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2018 Vol. 15, No. 35 Published: 2018-12-15

	8	Preliminary screening of differentially expressed genes in Inner Mongolia special constitutions based on transcriptome sequencing
		XUE Ziping KANG Lujiao ZHANG Yajun
		Objective To study the differential gene expression in the special constitution and the moderate constitution of Inner Mongolia by using the transcriptome sequencing technology, in order to explore the genesis, characteristics and related mechanisms of allergic diseases from the molecular level. Methods From September 2015 to September 2016, the Affiliated Hospital of Inner Mongolia Medical University, Tongliao City Hospital and the Physical Examination Center of Bayanur Hospital were investigated by epidemiology. The special constitution and the moderate constitution of the three generations of ancestors living in Inner Mongolia were selected as the research objects, the peripheral blood of 10 subjects were taken for transcriptome sequencing. Group sequencing and qPCR were used to verify the correlation between some differentially expressed genes and their related pathways and special constitution. Results Compared with moderate constitution, among all down-regulated genes in special constitution, HLA-DRB1, HLA-DRB5 and HLA-DQA2 were enriched in the asthma pathway; Toll like receptor 2 (TLR2) differentially expressed genes were enriched in the TLR signaling pathway, which was closely related to the special constitution. The qPCR test showed that the relative expression of CPNE3 genes in the special constitution was higher than that in the moderate constitution, the difference was statistically significant (P ＜ 0.05). Conclusion HLA class Ⅱ genes are closely related to special constitution and differentially express in the special constitution; TLR signaling pathway involved by gene TLR2 reflects that the signal transduction mechanism of allergic diseases may be closely related to special constitution; CPNE3 gene expression differences in special constitution and moderate constitution, indicating that there may be some differences in the expression of the two constitutions, but further studies are needed.
		2018 Vol. 15 (35): 8-11,16 [Abstract] ( 377 ) HTML (1 KB) PDF (966 KB) ( 110 )

	12	Effects of Epimedii Folium, Ligustri Lucidi Fructus and synergy of the two herbs on bone mass and endocrine organs in postmenopausal osteoporosis rats
		LI Xiaoxi1 CHEN Yuheng1 TANG Xiufeng1 GAO Yingying1 YU Ping1 MA Zitong1 LIU Renhui1,2
		Objective To research the effects of Epimedii Folium, Ligustri Lucidi Fructus and synergy of the two herbs on bone mass and endocrine organs in postmenopausal osteoporosis rats. Methods Forty-eight female SD rats of SPF level were divided into sham group, model group, Epimedii Folium group, Ligustri Lucidi Fructus group, synergy of Epimedii Folium and Ligustri Lucidi Fructus group (synergy group) and Raloxifene group (positive drug group) by random number table method. Except for sham group, the other groups were taken bilateral oophorectomy, and all rats were administrated with the corresponding medicines from postoperative 1 week to postoperative 12 weeks. The bone mass of right femurs was detected, and the uterus, adrenal gland and pituitary were collected to take hematoxylin-eosin staining and pathometriometric analysis. Results Compared with sham group, the bone mass, the uterus index, adrenal index and pituitary index in the model group were decreased significantly (P ＜ 0.05 or P ＜ 0.01), the endometrial thickness, uterine wall thickness, and the ratio of endometrial thickness to uterine wall thickness, the thickness of adrenal zona fasciculate, zona glomerulosa and cortex, and the number of basophil cells of pituitary in the model group were decreased significantly (P ＜ 0.05 or P ＜ 0.01). Compared with the model group, Epimedii Folium group, Ligustri Lucidi Fructus group and synergy group could significantly increase the bone mass, endometrial thickness, uterine wall thickness, and the ratio of endometrial thickness to uterine wall thickness, the thickness of adrenal zona fasciculate, zona glomerulosa and cortex and the number of basophil cells of pituitary (P ＜ 0.05 or P ＜ 0.01); synergy group could ignificantly increase adrenal index (P ＜ 0.05); synergy group and Epimedii Folium group could significantly increase pituitary index (P ＜ 0.01). Conclusion The effects of Epimedii Folium, Ligustri Lucidi Fructus and synergy of the two herbs in prevention and treatment of osteoporosis in rats with postmenopausal osteoporosis may be related to the improvement of the function of the endocrine organs.
		2018 Vol. 15 (35): 12-16 [Abstract] ( 297 ) HTML (1 KB) PDF (554 KB) ( 101 )

	17	Role mechanism of Metformin combined with Paclitaxel in inducing apoptosis of human breast cancer cell MCF-7
		LIANG Junwei1 FANG Zhihua2 LI Qingshan1 LYU Xiying1
		Objective To explore the role mechanism of Metformin combined with Paclitaxel in inducing apoptosis of human breast cancer cell MCF-7. Methods CCK-8 kit was used to detect the 50% inhibitory concentration (IC50 value) of cell proliferation after 48 h of single action of different concentrations of Metformin (0.25, 0.50, 1.00, 2.00, 4.00 mmol/L) or Paclitaxel (0.025, 0.050, 0.100, 0.200, 0.400 μmol/L) or two combined action on MCF-7 cell. And the flow cytometry was used to detect the cell cycle distribution after 48 h action of Metformin or Paclitaxel on MCF-7 cell. And Western blot method was used to detect the expression levels of MAPK pathway protein and Bcl-2, Bax proteins after 48 h of single action of Paclitaxel or Metformin or two combined action on MCF-7 cell. Results Low concentration of Metformin (0.25-4.00 mmol/L) combined with Paclitaxel (0.025-0.400 μmol/L) had a synergistic effect (CI<1). sp600125 could significantly inhibite MCF-7 cell proliferation, and the inhibitory effect of MCF-7 cell proliferation by Metformin combined with Paclitaxel was stronger than that by single action of the two. The number of G2/M phase cells by combined action of Metformin and Paclitaxel were less than by single action of Paclitaxel, but more than by single action of Metformin. The expression levels of p-JNK/SAPK and p-p38 proteins after 48 h of Metformin combined with Paclitaxel on MCF-7 cell were significantly higher than those by single action of the two, and the expression levels of p-ERK and Bcl-2 proteins were decreased (P < 0.05). Conclusion Metformin combined with Paclitaxel has a synergistic effect on human breast cancer cell MCF-7, and its inhibitory effect on cells is significantly enhanced when combined with sp600125. Metformin combined with Paclitaxel can inhibit cell aggregation and ERK pathway in G2/M phase, activate JNK and p38 pathway, and reduce the ratio of Bcl-2 and Bax proteins.
		2018 Vol. 15 (35): 17-21,25 [Abstract] ( 259 ) HTML (1 KB) PDF (841 KB) ( 121 )

	22	Effect of naringenin pretreatment on the energy metabolism after heart injury induced by ischemia/reperfusion in rats
		MENG Limin
		Objective To investigate the effect of naringenin pretreatment on the energy metabolism after heart injury induced by ischemia/reperfusion in rats. Methods According to random number table method, 50 adult male Sprague-Dawley (SD) rats were divided into five groups (n = 10): blank control group, modle group, and low, medium, high dose of naringenin group (5, 10, 20 μmol/L). The heart of rat in each group was treated with 30 min global ischemia followed by 120 min reperfusion; the rats of low, medium, high dose of naringenin group were treated with 5, 10, 20 μmol/L of naringenin perfusion before ischemia; after reperfusion, the myocardial content of lactate dehydrogenates and myocardial infarct size in each group were examined, the activities of Na+/K+-ATPase and Ca2+/Mg2+-ATPase in myocardial tissue were detected. Results After ischemia/reperfusion injury, compared with modle group, the contents of lactate dehydrogenates in low, medium, high dose of naringenin group were significantly decreased (P ＜ 0.05 or P ＜ 0.01), the myocardial infarct size was significantly reduced (P ＜ 0.05 or P ＜ 0.01), the activities of Na+/K+-ATPase and Ca2+/Mg2+-ATPase in myocardial tissue were significantly improved (P ＜ 0.05). Conclusion Narigenin palys a cardioprotective role may be through enhancing the myocardial energy metabolism of rats with ischemia/reperfusion.
		2018 Vol. 15 (35): 22-25 [Abstract] ( 205 ) HTML (1 KB) PDF (535 KB) ( 331 )

	26	Research progress on migraine and digestive diseases
		DU Na Meng Xiaoli YU Tingmin YAO Gang▲
		Migraine is a common and chronic recurrent neurovascular dysfunction, which seriously affects the life quality of patients. The pathogenesis of migraine is complex and related to many factors, and is not entirely clear. In recent years, it has been found that migraine has a close relationship with many diseases in the digestive system, such as Helicobacter pylori infection, irritable bowel syndrome, gastroparesis, liver and gallbladder disease and intestinal flora disorder. This article reviews the research on the correlation between migraine and digestive system diseases, and explores the co-development of migraine and digestive system diseases. It is expected to provide new ideas for the study of the pathogenesis and treatment of migraine.
		2018 Vol. 15 (35): 26-29 [Abstract] ( 284 ) HTML (1 KB) PDF (570 KB) ( 149 )

