date mining. Conclusion Nourishing liver and kidney, soothing liver and relieving depression, nourishing yin and clearing heat are the main methods in the treatment of hot flashes related to endocrine therapy of breast cancer.
2020 Vol. 17 (10): 138-141 [Abstract] ( 171 ) HTML (1 KB)  PDF (878 KB)  ( 128 )
142 Study on infrared thermal imaging characteristics of Yang Heel Channel in OSAHS patients with syndrome of internal blockade of phlegm dampness
LI Quan YANG Xiaoming HE Meiyan LIU Zhongda
Objective To study the infrared thermal imaging characteristics of Yang Heel Channel in the face of obstructive sleep apnea hyponea syndrome (OSAHS) patients with syndrome of internal blockade of phlegm dampness. Methods Sixty cases of OSAHS patients with syndrome of internal blockade of phlegm dampness treated in Department of Pulmonary Disease, Lishui Hospital of Traditional Chinese Medicine from September 2018 to May 2019 were collected as observation group. 60 healthy adults were selected as normal control group in the same period. Infrared thermal imaging was performed in two groups. The temperature of Yang Heel Channel acupoint on patients′ faces was measured and data analysis was carried out. Results Temperature values of Yang Heel Channel acupoint on patients′ faces (dìcāng, jùliáo, jīngmíng, cuánzhú and meíchōng) of observation group were significantly higher than those of control group (P ＜ 0.05). The highest temperature, the lowest temperature and the average temperature of observation group were significantly higher than those of control group (P ＜ 0.05). Conclusion Infrared skin temperature of Yang Heel Channel on patients′ faces in OSAHS with syndrome of internal blockade of phlegm dampness changes with high temperature and specificity, which provides a visual scientific basis for traditional Chinese medicine theory and disease diagnosis and treatment.
2020 Vol. 17 (10): 142-144,148 [Abstract] ( 163 ) HTML (1 KB)  PDF (996 KB)  ( 212 )
145 Clinical application value of telemonitoring electrocardiography monitoring system in diagnosis of arrhythmia
LI Hua1 WANG Shiguang1 LUO Xin1 WAN Shaoping2 GAO Lingyun3
Objective To investigate the clinical application value of telemonitoring electrocardiography monitoring system in diagnosis of arrhythmia. Methods From January 2016 to February 2017, 1030 cases who accepted telemonitoring electrocardiography monitoring system in East Hospital of Sichuan Provincial People′s Hospital were selected, the number of invalid patients was 38 cases. According to age, they were divided into group A (164 cases), group B (606 cases) and group C (222 cases). The three groups of routine demographic characteristics and laboratory data, remote dynamic electrocardiography data, and the number of arrhythmias were observed and compared. Results The levels of total cholesterol, triglyceride, high density lipoprotein cholesterol and low density lipoprotein cholesterol in group C were higher than those in group A, with statistically significant differences (all P < 0.05). The percentage of quarterly valid data in total wearing volume is 90.4% at the lowest and 98.7% at the highest. The number of patients with ectopic heart rhythm, atrial/ventricular pre-systolic, atrial/ventricular tachycardia, atrial fibrillation/flutter, conduction block and ventricular fusion wave/wave in group C were higher than those in group A, with statistically significant differences (all P < 0.05). The number of patients with ectopic heart rhythm, atrial/ventricular pre-systolic, atrial/ventricular tachycardia, atrial fibrillation/flutter, and conduction block in group C were less than that in group B, with statistically significant differences (all P < 0.05). The number of patients with ectopic heart rhythm, atrial/ventricular pre-systolic, atrial/ventricular tachycardia, atrial fibrillation/flutter and ventricular fusion wave/wave in group B were higher than those in group A, with statistically significant differences (all P < 0.05). Conclusion Telemonitoring electrocardiography monitoring system has accurate, real-time and efficient features. It is especially suitable for elderly patients with high incidence of arrhythmia. So it has broad prospects of clinical application.
