结肠镜活检组织检测MGMT和galectin-3的表达在结肠腺癌中的临床意义

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Abstract Objective To investigate the expression and clinical significances of DNA repair enzyme O6-methylguanine DNA methyltransferase (MGMT) and galectin-3 in colon adenocarcinoma tissues collected with fibro colonoscopy. Methods From January 2010 to January 2015, the tissues with fibro colonoscopy from 120 patients treated in Minzu Hospital of Guangxi Zhuang Autonomous Region were collected, including 60 colon adenocarcinomas, 30 inflammatory bowel diseases, and 30 colonic mucosal atypical hyperplasias. The expression of MGMT and galectin-3 were measured by immunohistochemical SP method and the prognosis was evaluated by follow-up visit. Results Compared with the inflammatory bowel disease group, the positive expression of MGMT significantly decreased and the positive expression of galectin-3 significantly increased in the colon adenocarcinomas group, the differences were statistically significant (P ＜ 0.05). Compared with medium-high differentiation colon adenocarcinoma group, the positive expression of MGMT significantly decreased and the positive expression of galectin-3 significantly increased in poor differentiation colon adenocarcinoma group, the differences were statistically significant (P ＜ 0.05); the expression of MGMT in colon adenocarcinoma decreased with the increase of TNM stage, and the expression of galectin-3 increased with the increase of TNM stage, the differences were statistically significant (P ＜ 0.05); the expression of MGMT and galectin-3 were not related to age and gender (P ＞ 0.05). There was a negative association between the expression level of MGMT and galectin-3 in colon adenocarcinoma (r = -0.399，P = 0.002); the positive expression rate of MGMT and galectin-3 in colon adenocarcinoma were significantly correlated with the 3-year survival rate of patients (P ＜ 0.05). Conclusion MGMT and galectin-3 might play important roles in tumorigenesis and development of colon adenocarcinoma, they are promising biomarkers for colon adenocarcinoma staging, metastasis and prognosis .

Key words： Inflammatory bowel disease Colonic mucosal atypical hyperplasia Colon adenocarcinoma MGMT Galectin-3

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	SU Geng1 LIANG Keqing1 LUO Xianke2 WEN Wei1

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SU Geng1 LIANG Keqing1 LUO Xianke2 WEN Wei1. Expression and the clinical significances of MGMT and galectin-3 in coloscopic biopsy specimens in colon adenocarcinoma[J]. 中国医药导报, 2018, 15(35): 94-97,109.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2018/V15/I35/94

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