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2017 Vol. 14, No. 26
Published: 2017-09-15
 
 
4 Meta analysis of efficacy and safety of hyperthermia combined with chemotherapy in the treatment of advanced or chest wall recurrence of breast cancer
XU Min CAO Dedong GE Wei
Objective To evaluate the effectiveness and safety of hyperthermia combined with chemotherapy in the treatment of late or chest wall recurrence of breast cancer. Methods Electronic databases including the PubMed, Web of Science, EMbase, VIP, China national knowledge internet, Chinese biomedical literature database and Wanfang database system were searched, search term from building to March 22, 2017. The inclusion criteria was efficacy and safety studies of controlled clinical studies in which hyperthermia combined with chemotherapy was compared with chemotherapy alone for patients with late or chest wall recurrence of breast cancer. Cochrane handbook 5.1.0 was applied in evaluating the quality of included trials and RevMan 5.1.0 software was used for data analysis. Results Eight studies including 519 cases of late or chest wall recurrence of breast cancer were included. The results of the Meta-analysis exhibited that compared with chemotherapy alone, hyperthermia combined with chemotherapy could increase effective rate (OR=2.15, 95%CI: 1.50-3.09, P ＜ 0.01) and disease control rate (OR = 2.26, 95%CI: 1.42-3.60, P=0.0006). But there were no significant differences in rate of leucopenia (OR = 0.75, 95%CI: 0.43-1.32, P=0.32), rate of neutropenia (OR = 1.12, 95%CI: 0.58-2.18, P=0.73), rate of gastrointestinal reaction (OR = 1.00, 95%CI: 0.59-1.70, P=1.00), rate of liver and kidney dysfunction (OR = 0.97, 95%CI: 0.55-1.74, P=0.93). Conclusion Compared with chemotherapy alone, hyperthermia combined with chemotherapymay be more effective for late or chest wall recurrence of breast cancer, whereas adverse reactions are similar. For the quality restriction and possible publication bias of the included studies, more high quality randomized controlled trials are required to further verify this conclusion.
2017 Vol. 14 (26): 4-8,20 [Abstract] ( 285 ) HTML (1 KB)  PDF (1425 KB)  ( 139 )
9 Inhibiting effect of apigenin on hepatocellar carcinoma xenografts in nude mice
GAO Aimei1 CHENG Xiaoli2
Objective To investigate the effect of apigenin (APG) on hepatocellar carcinoma xenografts in nude mice and the possible molecular mechanism. Methods Models of nude mice were transplanted with BEL-7402/doxorubicin (ADM), and randomly divided into 3 groups, each group had 8 mice. The groups of mice were treated i.p. as follow: ADM (3 mg/kg, control group), APG+ADM (50 mg/kg+3 mg/kg, APG group), miR-101 mimics +ADM (50 mg/kg+3 mg/kg, miR-101 mimics group), every three days for a total of seven times. The volumes of tumor were measured. After the end of medication, the mice were sacrificed for measurement of tumor weights. Tumor cell proliferation was analyzed by Ki-67 immunostaining. Nuclear factor erythroid-2-related factor 2 (Nrf2) protein level was measured by Western blot. miR-101 level was detected by Real-time PCR. Results The volumes and weights of tumors in APG group and miR-101 mimics group were decreased compared with the control group (P < 0.05). Compared to the control group, APG and miR-101 mimics resulted in inhibition of tumor cell proliferation (P < 0.05 or P < 0.01), inhibition of Nrf2 expression (P < 0.01), and up-regulation of miR-101 levels (P < 0.05). Conclusion APG can inhibit the growth of hepatocellar carcinoma, its mechanism may partly be to inhibit the expression of Ki-67 and Nrf2, up-regulate the level of miR-101.
2017 Vol. 14 (26): 9-12 [Abstract] ( 249 ) HTML (1 KB)  PDF (833 KB)  ( 194 )
13 Effects of Bulbus Fritillariae Cirrhosae medicated serum on bronchial smooth muscle cells and vascular endothelial growth factor
LI Houzhong1 LIU Li2 HUANG Wei3 ZHOU Fubo1 ZHAI Fengguo1 YANG Xudong1 ZHANG Yufei4
Objective To investigate the effect of Bulbus Fritillariae Cirrhosae medicated serum on the proliferation of the bronchial smooth muscle cells (BSMC), the tube formation and the expressions of vascular endothelial growth factor (VEGF) in BSMC. Methods The murine were sensititized and challenged with ovalbumin (OVA) to establish asthma model and Bulbus Fritillariae Cirrhosae medicated serum was prepared. The BSMC were cultured in vitro and randomly divided into the blank serum group, the low dose group and the high dose group. The proliferations of BSMC, the lengths of the tube formation, the expressions of VEGF and VEGF mRNA were detected. Results Compared with the blank serum group, the proliferations of BSMC, the lengths of the tube formation, the expressions of VEGF and VEGF mRNA of the low dose group and the high dose group were increased significantly (P < 0.05). Conclusion Bulbus Fritillariae Cirrhosae medicated serum can inhibit the proliferations of BSMC and the lengths of the tube formation, and the possible mechanisms may be related to reduce the expressions of VEGF.
2017 Vol. 14 (26): 13-16 [Abstract] ( 284 ) HTML (1 KB)  PDF (847 KB)  ( 118 )
17 Effect of Furong Tongmai Capsules on Smad7 expression in myocardium of rats with diabetes mellitus
WANG Lixin WANG Yuansong SU Yang▲ TIAN Fengsheng CUI Ronggang
Objective To investigate the expression of Furong Tongmai Capsules on Smad7 expression in myocardium of rats with diabetes mellitus. Methods Sixty rats were randomly divided into normal group (10 rats) and model group (50 rats) by random number table method. After the model was made, 40 rats with diabetes mellitus were randomly divided into diabetes mellitus group and low, medium, high dose group of Furong Tongmai Capsules, with 10 rats in each group. Low, medium, high dose group of Furong Tongmai Capsules were given 0.7, 1.4, 2.8 g/kg of Furong Tongmai Capsules by gavage, normal group and diabetes mellitus group were given equal quantity of purified water. After 8 weeks, the myocardium in rats was preserved to make pathological section. The positive expression of blood glucose, blood lipid, Smad7 protein in each group was observed. Results Before treatment and after treatment for 8 weeks, the levels of blood glucose in diabetes mellitus group and low, medium, high dose group of Furong Tongmai Capsules were all higher than those of normal group (P ＜ 0.05), while there were no significant differences of blood glucose within each group before and after treatment (P ＞ 0.05). After treatment for 8 weeks, the levels of total cholesterol, triacylglycerol in diabetes mellitus group and low, medium, high dose group of Furong Tongmai Capsules were all higher than those of normal group (P ＜ 0.05). The Smad7 of normal group showed high positive expression, which of diabetes mellitus group and low, medium, high dose group of Furong Tongmai Capsules was all decreased (P ＜ 0.05); compared with diabetes mellitus group and low dose group of Furong Tongmai Capsules, the Smad7 expression of medium, high dose group of Furong Tongmai Capsules was increased significantly (P ＜ 0.05). Conclusion Furong Tongmai Capsules have the function of increasing the Smad7 expression in myocardium of rats with diabetes mellitus, inhibiting myocardial cell injury.
2017 Vol. 14 (26): 17-20 [Abstract] ( 201 ) HTML (1 KB)  PDF (661 KB)  ( 87 )
21 Effects of hyperoxia on pulmonary inflammation and fibrosis in newborn mice
XU Fengdan1,2 WANG You1 WU Wenshen2 XIE Songmin2
Objective To observe the effects of hyperoxia exposure on pulmonary inflammatory  response and fibrosis in new born mice. Methods 40 Kunming mice aged 2 days were randomly divided into air group (n = 20) and hyperoxia group (n = 20), reared in air or (60±5)% oxygen respectively. The mice were examined daily and the weight was recorded the next day. At the 3rd, 7th, 14th, 21st day of the experiment, 5 mice of each group were sacrificed respectively, then  the appearance of lung tissue, lung wet/dry weight ratio were observed; the pathological structure of lung tissue was examination by HE staining; collagen fiber of lung tissue was examination by Sirius red staining. Results ①No mouse died in the two groups during the experiment. The weight of mousein hyperoxia group was significantly was lower than that of air group at the 7th day after exposured to oxygen, the difference was statistically significant (P < 0.01). ②The ratio of lung wet/dry weight in hyperoxia group was higher than that in air-group begin the 7th day after hyperoxia exposured, the difference was statistically significant (P < 0.05 or P < 0.01). ③In hyperoxia group, with the time of exposured to oxygen increasing, lung structure showed typical BPD: alveoli showed irregular structure, interstitial was large, partial alveoli fused, alveolar count decreased, partial region occured inflammatory closed; at the 14th, 21st day after hyperoxia exposured, RAC in hyperoxia group was lower than air group, the difference was statistically significant (P < 0.01). ④Compared with air group, collagen area in hyperoxia-group increased at yhe 7th, 14th, 21st day after hyperoxia exposured. Conclusion BPD micemodels were successfully produced by sustained hyperoxia exposure. Sustained hyperoxia exposure may increase lung inflammation and fibrosis in neonatal mice, which may be an important mechanism for the development of BPD.
