同型半胱氨酸与2型糖尿病中医证候关系研究

Abstract
Figure/Table
References (26)
Related Citation (15)

Download: PDF (765 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To study the relationship between homocysteine (Hcy) and traditional Chinese medicine syndrome of type 2 diabetes mellitus. Methods Two hundred patients with type 2 diabetes mellitus combined with hyperhomocysteinemia received treatment in Department of Endocrinology of Shunyi Hospital, Beijing Hospital of Traditional Chinese Medicine from January 2017 to June 2018 were selected as research subjects. All patients were divided into syndrome of spleen deficiency and stomach heat (96 cases), syndrome of deficiency of both qi and yin (38 cases), syndrome of yin deficiency of liver and kidney (36 cases), syndrome of deficiency of both yin and yang (30 cases) according to principal syndrome differentiation. In addition, they were divided into syndrome of turbidity (30 cases), syndrome of phlegm (33 cases), syndrome of dampness (59 cases), syndrome of stasis (78 cases) according to incidental symptom differentiation. The fully automatic biochemical analyser was used to determine the levels of Hcy. Results Hcy levels of patients with different traditional Chinese medicine main syndromes were significantly different (P < 0.05). There was significant difference in Hcy level between two types of traditional Chinese medicine main syndromes (P < 0.05), which was manifested as syndrome of deficiency of both yin and yang, syndrome of yin deficiency of liver and kidney, syndrome of deficiency of both qi and yin, syndrome of spleen deficiency and stomach heat. There was significant difference in Hcy level among different traditional Chinese medicine syndromes (P < 0.05). There was significant difference in Hcy level between two types of traditional Chinese medicine accompanying symptoms (P < 0.05), which was manifested as syndrome of stasis, syndrome of dampness, syndrome of phlegm, syndrome of turbidity. Conclusion Hcy may be the important factor in the development of diabetes mellitus. There is a certain correlation between Hcy level and different traditional Chinese medicine syndrome types of type 2 diabetes mellitus, which can provide some reference for the standardization and standardization of traditional Chinese medicine syndrome differentiation of type 2 diabetes mellitus.

Key words： Type 2 diabetes mellitus Traditional Chinese medicine syndromes Homocysteine Distribution of traditional Chinese medicine syndrome

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	LU Cong1 ZHAO Jinxi2 HUANG Weijun3 ZHANG Xiuyuan1▲

Cite this article:

LU Cong1 ZHAO Jinxi2 HUANG Weijun3 ZHANG Xiuyuan1▲. Study on relationship between homocysteine and traditional Chinese medicine syndrome of type 2 diabetes mellitus[J]. 中国医药导报, 2020, 17(10): 118-121.

URL:

http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2020/V17/I10/118

[1] 陈波，王小明.2型糖尿病合并肾病患者的血清脂联素、胱抑素C、同型半胱氨酸水平及其相关性[J].实验与检验医学，2019，37（1）：73-74. doi：10.3969/j.issn.1674-1129. 2019.01.023.
[2] 杨波，杜利君，张兵，等.血清胱抑素C和同型半胱氨酸联合检测在2型糖尿病肾病早期诊断中的临床价值[J].西部医学，2018，30（8）：1226-1228. doi：10.3969/j.issn.1672-3511.2018.08.032.
[3] Li J，Shi M，Zhang H，et al. Relation of homocysteine to early nephropathy in patients with type 2 diabetes [J]. Clin Nephrol，2012，77（4）：305-310.
[4] 刘媛，王永胜.胱抑素C、同型半胱氨酸及尿碱性磷酸酶在糖尿病肾病诊断中的临床价值[J].国际检验医学杂志，2018，39（9）：1038-1040. doi：10.3969/j.issn.1673-4130. 2018.09.004.
[5] 陈笑嬉.2型糖尿病肾病血清几丁质酶-3样蛋白-1、同型半胱氨酸水平的变化[D].北京：华北理工大学，2018.
[6] 曾洋，周蓉，徐雅虹，等.不同分期2型糖尿病肾病患者的血浆同型半胱氨酸水平及其临床意义[J].广西医学，2017，39（12）：1791-1793. doi：10.11675/j.issn.0253-4304. 2017.12.07.
[7] 马学毅.现代糖尿病诊断治疗学[M].北京：人民军医出版社，2007.
[8] 中华中医药学会.中医内科常见病诊疗指南·西医疾病部分[M].北京：中国中医药出版社，2008.
[9] 蓝海鹰，陈鹏龙，蓝蔚蔚，等.血清Hcy联合hs-CRP在妊娠期糖尿病肾病中的诊断价值[J].中国妇幼健康研究，2018，29（6）：752-755. doi：10.3969/j.issn.1673-5293.2018. 06.019.
[10] 李娟.糖尿病肾病同型半胱氨酸水平与炎症因子的相关性分析[J].糖尿病新世界，2017，20（13）：53-54. doi：10.16658/j.cnki.1672-4062.2017.13.053.
[11] 林丛.高同型半胱氨酸血症对冠状动脉微循环功能的影响[D].济南：山东大学，2017.
[12] 唐爱华，王振刚，李吉武，等.糖尿病肾病中医证型与Ⅳ型胶原、同型半胱氨酸的相关性研究[C]//中华中医药学会糖尿病分会2016年学术年会暨第十七次中医糖尿病大会论文集.广西中医药大学，2016：46.
[13] 都静，张晓明，吴姗姗.胱抑素C与同型半胱氨酸在糖尿病早期肾功能损害及中医证型间相关性分析[J].辽宁中医药大学学报，2018，20（11）：160-162. doi：10. 13194/j.issn.1673-842x.2018.11.045.
[14] 吴以岭.络病学概要[J].疑难病杂志，2004，3（1）：37-39.
[15] 桂欣悦.胱抑素C、同型半胱氨酸与2型糖尿病中医证型的相关性研究[D].上海：上海中医药大学，2017.
[16] 庄徽，蔡晓敏，张启高.高同型半胱氨酸血症与心血管疾病相关性研究进展[J].中国实用诊断与治疗杂志，2014， 28（5）：433-434. doi：10.3969/j.issn.1006-1959.2015. 36.268.
[17] 高言歌.Ⅳ型胶原、同型半胱氨酸与糖尿病肾病中医证型的相关性研究[D].南宁：广西中医药大学，2015.
[18] 黄焕宜，谢淑贤，肖树荣，等.血清CysC、Hcy和尿ALB/Cr检测对糖尿病肾病的早期诊断价值[J].中华保健医学杂志，2019，21（2）：183-184. doi：10.3969/.issn.1674-3245.2019.02.030.
[19] 李敏州，武忠，张瑞霞，等.中药太灵丹对STZ诱导糖尿病肾病大鼠肾脏保护作用的影响[J].西部中医药，2018， 31（12）：5-9.
[20] 王倩，严美花，李平，等.糖尿病肾病中医证候的现代研究[J].世界中医药，2018，13（6）：1320-1324，1331.
[21] 吕仁和.糖尿病及其并发症中西医诊治学[M].北京：人民卫生出版社，1997：128-130.
[22] 李兴，赵宝珍，白秀平，等.同型半胱氨酸在2型糖尿病微血管病变发病中作用的研究[J].中国微循环，2006， 10（2）：79-81.
[23] 董慧君.六味地黄丸对早期糖尿病肾病合并高同型半胱氨酸血症大鼠肾功能影响的实验研究[D].成都：成都中医药大学，2008. doi：10.7666/d.d168033.
[24] 唐爱华，王振刚，李吉武，等.糖尿病肾病中医证型与Ⅳ型胶原、同型半胱氨酸的相关性研究[J].中医临床研究，2016，8（17）：18-20. doi：10.3969/j.issn.1674-7860. 2016.17.005.
[25] 刘玉栋，孟祥云，程涛，等.糖尿病肾病中西医发病机制及治疗概述[J].西部中医药，2019，32（7）：134-138.
[26] Ramanathan G，Harichandana B，Kannan SS，et al. Association between end-stage diabetic nephropathy and MTHFR （C677T and A1298C） gene polymorphisms [J]. Nephrology（Carlton），2019，24（2）：155-159. doi：10.1111/nep.13208.