	30	Research progress of miRNAs in gastric and liver cancer
		XIONG Xianhui1,2 AO Hongshun1,2 FENG Yingting1,2 LAN Zhenwei1,2 DING Lei1,2 CUI Qinghua1,2
		microRNA (miRNA) is a class of short nucleotide sequence with only 20-24 nt, which is widely expressed in multicellular eukaryotes. miRNA regulates the target genes in post-transcriptional level by pairing with complimentary mRNAs. A great deal of recent studies showed that miRNAs play vital roles in many biological processes, such as cell proliferation, differentiation and apoptosis, they also involved in various cancer regulations. In China, the incidence of gastric and liver cancers increased significantly due to the alterations on the nutrition, environment and genetics following the economic development, which raised more heath concerns. This review focused on the miRNAs identified in these cancers, and addressed the regulatory mechanisms underlying the occurrence and development in the gastric and liver cancers. It would provide better understandings of the importance of miRNAs in these diseases and guide to the further research.
		2018 Vol. 15 (35): 30-33 [Abstract] ( 248 ) HTML (1 KB) PDF (576 KB) ( 54 )

	34	Research progress of leukemia complicated with epilepsy
		WANG Wenjie1,2 LIU Jinyu1,2 CHEN Xiaoqian1,2 YAN Lingzhi3 HU Xiaowei1,2
		Leukemia is a common malignant hematological disease in the clinic, and it can induce seizures or epilepsy during the treatment. This article reviews the latest literature on leukemia complicated with epilepsy and finds that leukemia with seizures and epilepsy are mainly caused by reversible posterior encephalopathy syndrome, hematopoietic stem cell transplantation and chemotherapy. Therefore, the promotion of leukemia treatment and active prevention of seizures are of great significance for improving the prognosis of patients.
		2018 Vol. 15 (35): 34-38 [Abstract] ( 235 ) HTML (1 KB) PDF (589 KB) ( 82 )

	39	Research progress in imaging of wrist injuries
		JIANG Jie1 LIANG Zhibo1 YOU Zhuangzhi2▲
		The anatomy of the wrist joint is complex and easily damaged. As a routine examination, the X-ray is often difficult to clearly distinguish the fracture site and the degree of injury due to skeletal overlap. Multi-slice spiral CT and post-processing techniques can clearly show the location and dislocation of the fracture, but the damage to the articular cartilage, tendon and ligament is less than that of magnetic resonance imaging. With the improvement and development of ultrasound technology, the evaluation of wrist injury has added a new method of image examination. It is of great significance to make full use of various imaging methods and to apply a variety of inspection techniques to diagnose wrist injuries. This article reviews the research progress of different imaging examination methods for the diagnosis of wrist injury.
		2018 Vol. 15 (35): 39-42 [Abstract] ( 265 ) HTML (1 KB) PDF (573 KB) ( 44 )

	43	Research progress on health education and management of cervical spondylosis
		MEI Rong JING Rong
		Cervical spondylosis is a degenerative disease of the cervical joint and its accessory structures. Health education is an important way to strengthen the self-management of patients with cervical spondylosis. Cervical spondylosis health education management contains two aspects, that is health education management mode and content. Hospital-centered, community-centered and hospital-community-family integration modes are the mainly modes at present. Basic knowledge of cervical spondylosis, living habbit, physical exercise and psychological counseling form the mainly content of health education management. Self-management and self-efficacy, a new idea that is brought in the health education management improves the quality of health education management significantly. This article reviews the health education management mode and health education content of cervical spondylosis, in order to provide guidance and reference for the health education and management of cervical spondylosis.
		2018 Vol. 15 (35): 43-46 [Abstract] ( 258 ) HTML (1 KB) PDF (603 KB) ( 127 )

	47	Influence of common metal ions on biological activity of Acinetobacter baumannii
		YUAN Weixi LIU Haiping CAO Shunwang YU Feng CHEN Wenfang LIU Liya
		Acinetobacter baumannii is the main pathogenic bacteria of hospital acquired infection. Multiple drug resistant Acinetobacter baumannii is rapidly increasing in clinical practice, which leads to a difficulty of anti-infection treatment. It is an urgent need to find better ways to effectively inhibit Acinetobacter baumannii. Metal ions are necessary to sustain the physiological process and keep virulence active in bacteria. They have been used to deal with bacterial infections before the advent of antibiotics. In this review, we focused on the influence of metal ions (Fe, Zn, Mn, Cu, etc.) on the bioactivity of Acinetobacter baumannii. We aimed to make the researchers fully understand the bacteriostasis of metal ions and supply new ways for the treatment of Acinetobacter baumannii infection.
		2018 Vol. 15 (35): 47-49,57 [Abstract] ( 196 ) HTML (1 KB) PDF (925 KB) ( 206 )

	50	Prevalence of overweight and obesity among high-school student in Central District of Ji′nan City in Shandong Province and discussion on TCM interventions
		XIN Yanyan1 CONG Deyu1 ZHANG Wei2 ZHANG Guiju3
		Objective To study the prevalence overweight and obesity among high-school student (aged between 15 and 17) in Central District of Ji′nan City, Shandong Province, aimed at providing a scientific basis for further study, and developing effective control measures. Methods The data of health examination collected by Ji′nan City Central Bureau of Education in November, 2017 were used. A total of 12 253 students in five high-schools in Central District Ji′nan were sampled as research object. The height and weight data were measured and collected. The overweight and obesity were defined according to the body mass index (BMI) screening criteria for Chinese school-aged children recommended by Li Hui. Results In Central District of Ji′nan City, Shandong Province, the overweight rate and obesity rate were 21.29% and 11.32% respectively. There were statistically significant difference between boys and girls both in overweight and obesity (P < 0.01), the overweight rate had a statistically significant difference among all age groups (P < 0.05), but the obesity rate had no statistically significant difference among all age groups (P > 0.05). The overweight and obesity rate had a downward trend with the increasing age in high-school student. Conclusion The detection rate of overweight and obesity in high-school student in Central District of Ji′nan City, Shandong Province were higher than national average level. We should execute early strategies and measures to control the overweight and obesity rate.
		2018 Vol. 15 (35): 50-53 [Abstract] ( 208 ) HTML (1 KB) PDF (371 KB) ( 263 )

	54	Effect of complex fractionated atrial electrograms combined with circumferential pulmonary vein isolation on atrial function in patients with persistent atrial fibrillation
		BAI Baobao WANG Fangfang▲ LIU Xiongtao ZENG Di LIAN Cheng LI Xue
		Objective To investigate the effect of complex fractionated atrial electrograms (CFAE) combined with circumferential pulmonary vein isolation (CPVI) on atrial function in patients with persistent atrial fibrillation. Methods A total of 124 patients with persistent atrial fibrillation having received treatment in the Second Affiliated Hospital of PLA Air Force Military Medical University from March 2014 to March 2017 were selected and they were divided into CPVI group and CPVA+CFAE group by random number table method, with 62 cases in each group. All the patients admitted to the hospital were routinely examined, and the operation time and X-ray fluoroscopy time of the two groups were recorded, and the operation results, ablation after the end of atrial fibrillation of the two groups were analyzed and compared. After 12 months′ follow-up, Kaplan-meier survival curve was used to analyze the maintenance of sinus rhythm in the two groups. Results The operation time of the CPVI+CFAE group was longer than that of the CPVI group, and the difference was statistically significant (P ＜ 0.05). The postoperative status and complications of the two groups were compared, and the differences were statistically significant (P ＜ 0.05). Kaplan-meier survival curve analysis showed that the maintenance rate of sinus rhythm in the CPVI+CFAE group was significantly higher than that in the CPVI group (P < 0.05). Conclusion CPVI+CFAE combined with ablation in the treatment of persistent atrial fibrillation has a high success rate in the termination or transformation during ablation, which can terminate or transform persistent atrial fibrillation into atrial tachycardia to a largest degree, and the maintenance rate is high.
		2018 Vol. 15 (35): 54-57 [Abstract] ( 243 ) HTML (1 KB) PDF (597 KB) ( 97 )