2017 Vol. 14 (26): 21-24 [Abstract] ( 254 ) HTML (1 KB)  PDF (936 KB)  ( 135 )
25 The influence of acupuncture combined with swimming training for the cognitive function in middle cerebral artery ischemia-reperfusion rats
CUI Jiawen MA Shujie CHU Lixi
Objective To observe the influence of acupuncture combined with swimming training for the cognitive function in middle cerebral artery ischemia-reperfusion rats. Methods SD rats were made into the model of right middle cerebral artery ischemia-reperfusion. After evaluation of neurological function test and water maze test operation, the 28 successful model rats were divided into model group, acupuncture group, swimming training group, and integrated acupuncture and swimming training group by random number table, with 7 rats in each group, 7 rats of sham-operation group were set separately. There was no treatment for sham-operation group and model group, the acupuncture group was given acupuncture therapy on GV 20, once per day, while the swimming training group was given swimming training, once per day, and integrated acupuncture and swimming training group was given integrated acupuncture therapy on GV 20 and swimming training, once per day. Total treatment time was 6 days. Each day before treatment, weight and neural functional test were evaluated. After treatment for 6 days, water maze test was detected for the ability of learning and remembering, after all treatment and evaluation, the brains were taken, then TUNEL staining was used to observe the cell apoptosis in hippocampus. Results After treatment, there was no interactive effect between acupuncture and swimming training (P ＞ 0.05), the neural function score of integrated acupuncture and swimming training group was lower than that of model group (P ＜ 0.05), the number of step through in water maze test of integrated acupuncture and swimming training group was more than that of model group (P ＜ 0.05). Conclusion The influence of acupuncture and swimming training for the cognitive function in middle cerebral artery ischemia-reperfusion rats may be better than acupuncture or swimming training only, more research needs to be done in the future.
2017 Vol. 14 (26): 25-28 [Abstract] ( 261 ) HTML (1 KB)  PDF (602 KB)  ( 114 )
29 Research progress on application safety of Cimetidine
LIU Yuming HE Ying SHEN Xianrong
The H2-receptor antagonist Cimetidine, an antiulcer drug, has many new pharmacologic actions and clinical applications. Due to its notable curative effect and good safety, Cimitidine is increasingly applied in clinic and its prescriptions is growing. But in recent years the studies have shown that Cimetidine has the possibility of leading to adverse reactions in several aspects, such as in nervous system, reproductive system, anaphylaxis, cardiovascular system, urinary system, endocrinium and drug interactions. All these adverse reactions include not only some high incidence adverse reactions, but also some potential or rare ones. This article reviews the research progress on the safety of cimetidine and its adverse effects, in order to improve therapeutic effect and safety of clinical medications. 
 
2017 Vol. 14 (26): 29-32 [Abstract] ( 269 ) HTML (1 KB)  PDF (598 KB)  ( 77 )
33 Research progress of ultrasound-targeted microbubble destruction technology promoting gene transfection with optimal parameters
MA Jie MU Yuming
The optimization of parameters is the most important in ultrasound-targeted microbubble destruction (UTMD), this parameter should achieve both high transfection efficiency while at the same time most of the cells without damage. At present, many studies have focused on optimizing the transfection parameters for those with high transfection efficiency and small tissue damage. However, there are many factors that affect the transfection effect, such asultrasound intensity, duty cycle, irradiation time, microbubble concentration, microbubble properties, plasmid concentration, different cell types. This article reviewes the best parameters of gene transfection in UTMD, and expectes to provide a basis for UTMD to be better applied to gene therapy.
2017 Vol. 14 (26): 33-36 [Abstract] ( 221 ) HTML (1 KB)  PDF (598 KB)  ( 252 )
37 Advances in treatment of post stroke depression
YUAN Jie1 LI Jinhao2 WANG Ning2 GAO Jing2 XIAO Jian2 WANG Jing3▲
Post stroke depression is a common complication of mental disorder after stroke. It has a high incidence in clinic. It is worth noting that a significant number of patients except depression as the main symptom, and often accompanied by some complications such as cognitive disorders, anxiety disorders, sleep disorders and movement disorders. These complications seriously affect the patient's daily life and social function. At present, the direction of treatment is mainly focused on the improvement of depressive symptoms in PSD patients, while the complications are ignored. In this case, the patient's recovery is very unfavorable. This article reviews the effects of drugs, psychological rehabilitation and acupuncture in the treatment of PSD and its complications.
2017 Vol. 14 (26): 37-40 [Abstract] ( 262 ) HTML (1 KB)  PDF (653 KB)  ( 168 )
41 General situation of traditional Chinese medicine on prevention and treatment of bone marrow depression after chemotherapy for malignant tumor
YU Yingying YIN Qiliang WU Di
The incidence of malignant tumors is increased year by year, chemotherapy plays an important role in the treatment of malignant tumors. But bone marrow suppression during chemotherapy makes a decline in the quality of life of patients, even makes patients discontinue treatment due to intolerance. With the deepening study of traditional Chinese medicine, it is found that traditional Chinese medicine plays an important role in the prevention and treatment of bone marrow suppression after chemotherapy. This article refers to the related literatures in recent 10 years at home and abroad on traditional Chinese medicine for prevention and treatment of bone marrow suppression after chemotherapy, introduces the active ingredients of traditional Chinese medicine, the important effect of single and compound traditional Chinese medicine in prevention of bone marrow suppression.
2017 Vol. 14 (26): 41-44 [Abstract] ( 246 ) HTML (1 KB)  PDF (643 KB)  ( 145 )
45 Advances in the chemical constituents and pharmacological effects of Ligusticum sinense Oliv cv. Chaxiong
HAN Wei
Ligusticum sinense Oliv cv. Chaxiong that belongs to the species of Ligusticum of the umbelliferae family, which contains phthalides, organic acids, flavonoids, coumarins, alkaloids, volatile oil, polysaccharides and other effective components. The dried rhizome of Chaxiong is used as one of Chinese medicine for activating blood, promoting the circulation of Qi, dispelling wind and relieving pain. Modern pharmacological research indicates that Chaxiong has significant pharmacological effects in the central nervous system, cardiovascular system, uterine smooth muscle and enhance immunity, etc. This paper summarizes domestic and foreign reports on the pharmacological activities and active ingredients for its further research.
2017 Vol. 14 (26): 45-48 [Abstract] ( 232 ) HTML (1 KB)  PDF (831 KB)  ( 158 )
49 Research progress of the role of Th17 lymphocyte in pathogenesis of rheumatic immunologic disease
WEN Lidan YANG Haiyu▲
In 2005 firstly described a newly CD4+T helper cell, the identification of the new subpopulation of T helper cells and it was named Th17. Th17 cells have independence capable of differentiation and development process. IL-17 is an early startup-factor of inflammatory response induced by T cell, can promote the release of inflammatory cytokines to amplify inflammatory response. Th17 cells have been shown play an important role in pathogenesis of rheumatic immunologic disease. However, the role of Th17 cells and regulation mechanism is not clear and needs further discussion and research. The research progress of Th17 cells and their secretion of cytokines involved in rheumatic immunologic disease is reviewed in this article.
