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| Study on the rule of traditional Chinese medicine in the treatment of hot flashes related to endocrine therapy of breast cancer |
| ZHANG Ying1 LIU Qing2 ZHOU Xin1 LYU Lingyan1 WAN Donggui2 |
1.Clinical Medical College, China-Japan Friendship Hospital, Beijing University of Chinese Medicine, Beijing 100029, China;
2.Internal Oncology Department of Integrated Chinese and Western Medicine, China-Japan Friendship Hospital, Beijing 100029, China |
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Abstract Objective To explore the rules of traditional Chinese medicine on hot flashes related to endocrine therapy of breast cancer. Methods Clinical researches about hot flashes related to endocrine therapy were collected by using CNKI, Wanfang and VIP from the time of the database established to July 2019, with the terms “traditional Chinese medicine, breast cancer, endocrine therapy, hot flashesl”. The medication frequency of efficacy, four qi, five flavors and meridian entry were analyzed. The association rules and cluster analysis were used to find the drug pairs and the new formulas. Results Sixty-two articles were included, involving 114 medicines. The most used ones were Radix Paeoniae Alba. The most frequently used were tonifying and heat-clearing medicines. The medicines those were sweet and cold were widely used and the meridians of traditional Chinese medicine were mainly liver and kidney. 10 drug pairs and 4 new formulas were found by date mining. Conclusion Nourishing liver and kidney, soothing liver and relieving depression, nourishing yin and clearing heat are the main methods in the treatment of hot flashes related to endocrine therapy of breast cancer.
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