	58	Connection of homocysteine, hig sensitivity C-reative protein and cystatin C with coronary atherosclerosis
		KUAI Lin HONG Mei▲
		Objective To explore the connection between levels of serum homocysteine (Hcy), high sensitivity C-reative protein (hs-CRP) and cystatin C (Cys C) and coronary atherosclerotic. Methods A total of 245 patients accepting Multi-Slics spiral CT coronary angiography (MSCTCA) in Department of Cardiology, the Second Affiliated Hospital of Nanjing Medical University from August 2016 to January 2018 were selected. According to whether coronary stenosis≥50% or not, all the cases were divided into non coronary stenosis group (90 cases) and coronary stenosis group (155 cases)(116 patients with hypertention). According to number of affected vessel with coronary stenosis≥50%, all the cases were divided into single vessel affected group (48 cases), double vessels affected group (45 cases), multiple vessels affected group (62 cases). According to degree of coronary artery stenosis, the patients were divided into four groups: degreeⅠ group: reduced lumen area 1%-25% (30 cases); degree Ⅱ group: reduced lumen area ＜25%-50% (60 cases); degree Ⅲ group: reduced lumen area ＜50%-75% (120 cases); degree Ⅳ group: reduced lumen area ＜75%-100% (35 cases). Hcy, hs-CRP and Cys C were compared among the coronary atherosclerotic with different types. Results Compared with the non coronary stenosis group, Hcy, hs-CRP and Cys C coronary in the stenosis group were higher (P ＜ 0.05). Compared with coronary stenosis group, Hcy, hs-CRP and Cys C of patients with hypertension of coronary stenosis group were higher (P ＜ 0.05). Compared with the non coronary stenosis group, Hcy, hs-CRP, Cys C were higher in the other groups (P ＜ 0.05). Compared with the single vessel affected group, Hcy, hs-CRP in double vessels affected group and multiple vessels affected group were higher (P ＜ 0.05). Compared with the dagree Ⅰgroup, Hcy, hs-CRP, Cys C were higher in the degreeⅡ-Ⅲ groups, Hcy, hs-CRP in the degree Ⅳ group were higher (P ＜ 0.05). Compared with the dagree Ⅱ group, Hcy, hs-CRP, Cys C in the degree Ⅲ group were higher, Hcy, hs-CRP in the degree Ⅳ group were higher (P ＜ 0.05). Compared with the dagree Ⅲ group, Hcy, hs-CRP in the degree Ⅳ group were higher (P ＜ 0.05). Conclusion High levels of serum Hcy, hs-CRP and Cys C have relationship with coronary atherosclerosis. Combined with normal test, regularly testing the levels of serum Hcy, hs-CRP and Cys C is helpful for the evaluation of coronary artery affected vessel number and stenosis degree, which can guide clinical treatment and improve coronary atherosclerosis patients′ treatment efficacy and prognosis.
		2018 Vol. 15 (35): 58-61 [Abstract] ( 226 ) HTML (1 KB) PDF (552 KB) ( 152 )

	62	The anticoagulant efficacy and safety of Bivalirudin on primary percutaneous coronary intervention in female patients with acute ST-segment elevation myocardial infarction
		WANG Wenbin CAO Xingmei LI Xin CHENG Guojie TANG Xuehong
		Objective To evaluate anticoagulant efficacy and safety of Bivalirudin on primary percutaneous coronary intervention (PCI) in female patients with acute ST-segment elevation myocardial infarction (STEMI). Methods A total of 182 female patients diagnosed with STEMI undergoing primary PCI in Beijing Daxing District People′s Hospital from January 2016 to January 2018 were selected. According to the using of anticoagulant drugs during primary PCI, they were divided into Bivalirudin group (94 cases) and Heparin with or without Tirofiban group (88 cases). Major adverse cardio cerebral vascular events (MACCE), including cardiac death, non-lethal myocardial infarction, revascularization, stent thrombosis, and ischemic stroke, during hospitalization and within 30 days after primary PCI were evaluated. Bleeding events during hospitalization and within 30 days after primary PCI were evaluated. Results After 30 days′ follow-up, 2 patients occurred MACCE in the Bivalirudin group and 5 patients in the Heparin with or without Tirofiban group, there was no statistically significant difference (P ＞ 0.05). There was no statistically significant difference in bleeding events ratio between the two groups (P ＞ 0.05), but the incidence of hemorrhage during 30 days′ follow-up in the Heparin with or without Tirofiban group was higher than that in the Bivalirudin group, and the difference was statistically significant (P ＜ 0.05). Conclusion To female patients with acute ST- segment elevation myocardial infarction, it can achieve the same anticoagulant effects with better safety by Bivalirudin when the patients are treated with PCI.
		2018 Vol. 15 (35): 62-65,73 [Abstract] ( 210 ) HTML (1 KB) PDF (568 KB) ( 182 )

	66	Relationship between left atrial diameter, high sensitivity C reactive protein, brain natriuretic peptide and non-valvar atrial fibrillation in elderly patients
		ZHANG Lin1 CHEN Yanjiong1 WU Boyun2 LIU Junhui1 HONG Zhou2 LI Na3 FENG Jing1 TAO Dan1
		Objective To investigate the relationship between left atrial diameter (LAD), high sensitivity C reactive protein (hsCRP), brain natriuretic peptide (BNP) and non-valvar atrial fibrillation in elderly patients. Methods A total of 103 elderly patients with non-valvular atrial fibrillation admitted to the First Affiliated Hospital of Xi′an Jiaotong University ("our hospital" for short) from February 2015 to December 2017 were enrolled as the study group; 90 patients with senile non-atrial fibrillation who had sinus rhythm in the same period were selected as the control group. According to the classification of atrial fibrillation, the study group was divided into paroxysmal (n = 28), persistent (n = 34), permanent (n = 41). Patients in the study group were divided into non-thrombotic group (n = 61) and thrombotic group (n = 42) according to whether there was thrombosis in the left atrium. The hsCRP, BNP and LAD of the patients with different atrial fibrillation, non-thrombosis and thrombosis groups were compared between the control group and the study group and the study group. Pearson analysis was used to analyze the correlation between hsCRP, BNP and LAD in the study group. Multivariate Logistic regression analysis was used to analyze the influencing factors of non-valvar atrial fibrillation. Results The hsCRP, BNP and LAD of the study group were higher than those of the control group (P < 0.05). Patients with permanent, persistent atrial fibrillation had higher hsCRP, BNP, and LAD than patients with paroxysmal atrial fibrillation, and patients with permanent atrial fibrillation were more likely to have persistent atrial fibrillation (P < 0.05). The levels of hsCRP, BNP and LAD in thrombotic group were higher than those in non-thrombotic group (P < 0.05). There was a positive correlation between LAD and hsCRP and BNP in the study group(r = 0.468, 0.517, all P ＜ 0.01). Multivariate Logistic regression analysis showed that hsCRP, BNP and LAD were influencing factors of non-valvar atrial fibrillation in elderly patients(P < 0.01). Conclusion HsCRP, BNP and LAD are closely related to the occurrence and development of non-valvar atrial fibrillation in elderly patients.
		2018 Vol. 15 (35): 66-69 [Abstract] ( 218 ) HTML (1 KB) PDF (562 KB) ( 67 )

	70	Clinical effect of Yiqi Fumai Injection combined with statins in the treatment of chronic heart failure complicated with atrial fibrillation
		SU Haiyan1 WANG Kelong2
		Objective To investigate the clinical effect of Yiqi Fumai Injection combined with statins in the treatment of chronic heart failure (CHF) with atrial fibrillation. Methods A total of 103 patients with CHF and atrial fibrillation who were admitted to the No.215 Hospital of Shaanxi Nuclear Industry from January 2016 to December 2017 were divided into the control group (n = 51) and the observation group (n = 52) by random number table method. The control group was given Rosuvastatin on the basis of conventional treatment, and the observation group was given Yiqi Fumai Injection on the basis of the control group. N-terminal B-brain natriuretic peptide (NT-proBNP) level, 6-min walking distance (6MWT), left ventricular end-diastolic diameter (LVEDd), left ventricular short-axis shortening rate (LVFS), left ventricle were observed before and after treatment. The recurrence rate of paroxysmal atrial fibrillation, the incidence of permanent atrial fibrillation and clinical efficacy were calculated. Results Compared with before treatment, the levels of 6MWT, LVFS and LVEF in the two groups were significantly increased after treatment (P < 0.05), and the observation group was significantly higher than the control group (P < 0.05). The levels of NT-proBNP and LVEDd in the two groups after treatment were significantly lower than those before treatment (P < 0.05), and the observation group was significantly lower than the control group (P < 0.05). The recurrence rate of atrial fibrillation and the rate of conversion to permanent atrial fibrillation in the observation group were significantly lower than those in the control group (P < 0.05). The clinical effective rate in the observation group was higher than that in the control group, and the difference was statistically significant (P < 0.05). Conclusion Yiqi Fumai Injection combined with Rosuvastatin can reduce NT-proBNP levels in patients with CHF complicated with atrial fibrillation, improve cardiac function, and effectively control ventricular rate, which is worthy of clinical promotion and application.
		2018 Vol. 15 (35): 70-73 [Abstract] ( 246 ) HTML (1 KB) PDF (546 KB) ( 108 )