2017 Vol. 14 (26): 49-52 [Abstract] ( 269 ) HTML (1 KB)  PDF (603 KB)  ( 114 )
53 Application value and progress of ultrasound in thyroid microcarcinoma
LI Anqi MA Fucheng
Now thyroid microcarcinoma is a common malignancy, it′s tiny and usually has no clinical symptoms. Ultrasound scanning has become the most common and effective method for diagnosing thyroid disease, determining their biological behavior and following-up the people who have thyroid cancer. Ultrasound also makes great help for the diagnosis and treatment, focus on their image, elastosonography, contrast-enhanced ultrasound, fine-needle aspiration, and follow-up. The article reviews the clinical application and progress of ultrasound in diagnosing thyroid microcarcinoma.
2017 Vol. 14 (26): 53-56 [Abstract] ( 730 ) HTML (1 KB)  PDF (644 KB)  ( 55 )
57 46 cases of central type atrial septal defect intervention by percutaneous closure with color Doppler ultrasound
ZHANG Shengkang YIN Xiaoqing XU Zhaojun WANG Zhaoli YANG Jin CHENG Yu XIE Xinlong
Objective To investigate the effect and application of percutaneous transcatheter closure of atrial septal defect with color Doppler ultrasound. Methods From January 2015 to March 2016, in Department of Cardiothoracic Surgery, First Affiliated Hospital of Hu'nan University of Traditional Chinese Medicine, 46 patients with central type atrial septal defect underwent ultrasound guided percutaneous interventional therapy were selected, internal jugular vein or femoral vein was chosen as the surgical approach according to the size and location of the atrial septal defect, and the patients' own situation. Results 42 cases were blocked by femoral vein approach, 41 cases were successful, 1 case was converted into thoracic plugging. 4 cases were blocked by internal jugular vein approach, 3 cases were successful, 1 case was transferred to thoracic plugging. The 44 successful cases recovered fast with no complications such as occluder dislocation, residual shunt, thrombus, hemolysis in Postoperative followed-up. Conclusion Percutaneous closure of atrial septal defect with color Doppler ultrasound may be a new treatment method to replace the traditional method.
[Key words] Atrial septal defect; Color Doppler ultrasound guidance; Minimally invasive; Occlusion
2017 Vol. 14 (26): 57-59,71 [Abstract] ( 191 ) HTML (1 KB)  PDF (771 KB)  ( 91 )
60 Clinical value analysis of peripheral blood sST2 on risk stratification and prognosis in patients with AHF
ZONG Bin
Objective To discuss the clinical value of peripheral blood sST2 on risk stratification and prognosis in patients with acute heart failure (AHF). Methods From June 2014 to December 2015, in Xuzhou Central Hospital, 162 AHF patients were selected, 58 healthy persons were chosen as control group. All patients were followed-up 1 year after AHF attack. The incidence of end point was recorded. The sST2 levels were determined by ELISA and the levelsof NT-proBNP and TNI were detected by automatic biochemical analyzer. The value of them on prognosis were analyzed by ROC curve. Results The levels of sST2, NT-proBNP and TNI in AHF patients were significantly higher than healthy people, the differences were statistically significant (P < 0.05). The levels of sST2, NT-proBNP and TNI in mild AHF patients were significantly higher than severe AHF patients, the differences were statistically significant (P < 0.05); 63 patients occurred recurrence of heart failure or cardiac death, and the incidence of the end of observation was 38.89%, the sST2 level in AHF patients with the end of observation was significantly higher than AHF patients without the end of observation, the differences were statistically significant (P < 0.05). The results of Logistic multifactor regression analysis showed thatthe levels of sST2, NT-proBNP and clinical heart function grade had independent predicting value of AHF (OR = 4.003, 3.741, 7.862). The area under the ROC curve on prognosis of sST2 (AUC = 0.820) was slightly higher than NT-proBNP (AUC = 0.769), but the difference was not statistically significant (P > 0.05). The prognosis value combined sST2 with NT-proBNP was significantly increased (AUC = 0.938). Conclusion The level of peripheral blood sST2 may be used toevaluaterisk stratification and prognosis in patients with AHF. It will be better to evaluatethe prognosis combining sST2 with other biomarkers such as NT-proBNP.
2017 Vol. 14 (26): 60-63 [Abstract] ( 231 ) HTML (1 KB)  PDF (515 KB)  ( 80 )
64 Analysis of the risk factors affecting prognosis of patients with advanced valvular hear disease afterartificial cardiac valve replacement
MA En WANG Zongshe SHU Duanchao WANG Xiaojun ZHAO Long
Objective To explore the risk factors affecting the prognosis of patients with advanced valvular hear disease after artificial cardiac valve replacement. Methods From January 2014 to December 2016, in Baoji Central Hospital, the clinical data of 200 patients with advanced valvular hear disease were retrospectively analyzed, the risk factors affect the postoperative prognosis of patients were analyzed. Results Regular follow-up was carried among all the 200 pa?鄄tients, the average follow-up time was (18.2±6.7) months, and 28 cases dead and 172 cases survived. Single factor analysis results showed that age, body mass index, cardiac functional grading, combined diabetes and kidney disease preoperative, protopathy,history of preoperative cardiac surgery, operation method, cardiopulmonary bypass time, time of arterial blocking between survival and dead patients had statistically significant difference (P < 0.05). Logistic multiple factors regression analysis results showed that age>60 years, body mass index<20 kg/m2 or >35 kg/m2, cardiac functional grade Ⅲ-Ⅳ, combined diabetes and kidney disease preoperative, protopathy,history of preoperative cardiac surgery, cardiopulmonary bypass time≥160 min, time of arterial blocking≥120 min were the influence factors ofprognosis of patients with severe valvular heart disease after artificial valve replacement. Conclusion Prognosis of patients with advanced valvular hear disease after artificial cardiac valve replacement can be influenced by many factors, so the positive and effective measures should be taken out to cope with the situation aimed at these factors,and to improve the prognosis of patients.
2017 Vol. 14 (26): 64-67 [Abstract] ( 230 ) HTML (1 KB)  PDF (443 KB)  ( 141 )
68 Clinical study of different skin care interventions for prevention of scalp injury induced by video electroencephalogram in children
HUO Guangyan1 ZHANG Xiaoxue2 ZHAN Yan1 WANG Yuping3 ZHAO Xuan1 ZHU Xiaoying1 LI Ting1 LI Rui1
Objective To explore the effect of different skin care interventions for prevention of scalp injury induced by video electroencephalogram (VEEG) in children. Methods From January 2015 to June 2016, 250 cases of children provided with VEEG in Pediatrics Department of Xuanwu Hospital, Capital Medical University were selected, and randomly divided into the medical cotton ball group, 3M hydrocolloid dressings group, 3M silicone adhesive group, Comfeel hydrocolloid dressing group and control group, each group had 50 cases. Patients were given corresponding treatments of medical cotton ball, 3M hydrocolloid dressings, 3M silicone adhesive and Comfeel hydrocolloid dressing for scalp protection during VEEG, while patients in the control group were given the convention electrode fixed method during VEEG. The severity of scalp injury was compared among these groups. Results There was statistically significant difference in severity of scalp injury among the five groups (P < 0.01); pairwise comparison results showed that the differences in severity of scalp injury between the medical cotton ball group, 3M silicone adhesive group and the control group had statistically significant (P < 0.01 or P < 0.05). Conclusion The application of medical cotton ball and 3M silicone adhesive can reduce the severity of scalp injury induced by VEEG in children, which provides reference for clinical practice.
2017 Vol. 14 (26): 68-71 [Abstract] ( 232 ) HTML (1 KB)  PDF (499 KB)  ( 95 )
72 Effects of menopausal hormone treatment on patients with uterine fibroids during peri-menopausal period
CHEN Minghua CHEN Daozhen GONG Jian
Objective To investigate the effect of menopausal hormone treatment on patients with uterine fibroids during peri-menopausal period. Methods 193 patients with uterine fibroids during peri-menopausal period treated in Wuxi Maternal and Child Health-Care Hospital Affiliated to Nanjing Medical University from January 2010 to September 2014 were selected. All patients received estrogen progesterone cycle sequential therapy. The Kupperman score was used to evaluate the symptoms of perimenopausal syndrome before medication and 3, 6, 9, 12, 24 months after medication. Uterine volume, fibroid volume and endometrial thickness were monitored by vaginal ultrasound. The levels of serum follicle stimulating hormone, luteinizing hormone and estradiol were measured by chemiluminescent immunoassay. Results After medication the total score and item scores of Kupperman were significantly lower than before medication (P < 0.05). 9, 12, 24 months after medication the uterine volumes were significantly smaller than before medication (P < 0.05), however, there were no significant differences in endometrial thickness and fibroid volume among before and after medication (P > 0.05). After medication the levels of follicle-stimulating hormone were significantly lower than before medication (P < 0.05), however, there were no significant differences in luteinizing hormone and estradiol levels among before and after medication (P > 0.05). Conclusion Menopausal hormone treatment for patients with uterine fibroids during peri-menopausal period can effectively improve peri-menopausal symptoms, but has no obvious effect on the uterine fibroids.
