孕早期血红蛋白水平在妊娠期糖尿病中的预测价值

Abstract
Figure/Table
References (25)
Related Citation (14)

Download: PDF (511 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To explore the predictive value of hemoglobin (Hb) level during early pregnancy gestational diabetes mellitus. Methods A total of 124 gestational diabetes mellitus in Chengdu Women′s and Children′s Center Hospital ("our hospital " for short) from March 2016 to December 2017 were selected as case group. At the same time, 50 healthy pregnant women who were admitted to our hospital for prenatal examination were randomly selected as control group. The basic data such as age, height, weight, etc were recorded, the glucose tolerance (GTT), glycosylated hemoglobin and the blood routine were detected, the predictive value of Hb for gestational diabetes mellitus was analyzed. Results The pregnancy women over 35 years old and body mass index (BMI)≥24 kg/m2 had a higher proportion in case group than those in control group, the levels of fasting blood glucose, blood glucose, HbA1c, Hb, platelet (PLT), red blood cell (RBC) in case group were higher than those in control group, the differences were statistically significant(P < 0.05). Multivariate Logistic regression analysis showed that age, BMI, fasting blood glucose, 2 h post-meal blood glucose, HbA1c, Hb, PLT and RBC were the independent risk factors for gestational diabetes mellitus (OR = 1.147, 1.096, 1.229, 1.191, 1.353, 1.195, 1.226, 1.124, all P < 0.05). The area under the ROC curve was used to assess the predictive value of Hb in gestational diabetes mellitus during the first trimester, the results showed that the area under ROC curve was 0.882 (95%CI: 0.753, 0.921), and the sensitivity, specificity, accuracy were 0.76, 0.83, 0.79, respectively, the best cutoff value for Hb was 129.76 g/L. Conclusion The detection of Hb in early pregnancy can effectively predict gestational diabetes mellitus, so as to provide reference for early intervention and formulate corresponding measures in clinic.

Key words： Early pregnancy Hemoglobin Gestational diabetes mellitus Predictive value

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	WANG Lu1 ZHANG Tianchi1 LI Ping2

Cite this article:

WANG Lu1 ZHANG Tianchi1 LI Ping2. Predictive value of hemoglobin level during early pregnancy in gestational diabetes mellitus[J]. 中国医药导报, 2018, 15(35): 86-89.

URL:

http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2018/V15/I35/86

[1] Du HY，Jiang H，O K，et al. Association of dietary pattern during pregnancy and gestational diabetes mellitus：a prospective cohort study in northern China [J]. Biomed Environ Sci，2017，30（12）：887-897.
[2] 姚观昀.血糖控制对妊娠期糖尿病孕妇母婴结局的影响分析[J].糖尿病新世界，2017，20（19）：66-67，139.
[3] Secher AL，Bytoft B，Tabor A，et al. Fetal sonographic characteristics associated with shoulder dystocia in pregnancies of women with type I diabetes [J]. Acta Obstet Gynecol Scand，2015，94（10）：1105-1111.
[4] Alwan NA，Cade JE，Greenwood DC，et al. Associations of maternal Iron intake and hemoglobin in pregnancy with offspring vascular phenotypes and adiposity at age 10：findings from the Avon longitudinal study of parents and children [J]. PLoS One，2014，9（1）：e84 684.
[5] 俞琳，许岚，蒋艳敏，等.孕早期血红蛋白在妊娠期糖尿病发病中的重要性[J].南京医科大学学报：自然科学版，2017，37（7）：886-889.
[6] Granada C，Forbes J，Sangi-Haghpeykar H，et al. Can overt diabetes mellitus be predicted by an early A1C value in gestational diabetics? [J]. J Reprod Med，2014，59（7/8）：343-347.
[7] 吴红丽，孙健，孙冀兵，等.孕早期糖化血红蛋白水平检查在诊断妊娠期糖尿病中的效果评价[J].中国实验诊断学，2017，21（3）：455-458.
[8] 蔡慧华，何援利，王雪峰，等.糖化血红蛋白联合空腹血糖监测在妊娠期糖尿病筛查中的应用价值[J].实用妇产科杂志，2014，30（3）：205-206.
[9] 张秋菊，苏丽英.孕期饮食和运动干预对妊娠期糖尿病的发病率及妊娠结局的影响[J].河北医学，2017，23（3）：475-477.
[10] 涂飞容.膳食指导和体重控制对妊娠期糖尿病、高血压及胎儿影响的研究[J].中国医药科学，2017，7（13）：36-39.
[11] 陶鑫焱，符星星，叶永青.妊娠期糖代谢异常的医学营养治疗对妊娠结局的影响[J].海南医学，2011，22（9）：37-39.
[12] Saglam B，Uysal S，Sozdinler S，et al. Diagnostic value of glycemic markers HbA1c，1，5-anhydroglucitol and glycated albumin in evaluating gestational diabetes mellitus [J]. Ther Adv Endocrinol Metab，2017，8（12）：161-167.
[13] Mousavi SN，Kamali K，Mirbazel M，et al. The best cut-off value for HbA1c as a screening tool in iranian women with gestational diabetes mellitus [J]. J Family Reprod Health，2017，11（1）：37-42.
[14] Claesson R，Ignell C，Shaat N，et al. HbA1c as a predictor of diabetes after gestational diabetes mellitus [J]. Prim Care Diabetes，2017，11（1）：46-51.
[15] 姜莹，肖鸽飞.孕期糖化血红蛋白水平检查在诊断妊娠期糖尿病中的效果分析[J].中国医药科学，2018，8（11）：121-123.
[16] Agarwal MM. Gestational diabetes mellitus：Screening with fasting plasma glucose [J]. World J Diabetes，2016，7（14）：279-289.
[17] Voormolen DN，abell SK，James R，et al. Diagnostic criteria and treatment for gestational diabetes mellitus [J]. Semin Reprod Med，2016，34（2）：102-109.
[18] Sani M，Ayubi E，Khazaei S，et al. Investigation of the relationship between hemoglobin and serum iron levels and early-phase insulin secretion in non-diabetic subjects：statistical and methodological issues [J]. Acta Diabetol，2017，54（5）：513-514.
[19] 张克良，刘大成，孟小望，等.2型糖尿病患者强化治疗前后血清铁变化与胰岛素抵抗的关系[J].中国糖尿病杂志，2017，25（5）：411-414.
[20] Chen X，Scholl TO，Stein TP. Association of elevated serum ferritin levels and the risk of gestational diabetes mellitus in pregnant women：the Camden study [J]. Diabetes Care，2006，29（5）：1077-1082.
[21] Tarim E，Kilicdag E，Bagis T，et al. High maternal hemoglobin and ferritin values as risk factors for gestational diabetes [J]. Int J Gynaecol Obstet，2004，84（3）：259-261.
[22] 王婧，陈卓，马润玫，等.昆明地区妊娠早期母体红细胞参数与妊娠期糖尿病的关系[J].中华围产医学杂志，2012， 15（12）：705-709.
[23] 靳晴，沈冉，牛兆仪，等.孕前空腹血糖及体质指数对妊娠期糖尿病的预测价值[J].成都医学院学报，2016，11（2）：172-175.
[24] 钟艳萍，邢彦君，赵卓姝.体重指数管理及血糖控制对妊娠期糖尿病孕妇围产结局的影响[J].中国医药科学，2016，6（16）：117-119.
[25] Agarwal MM，Dhatt GS，Shah SM. Gestational diabetes mellitus：simplifying the international association of diabetes and pregnancy diagnostic algorithm using fasting plasma glucose [J]. Diabetes Care，2010，33（9）：2018-2020.