	74	The effect of Argatroban sequential therapy combined with Safflower Yellow Pigment in the treatment of multiple lacunar cerebral infarction in the elderly
		WANG Hongjiao1 ZHOU Jiexin1 MU Yuyuan1 LIU Yang1 TAN Chenxi1 MENG Xin2▲
		Objective To discuss the effect in the treatment of senile multiple lacunar infarction with Argatroban sequential therapy and Safflower Yellow Pigment. Methods One hundred and eighteen elderly patients with multiple lacunar cerebral infarction admitted to the Department of Neurology, the Second Affiliated Hospital of Qiqihar Medical University from December 2015 to December 2016 were selected as the study objects. The random number table method was used to divide the patients into observation group and the control group, with 59 cases in each group. The control group was treated with Argatroban sequential therapy on the basis of conventional drugs, while the observation group was treated with Safflower Yellow Pigment on the basis of the treatment regimen of the control group, and the therapeutic effect, neurological function, cerebral blood flow velocity and the effect on liver and kidney function and coagulation indexes were compared between the two groups. Results After 2 months of treatment, the therapeutic effect of the two groups was compared, and the difference was statistically significant (P ＜ 0.05). The scores of national institule of health seroke scale (NIHSS) and medified rankin scale (MRS) of the two groups after treatment were lower than those before treatment, the differences were statistically significant (P ＜ 0.05). The NIHSS and MRS scores of the observation group were lower than those of the control group after treatment, the differences were statistically significant (P ＜ 0.05). After treatment, the maximal blood flow velocity in the systolic period of basilar artery (BA), middle cerebral artery (MCA) and anterior cerebral artery (ACA) of intracranial vessels in the two groups were higher than those before treatment, the differences were statistically significant (P ＜ 0.05). After treatment, the rates of BA, MCA and ACA in the observation group were significantly higher than those in the control group, with statistically significant differences (P ＜ 0.05). There was no statistically significant difference in liver and kidney function and coagulation indexes between the two groups before and after treatment (P ＞ 0.05), and no serious adverse drug reactions occurred during the treatment. Conclusion Argatroban sequential therapy combined with Safflower Yellow Pigment can effectively treat multiple lacunar cerebral infarction in the elderly, improve the neurological defects and disability of patients, and promote blood supply to brain tissues.
		2018 Vol. 15 (35): 74-77,81 [Abstract] ( 223 ) HTML (1 KB) PDF (441 KB) ( 120 )

	78	Effect of Butylphthalide on acute cerebral infarction complicated with mild cognitive impaiment
		WANG Yanru
		Objective To investigate the effect of butylphthalide on acute cerebral infarction complicated with mild cognitive dysfunction. Methods From June 2017 to March 2018, 120 patients with acute cerebral infarction combined with mild cognitive impairment who were hospitalized in the Second Department of Internal Medicine of Jizhou District Hospital in Hengshui City, Hebei Province were selected. According to the random number table, all patients were divided into observation group and control group, each group of 60 cases. The control group received the routine drug treatment, the observation group was treated with Batylphthdide on the basis of ontrol group, two groups received continuous treatment of 14 d. After treatment, the scores of the mini-mental state examination (MMSE) and the clinical efficacy of the two groups were compared. Results There was no significant difference in MMSE scores before treatment between the two groups (P ＞ 0.05). The time, place, instant memory, attention and computational power, delayed memory, language and visuospatial scores of the observation group were significantly higher than those of the control group, with statistically significant differences (P ＜ 0.05). After treatment, the total clinical efficacy of the observation group was significantly higher than that of the control group, with statistically significant difference (P ＜ 0.05). Conclusion The efficacy of Butylphthalide in the treatment of acute cerebral infarction complicated with mild cognitive impainnent is definite, which can significantly improve the cognitive dysfunction of patients and is worthy of wide clinical application.
		2018 Vol. 15 (35): 78-81 [Abstract] ( 255 ) HTML (1 KB) PDF (443 KB) ( 61 )

	82	Expression of CD44 and Nanog in tissues with epithelial ovarian cancer and its clinical significance
		DU Wensheng WEI Min
		Objective To explore the expression levels of CD44 and transcription factor Nanog in tissues with epithelial ovarian cancer and its clinical significance. Methods A total of 80 ovarian tissues of patients with epithelial ovarian cancer treated by operation in Affiliated Hospital of Xuzhou Medical University from January to December 2012 were collected as case group. At the same time, 60 ouarian tissues of patients with benign ovarian tumors were randomly selected as control group. The expression levels of CD44 and Nanog of two groups were detected by immunohistochemistry. Results The positive expression rate of CD44 and Nanog in case group were both higher than the control group, the differences were statistically significant (P < 0.05). The positive rate in patients with tumor diameter ≥ 3 cm, low differentiation, T3+T4 stage of infiltration depth, FIGO stage Ⅲ+Ⅳ, lymph node metastasis were higher than those with tumor diameter <3 cm, medium and high differentiation, T1+T2 stage of infiltration depth, FIGO stage Ⅰ+Ⅱ, no lymph node metastasis, the differences were statistically significant (P < 0.05). Spearman rank correlation analysis showed that a positive correlation between CD44 and Nanog expression in case group was found (rs = 0.592, P < 0.05). The 5-year survival rate in patients with CD44 positive expression was lower than that in patients with CD44 negative expression, and the 5-year survival rate in patients with Nanog positive expression was lower than that in patients with Nanog negative expression, the differences were statistically significant (P < 0.05). Conclusion The up-regulated expression of CD44 and Nanog is involved in the occurrence and development of epithelial ovarian cancer. Early detection of CD44 and Nanog can be used as an important markers for diagnosing epithelial ovarian cancer and evaluating the severity of disease and predicting prognosis.
		2018 Vol. 15 (35): 82-85,93 [Abstract] ( 247 ) HTML (1 KB) PDF (506 KB) ( 159 )

	86	Predictive value of hemoglobin level during early pregnancy in gestational diabetes mellitus
		WANG Lu1 ZHANG Tianchi1 LI Ping2
		Objective To explore the predictive value of hemoglobin (Hb) level during early pregnancy gestational diabetes mellitus. Methods A total of 124 gestational diabetes mellitus in Chengdu Women′s and Children′s Center Hospital ("our hospital " for short) from March 2016 to December 2017 were selected as case group. At the same time, 50 healthy pregnant women who were admitted to our hospital for prenatal examination were randomly selected as control group. The basic data such as age, height, weight, etc were recorded, the glucose tolerance (GTT), glycosylated hemoglobin and the blood routine were detected, the predictive value of Hb for gestational diabetes mellitus was analyzed. Results The pregnancy women over 35 years old and body mass index (BMI)≥24 kg/m2 had a higher proportion in case group than those in control group, the levels of fasting blood glucose, blood glucose, HbA1c, Hb, platelet (PLT), red blood cell (RBC) in case group were higher than those in control group, the differences were statistically significant(P < 0.05). Multivariate Logistic regression analysis showed that age, BMI, fasting blood glucose, 2 h post-meal blood glucose, HbA1c, Hb, PLT and RBC were the independent risk factors for gestational diabetes mellitus (OR = 1.147, 1.096, 1.229, 1.191, 1.353, 1.195, 1.226, 1.124, all P < 0.05). The area under the ROC curve was used to assess the predictive value of Hb in gestational diabetes mellitus during the first trimester, the results showed that the area under ROC curve was 0.882 (95%CI: 0.753, 0.921), and the sensitivity, specificity, accuracy were 0.76, 0.83, 0.79, respectively, the best cutoff value for Hb was 129.76 g/L. Conclusion The detection of Hb in early pregnancy can effectively predict gestational diabetes mellitus, so as to provide reference for early intervention and formulate corresponding measures in clinic.
		2018 Vol. 15 (35): 86-89 [Abstract] ( 251 ) HTML (1 KB) PDF (511 KB) ( 96 )

	90	Transvaginal ultrasonography parameters and anti Mullerian hormone levels in patients with polycystic ovary syndrome and its clinical significance
		TANG Yan WANG Yingxia JIN Xiaodan FU Yuanchun ZHANG Jianglin
		Objective To investigate the parameters of transvaginal ultrasonography (TVS) and the level of anti-Mullerian hormone (AMH) in patients with polycystic ovary syndrome (PCOS) and its clinical significance. Methods From January 2015 to May 2018, in Hu′nan Maternal and Child Health Care Hospital， 67 patients with PCOS were selected as observation group and 70 healthy volunteers as control group, all patients were examined by TVS and the number of follicles (FN), ovarian volume (OV), ovarian interstitial area (SA), ovarian interstitial area/total area (SA/TA) and peak velocity of interstitial artery (Vmax), pulsatile index (PI) and resistance index (RI) were compared between two groups, and the serum level of AMH was measured. Results The FN, OV, SA, SA/TA and Vmax of mesenchyme artery in the observation group were significantly higher than those in the control group (P < 0.01); the PI and RI of mesenchyme artery were significantly lower than those in the control group (P < 0.01). The serum AMH of the observation group was significantly higher than that of the control group (P < 0.05). SA/TA and RI were positively correlated with AMH (r = 0.723, 0.693, all P < 0.05); the sensitivity of TVS combined with AMH for diagnosing PCOS was 94.03%, which were significantly higher than that of TVS (73.13%) and AMH (80.60%) (P < 0.01). Conclusion TVS parameters and AMH levels are significantly abnormal in PCOS patients, and the TVS parameters SA / TA and RI are related to serum AMH.
		2018 Vol. 15 (35): 90-93 [Abstract] ( 258 ) HTML (1 KB) PDF (531 KB) ( 102 )