2020 Vol. 17 (10): 145-148 [Abstract] ( 149 ) HTML (1 KB)  PDF (395 KB)  ( 185 )
149 Clinical effect of Trimetazidine in the treatment of hypertensive heart disease
YANG Hui ZHONG Jianghua SU Yujiang MA Tianyi
Objective To study the clinical effect of Trimetazidine in the treatment of hypertensive heart disease. Methods A total of 80 patients with hypertensive heart disease admitted to Haikou Hospital Affiliated to Xiangya Hospital Central South University were selected as the research object. According to the random number table method, they were divided into experimental group and routine group, with 40 cases in each group. The conventional group was treated with conventional therapy, and the experimental group was treated with Trimetazidine Tablets on the basis of the conventional group. The dosage of Trimetazidine Tablets was 20 mg/time, 3 times/day, and the patients in both groups were treated for 3 months. Clinical treatment effect, clinical symptoms, cardiac function changes and adverse symptoms were compared between the two groups. Results After treatment, the overall productivity of the experimental group was higher than that of the conventional group, and the difference was statistically significant (P ＜ 0.05). After treatment, the frequency of angina pectoris, the duration of angina pectoris and the amount of nitroglycerin used in the experimental group were all lower than those in the conventional group, and the amount of exercise for 7 min was higher than that in the conventional group, with statistically significant differences (all P ＜ 0.05). Before treatment, there was no statistically significant difference in left ventricular ejection fraction (LVEF), left ventricular end-systolic volume index (LVESVI) and left ventricular end-diastolic volume index (LVEDVI) between the two groups (P ＞ 0.05). After treatment, LVEF in the two groups was higher than that before treatment, LVESVI and LVEDVI were lower than those before treatment, and LVEF in the experimental group was higher than that in the conventional group, and LVESVI and LVEDVI were lower than those in the conventional group, with statistically significant differences (all P ＜ 0.05). During the treatment period, there was no statistically significant difference in the incidence of adverse symptoms between the two groups (P ＞ 0.05). Conclusion The use of Trimetazidine on the basis of conventional drug treatment can significantly increase the curative effect of patients with hypertensive heart disease, can significantly reduce the frequency of angina pectoris and the amount of nitroglycerin, can under the premise of the control of blood pressure, make the patient′s heart function and exercise were promoted, so as to improve the prognosis of patients.
2020 Vol. 17 (10): 149-152 [Abstract] ( 131 ) HTML (1 KB)  PDF (444 KB)  ( 28 )
153 Effect of Peramivir in the treatment of children with influenza and pneumonia
AN Zhihua1 ZHANG Guying1 DONG Lei1 JIA Chenhong1 FU Haiyan2
Objective To investigate the clinical effects and adverse reactions of Peramivir Sodium Chloride Injection in the treatment of children with influenza and pneumonia. Methods A total of 100 children hospitalized in Hebei Children′s Hospital from November 2018 to March 2019 were collected and divided into the control group and the observation group according to the random number table method, with 50 cases in each group. The control group was treated with Oseltamivir Phosphate Granules, and the observation group was treated with Peramivir Sodium Chloride Injection. The clinical efficacy, total effective rate, viral antigen negative conversion rate, adverse reactions and blood routine changes after 5 days of the two groups during the treatment were compared. Results The duration of fever, cough, lung rales and hospital stay in the observation group were significantly shorter than those in the control group, with statistically significant differences (all P ＜ 0.05). However, there was no statistically significant difference in the duration of pharyngeal congestion between the two groups (P ＞ 0.05). The total effective rate and viral antigen negative conversion rate of the observation group were higher than those of the control group, with statistically significant differences (all P ＜ 0.05). There was no statistically significant difference in the incidence of adverse reactions between the two groups (P ＞ 0.05). There was no statistically significant difference between the two groups in blood routine indexes before treatment (P ＞ 0.05). After 5 days of treatment, the percentage of neutrophils in the two groups was significantly higher than before treatment, and the observation group was higher than the control group, while the C-reactive protein was significantly lower than before treatment, and the observation group was lower than the control group, with statistically significant differences (all P ＜ 0.05). Platelets were higher in the control group 5 days after treatment than before treatment, and the difference was statistically significant (P ＜ 0.05). However, there was no statistically significant difference in white blood cells, red blood cells, the percentage of lymphocytes and platelets between the two groups after 5 days of treatment (P ＞ 0.05). Conclusion In the treatment of children with influenza and pneumonia, the clinical effect of Peramivir is better than Oseltamivir, can improve the total effective rate, shorten the hospital stay, and the virus antigen conversion rate is higher, blood routine to normal value is more obvious, the effect is fast, worthy of clinical promotion.