2017 Vol. 14 (26): 72-75 [Abstract] ( 208 ) HTML (1 KB)  PDF (466 KB)  ( 101 )
76 Clinical effect of laparoscopy combined with Leuprolide Acetate in the treatment of endometriosis complicated with infertility
LONG Ping LUO Ruoyu
Objective To investigate the clinical effect of laparoscopy combined with Leuprolide Acetate in the treatment of endometriosis complicated with infertility. Methods 105 cases of patients with endometriosis complicated with infertility treated in Renmin Hospital of Wuhan University from July 2014 to January 2016 were selected. According to the different treatment methods, patients were divided into the control group (50 cases) and the observation group (55 cases). Patients of the control group were given laparoscopic surgery treatment, patients of the observation group were given drug therapy on the basis of the laparoscopic surgery. The clinical efficacy, postoperative complication rate, serum CA125 level and the rate of pregnancy in 1 year were compared between the two groups. Results The total clinical efficacy rate of the observation group was 96.36%, which was higher than 80.00% of the control group, with statistically significant difference (P < 0.05). There were no statistically significant differences in serum CA125 levels before and after treatment between the two groups (P > 0.05), however, after treatment the serum CA125 levels of the two groups were decreased than before treatment (P < 0.05). The complication rate of the observation group was 1.82%, which was lower than 8.00% of the control group, but the difference was not statistically significant (P > 0.05). The pregnancy rate in 1 year of the observation group was 56.36%, which was higher than 14.00% of the control group, with statistically significant difference (P < 0.05). Conclusion Laparoscopy combined with Leuprolide Acetate in the treatment of endometriosis complicated with infertility has better efficacy, lower complications and higher pregnancy rate. It is worthy of clinical application.
2017 Vol. 14 (26): 76-78,82 [Abstract] ( 256 ) HTML (1 KB)  PDF (808 KB)  ( 145 )
79 Comparison of effective of two operation methods for treating Siewert Ⅱ type and Ⅲ type adenocarcinoma of esophagogastric junction via abdominal approach
ZHANG Rui1 LI Xiao2▲
Objective To compare two operation methods for treating Siewert Ⅱ, Ⅲtype adenocarcinoma of esophagogastric (AEG) junction via abdominal approach, namely total gastrectomy and proximal gastrectomy. Methods The clinical data of 51 patients with Siewert Ⅱ,Ⅲ type AEG, from October 2007 to May 2011, in Department of Surgery, Baoji Hospital of Traditional Chinese Medicine, were analyzed retrospectively, among them, 32 cases were given total gastrectomy and 19 cases were given proximal gastrectomy. The differences in patients' age, clinical and pathological characteristics, operation time, intra-operative blood loss, postoperative pathologic staging, nutritional status and postoperative survival situation between the two groups were compared. Results Total gastrectomy group was better on lymph nody excision than the proximal gastrectomy group, while average operation time and average intra-operative blood loss were higher than those of proximal gastrectomy, the differences were statistically significant (P < 0.05); There were no statistically significant differences in occurrence rate of complications during perioperative period between the two groups (P > 0.05). Compared with total gastrectomy group, proximal gastrectomy group was more licked to occured the esophagogastricl reflux after operation 1 year, the differences were statistically significant (P < 0.05). There was statistically significant difference in nutritional status between the two groups after operation 1 year (P > 0.05). The survival rate of the two groups had no statistically significant difference  after operation 5 years (P > 0.05),  5-year survival rate of Ⅲ phase patients in total gastrectomy group was 12.50%, that in proximal gastrectomy group was 10.53%. Conclusion The occurrence rate of esophagogastric reflux for total gastrectomy is significantly lower than proximal gastrectomy and the risk of operation will not be increased, there is no significant difference between total gastrectomy and proximal gastrectomy in postoperative nutritional status, it is a suitable operation method for Siewert Ⅱ type and Ⅲ type AEG patients.
2017 Vol. 14 (26): 79-82 [Abstract] ( 231 ) HTML (1 KB)  PDF (551 KB)  ( 113 )
83 Transcatheter arterial chemoembolization in the treatment of advanced bladder cancer with hemorrhage
LU Wei YANG Chao MA Junpeng DU Peng JIANG Fuqiang YANG Jian XIE Peng ZHANG Zhe
Objective To investigate effects of transcatheter arterial chemoembolization (TACE) in the treatment of controlling the bladder bleeding and inhibiting the tumor growth in advanced bladder cancer. Methods From January 2015 to December 2016, in Navy General Hospital, 43 patients with advanced bladder cancer and gross hematuria were selected, they were treated with bladder arteries chemoembolization (TACE). All the patients presented macroscopic haematuria. The catheters were inserted into bladder supplying arteriesand anticancer drugs infusion and followed by embolization with microsphere. Procedures were repeated 30 d after the first treatment. The success rate of hemostasis, shrinkage of tumor and downstage of tumors after TACE was observed. Results Bladder bleeding stopped after the first TACE in all patients. Bladder tumor shrinkageof more than 50% in 27 patients (62.8%) was found by MRI 30 d after the second treatment. Down stage of tumors were found in 12 patients (28.0%). The differences of tumor stage between pre and post treatment were statistical significant (P < 0.05). No serious side effects and complications were developed in all patients. Conclusion TACE is effective in controlling bladder bleeding in advanced bladder cancer. The tumor growth is significantly inhibited by the procedures.
2017 Vol. 14 (26): 83-85,93 [Abstract] ( 186 ) HTML (1 KB)  PDF (696 KB)  ( 156 )
86 Risk factors analysis of peripherally inserted central catheter associated thrombosis in lung cancer patients with chemotherapy
YUAN Na1 WANG Lei2 WU Xueliang3
Objective To discuss the incidence rate and risk factors of peripherally inserted central catheter (PICC) related thrombosis in patients with lung cancer receiving chemotherapy. Methods From January 2014 to January 2015, in First Affiliated Hospital of Hebei North University, 157 patients with lung cancer receiving chemotherapy and PICC were selected and observed for 180 days. The diagnosis of thrombosis was based on Doppler Sonography. Age, gender, tumor type, clinical stage, treatment,c omplications, PICC catheter selection of vein, PICC catheter time, different chemotherapy drugs and the influence of PICC related thrombosis were analyzed by single factor and the multiple Logistic regression to study. Results Among 157 caces, 17 cases (10.8%) ocurred symptomatic PICC-related thrombosis. The patients were individed into PICC-related thrombosis group and no-PICC-related thrombosis group according into thrombosis occurrence. PICC-related thrombosis group and no-PICC-related thrombosis group were compared, the differences of gender, clinical stage, using Etoposide were statistically significant (P < 0.05), the differences of the age, tumor type, treatment, complication, PICC catheter selection of vein and PICC catheter time were not statistically significant (P > 0.05). the multiple Logistic regression analysis suggested that the risk of PICC related thrombosis with patients with lung cancer receiving of etoposide treatment increased 1.373 times, the risk of PICC related thrombosis in female was 1.219 times that in male,and the risk of ⅢB-Ⅳ stages was 4.347 times that ofⅡ-ⅢA stages. Conclusion The gender, clinical stages and using Etoposide are the risk factors in lung patients with PICC-related thrombosis.