	94	Expression and the clinical significances of MGMT and galectin-3 in coloscopic biopsy specimens in colon adenocarcinoma
		SU Geng1 LIANG Keqing1 LUO Xianke2 WEN Wei1
		Objective To investigate the expression and clinical significances of DNA repair enzyme O6-methylguanine DNA methyltransferase (MGMT) and galectin-3 in colon adenocarcinoma tissues collected with fibro colonoscopy. Methods From January 2010 to January 2015, the tissues with fibro colonoscopy from 120 patients treated in Minzu Hospital of Guangxi Zhuang Autonomous Region were collected, including 60 colon adenocarcinomas, 30 inflammatory bowel diseases, and 30 colonic mucosal atypical hyperplasias. The expression of MGMT and galectin-3 were measured by immunohistochemical SP method and the prognosis was evaluated by follow-up visit. Results Compared with the inflammatory bowel disease group, the positive expression of MGMT significantly decreased and the positive expression of galectin-3 significantly increased in the colon adenocarcinomas group, the differences were statistically significant (P ＜ 0.05). Compared with medium-high differentiation colon adenocarcinoma group, the positive expression of MGMT significantly decreased and the positive expression of galectin-3 significantly increased in poor differentiation colon adenocarcinoma group, the differences were statistically significant (P ＜ 0.05); the expression of MGMT in colon adenocarcinoma decreased with the increase of TNM stage, and the expression of galectin-3 increased with the increase of TNM stage, the differences were statistically significant (P ＜ 0.05); the expression of MGMT and galectin-3 were not related to age and gender (P ＞ 0.05). There was a negative association between the expression level of MGMT and galectin-3 in colon adenocarcinoma (r = -0.399，P = 0.002); the positive expression rate of MGMT and galectin-3 in colon adenocarcinoma were significantly correlated with the 3-year survival rate of patients (P ＜ 0.05). Conclusion MGMT and galectin-3 might play important roles in tumorigenesis and development of colon adenocarcinoma, they are promising biomarkers for colon adenocarcinoma staging, metastasis and prognosis .
		2018 Vol. 15 (35): 94-97,109 [Abstract] ( 265 ) HTML (1 KB) PDF (519 KB) ( 107 )

	98	Effect of Rituximab Injection combined with GDP chemotherapy on the efficacy and immune function of patients with non Hodgkin lymphoma
		SHENG Weiwei1 SHAO Yu2▲
		Objective To explore the effect of Rituximab Injection combined with GDP chemotherapy on the efficacy and immune function of patients with non Hodgkin lymphoma (NHL). Methods Ninety-three NHL patients admitted to Taikang Xianlin Drum Tower Hospital of Nanjing City in Jiangsu Province from May 2014 to December 2017 were selected as the research subjects. The patients were divided into control group (n = 46) and study group (n = 47) according to the random number table method. The control group was treated with the GDP chemotherapy regimen, and the study group was treated with Rituximab Injection on this basis. The clinical efficacy after treatment, immune function indexes [immunoglobulin (Ig) A, IgM, IgG and the body fluid complement C3, C4], tumor markers [thymine deoxy kinase (TK-1), vascular endothelial growth factor (VEGF)] before and after treatment were compared in the two groups. The adverse reactions of the two groups during treatment were observed. Results After treatment, the total effective rate of the study group was significantly higher than the control group (P ＜ 0.05). IgA, IgM, IgG, C3, C4 of the two groups after treatment were lower than those before treatment, C3 and C4 of the study group were lower than those of the control group, the differences were statistically significant (P ＜ 0.05); there was no significant difference in IgA, IgM, IgG between the two groups after treatment (P ＞ 0.05). After treatment, TK-1 and VEGF of the two groups were lower than those before treatment, which of the study group were lower than those of the control group, the differences were statistically significant (P ＜ 0.05). There was no significant difference in the incidence of adverse reactions between the two groups during treatment (P ＞ 0.05). Conclusion Rituximab Injection combined with GDP chemotherapy in the treatment of NHL has a certain effect and can effectively protect the immune functions of the patients, significantly decrease the levels of serum TK-1 and VEGF, and does not increase the incidence of adverse reactions. It has certain clinical application value.
		2018 Vol. 15 (35): 98-101 [Abstract] ( 177 ) HTML (1 KB) PDF (501 KB) ( 107 )

	102	Analysis of correlation and risk factors of perioperative malnutrition and complications in patients with esophageal cancer
		LIU Juan ZHANG Xia
		Objective To analyze the correlation and risk factors of malnutrition and complications of patients in the perioperative period of esophageal cancer. Methods A total of 110 patients with esophageal cancer undergoing operations in China People′s Liberation Army Bethune International Peace Hospital from December 2015 to December 2017 were included in the study. The correlation and risk factors of malnutrition and complications were investigated. Results There were 48 cases of malnutrition with an incidence of 43.64%. The univariate analysis showed that age, clinical stages and preoperative complications were related with malnutrition (P ＜ 0.05); the multiple regression analyses of complications showed that age [OR = 1.490, 95%CI (1.207-4.051), P ＜ 0.01], clinical stages [OR = 2.288, 95%CI (1.522-6.061), P ＜ 0.01] and preoperative complications [OR = 1.972, 95%CI (1.706-6.851), P ＜ 0.01] were independent risk factors of perioperative malnutrition. There were 34 cases of complication with an incidence of 30.91%. The univariate analysis showed that age, intraoperative blood loss, clinical stages, preoperative complications and malnutrition were correlated with complications (P ＜ 0.05); the multiple regression analyses showed that age [OR = 2.291, 95%CI (1.308-4.011), P ＜ 0.01], clinical stages [OR = 3.485, 95%CI (1.414-10.087), P ＜ 0.05], preoperative complications [OR = 1.752, 95%CI (1.017-2.159), P ＜ 0.01] and malnutrition [OR = 1.281, 95%CI (0.867-1.899), P ＜ 0.05] were independent risk factors of complications. Conclusion Age, preoperative complications and clinical stages are independent risk factors of perioperative malnutrition and complications in patients with esophageal cancer, and malnutrition are the independent risk factor of complications.
		2018 Vol. 15 (35): 102-105 [Abstract] ( 263 ) HTML (1 KB) PDF (505 KB) ( 54 )

	106	Clinical treatment review of intraperitoneal aggressive fibromatosis
		WU Hongxue ZOU Li KE Dong TONG Shilun
		Objective To investigate the clinical characteristics, treatment and prognosis of intraperitoneal aggressive fibromatosis. Methods The clinical data of 26 patients with intraperitoneal aggressive fibromatosis in Renmin Hospital of Wuhan University from January 2007 to June 2017 were analyzed retrospectively. All patients were confirmed by pathological diagnosis. The survival rate was analyzed between the patients undergoing radical surgery and those only undergoing radiotherapy or chemotherapy, and the survival curve was drawn by Kaplan-Meier method for the group with the tumor diameter larger than 10 cm(8 cases) and the group with the tumor diameter less than 10 cm(18 cases) respectively. The survival rate of two groups were compared with χ2 test and the survival curve was tested by Log-rank test. Results All the 26 patients were examined by CT or MRI before operation, only 1 case was considered as intraperitoneal aggressive fibromatosis. Among 22 patients who underwent radical resection, only 1 case dead in follow-up period, the overall survival rate was 95.45%; among 4 patients who only accepted radiotherapy or chemotherapy, 3 cases dead in follow-up period, overall survival rate was 25.00%, the difference in overall survival rate between the two groups was highly statistically significant (P ＜ 0.01). There was significant prognosis difference between the groups of tumor diameter larger than 10 cm and less than 10 cm (P = 0.033). Conclusion Intraperitoneal aggressive fibromatosis is difficult to diagnose before operation. Whether surgical treatment is the first choice, whether to perform radical resection and tumor size are the key factors affecting prognosis.
		2018 Vol. 15 (35): 106-109 [Abstract] ( 244 ) HTML (1 KB) PDF (520 KB) ( 58 )

