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Progress of experimental research in the treatment of bronchial asthma with Chinese medicine based on NF-κB signaling pathway |
WU Mingyun1,2 YU Jian′er1 BAI Li3 XUE Zheng1,3 JIANG Shenhua1,2 XU Wanchao1,2 |
1.Institute of Pediatrics of Traditional Chinese Medicine Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200071, China;
2.Shanghai Clinical College of Traditional Chinese Medicine Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 201203, China; 3.Department of Pediatrics, Shanghai Municipal Hospital of Traditional Chinese Medicine Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200071, China |
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Abstract This paper reviews the experiment research progress of Chinese medicine in the treatment of bronchial asthma via nuclear factor-κB (NF-κB) signaling pathway. NF-кB signaling pathway can regulate immune/inflammatory cells and airway structure cells, inducing the occurrence and development of bronchial asthma. In recent years, experimental studies have shown that a variety of traditional Chinese medicine compounds, traditional Chinese medicine single-drugs and their extracts and traditional Chinese medicine monomers can be passed inhibits NF-κB pathway, improves asthma symptoms, reduces airway inflammation and airway hyperresponsiveness, reverses airway remodeling, and achieves significant effects in preventing and treating bronchial asthma.
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