2017 Vol. 14 (26): 86-89,97 [Abstract] ( 224 ) HTML (1 KB)  PDF (867 KB)  ( 121 )
90 Diagnostic value of breast ultrasound DOT combined with serum CA15-3 and CEA detection in breast tumors
TUO Youlin
Objective To explore the diagnostic value of breast ultrasound DOT combined with serum CA15-3 and CEA detection in breast tumors. Mehtods From August 2012 to December 2015, in Sichuan Province People's Hospital, 136 female breast cancer patients were selected as group A, 120 female benign breast tumor patients were selected as group B, 120 female healthy physical examination were selected as group C, the MHC, serum CA15-3 and CEA levels in three groups were detected and analyzed. Results The levels of CA15-3 and CEA in group A were significantly higher than those in group B and group C, the differences were statistically significant (P < 0.05), CA15-3 and CEA levels in group B and group C were compared, the differences were not statistically significant (P > 0.05). Ultrasound, combined serum CA15-3, CEA detecting breast tumor positive rate was significantly higher than the respective single detecting, the differences were statistically significant (P < 0.05), ultrasound, combined serum CA15-3, CEA detecting breast cancer sensitivity rate was significantly higher than the respective single detecting, the differences were statistically significant (P < 0.05). ROC curve analysis of joint detection in the diagnosis of breast malignant tumor AUC was 0.886 (95%CI 0.689-0.993), the maximum diagnostic threshold was 135.0 μmol/L, the maximum value of Youden's index was 0.70, the specificity was 91.5%, sensitivity was 95.5%. Conclusion Breast ultrasound DOT combined with serum CA15-3, CEA detection can make up for the defect of single index examination, so as to improve the diagnosis rate of breast cancer, breast cancer has good auxiliary diagnostic value.
2017 Vol. 14 (26): 90-93 [Abstract] ( 251 ) HTML (1 KB)  PDF (574 KB)  ( 73 )
94 Effects of low-dose Simvastatin on serum complement system in patients with cardiorenal syndrome
WANG Zhi HUANG Jin▲ LI Yimin YAN Xuejiao
Objective To investigate the effects of low-dose Simvastatin on serum levels of C3, C4 and mRNA levels of type Ⅰ (CR1) and Ⅱ (CR2) complement receptor in patients with cardiorenal syndrome (CRS). Methods Totally 56 patients with CRS were enrolled from January to December in 2012 and treated with Simvastatin (10 mg once per night) for 8 weeks. The serum levels of C3 and C4 were measured. Peripheral blood mononuclear cells were extracted from patients before and after treatment with Simvastatin. RT-PCR was performed to detect the mRNA expression of CR1 and CR2. The left ventricular ejection fraction was determined by Doppler spectrum analysis. Results After therapy, the mean levels of serum C3 was significantly decreased in patients with CRS [(1.14±0.35) vs (1.22±0.31) g/L, P < 0.05]. Contrarily, the mean mRNA level of CR1 increased after therapy (0.76±0.10 vs 0.70±0.11, P < 0.05). Conclusion The down-regulation of serum level of C3 as well as up-regulation of CR1 after treatment with low-dose Simvastatin is probably associated with improvement of heart and renal function in patients with CRS.
2017 Vol. 14 (26): 94-97 [Abstract] ( 239 ) HTML (1 KB)  PDF (549 KB)  ( 93 )
98 Risk factors of diabetic foot in middle aged and elderly people in China: a Meta analysis
ZHENG Huiqiu LING Xiong WANG Xuemei
Objective To evaluate the relationship between body mass index (BMI), high density lipoprotein cholesterol (HDL-C), triglyceride (TG) and diabetic foot in Chinese middle aged and elderly people. Methods The following database such as PubMed, China national knowledge infrastructure (CNKI), Wanfang database were searched to collect case-control study on related risk factors of diabetic foot in China. The retrieval time was from January 2007 to April 2016. The Meta analysis was performed by RevMan5.3 software. The risk factors were analyzed by fixed effect model or random effect model, count pooled mean difference (MD) and 95% confidence interval (95%CI), with stability evaluated by sensitivity analysis. Moreover, the funnel plot was to assess the published bias of articles. Results A total of 17 articles were included, Meta analysis showed that BMI (MD = -0.93, 95%CI: -1.67 - -0.18, P = 0.01), HDL-C (MD = -0.20, 95%CI: -0.33 - -0.07, P = 0.004) had significant difference between the diabetic foot group and the non-diabetic foot group; there was no obvious difference in TG (MD = 0.01, 95%CI: -0.36 - 0.37, P = 0.98) between diabetic foot group and the non-diabetic foot group. Conclusion Lower BMI and lower HDL-C may be the risk factors of diabetic foot.
2017 Vol. 14 (26): 98-101,105 [Abstract] ( 220 ) HTML (1 KB)  PDF (1163 KB)  ( 101 )
102 Clinical study on the relation of cognitive function and red blood cell index in male patient with alcohol dependence
YANG Jun ZHOU Xuhui GUO Yujun LUO Qiong
Objective To study the correlation of cognitive function and red blood cells index in male patients with alcohol dependence. Methods 65 male patients with alcohol dependence were selected as research group in Hu′nan Province Brain Hospital from January 2016 to April 2017, and 65 healthy check-up were selected as control group. The cognitive function were assessed by Montreal cognitive ment scale (MoCA), the content of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and gamma-pancreatic phthalein transferase (GGT) were tested by automatic biochemical analyzer, the red blood cell count (RBC), hemoglobin (HGB), hematocrit (HCT), red cell volume (RCV), average red blood cell hemoglobin content (MCH) and hemoglobin concentration (MCHC) were detected by fully automatic classification of five blood cell analyzer. Results The score of MoCA in research group was significantly lower than that in control group, and the liver function index of ALT, AST and GGT were significantly higher than that in control group, the differences were statistically significant (P < 0.05). The RBC, HGB and HCT in research group were significantly lower than that in control group, the differences were statistically significant (P < 0.05). RCV, MCH and MCHC in two groups were no statistically significant difference (P > 0.05). The score of MoCA in research group was positive related to RBC, HGB and HCT (r = 0.61, 0.63, 0.72, P < 0.05). There were no correlation between MoCA score and MCV, MCH and MCHC in research group (P > 0.05). ALT in research group was negatively related to RBC, HGB and HCT (r =-0.63, -0.65, -0.73, P < 0.05). There was no correlation between ALT and MCV, MCH and MCHC in research group (P > 0.05). AST and GGT were not correlated with erythrocyte correlation (P > 0.05). Conclusion The cognitive function and red blood cells index in male patients with alcohol dependence are changed, the cognitive function and red blood cells index are closely related.
2017 Vol. 14 (26): 102-105 [Abstract] ( 232 ) HTML (1 KB)  PDF (551 KB)  ( 97 )
106 Effects of comprehensive rehabilitation therapy on cognitive function and motor function of patients with acute stroke
LI Zheng LIU Yang SUN Guojian
Objective To explore and analyze the effects of comprehensive rehabilitation therapy on cognitive function and motor function in patients with acute stroke. Methods Ninety cases of patients with acute stroke treated in Liaocheng People's Hospital from May 2014 to May 2016 were selected, they were divided into control group and observation group by random number table, with 45 cases in each group. The control group was given routine rehabilitation therapy, and the observation group was given comprehensive rehabilitation therapy. The scores of mini-mental state examination (MMSE), Fugl-Meyer motor scale (FM) and Barthel index (BI) in the two groups were compared. Results After treatment for 1, 3 months, the scores of MMSE, FM and BI in the two groups were all higher than those before treatment, with statistically significant differences (all P ＜ 0.05). After treatment for 3 months, the scores of MMSE, FM and BI in the two groups were all higher than those after treatment for 1 month, with statistically significant differences (all P ＜ 0.05), and the scores of indexes above in the observation group were all higher than those of control group, with statistically significant differences (all P ＜ 0.05). Conclusion Comprehensive rehabilitation therapy can improve the cognitive function and motor function of patients with acute stroke, with high safety.
2017 Vol. 14 (26): 106-108,125 [Abstract] ( 211 ) HTML (1 KB)  PDF (901 KB)  ( 61 )
109 Clinical study of Th1/Th2/Treg/Th17 immune response in patients with tuberculosis
CHENG Tao1 WU Weiling2 HUANG He3
Objective To study Th1/Th2/Treg/Th17 immune response in patients with tuberculosis. Methods Patients with recurrent tuberculosis and primary tuberculosis who received treatment in 458th Hospital of PLA during May 2013 to October 2016 were selected as recurrent tuberculosis group (n=38) and primary tuberculosis group (n=47) respectively; healthy volunteers who received physical examination during the same period were selected as control group (n=50). The contents of Th1, Th2, Treg and Th17 cells as well as corresponding cytokines in peripheral blood, and the contents of inflammatory mediators in serum were determined. Results Th1 and Th17 cell contents as well as IFN-γ contents inperipheral blood of recurrent tuberculosis group and primary tuberculosis group were significantly lower than those of control group while Th2 and Treg cell contents as well as IL-4, IL-5, IL-10, IL-17, TGF-β, HMGB1, sTREM1, MCP1 and HBD2 contents were significantly higher than those of control group(P < 0.05); Th1, Th17 cell contents as well as IFN-γ contents in peripheral blood of recurrent tuberculosis group were significantly lower than those of primary tuberculosis group while Th2, Treg cell contents as well as IL-4, IL-5, IL-10, IL-17, TGF-β, HMGB1, sTREM1, MCP1 and HBD2 contents were significantly higher than those of primary tuberculosis group(P < 0.05); HMGB1, sTREM1, MCP1 and HBD2 were negatively correlated with Th1 and Th17, positively correlated with Th2 and Treg (P < 0.05). Conclusion The change of tuberculosis is closely related to Th1/Th2/Treg/Th17 immune response imbalance.