	110	Short and long term curative effects observation of intracranial stenting in the treatment of intracranial atherosclerotic stenosis and analysis on the risk factors of restenosis
		WANG Jing1 XIE Yanzhao2 LIU Yun′e1 QIN Shijie1 ZHU Qian1
		Objective To investigate the short and long term effect of intracranial stenting in the treatment of intracranial atherosclerotic stenosis and the risk factors of restenosis. Methods The clinical data of 78 patients with intracranial atherosclerotic stenosis and intracranial stent implantation admitted to the First Hospital of Shijiazhuang City from March 2013 to March 2015 were retrospectively analyzed. The incidence rate of postoperative restenosis was determined by imaging examination, and the incidence of postoperative end-point events was evaluated after 36 months of follow-up. According to the follow-up results, the patients were divided into restenosis group (21 cases) and non-restenosis group (57 cases), and the risk factors of postoperative restenosis were compared and analyzed. Results Among the 78 patients selected, the success rate of operdtion was 94.87%, preoperative and postoperative stenosis rates were significantly different (P < 0.05). Among the 78 patients selected, the restenosis rate was 26.92%, the results of univariate analysis showed that age > 55 years old, history of diabetes, history of hypertension, diameter of stent implantation ≥ 4.5 mm, hs-CRP > 3 mg/L were risk factors for in-rack restenosis (P < 0.05). Multivariate Logistic regression analysis showed that patients had a history of diabetes (OR = 3.87, 95%CI: 1.68-5.37, P = 0.043), a history of hypertension (OR = 1.81, 95%CI: 0.23-2.06, P = 0.037), stent diameter ≥ 4.5 mm (OR = 1.41, 95%CI: 0.61-2.48, P = 0.003), and hs-CRP > 3 mg/L (OR = 5.01, 95%CI: 1.26-8.04, P = 0.016) was an independent risk factor for restenosis after intracranial stent implantation. Conclusion The success rate of intracranial stenting in the treatment of intracranial atherosclerotic stenosis is high, and the recent curative effect is definite, but its long-term prognosis is not satisfactory. With a history of diabetes, hypertension, stent diameter ≥ 4.5 mm and hs-CRP ＞ 3 mg/L are independent risk factors for restenosis after intracranial stent implantation. Reasonable intervention against these risk factors can effectively control the risk of restenosis after intracranial stent implantation.
		2018 Vol. 15 (35): 110-113 [Abstract] ( 262 ) HTML (1 KB) PDF (708 KB) ( 147 )

	114	The relationship between lymph node metastasis and thyroglobulin in thyroid papillary carcinoma
		WANG Sisi WANG Bo XIE Chao ZHAO Wenxin▲
		Objective To analyze the relationship between the degree of lymph node metastasis in patients with thyroid papillary carcinoma (PTC) and the level of thyroglobulin (Tg), and to explore the significance and feasibility of preoperative Tg detection in PTC patients for the risk assessment of preoperative lymphatic metastasis. Methods Clinical complete data of 360 cases of PTC patients from January 2016 to December 2017 in Fujian Medical University Union Hospital were retrospectively analyzed, all patients had preoperatie test for Tg, and receired thyroideetony with neck dissectiou by the same group of doctors, according to the lymph node metastasis of postoperative, they were divided into no transfer group (N0 group), the central lymph node metastasis group (N1a group), lateral transfer analysis group (N1b group), the three groups of patients with preoperative differences in the levels of Tg were analyzed, and each group within the number of lymph node metastasis and the differences in the levels of Tg were analyzed. Results There were highly statistically significant differences in preoperative serum Tg levels between the three groups (P ＜ 0.01). Pairwise comparison was also statistically significant (all P < 0.05). The comparison of serum Tg level before operation between different T-staging was highly statistically significant (P ＜ 0.01). Among them, there was no significant difference in Tg level between T2 and T3, T2 and T4 staging patients (P > 0.05), while there were highly statistically significant differences in Tg level between the other groups (P ＜ 0.01). There were no significant correlation coefficients between the number of lymph node metastases in central and lateral neck metastases and the Tg level (r = 0.006, 0.161, P > 0.05). Conclusion The preoperative Tg level is correlated with the risk of lymph node metastasis in the central region and lateral neck lymph node metastasis in PTC patients, and has no significant correlation with the number of metastases. It can be used as a reference for the assessment of lymph node metastasis before surgery, and has certain value for the prediction of pathological T-staging.
		2018 Vol. 15 (35): 114-117 [Abstract] ( 200 ) HTML (1 KB) PDF (717 KB) ( 67 )

	118	Effect of Tiotropium Bromide combined with Seretide in the treatment of severe chronic obstructive pulmonary disease
		PAN Gujie1 TAO Xuefang2 MAO Nengyong1 SUN Wuming1 SHEN Jianying1 YANG Jinrong1
		Objective To observe the effect of Tiotropium Bromide combined with Seretide in the treatment of severe chronic obstructive pulmonary disease (COPD). Methods According to the random number table method, 89 patients with severe COPD diagnosed and treated in Shaoxing Central Hospital of Zhejiang Province from August 2015 to November 2017 were divided into observation group (45 cases) and control group (44 cases). The control group was treated with Seretide, the observation group was treated with Tiotropium Bromide and Seretide. After 12 weeks of intervention in the two groups, the lung function [forced expiratory volume in 1 second (FEV1) and forced vital capacity (FVC), FEV1% predicted value], exercise tolerance [6 min walking distance (6 MWD)], dyspnea score and serum inflammatory factors [interleukin 6 (IL-6), matrix metalloproteinase-9 (MMP-9), tumor necrosis factor alpha (TNF-α)] changes, record adverse drug reactions were evaluated. Results Compared to before treatment, the FVC, FEV1, FEV1% predicted value and 6MWD in the two groups were significantly increased while the dyspnea score, serum IL-6, MMP-9 and TNF-α levels were significantly decreased(P ＜ 0.05). The FVC, FEV1, FEV1% predicted value and 6MWD of the observation group after treatment were significantly higher than those of the control group. The dyspnea score, serum IL-6, MMP-9 and TNF-α levels in the observation group after treatment were significantly lower than those in the control group (P ＜ 0.05). There was no significant difference in the incidence of adverse drug reactions between the two groups (P ＞ 0.05). Conclusion Tiotropium Bromide combined with Seretide can significantly improve the pulmonary function of patients with severe COPD, improve their exercise endurance and inhibit inflammatory reaction.
		2018 Vol. 15 (35): 118-121 [Abstract] ( 196 ) HTML (1 KB) PDF (659 KB) ( 73 )

	122	Evaluation of early left ventricular function in patients with diabetes mellitus by three-dimensional speckle tracking technique
		ZHENG Yingjuan1 WEN Dehui1▲ LIU Weiliang1 SHI Baolin2 GU Jun3 XU Le1 SUN Chenxi1
		Objective To evaluate left ventricular function in early stage of diabetes mellitus by three-dimensional speckle tracking technique. Methods From January 2017 to April 2018, 83 patients with type 2 diabetes who were outpatient or hospitalized in the First Affiliated Hospital of Hebei North University were selected, including 44 cases of type 2 diabetes (diabetes group), 39 cases of diabetes complicated with hypertension (diabetes complicated with hypertension group), and 40 cases of healthy people in the same period (control group). Conventional echocardiography and three-dimensional speckle tracking technology were used to measure the overall left ventricular strain, including global longitudinal strain (GLS), global circumferential strain (GCS), global area strain (GAS), global radial strain (GRS) and three-dimensional left ventricular ejection fraction (3D-LVEF), and the differences between the three groups were compared. Results The value of conventional echocardiography such as two-dimensional left ventricular ejection fraction(2D-LVEF) in each groups had no significant difference(P ＞ 0.05).Compared with the control group, GLS, GAS, GCS and GRS in the diabetes group were significantly reduced, with highly statistically significant differences (P ＜ 0.01). GLS, GAS, GCS, GRS and 3D-LVEF were significantly reduced in the diabetes complicated with hypertension group, and the differences were highly statistically significant (P ＜ 0.01). Compared with the diabetes group, GLS, GAS, GRS and 3D-LVEF in the diabetes complicated with hypertension group were decreased, and the differences were statistically significant (P ＜ 0.05). Conclusion Three-dimensional spot tracking technology can detect changes in diabetic heart function early when 2D-LVEF is normal in diabetic patients, providing imaging basis for clinical prevention of diabetic heart and cerebrovascular complications.
		2018 Vol. 15 (35): 122-125,133 [Abstract] ( 206 ) HTML (1 KB) PDF (878 KB) ( 81 )

	126	Effect of intrahepatic transplantation of hepatic artery autologous bone marrow stem cells influence on clinical outcome, liver function and coagulation parameters of decompensated liver cirrhosis
		HAO Deyan1 SONG Zhi2▲ MENG Xingkai1
		Objective To observe the clinical effect of hepatic arterial autologous bone marrow stem cell intrahepatic transplantation for decompensated cirrhosis and its influence on liver function and coagulation indicators. Methods A total of 68 patients with decompensated liver cirrhosis admitted to Department of Surgery of the Affiliated Hospital of Inner Mongolia Medical University from December 2016 to December 2017 were selected and intrahepatic transplantation of hepatic artery autologous bone marrow stem cells was performed on all of the patients. The clinical efficacy and complications were observed. The symptoms, liver function, coagulation index and quality of life were compared before and after treatment. Results The total effective rate was 68.6% in 68 patients, and the postoperative complication rate was 8.82%. After treatment, the scores of fatigue, anorexia, abdominal distension, jaundice and ascites were lower than those before treatment (P < 0.05). The liver function index (tatal bilirubin aspartate asninotransferose, alanine amin of ranferase, albwnin) after treatment were improved compared with those before treatment (P < 0.05). The physical health, mental health, social function, material life score and total score after treatment were improved compared with those before treatment (P < 0.05). Conclusion For patients with decompensated cirrhosis, intrahepatic transplantation of hepatic artery autologous bone marrow stem cells is effective, the symptoms are relieved, liver function is improved, coagulation function is not affected, and the quality of life of patients is improved, and it is safe and effective.
		2018 Vol. 15 (35): 126-129 [Abstract] ( 217 ) HTML (1 KB) PDF (656 KB) ( 101 )