2020 Vol. 17 (10): 153-156 [Abstract] ( 139 ) HTML (1 KB)  PDF (446 KB)  ( 73 )
157 Effect of continuous infusion meropenem in the treatment of severe melioidosis pneumonia
XIE Tian1 WANG Min2 WU Haihong1
Objective To observe the effect of continuous infusion meropenem in the treatment of severe melioidosis pneumonia. Methods A total of 39 cases of severe melioidosis pneumonia admitted to Hainan Genaral Hospital from January 2017 to March 2019 were selected. The patients were randomly divided into the study group (19 cases) and control group (20 cases) according to the method of random number table. The study group was given Meropenem treatment by continuous infusion, the control group was given Meropenem treatment by intermittent infusion. The total number of white blood cells, C-reactive protein (CRP), calcitonin (PCT) and acute physiology and chronic health evaluation system Ⅱ(APACHE Ⅱ) score, mechanical ventilation time, clinical curative effect, etiology clearance, 28-day-mortality and hospitalization cost of two groups were observed. Results The duration of mechanical ventilation and total hospitalization expenses in the study group were lower than those in the control group, with statistically significant differences (P ＜ 0.05). The PCT, CRP, total number of white blood cells, APACHE Ⅱ of two groups after treatment were lower than those before treatment, the differences were statistically significant (P ＜ 0.05). And the PCT, CRP, total number of white blood cells, APACHE Ⅱ were lower than the control group, the differences were statistically significant (P ＜ 0.05). The total clinical effective rate of the study group was higher than that of the control group, and the difference was statistically significant (P ＜ 0.05). There was no statistically significant difference between the two groups in etiological clearance rate, total length of stay and 28-day-mortality (P ＞ 0.05). Conclusion Continuous infusion Meropenem may provide better clinical efficacy and less economic cost than intermittent infusion on the premise of fixed dose．
2020 Vol. 17 (10): 157-160 [Abstract] ( 170 ) HTML (1 KB)  PDF (448 KB)  ( 41 )
161 Application value of combined detection of procalcitonin, C-reactive protein, erythrocyte sedimentation rate and white blood cell count in the diagnosis of respiratory tract infection
CAO Jinjin CUI Fan LIU Furong XU Chengquan QIAN Zengkun
Objective To explore the value of the combined detection of procalcitonin (PCT), C-reactive protein (CRP), erythrocyte sedimentation rate (ESR) and white blood cell (WBC) count in the diagnosis of respiratory tract infection. Methods From February 2018 to July 2019 in Wuhu NO.1 People′s Hospital, a total of 60 patients with respiratory tract infection were selected as experimental group. According to whether the bacterial infection, they were divided into bacterial infection group (33 cases) and non-bacterial infection group (27 cases). While another 30 healthy subjects were selected as the control group during the same period. The serum PCT, CRP, ESR and WBC count levels of each group were detected quantitatively and compared. Results In the combined detection of PCT, CRP, ESR and WBC counts, the positive rate of the bacterial infection group were significantly higher than those of the nonbacterial infection group and the control group, and the differences were statistically significant (P ＜ 0.05). The area under the ROC curve was the largest during the combined detection, followed by the WBC count, PCT, and ESR, and the CRP was the smallest. The accuracy, sensitivity, and specificity of the combined detection of all indicators were higher than those of the single detection, and the differences were statistically significant (P ＜ 0.05). Conclusion The combined quantitative detection of PCT, CRP, ESR and WBC counts has higher diagnostic value for respiratory infections. It can distinguish bacterial and non-bacterial respiratory infections, and provide a basis for clinical rational drug use.