2017 Vol. 14 (26): 109-112 [Abstract] ( 247 ) HTML (1 KB)  PDF (583 KB)  ( 88 )
113 Clinical efficacy and safety of calcium channel blockers versus nitrates treating chronic anal fissure：a Meta analysis
DU Tiancong MENG Qiang▲ ZOU Jie LI Qiang
Objective To evaluate the clinical efficacy and safety of calcium channel blockers (CCBs) and nitrates in the treatment of chronic anal fissure. Methods Clinical randomized control trials regarding CCBs and nitrates treating chronic anal fissure were searched in databases of CBMdisc, CNKI, Wanfang Database, VIP, PubMed, Embase, Crochane Library, Web of science, Clinical Trials and from their inception to May 1st 2017. The quality of RCTs was appraised and data were extracted. Review Manager 5.3 and Stata 14.0 were used for Meta analysis. Results 11 literatures with 862 patients were included finally. The Meta-analysis showed the effects of CCBs on improving the cure rate and reducing the incidence of recurrence were better than those of nitrates [RR=1.13, 95%CI(1.04, 1.23), P=0.003; RR=0.68, 95%CI(0.49, 0.95), Z=2.28, P＝0.02]. The effect of CCBs on reducing the incidence of side effects was better than that of nitrates [RR=0.31, 95%CI(0.19, 0.53), P < 0.01]. Conclusion CCBs treating chronic anal fissure is superior to nitrates in clinical efficacy and safety.
2017 Vol. 14 (26): 113-117 [Abstract] ( 228 ) HTML (1 KB)  PDF (1117 KB)  ( 105 )
118 Application of 5S management in drug administration in Hospital Pharmacy of  Maternal and Child Health Agencies
ZHANG Huajun1 CHEN Lihui2 BAI Feng2
Objective To explore the role of 5S management in drug administration of Hospital Pharmacy, in order to ensure patients′ medication safety. Methods The date of drugs utilization in Hospital Pharmacy of Maternity and Child Care Center of Qinhuangdao from August 2014 to July 2016 were selected. Accroding to whether 5S management method adopted dividied into before implementation from August 2014 to July 2015 and after implementation from August 2015 to July 2016. The management methods involved five links, including SEIRI, SEITON, SEISO,SEIKEETSU and SHITSUKE. The speed of drug transfer, drug dispensing error and prescription checking were compared before and after implementation of 5S management. Results After the implementation of 5S management, the speed of drug transfer increased significantly (P < 0.05), drug dispensing errors and drug loss reporting events significantly decreased (P < 0.05), the detection rate of irrational drug using by pharmacists and the rate of qualified prescriptions in clinical departments increased at the same time (P < 0.05). Conclusion The 5S management method can effectively reduce mistakes and accidents in drug dispensing, enhance the detection rate of irrational prescriptions and improve the security of drug using.
2017 Vol. 14 (26): 118-121 [Abstract] ( 199 ) HTML (1 KB)  PDF (516 KB)  ( 101 )
122 Application of PDCA circulation method in improving the quality of the pharmacy management and reducing the drug application error rate
SHU Fang1 Siriguleng2
Objective To study the effect of PDCA circulation method in improving the quality of the pharmacy management and reducing the drug application error rate. Methods The data in Outpatient Pharmacy of Inner Mongolia People's Hospital without PDCA circulation method from February 2014 to February 2015 were chosen as the control group. The data in Outpatient Pharmacy of the hospital with PDCA circulation method from April 2015 to April 2016 were chosen as the observation group. A total of 25 cases of pharmacists, 2000 kinds of drugs, 100 cases of patients were investigated in this study. The pharmacy management quality score; drug inventory, lack of drugs, error rate of drug batch number management under pharmacy management mode; time of check a single prescription in pharmacy deployment, error rate of dispensing, satisfaction of patients were compared between the two groups. Results The pharmacy management quality scores, including scores of pharmacy environmental management, working comfort, drugs classification, drug preservation methods in the observation group were higher than those in the control group, with statistically significant differences (P < 0.05). The drug inventory, lack of drugs, error rate of drug batch number management in the observation group were lower than those in the control group, with statistically significant differences (P < 0.05). The time of check a single prescription in pharmacy deployment, error rate of dispensing in the observation group were shoter or lower than those in the control group, while the satisfaction of patients was higher in the observation group, with statistically significant differences (P < 0.05). Conclusion PDCA circulation method can improve the quality of the pharmacy management, reduce the error rate of drug use and errors, improve satisfaction of patients, which can be applied in pharmacy management.
2017 Vol. 14 (26): 122-125 [Abstract] ( 202 ) HTML (1 KB)  PDF (511 KB)  ( 132 )
126 Clinical application statistics of antihistamine drugs in our hospital from 2014 to 2016
LI Wei
Objective To investigate the clinical utilization situation of antihistamine drugs in Hanzhong Central Hospital ("our hospital" for short), so as to provide references for clinical rational drug use. Methods The total drug sales amounts and sort, DDDs, DDC and sort ratio (B/A) of antihistamine drugs in our hospital from 2014 to 2016 were retrospectively analyzed. Results In the past three years, the trend of total drug sales amount of antihistamine agents decreased year by year, especially the first generation of antiallergic histamines. The sales amount sorting of all kinds of antihistamine drugs had few changes, Desloratadine Citrate Disodium Tablet and Desloratadine Tablet ranked the top two, rankings of Cetirizine raised year after year, other drugs sorting changed slightly. The top three DDDs of antihistamine drugs were the third generation of antiallergic histamines, drugs with Chloropressin composition always ranked the front of the list. The B/A values of Cetirizine Drops were always <1, and the B/A values of Chlorobenzene and Isopropyrazine were all >1. There were irrational use of antihistamine drugs in prescriptions, including improper drug combination, improper dosage, improper frequency for drugs giving, with total of 213 cases. Conclusion The DDDs sort of antihistamine drugs in our hospital is basically reasonable, but the clinical rational application of the second and third generation of antihistamine drugs should be further strengthened, in order to reduce improper use of drugs.
2017 Vol. 14 (26): 126-129 [Abstract] ( 191 ) HTML (1 KB)  PDF (484 KB)  ( 127 )
130 Clinical effect of Sodium Tanshinone ⅡA Sulfonate Injection in the treatment of senile pulmonary heart disease
QIN Hongjie1 CHEN Xinguang2
Objective To investigate the clinical effect of Sodium Tanshinone ⅡA Sulfonate Injection in the treatment of senile pulmonary heart disease. Methods Eighty-six cases of elderly patients with acute stage of pulmonary heart disease treated in Beijing Luhe Hospital, Capital Medical University from June 2013 to June 2015 were selected and divided into control group and observation group by random number table method, with 43 cases in each group. Both groups were given conventional treatment, on basis of which, the observation group was added with Sodium Tanshinone ⅡA Sulfonate Injection, intravenous drip. The clinical effect of the two groups was observed, the indexes of hemorheology, arterial blood gas analysis, pulmonary artery systolic pressure of the two groups before and after treatment were compared, the adverse reactions of the two groups during the course of treatment were recorded. Results The total effective rate of observation group (88.37%) was higher than that of control group (76.74%), the difference was statistically significant (P ＜ 0.05). After treatment, the indexes of hemorheology (whole high blood viscosity, whole low blood viscosity, plasma viscosity, hematocrit, red cell assembling index, platelet aggregation rate, fibrinogen) in the two groups were all lower than those before treatment, the differences were statistically significant (P ＜ 0.05); after treatment, the indexes of hemorheology above in the observation group were all lower than those of control group, the differences were statistically significant (P ＜ 0.05). Compared with before treatment, the PaO2 of the two groups after treatment were increased, PaCO2 and pulmonary artery systolic pressure were decreased, the differences were statistically significant (P ＜ 0.05). After treatment, the PaO2 of observation group was higher than that of control group, the PaCO2 and pulmonary artery systolic pressure were lower than those of control group, the differences were statistically significant (P ＜ 0.05). Both groups had no obvious adverse reactions during the treatment. Conclusion Sodium Tanshinone ⅡA Sulfonate Injection in the treatment of senile pulmonary heart disease has significant effects, which can reduce the clinical signs and symptoms, improve the cardiac function and the states of hemorheology and pulmonary arterial hypertension, and the safety is high, which is worthy of clinical promotion and application.