	130	Clinical application of selective bile pancreatic duct intubation in painless endoscopic retrograde cholangiopancreatography within limited time
		ZUO Xuhui1 XIAO Xiang2 RAO Huibo3
		Objective To explore the clinical application of selective bile pancreatic duct intubation in painless endoscopic retrograde cholangiopancreatography (ERCP) within limited time. Methods One hundred and twenty patients taking ERCP diagnosis and treatment in Xiangtan County People′s Hospital from February 2014 to January 2016 were selected. They were divided into control group and experimental group by random number table method with 60 cases in each group. The control group was given routine sedation and ERCP, while the experimental group was given intravenous general anesthesia and ERCP. Successful intubation time within limited time, operation time, hospitalization time, postoperative complications and SAS, SDS scores before and after treatment were compared between the two groups. Results Actual successful intubation time within the limited time of 5, 10, 20 min in the experiment group were significantly shorter than those in the control group (P ＜ 0.05); operation time and hospitalization time of the experiment group were significantly shorter than those of the control group (P ＜ 0.05); the complication rate of the experiment group was significantly lower than that of the control group (P ＜ 0.05). Before treatment, there was no difference in SAS and SDS scores between the two groups (P ＞ 0.05), while after treatment SAS and SDS scores in the experiment group were significantly lower than those before treatment (P ＜ 0.05). SDS score in the control group decreased after treatment (P ＜ 0.05), but SAS score had no difference before and after treatment (P ＞ 0.05). After treatment, SAS and SDS scores in the experimental group were lower than those in the control group (P ＜ 0.05). Conclusion The painless ERCP has superiority that can reduce intubation tube time and the total time of operation, reduce the incidence of postoperative complications, and it is worthy of clinical promotion and application.
		2018 Vol. 15 (35): 130-133 [Abstract] ( 201 ) HTML (1 KB) PDF (696 KB) ( 88 )

	134	Efficacy of endoscopic ligation combined with Carvedilol for prevention of esophageal varices rebleeding
		YUAN Shanshan ZHANG Xin ZHANG Yanting YANG Zhenwei TANG Hailing LI Yijun ZHUANG Kun
		Objective To observe the efficacy of endoscopic ligation combined with Carvedilol in the prevention of esophageal varices rebleeding. Methods A total of 126 patients with cirrhosis of esophageal varices treated in Xi'an Central Hospital from October 2016 to June 2017 were enrolled. The patients were divided into experimental group, control group A and control group B by random number table method with 42 cases in each group. The control group A was treated with endoscopic ligation alone. The control group B was treated with endoscopic ligation combined with Propranolol. The experimental group was treated with endoscopic ligation combined with Carvedilol. Oneyear follow-up was performed after operation. Clinical effect, rebleeding rate, Child-Pugh classification of liver function, esophageal varices classification, and spleen hardness were compared before and after treatment. Results The total effective rate of the experimental group was higher than that of the control group A and the control group B (P ＜ 0.05). The rebleeding rate in the experimental group was lower than that in the control group A and the control group B (P ＜ 0.05). One year postoperation, the Child-Pugh classification of liver function in the experimental group was better than that before treatment, and it was better than that in the control group A and the control group B (P ＜ 0.05). The grades of esophageal varices in the three groups all improved than those before treatment, and the experimental group was superior to the control group A and the control group B (P ＜ 0.05). The spleen hardness of the three groups were lower than those before treatment, and the experimental group was lower than that in the control group A and the control group B (P ＜ 0.05). Conclusion Endoscopic ligation combined with Carvedilol treating patients with cirrhosis of esophageal varices can enhance the efficacy, reduce rebleeding, improve liver function and esophageal varices, and reduce spleen stiffness.
		2018 Vol. 15 (35): 134-137,145 [Abstract] ( 228 ) HTML (1 KB) PDF (947 KB) ( 109 )

	138	Effect of bow and arrow step training on the contraction function of shank muscles in stroke patients with hemiplegia
		CHEN Chuanbang ZHOU Ying ZHOU Xuezhen WANG Zhewei LI Haiyan ZHOU Chengye▲
		Objective To explore the effect of bow and arrow step training on the contraction function of shank muscles in stroke patients with hemiplegia. Methods Sixty stroke patients with hemiplegia treated in Department of Rehabilitation, the First Affiliated Hospital of Wenzhou Medical University from June 2016 to January 2018 were enrolled in this study, and they were divided into control group and observation group by random number table method with 30 cases in each group. The control group received routine rehabilitation training combined with the stretching exercise of shank muscles. Bow and arrow step training was added to the observation group on the basis of the training in the control group. Both groups trained for eight weeks continuously. The composite spasticity index (CSI), balance scale (Berg) and Fugl-Meyer scale (FMA-L) were used to evaluate the degree of spasm, balance ability and lower extremity function respectively. Meanwhile, the Hollde scale was used to evaluate walking function, the stride and maximum speed were counted. The surface electromyogram (SEMG) signals was used to evaluate the function of shank muscles. Results After treatment, FMA-L score, Berg score, Hollde score, iEMG, stride and maximum speed significantly increased in the two groups than those before treatment （P ＜ 0.05）; after treatment, the CSI index, RMS of tibialis anterior, gastrocnemius, soleus significantly decreased than those before treatment （P ＜ 0.05）. Meanwhile, FMA-L score, Berg score, Hollde score, iEMG, stride and maximum speed in the observation group were higher than those in the control group （P ＜ 0.05）, and the CSI index, RMS of tibialis anterior, gastrocnemius and soleus were lower than those in the control group significantly (P ＜ 0.05). Conclusion Bow and arrow step training can improve the contractile function of shank muscles, exercise ability and balance ability in stroke patients with hemiplegia, as well as paralysis and improve walking ability.
		2018 Vol. 15 (35): 138-141 [Abstract] ( 212 ) HTML (1 KB) PDF (693 KB) ( 87 )

	142	Effects of new healthcare reform on pharmaceutical supply system of China
		YAN Shu XU Dongzi OUYANG Zhaolian
		A series of policies and measures on pharmaceutical research and development, production and distribution are released and carried out under China′s ongoing new healthcare reform, which have brought profound effects on pharmaceutical supply system. This paper classifies and studies recent key documents, measures and achievements of the reform, which are aimed to advance pharmaceutical supply system in three categories. It is found that these policies and measures have provided benefits to the pharmaceutical supply system in many aspects including innovation stimulating, production capability raising and distribution environment optimizing. However, new challenges may appear since the reform has entered the “deep water zone”, suggestions that the reform should pay more attention to policies implementation and enhance policy coherence, establish reform assessment process, reinforce the coordination of medical care, medical insurance and pharmaceutical industry and construct compensation rules, as well as improve the ability to foresight and respond to the new problems are given.
		2018 Vol. 15 (35): 142-145 [Abstract] ( 248 ) HTML (1 KB) PDF (405 KB) ( 138 )

	146	Clinical effect of Yupingfeng Powder combined with BCG polysaccharide nucleic acid for treatment of chronic urticaria
		HE Qiang1 PAN Wulin1 YU Zhihua2
		Objective To explore the clinical efficacy of Yupingfeng Powder combined with BCG polysaccharide nucleic acid for treatment of chronic urticaria. Methods From January 2016 to December 2017 in Hubei Provincial Hospital of Integrated Chinese and Western Medicine, 80 patients with chronic urticaria were selected. They were divided into control group and treatment group according to random number table method, with 40 cases in each group. The control group was treated with BCG polysaccharide nucleic acid injection, the treatment group was treated with Yupingfeng Powder combined with BCG polysaccharide nucleic acid injection, two groups were treated for 12 weeks cowtinuously. The UAS scores, DLQI scores, serum IFN-γ, IL-2, IL-4 and IL-10 in the two groups before and after treatment were compared. The clinical efficacy and the adverse reaction rate of the two groups were compared. Results After treatment, the UAS scores, DLQI scores, levels of serum IL-4, IL-10 in the two groups were significantly lower than those before treatment, the levels of serum IFN-γ, IL-2 in the two groups were significantly higher than those before treatment, and the UAS scores, DLQI scores, levels of serum IL-4, IL-10 in the treatment group were obviously higher than those in the control group, the levels of serum IFN-γ, IL-2 in the treatment group were lower than those in the control group, the differences were statistically significant (P < 0.05). The total effective rate of treatment group was significantly higher than those of the control group, the difference was statistically significant (P < 0.05). There was no significantly difference in the adverse reaction rate between the two groups during treatment (P > 0.05). Conclusion Yupingfeng Powder combined with BCG polysaccharide nucleic acid injection for treatment of chronic urticaria has a good efficacy and few adverse reactions, which can relieve clinical symptoms, improve life quality and the levels of serumIFN-γ, IL-2, reduce the levels of serum IL-4, IL-10, and it is worthy clinical application.
		2018 Vol. 15 (35): 146-149 [Abstract] ( 211 ) HTML (1 KB) PDF (0 KB) ( 42 )