2020 Vol. 17 (10): 161-164 [Abstract] ( 218 ) HTML (1 KB)  PDF (403 KB)  ( 109 )
165 Study on scientific research construction of tertiary hospital based on three-ring theory
WEI Xiao1 ZHU Min2 PENG Yuzhu1,2▲
Objective To explore the effectiveness and shortcomings of scientific research construction guided by the three-ring theory since the development of the discipline construction, and to promote the further improvement of hospital scientific research capabilities. Methods The Nanjing Drum Tower Hospital was taken as an example, the subject construction was officially launched in 2015, and the research started and ended from January to July 2018. The construction of the three parts of the scientific research construction knowledge system, management system, and resource elements since the development of the discipline construction were reviewed. Scientific research projects and outputs before the construction of the discipline (2013-2014) and after the development of the discipline (2016-2017) were analyzed separately. Results There were statistically significant differences in the number of project projects before and after the discipline construction (P ＜ 0.05). There was a statistical difference in the number of SCI papers before and after the discipline construction between the low, medium and high groups (P ＜ 0.05). There was no statistically significant difference in scientific and technological achievements before and after the discipline construction (P ＞ 0.05). Before and after the development of discipline construction, the differences between different types of patents were statistically significant (P ＜ 0.05). Conclusion Since the construction of the discipline, the scientific research construction guided by the three-ring theory has achieved certain results, but the high-level scientific and technological output is relatively small. New technology innovation and application should be promoted to strengthen discipline construction and development; strengthen scientific research information management and improve the scientific research management evaluation system; increase scientific research investment to ensure the implementation conditions of scientific research; take the three-ring theory as a guarantee and introduce refined management concepts, enhance scientific research capabilities, and promote discipline development.
2020 Vol. 17 (10): 165-168 [Abstract] ( 122 ) HTML (1 KB)  PDF (371 KB)  ( 122 )
169 “Internet + medical” service status of hospitals and research on the development strategy of hospital informatization in 5G era
JIANG Weina1 QIU Zhiyuan2 WANG Jiafei1，3 YAN Ting1，3 CUI Shuzheng1，3 ZHU Lili2
With the rise of 5G medical, the development strategy of hospital informatization in 5G era has become a key issue to be solved urgently. Based on the current situation of “internet + medical” service provided by hospitals, this paper makes use of the common strategic analysis tool- SWOT analysis, analyzes the strengths, weaknesses, opportunities and threats for the development of 5G medical care in hospitals and discusses the problems of lack of compound talents, inconsistent information standards, lack of 5G medical top-level design, and insufficient verification of 5G technology in the development process. Finally, the development strategy is put forward from the national and hospital levels, that is, the top-level design of 5G medical treatment should be done well at the national level, and the 5G medical treatment should be positively, scientifically and differently distributed at the hospital level.
2020 Vol. 17 (10): 169-172,176 [Abstract] ( 242 ) HTML (1 KB)  PDF (859 KB)  ( 377 )
173 Application of targeted nursing and double-loop learning concept in the nursing of patients with early onset severe preeclampsia
XU Shuting ZHOU Yue WANG Yang WANG Li′na FENG Jingjing QU Guangjin
Objective To discuss the effect of targeted nursing and double-loop learning concept in the nursing of patients with early onset severe preeclampsia. Methods From March 2018 to March 2019, 110 patients with early onset severe preeclampsia who admitted to the First Affiliated Hospital of Harbin Medical University were selected as the study subjects. According to the random number table method, they were divided into experimental group and the control group, with 55 cases in each group. The control group adopted routine nursing, the experimental group adopted targeted nursing and double-loop learning concept. Blood pressure, neonatal Apgar score and quality of life score were compared between the two groups. Results Before nursing intervention, there was no significant difference in blood pressure between the two groups (P ＞ 0.05). After nursing intervention, both the systolic and diastolic blood pressure levels of the two groups were lower than before nursing, and the experimental group was lower than the control group, with statistically significant differences (P ＜ 0.05). Apgar score, survival rate and quality of life score of neonates in the experimental group were higher than those in the control group, with statistically significant differences (P ＜ 0.05). Conclusion For patients with early onset severe preeclampsia, targeted nursing and double-loop learning concept can effectively improve patients′ blood pressure, reduce the incidence of adverse neonatal outcomes, and improve patients′ quality of life to a certain extent, which is worthy of clinical application and promotion.