2017 Vol. 14 (26): 130-133 [Abstract] ( 154 ) HTML (1 KB)  PDF (367 KB)  ( 90 )
134 Analysis of distress and related factors in patients with breast cancer at early stage of treatment
SU Yali1 WANG Pilin1 LIU Jun′e2 HAN Jing2 QU Gengbao1 QIU Binbin1
Objective To investigate the psychological distress levels of breast cancer patients in their early treatment and explore the related factors. Methods Descriptive research design was used. 122 patients with breast cancer within 3 months collected by convenient sampling method were from Department of Breast Surgery, Beijing Tiantan Hospital, Capital Medical University, during their treatment from April to December in 2016. General questionnaire and psychological pain management screening tools were used for questionnaire survey. Results 63.9% of participants reported moderate or severe distress with scores ≥ 4. Worrying about recurrence (68.9%), fatigue (63.1%) and daily life being disrupted (62.3%) were the first three related problems. Distress level of participants were significantly affected by diagnostic methods. The distress scores and incidences of severe distress among participants were diagnosed during operation are significantly higher than cases identified by needle biopsy, received neoadjuvant chemotherapy or exairesis. Conclusion Early treatment of breast cancer patients with higher stress levels, diagnostic methods of significant impact on them.
2017 Vol. 14 (26): 134-137,141 [Abstract] ( 243 ) HTML (1 KB)  PDF (636 KB)  ( 162 )
138 Application effect of comfort care in patients with laparoscopic hysteromyomectomy
ZHANG Jingxia
Objective To investigate the application effect of comfort care in patients with laparoscopic hysteromyomectomy. Methods The clinical data of 87 patients underwent laparoscopic hysteromyomectomy admitted to the First Affiliated Hospital of Liaoning University of Traditional Chinese Medicine from January to November 2015 was analyzed retrospectively. According to different nursing methods, the patients were divided into control group (43 cases, routine nursing) and observation group (44 cases, comfort care). The operation indicators (operation time, postoperative leaving bed time, hospital stay), scores of anxiety and depression, incidence of postoperative complications between the two groups were compared. Results The operation time, postoperative leaving bed time and hospital stay in the observation group was all shorter than those of control group, the differences were all statistically significant (P ＜ 0.05). After nursing, the scores of self-rating anxiety scale and self-rating depression scale in the observation group were all lower than those of control group, the differences were all statistically significant (P ＜ 0.05). The incidence of postoperative complications in the observation group (13.64%) was lower than that of control group (30.23%), the difference was statistically significant (χ2=28.411, P ＜ 0.05). Conclusion Comfort care can effectively shorten the operation time, postoperative leaving bed time, hospital stay, alleviate negative emotions, reduce incidence of complications, and improve the quality of nursing care.
2017 Vol. 14 (26): 138-141 [Abstract] ( 248 ) HTML (1 KB)  PDF (618 KB)  ( 108 )
142 Effects of rehabilitation pathway on functional restoration in patients with CroweⅣ developmental dysplasia of hip underwent total hip arthroplasty combined with subtrochanteric osteotomy
YANG Yuxia TANG Yanfeng CAI Hongmin FAN Ru LIU Youwen▲
Objective To evaluate the effects of rehabilitation pathway on functional restoration in patients with CroweⅣ developmental dysplasia of hip underwent total hip arthroplasty combined with subtrochanteric osteotomy. Methods Twenty patients with CroweⅣ developmental dysplasia of hip underwent total hip arthroplasty combined with subtrochanteric osteotomy in the Second Department of Hip Injury, Luoyang Orthopaedic Hospital of He'nan Province from January 2012 to October 2015 were selected as research objects, all patients were taken postoperative rehabilitation pathway. Postoperative lower extremity length and complications were observed, and preoperative and one-year postoperative hip Harris scores were recorded. Results All patients were followed-up postoperatively, with average of 30 months (13-50 months). The one-year postoperative hip Harris score [(82.7±4.2) points] was higher than that before operation [(42.7±2.8) points], with statistically significant difference (P ＜ 0.05). During follow up, one patient had hip prosthesis dislocation and the patient was treated successfully by reduction; four patients had sciatic nerve injury and they were recovered by conservative rehabilitation; two patients with delayed union were healed after conservative rehabilitation; four patients remained mild claudication and shortening of the lower extremities, but the function of hip joints remained good. Conclusion Postoperative rehabilitation pathway can accelerate functional restoration and prevent complications of patients with CroweⅣ developmental dysplasia of hip underwent total hip arthroplasty combined with subtrochanteric osteotomy.
2017 Vol. 14 (26): 142-145,168 [Abstract] ( 180 ) HTML (1 KB)  PDF (1051 KB)  ( 92 )
146 Effects of special nursing on spuc time, mode of delivery, maternal complications of preterm premature rupture of membranes
FENG Qiong YU Wenliang WANG Jun CAI Yin▲
Objective To investigate the effect of special nursing on expectant treatment effect of preterm premature rupture of membranes (PROM). Methods 80 cases of patients with PPROM in Department of Obstetrics and Gynecology, Mianyang Central Hospital from January 2015 to January 2017 were selected, these patients were divided into special nursing group (40 cases) and conventional nursing group (40 cases) according to random number table method. The conventional nursing group was treated by conventional nursing, while the special nursing group was treated by conventional nursing combined with special nursing, nursing for 1 months, then the spuc time, modes of delivery, maternal complications of the two groups were statistically analyzed. Results The spuc time of the special nursing group was significantly longer (P < 0.05), the difference between the delivery methods of two groups was statistically significant (P < 0.05), the maternal complication rate was significantly lower than the conventional nursing group (P < 0.05). Conclusion Special nursing can effectively prolong the spuc time, improve the normal rate, reduce the incidences of cesarean section and maternal complications, thus improve the expectant treatment effect of preterm premature rupture of membranes.
2017 Vol. 14 (26): 146-148 [Abstract] ( 282 ) HTML (1 KB)  PDF (610 KB)  ( 128 )
149 The effect of the education on clinical indicators and the quality of life in patients with angina pectoris of coronary heart disease
LIAN Ailing CHEN Ye SUN Kuan
Objective To explore and analyze the effects of human nursing combined with health education on clinical indicators and quality of life in patients with angina pectoris of coronary heart disease. Methods From January 2015 to January 2017, 90 patients with angina pectoris of coronary heart disease in the First Affiliated Hospital of Harbin Medical University were selected and divided into control group and observation group by random number table method, with 45 cases in each group. The control group was treated by routine nursing, the observation group was treated by the humanized nursing health education. The clinical index and quality of life in the two groups were compared. Results After nursing, the heart rate, lower blood pressure, heart rate× blood pressure and the number of angina attacks in the two groups were decreased, and the improvement of observation group was more remarkable than that of the control group, with statistically significant difference (P < 0.05). After nursing, the scores of physical function, role function, cognitive function, emotional function and social function in the two groups were increased, and the improvement of observation group was more remarkable than that of the control group, with statistically significant difference (P < 0.05). Conclusion The human nursing combined with health education can improve clinical index and the quality of life in patients with angina pectoris of coronary heart disease.
