血清同型半胱氨酸、高敏C反应蛋白、胱抑素C水平与冠状动脉粥样硬化的关系

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Abstract Objective To explore the connection between levels of serum homocysteine (Hcy), high sensitivity C-reative protein (hs-CRP) and cystatin C (Cys C) and coronary atherosclerotic. Methods A total of 245 patients accepting Multi-Slics spiral CT coronary angiography (MSCTCA) in Department of Cardiology, the Second Affiliated Hospital of Nanjing Medical University from August 2016 to January 2018 were selected. According to whether coronary stenosis≥50% or not, all the cases were divided into non coronary stenosis group (90 cases) and coronary stenosis group (155 cases)(116 patients with hypertention). According to number of affected vessel with coronary stenosis≥50%, all the cases were divided into single vessel affected group (48 cases), double vessels affected group (45 cases), multiple vessels affected group (62 cases). According to degree of coronary artery stenosis, the patients were divided into four groups: degreeⅠ group: reduced lumen area 1%-25% (30 cases); degree Ⅱ group: reduced lumen area ＜25%-50% (60 cases); degree Ⅲ group: reduced lumen area ＜50%-75% (120 cases); degree Ⅳ group: reduced lumen area ＜75%-100% (35 cases). Hcy, hs-CRP and Cys C were compared among the coronary atherosclerotic with different types. Results Compared with the non coronary stenosis group, Hcy, hs-CRP and Cys C coronary in the stenosis group were higher (P ＜ 0.05). Compared with coronary stenosis group, Hcy, hs-CRP and Cys C of patients with hypertension of coronary stenosis group were higher (P ＜ 0.05). Compared with the non coronary stenosis group, Hcy, hs-CRP, Cys C were higher in the other groups (P ＜ 0.05). Compared with the single vessel affected group, Hcy, hs-CRP in double vessels affected group and multiple vessels affected group were higher (P ＜ 0.05). Compared with the dagree Ⅰgroup, Hcy, hs-CRP, Cys C were higher in the degreeⅡ-Ⅲ groups, Hcy, hs-CRP in the degree Ⅳ group were higher (P ＜ 0.05). Compared with the dagree Ⅱ group, Hcy, hs-CRP, Cys C in the degree Ⅲ group were higher, Hcy, hs-CRP in the degree Ⅳ group were higher (P ＜ 0.05). Compared with the dagree Ⅲ group, Hcy, hs-CRP in the degree Ⅳ group were higher (P ＜ 0.05). Conclusion High levels of serum Hcy, hs-CRP and Cys C have relationship with coronary atherosclerosis. Combined with normal test, regularly testing the levels of serum Hcy, hs-CRP and Cys C is helpful for the evaluation of coronary artery affected vessel number and stenosis degree, which can guide clinical treatment and improve coronary atherosclerosis patients′ treatment efficacy and prognosis.

Key words： Homocysteine High sensitivity C-reative protein Cystatin C Coronary atherosclerosis

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	KUAI Lin HONG Mei▲

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KUAI Lin HONG Mei▲. Connection of homocysteine, hig sensitivity C-reative protein and cystatin C with coronary atherosclerosis[J]. 中国医药导报, 2018, 15(35): 58-61.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2018/V15/I35/58

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