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| The relationship between lymph node metastasis and thyroglobulin in thyroid papillary carcinoma |
| WANG Sisi WANG Bo XIE Chao ZHAO Wenxin▲ |
| Department of Thyroid Surgery, Fujian Medical University Union Hospital, Fujian Province, Fuzhou 350001, China |
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Abstract Objective To analyze the relationship between the degree of lymph node metastasis in patients with thyroid papillary carcinoma (PTC) and the level of thyroglobulin (Tg), and to explore the significance and feasibility of preoperative Tg detection in PTC patients for the risk assessment of preoperative lymphatic metastasis. Methods Clinical complete data of 360 cases of PTC patients from January 2016 to December 2017 in Fujian Medical University Union Hospital were retrospectively analyzed, all patients had preoperatie test for Tg, and receired thyroideetony with neck dissectiou by the same group of doctors, according to the lymph node metastasis of postoperative, they were divided into no transfer group (N0 group), the central lymph node metastasis group (N1a group), lateral transfer analysis group (N1b group), the three groups of patients with preoperative differences in the levels of Tg were analyzed, and each group within the number of lymph node metastasis and the differences in the levels of Tg were analyzed. Results There were highly statistically significant differences in preoperative serum Tg levels between the three groups (P ＜ 0.01). Pairwise comparison was also statistically significant (all P < 0.05). The comparison of serum Tg level before operation between different T-staging was highly statistically significant (P ＜ 0.01). Among them, there was no significant difference in Tg level between T2 and T3, T2 and T4 staging patients (P > 0.05), while there were highly statistically significant differences in Tg level between the other groups (P ＜ 0.01). There were no significant correlation coefficients between the number of lymph node metastases in central and lateral neck metastases and the Tg level (r = 0.006, 0.161, P > 0.05). Conclusion The preoperative Tg level is correlated with the risk of lymph node metastasis in the central region and lateral neck lymph node metastasis in PTC patients, and has no significant correlation with the number of metastases. It can be used as a reference for the assessment of lymph node metastasis before surgery, and has certain value for the prediction of pathological T-staging.
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