2017 Vol. 14 (26): 149-152 [Abstract] ( 216 ) HTML (1 KB)  PDF (583 KB)  ( 66 )
153 Risk factors and related nursing strategies of nosocomial infection in pediatric inpatients
LI Yerong LIU Guoqiang
Objective To explore the risk factors and related nursing strategies of nosocomial infection in pediatric inpatients. Methods The clinical data of 87 children suffered from nosocomial infection (study group) in the Affiliated Hospital of Inner Mongolia Medical University from January 2016 to February 2017 and another 87 children without nosocomial infection (control group) was analyzed retrospectively. The training of medical staff, disinfection, infected factors, infected sites, and age distribution in the two groups were compared and analyzed. Results The risk factors of nosocomial infection were mainly associated with antibiotics use, extra beds in the ward, critical conditions, prolonged hospital stay, unqualified air sterilization and medical apparatus and instruments, and no training to the medical staff; digestive system and respiratory system were found to be the major sites of nosocomial infection, up to 45.97% and 39.08% respectively; the cases of training on nosocomial infection (76 cases), qualified aseptic operation (77 cases) and qualified air sterilization (77 cases) in the control group were all more than those in observation group (56, 59, 66 cases), the differences were statistically significant (P ＜ 0.01 or P ＜ 0.05). Conclusion There are many factors that can incur nosocomial infection for children. By establishing a reasonable disinfection system and an infection management system, standardizing the operation of nursing staff, and enhancing the awareness of prevention and control, the incidence of nosocomial infection can be significantly reduced.
2017 Vol. 14 (26): 153-156 [Abstract] ( 300 ) HTML (1 KB)  PDF (590 KB)  ( 72 )
157 Current situation and future trend of mobile medical APP with the example of Ping′an good doctor
CHENG Xiao LIU Yuqi
Through the analysis of the status questions and problems of the "Ping′an good doctor" APP, this paper extends to the current situation of the whole mobile medical industry, and puts forward the corresponding solution for these situations and specific problems. According to the survey results show that China′s medical APP has not been fully popular, consumers are still accustomed to the choice of ordinary hospital registration mode, the online inquiry method is not fully understood, and the safety of which skeptical. "Software+Internet+medical" profit model, developing segmentation market and the deeply combine of "on line" and "offline" will be the development trend of future mobile medical treatment.
2017 Vol. 14 (26): 157-160 [Abstract] ( 289 ) HTML (1 KB)  PDF (827 KB)  ( 184 )
161 Research on regional medical information platform construction and collaborative medical service promotion strategy in Ningbo City
ZHAO Jing
Medical information is an important part of the development of China's information society, but also an important support for the new medical reform. This article takes Ningbo City as an example, investigates the current construction situation of Ningbo regional medical information platform, after analysis, it is considered that the platform has low information integration, poor coordination between health institutions, information security and legal protection issues remain to be resolved, low level of informatization of primary institutions, irrational investment structure, has not yet formed a sustainable business model, social security card function single and other issues, proposes that the platform construction should be led by the government and the government to do top-level design and project control, speed up the construction of digital hospitals and improve the standard, from the technical and legal aspects to enhance the safety and reliability of the platform, establish a sustainable business model, change the medical service management system, unify identity and improve social security card function and other recommendations. Through the above research, to promote the improvement of the Ningbo regional medical information platform and the advancement of medical service coordination system, and provide reference for other regions in China.
2017 Vol. 14 (26): 161-164,172 [Abstract] ( 161 ) HTML (1 KB)  PDF (682 KB)  ( 124 )
165 The problems and reflections on research of primary processing of traditional Chinese medicinal materials
LIU Lei1,2 WANG Lianzhi1,2 ZHANG Xiaoyan1,2 GUAN Feng3 WU Lun1,2 ZHANG Shuxiang1,2 TIAN Zhenkun1,2
The internationalization of traditional Chinese medicine (TCM) is not only the objective which is our scholars of TCM unswerving pursuit of, but also is a complex and difficult task. The important reasons of restricting it are safety and effectiveness of TCM. And the primary processing of traditional Chinese medicinal materials(TCMM) is one of major factors which influence the safety and effectiveness of TCM. Consequently, it is obliged to standardize the processing methods, supervise the processing strictly, and control the quality from the origination of production. Through the literature and investigation, this article summarized and analyzed the problems on the research of primary processing of TCMM, and expressed a few of my thoughts and opinions. To hope that scholars can put more emphasis on primary processing of TCMM, especially strengthen the mechanization and standardization researching, and apply more advanced techniques and concepts to it.
2017 Vol. 14 (26): 165-168 [Abstract] ( 251 ) HTML (1 KB)  PDF (649 KB)  ( 184 )
169 An analysis of development status of family doctor's contract service in China
SHEN Pengyue LIU Xiaoshan LI Ruifeng
Carrying out the contract service of family doctor is an important measure in China's medical system reform, which is of great significance to realize the first-class diagnosis, hierarchical medical and change the mode of medical and health services. This article combs the policy documents and the historical process of the development of the contract service of the family doctor, and analyzes the current situation of family doctor's contract service from three aspects of the coverage of family doctor's contract service, the service content and the arrangement and management of the family doctor. Finally, this article puts forward suggestions such as exploring the contract service contents in line with the needs of residents and strengthening the construction and management of family doctors. To explore the service model that meets the needs of the residents, for establishing the family doctor's contract service system to provide a reference.
2017 Vol. 14 (26): 169-172 [Abstract] ( 321 ) HTML (1 KB)  PDF (646 KB)  ( 285 )
173 Drug resistance analysis of mycobacterium tuberculosis in Yiyang region
LI Yu1 ZENG Wei2 XU Qunfang1 YANG Zehua1 WANG Jin1 ZHOU Lin1 LI Mosi1 ZENG Fansheng1
Objective To understand the drug resistance and drug resistance spectrum of mycobacterium tuberculosis in Yiyang region, to provide the reference for the region of tuberculosis patients to take effective prevention and control measures. Methods 854 cases of pulmonary tuberculosis patients with sputum culture specimens, and cultivation of mycobacterium tuberculosis in preliminary appraisal were collected in June 2013 to December 2016 in Yiyang Central Hospital, Affiliated Hospital of Yiyang Medical College, Yiyang Fourth People′s Hospital. Overall resistance of infected strains, resistance situation of isolated strains between different anti-tb drug, resistance situation of isolates isolated strains between different gender and age were analyzed. Results 1054 cases of tuberculosis patients, 436 cases were isolated drug-resistant bacteria, total resistance was 41.4%, including untreated patients of 106 cases (120, 30.0%), recurrent patients of 297 cases (316, 70.0%), the difference of resistance rate in patients with two types was statistically significant (P < 0.05). 10 kinds of anti-tb drug susceptibility spectrum, among them INH resistance was the highest (54.63%), RFP was second of 44.09%, the third was RFT (42.86%), PAS was lowest of 23.94%. The patients resistant rate in women was higher than that in men, the difference was statistically significant (P < 0.05).In the whole age composition for all resistant,66-86 age group was priority to the other, 16 and 35 was less proportion (P < 0.05）. Conclusion The drug resistance situation of mycobacterium tuberculosis in Yiyang region is more serious. Percentages of tuberculosis of the region is affected by patient age, gender, etc, the clinical and relevant departments should strengthen the detection of drug-resistant bacteria.
2017 Vol. 14 (26): 173-176 [Abstract] ( 223 ) HTML (1 KB)  PDF (649 KB)  ( 96 )
177 Analysis of rational drug use based on the adverse reaction report of Chinese patent medicine
WANG Huan ZHU Qingxia YUAN Yongfang▲
Objective To analyze the occurrence of adverse drug reaction (ADR) induced by Chinese patent medicine in Shanghai Ninth People's Hospital (North), Shanghai Jiaotong University School of Medicine (for short "our hospital") from January 2014 to December 2016, in order to provide reference for rational clinical drug use. Methods All reports of ADR induced by Chinese patent medicine in our hospital were exported for statistical analysis by using tabulation, including age, gender, original disease, suspect drug, administration route, the reporter and the name of ADR. Results The ADR incidence of respiratory system as original disease was the highest, which make up 48.63% of 1360 reports. The incidence of ADR was the highest in children aged 2 to 11, accounting for 34.12%, followed by 61 to 71 years old, accounting for 14.90%. ADR involved organs with the highest response to skin and accessories, accounting for 40.27%, mainly with rash and pruritus, followed by the digestive system, accounting for 25.6%, mainly with stomach upset. Conclusion Attention should be paid to monitoring ADR induced by Chinese patent medicine. Rational and standardized use of traditional Chinese medicine is of greater importance to reduce the occurrence of ADR.
2017 Vol. 14 (26): 177-180 [Abstract] ( 201 ) HTML (1 KB)  PDF (684 KB)  ( 70 )
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