2020 Vol. 17 (10): 173-176 [Abstract] ( 111 ) HTML (1 KB)  PDF (596 KB)  ( 67 )
177 Application effect of clinical nursing path way in rehabilitation nursing of ischemic stroke
WANG Ping1 WANG Sijie2 CHANG Haixia3 KONG Xiangfeng1 GAO Hua1 WANG Shanshan1 QI Yuxia1
Objective To analyze the application effect of clinical nursing pathway in rehabilitation nursing of ischemic stroke. Methods A total of 90 patients who received ischemic stroke treatment in the Department of Neurology of The Fifth Affiliated Hospital of Xinjiang Medical University from May 2017 to June 2018 were selected. The patients were randomly divided into the observation group and the control group by random draw, with 45 patients in each group. The control group received routine nursing, and the observation group received combined clinical nursing pathway based on the control group. The scores of simple mental state examination scale (MMSE), national institutes of health stroke scale (NIHSS), activity of daily living (ADL) scale and satisfaction with nursing care were compared before and after nursing care between the two groups. Results There was no statistically significant difference in MMSE, NIHSS and ADL scores between the two groups before nursing (P ＞ 0.05). After nursing, MMSE and ADL scores in the two groups were higher than before nursing, and NIHSS score was lower than before nursing, and MMSE and ADL scores in the observation group were higher than those in the control group, and NIHSS score was lower than those in the control group, with statistically significant differences (all P ＜ 0.05). The total nursing satisfaction in the observation group was higher than that in the control group, and the difference was statistically significant (P ＜ 0.05). Conclusion The application of clinical nursing pathway in rehabilitation nursing of ischemic stroke can promote the improvement of patients′ condition, improve their self-care ability, and further improve nursing satisfaction, clinical application and promotion value is high.
2020 Vol. 17 (10): 177-180 [Abstract] ( 159 ) HTML (1 KB)  PDF (641 KB)  ( 158 )
181 Effect of cluster nursing on quality of life and psychological burden of myeloma patients
SUN Xiumei XU Hongyan LI Caihui YU Jinhua
Objective To explore the effect of cluster nursing on quality of life and psychological burden of patients with multiple myeloma. Methods From February 2017 to February 2018, 104 myeloma patients who admitted to the department of Hematology, The Third Hospital of Hebei Medical University were selected. According to the random number table method, all the patients were divided into the control group and the observation group, with 52 cases in each group. The control group received routine nursing, and the observation group received cluster nursing on the basis of the control group. The two groups were compared in terms of psychological burden, pain, toxic and side effects, coagulation indexes and quality of life. Results After intervention, the self-rating anxiety scale scores and self-rating depression scale scores of the two groups were significantly reduced than those befere intervention, and the scores of the observation group were significantly lower than those of the control group (P ＜ 0.05). The level of coagulation index in both groups was lower than that before the intervention, and the observation group was lower than the control group (P < 0.05). During chemotherapy, the observation group level of pain during chemotherapy was mild and the proportion of the toxic and side reaction Ⅰ-Ⅱ magnitude ratio are higher than the control group (all P ＜ 0.05). Conclusion For patients with myeloma, cluster nursing can alleviate anxiety and depression, alleviate psychological burden of patients, alleviate pain, reduce toxic and side effects of chemotherapy, and improve the quality of life of patients.
2020 Vol. 17 (10): 181-184 [Abstract] ( 134 ) HTML (1 KB)  PDF (636 KB)  ( 103 )
185 Effect of refined nursing on parents′ psychological stress and social support in patients with inguinal hernia repair and their parents
HU Yiping1 SUN Lili1 CHEN Hong1 CHEN Chunju1 GUO Yangbo1 SONG Chen bing1 GAO Jinling2▲
Objective To investigate the effect of refined nursing on parents′ psychological stress and social support in patients with inguinal hernia repair and their parents. Methods A total of 104 children with inguinal hernia repair and 104 parents who visited the First Hospital of Hebei Medical University from March 2016 to December 2017 were selected as the study subjects. According to the random number table method, they were divided into the observation group and the control group, with 52 children in each group. The control group received routine care and the observation group implemented refined nursing. The influence of intensive care on children and their parents was evaluated by comparing the operation time, bleeding volume, total nursing satisfaction, complications, parents′ Hamilton anxiety (HAMA) scale and social support scale before and after the intervention. Results The operation time, bleeding volume and complication rate of the observation group were lower than those of the control group (P ＜ 0.05). The total nursing satisfaction of the observation group was significantly higher than that of the control group (P ＜ 0.05). After the intervention, the parental stress scores of both groups were lower than before the intervention, and the observation group was lower than the control group (P < 0.05). After the intervention, the social support scores of parents in both groups were higher than before the intervention, and the observation group was higher than the control group (P ＜ 0.05). Conclusion Meticulous nursing can significantly shorten the operation time, reduce the amount of bleeding and postoperative complications, and effectively relieve the psychological pressure of parents and improve their social support.