	150	Effects of family-centered clinical nursing programs on limb function rehabilitation and family satisfaction after developmental hip dislocation in children
		ZHOU Xiaoyu LI Lianyong
		Objective To investigate the effect of family-centered clinical nursing program on limb function rehabilitation and family satisfaction of children with developmental dislocation of the hip. Methods A total of 88 patients with pediatric developmental dislocation of the hips who underwent surgical treatment from April 2006 to April 2018 in Shengjing Hospital of China Medical University were divided into control group and observation group by random number table. There were 44 cases in each group. The control group received routine care after surgery, and the observation group added a family-centered clinical care program based on the control group. The rehabilitation of limb function, the satisfaction score of family members and the incidence of postoperative complications were compared between the two groups. Results The simplified Fugl-Meyer assessment (FMA) and Barthel scores of the two groups were significantly higher than those before the nursing, and the differences were statistically significant (P ＜ 0.05). The nursing attitude score, nursing comfort score, communication ability score and comprehensive score of the family members in the observation group were higher than the control group, and the differences were statistically significant (P ＜ 0.05). The incidence of constipation, abdominal distension, skin damage and wound infection in the observation group was lower than that in the control group, and the difference was statistically significant (P ＜ 0.05). Conclusion The family-centered clinical nursing program is superior to conventional nursing. It can improve the limb function of children after developmental dislocation of the hip, and the incidence of various complications is low. The family members′ satisfaction in all aspects has improved.
		2018 Vol. 15 (35): 150-153 [Abstract] ( 222 ) HTML (1 KB) PDF (462 KB) ( 65 )

	154	The influence of case management model on self-management ability and psychological resilience of patients with tuberculosis and AIDS
		ZHOU Yanyan1 SHU Jiaojiao1 LIU Ran1 GUO Yali1 PENG Qiaojun2
		Objective To explore the impact of case management mode on self-management ability and psychological resilience of tuberculosis patients with AIDS. Methods A total of 132 patients who received anti-tuberculosis and anti-viral treatment in Xinjiang Uygur Autonomous Region Sixth People′s Hospital from May to December 2017 were randomly divided into the control group and the observation group by random number table method, with 66 cases in each group. The control group was given routine nursing management, and the observation group was given case management model. The self-management ability and psychological elasticity scores of the two groups were compared. Results There was no significant difference in self-management ability and psychological elasticity score between the two groups before intervention (P > 0.05). The above indexes of the two groups were higher than those of the same group before intervention, the above indexes of the observation group were significantly higher than those of the control group, the differences were statistically significant (P < 0.05). Conclusion The implementation of case management can effectively improve the self-management ability of tuberculosis patients with AIDS and enhance their psychological resilience.
		2018 Vol. 15 (35): 154-157,168 [Abstract] ( 192 ) HTML (1 KB) PDF (871 KB) ( 214 )

	158	A case report and literature analysis of obstruction caused by small bowel metastasis of renal cell carcinoma
		DAI Qiuying ZHANG Shuxin CHEN Hang WANG Rui GAO Jing JING Tao FU Liyuan LU Yu
		Renal cell carcinoma (RCC) accounts for about 2%-3% of all malignant tumors. 25%-30% patients had metastases at the time of diagnosis of RCC, and 20%-30% patients have metastases during follow-up after treatment of primary lesion. Only 4% RCC metastasizes to the small intestine. In previous literature, renal cell carcinoma metastasis to the small intestine is mostly reported as a isolated case. This article presents a case of 85-year-old man with small intestine metastases, eight years after the radical resection of left kidney for RCC. This artile searches in PubMed, Embase and Chinese database and reviews the medical records of small intestine metastasis after treatment of primary renal cell carcinoma.
		2018 Vol. 15 (35): 158-160 [Abstract] ( 232 ) HTML (1 KB) PDF (376 KB) ( 176 )

	161	Construction and application effect evaluation of integrated management platform of intelligent hospital based on big data analysis
		CHEN Qiang1 LU Yan2
		Objective To evaluate the construction and application effect of integrated management platform of intelligent hospital based on big data analysis and to discuss the optimization and promotion countermeasures. Methods Since January 2017, an integrated management platform of intelligent hospital based on big data analysis has been established in the Second People′s Hospital of Changzhou City (“our hospital” for short), covering the digital information management system in the hospital and the information service platform outside the hospital. The changes of various data such as the hospital medical quality index, workload, staff satisfaction, patient′s visit smoothness, satisfaction, hospitalization day, treatment cost before (from January to December 2016) and after the establishment of the integrated management platform (from January to December 2017) were compared, and the application effect of the integrated management platform of intelligent hospital was evaluated. Results The utilization rate of beds in our hospital in 2017 and the total bed days occupied by discharged patients were higher than those in 2016. The employee satisfaction in our hospital in 2017 was higher than that in 2016, and the patient′s smooth degree and satisfaction degree were higher than those in 2016, the differences were statistically significant (P ＜ 0.05). In 2017, the average number of days in hospital and the average cost of treatment for patients in our hospital were lower than those in 2016, the differences were statistically significant (P ＜ 0.05). Conclusion The integrated management platform of intelligent hospital based on big data analysis can improve the hospital operation efficiency, reduce the hospitalization time and treatment cost of patients, which is worthy of further optimization and extensive promotion.
		2018 Vol. 15 (35): 161-164,172 [Abstract] ( 212 ) HTML (1 KB) PDF (978 KB) ( 235 )

	165	Analysis of traditional Chinese medicine postgraduate education mode from the perspective of traditional Chinese classical culture
		TIAN Yuan1 CHANG Xing2 YAN Peizheng2
		In recent years, with the development of modern education and the impact of Western medicine, modern Chinese medicine postgraduates generally lack the thinking mode of traditional Chinese medicine. In view of the existing problems in the education and training of Chinese medical graduate students, this paper analyzes the training objectives of the postgraduate students, the setting of classical culture course of postgraduates, the application of traditional Chinese medicine in the clinic and the role of traditional Chinese medicine in the training of clinical postgraduates of traditional Chinese medicine. The research ability and clinical level of medical graduate students are the main training targets, and the connotation of development of traditional Chinese medicine is emphasized in two aspects of classical clinical and traditional culture, which is of great significance for the training of clinical graduate students of traditional Chinese medicine.
		2018 Vol. 15 (35): 165-168 [Abstract] ( 237 ) HTML (1 KB) PDF (597 KB) ( 142 )

	169	Application and effectiveness of PDCA cycle in the improvement of bid success quantity of hospital′s scientific research projects
		ZHANG Di1 WANG Xinya2 JIANG Xiaoying1 CHEN Mengmeng1 ZHANG Zongde1 MI Fengling1
		Scientific research provides an inexhaustible driving force for medical technology innovation and discipline development. As a key link to support scientific research, scientific research projects are key indicators for reflecting the level of medical technology in hospitals. It occupies a key position in the evaluation of scientific and technological influence and appraisal of scientific research performance. This paper takes Beijing Chest Hospital, Capital Medical University as an example. Given the low number of scientific research projects, the Department of Science and Technology analyzes the factors affecting the application for scientific research projects by means of the PDCA management method and proposes a direction for solution. In concert with multiple departments, it adopts targeted measures in terms of scientific research tutoring and nurturing, promotion of titles, incentives and performance management to improve the quantity and quality of scientific research projects, thereby enhancing the number of successful bids for scientific research projects. The paper has the opinion that the PDCA theory is feasible in the improvement of the number of successful bids for scientific research projects. The number of scientific research projects has steadily improved, and the new multi-sector linkage measures adopted in the specific problem-solving have achieved remarkable results. PDCA management can be applied to scientific research management, and, in cooperation with multiple departments, enhance the medical research level in hospitals and facilitate the sustainable development of disciplines.
		2018 Vol. 15 (35): 169-172 [Abstract] ( 250 ) HTML (1 KB) PDF (683 KB) ( 165 )

	173	Strategic analysis of Chinese herbal medicine market in Heilongjiang Province based on SWOT analysis
		YU Qinming1* FENG Guang2* CHEN Zhuo3 LIU Juntao4 FU Wendi5▲
		As a resource province of wild Chinese medicinal materials, Heilongjiang Province is rich in medicinal materials and medicinal materials. With the liberalization of Chinese pharmaceutical retail market in the new era, the competition of Chinese herbal medicine market is increasingly fierce at home and abroad. At present, the competition among Chinese medicinal materials industry is basically on lowering prices, and the excessive price reduction competition has seriously hindered the development of the Chinese medicine market. Therefore, based on SWOT analysis, the advantages, disadvantages, opportunities, threats of Chinese medicinal materials in Heilongjiang Province are analyzed in depth. On the basis of thorough understanding of the distribution of resources, the development of resources and the full grasp of the market trend, suggestions for improving the markert strategy of Chinese herbal medicines are proposed from the aspects of the distribution and use of existing resources, the possession and utilization of external resources, the organization and adjustment of the industrial structure, quality brand building and publicity.
		2018 Vol. 15 (35): 173-176 [Abstract] ( 233 ) HTML (1 KB) PDF (743 KB) ( 237 )

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