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| Research progress of ginseng and ginsenoside in the treatment of rheumatic diseases |
| HAN Guangtao LI Haohuan |
| Department of Orthopedics, Renmin Hospital of Wuhan University, Hubei Province, Wuhan 430060, China |
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Abstract Inflammation protects the body from pathogens and danger signals caused by cellular changes. Although inflammation is a host defense mechanism, chronic inflammation is considered a major risk factor for the development of various inflammatory autoimmune diseases. Rheumatic diseases are systemic inflammatory and degenerative diseases, which mainly affect connective tissue and can lead to severe chronic connective tissue inflammation, ultimately leading to the degeneration of connective tissue. Ginseng and its ginsenoside have been proved to have anti-inflammatory activities and pharmacological effects on a variety of rheumatic diseases by inhibiting the expression and production of inflammatory mediators. This review gives a brief overview of ginseng and ginsenoside, and discusses recent studies on their pharmacological effects on the pathogenesis of rheumatic diseases. These insights may facilitate the development of ginseng and ginsenoside drugs to prevent and treat rheumatic diseases.
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