2020 Vol. 17 (10): 185-188 [Abstract] ( 115 ) HTML (1 KB)  PDF (637 KB)  ( 192 )
189 Application value of intensive care based on evidence based concept in prevention of catheter related infection
DING Yun1 CHEN Yan2 WANG Lianying3
Objective To explore the application value of evidence based intensive care in the prevention of catheter related infection. Methods Sixty-two ICU patients who admitted to the First People′s Hospital of Kashgar, Xinjiang Uygur Autonomous Region (hereinafter referred to as “our hospital”) from July 2017 to June 2018 were selected as the observation group, intensive care based on evidence based concept was used for intervention. Sixty-two ICU patients who admitted to our hospital from February 2015 to January 2016 were selected as the control group, and routine nursing was adopted. Both groups were nursed by the same group, and catheter indwelling time and ICU stay time were recorded in both groups. The incidence of urinary catheter related urinary tract infection (CAUTI), central venous catheter-related bloodstream infection (CLABSI), and ventilator-related pneumonia (VAP) was compared between the two groups. The measures of catheter infection prevention were used to evaluate the sensitivity and core competence of the intervention personnel respectively. Results The duration of indwelling catheter and ICU stay in the observation group was significantly shorter than that in the control group (P ＜ 0.05). The incidence of CAUTI, CLABSI and VAP in the observation group was significantly lower than that in the control group (P ＜ 0.05). The scores of attitude, behavior, indication of catheter indwelling, infection prevention strategy and total scores in the observation group were significantly higher than those in the control group (P ＜ 0.01). The scores of emergency ability, health education ability, communication ability and total scores in the observation group were significantly higher than those in the control group (P ＜ 0.05). Conclusion Compared with the routine nursing, the intensive care based on the evidence based concept can shorten the time of indwelling catheter and ICU stay, and improve the sense control ability and nursing ability of the intervention personnel.
2020 Vol. 17 (10): 189-192 [Abstract] ( 227 ) HTML (1 KB)  PDF (637 KB)  ( 126 )
193 Analysis of clinical practice teaching effect of medical nursing under the synchronous prcutice teaching mode based on information environment
LU Xia1 LIU Yanli1 HUANG Zhen2 GUO Wei1 WANG Shasha1
Objective To explore the teaching effect of clinical probation of internal medicine nursing under synchronous practice teaching mode based on information environment. Methods A total of 116 nursing students from two nursing English classes in 2015 and 2016 in Shandong University of Traditional Chinese Medicine from September 2018 to January 2019 were selected as the research object. In the clinical practice teaching of internal medicine nursing, the convenience sampling method was adopted to select the 2016 undergraduate English nursing class as the the experimental group (n = 57), and the synchronous practice clinical teaching mode based on the information environment was adopted. The English direction class of 2015 nursing undergraduate course is the control group (n = 59), which adopts the traditional clinical teaching mode. The teaching effect of the two groups was evaluated. Results The comprehensive theoretical score and operation score of basic practical skills of the experimental group were significantly higher than that of the control group, and the difference was statistically significant (P ＜ 0.05). Conclusion The clinical practice teaching of internal medicine nursing under the synchronous practice teaching mode based on information environment is conducive to the close combination of theory and practice, to enhance the clinical comprehensive ability of nursing students, and to improve the quality of clinical practice of internal medicine nursing students.
2020 Vol. 17 (10): 193-196 [Abstract] ( 119 ) HTML (1 KB)  PDF (697 KB)  ( 81 )
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