热疗联合化疗治疗晚期或胸壁复发乳腺癌疗效及安全性的Meta分析

Abstract
Figure/Table
References (22)
Related Citation (15)

Download: PDF (1425 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To evaluate the effectiveness and safety of hyperthermia combined with chemotherapy in the treatment of late or chest wall recurrence of breast cancer. Methods Electronic databases including the PubMed, Web of Science, EMbase, VIP, China national knowledge internet, Chinese biomedical literature database and Wanfang database system were searched, search term from building to March 22, 2017. The inclusion criteria was efficacy and safety studies of controlled clinical studies in which hyperthermia combined with chemotherapy was compared with chemotherapy alone for patients with late or chest wall recurrence of breast cancer. Cochrane handbook 5.1.0 was applied in evaluating the quality of included trials and RevMan 5.1.0 software was used for data analysis. Results Eight studies including 519 cases of late or chest wall recurrence of breast cancer were included. The results of the Meta-analysis exhibited that compared with chemotherapy alone, hyperthermia combined with chemotherapy could increase effective rate (OR=2.15, 95%CI: 1.50-3.09, P ＜ 0.01) and disease control rate (OR = 2.26, 95%CI: 1.42-3.60, P=0.0006). But there were no significant differences in rate of leucopenia (OR = 0.75, 95%CI: 0.43-1.32, P=0.32), rate of neutropenia (OR = 1.12, 95%CI: 0.58-2.18, P=0.73), rate of gastrointestinal reaction (OR = 1.00, 95%CI: 0.59-1.70, P=1.00), rate of liver and kidney dysfunction (OR = 0.97, 95%CI: 0.55-1.74, P=0.93). Conclusion Compared with chemotherapy alone, hyperthermia combined with chemotherapymay be more effective for late or chest wall recurrence of breast cancer, whereas adverse reactions are similar. For the quality restriction and possible publication bias of the included studies, more high quality randomized controlled trials are required to further verify this conclusion.

Key words： Hyperthermia combined with chemotherapy Chemotherapy Breast cancer Meta analysis

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	XU Min CAO Dedong GE Wei

Cite this article:

XU Min CAO Dedong GE Wei. Meta analysis of efficacy and safety of hyperthermia combined with chemotherapy in the treatment of advanced or chest wall recurrence of breast cancer[J]. 中国医药导报, 2017, 14(26): 4-8,20.

URL:

http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2017/V14/I26/4

[1] Jemal A，Bray F，Center MM，et al. Global cancer statistics [J]. CA Cancer J Clin，2011，61（2）：69-90.
[2] Farid G，Rasool MI. Locoregional recurrence after management of carcinoma breast [J]. J Coll Physicians Surg Pak，2005，15（4）：218-220.
[3] Wust P，Hildebrandt B，Sreenivasa G，et al. Hyperthermia in combined treatment of cancer [J]. Lancet Oncol，2002，3（8）：487-497.
[4] Raut CP，Evans DB，Crane CH，et al. Neoadjuvant therapy forispectable pancreatic cancer [J]. Surg Oncol Clin North Am，2004，13（4）：639-661.
[5] 张若申，孙兴亮，孙兴云.高频热疗配合化疗治疗晚期乳腺癌的效果观察[J].社区医学杂志，2014，12（17）：37-38.
[6] 沈健美，吴倩，张文涛.化疗联合热疗与单纯化疗治疗乳腺癌肺转移疗效的对比研究[J].肿瘤学杂志，2014，20（10）：866-868.
[7] 许秀灵，梁存昀.热疗联合化疗与单纯化疗治疗晚期乳腺癌的临床研究[J].临床研究，2015，15（68）：54-55.
[8] 邵新宇.微波热疗+化疗治疗晚期乳腺癌21例疗效观察[J].医护论坛，2010，17（26）：176.
[9] 王颖杰.微波热疗联合GP方案治疗晚期乳腺癌的临床观察[J].肿瘤防治研究，2009，36（1）：63-65.
[10] 吴辰.局部微波热疗与化疗联合应用于胸壁复发乳腺癌的近期疗效分析[J].临床和实验医学杂志，2012，11（24）：1940-1941.
[11] 裴玲，马昌义，唐文.局部微波热疗与化疗联合应用于胸壁复发乳腺癌的疗效观察[J].四川医学，2011，32（4）：489-491.
[12] 闰岩.局部微波热疗与化疗联合应用于胸壁复发乳腺癌的疗效观察[J].世界最新医学信息文摘，2016，16（48）：163.
[13] 殷蔚伯，余子豪，徐国镇，等.肿瘤放射治疗学[M].北京：中国协和医科大学出版社，2008：307-321.
[14] 孙瑞梅，王晓莉.肿瘤热疗的机理及临床研究[J].科技资讯，2016，25（181）：1672-3791.
[15] Franckena M. Hyperthermia for the treatment of locally advanced cervix cancer [M]. Rotterdam：Erasmus University Rotterdam，2010：9-14.
[16] Xu MJ，Alberts DS. Potentiation of platinum analogue cytotoxicity by hyperthermia [J].Cancer Chemother Pharraacol，1988，21（3）：191-196.
[17] 张亚萍，李康，张秀敏.磁流体肿瘤热疗中超声无损测温技术的研究进展[J].北京生物医学工程，2016，35（3）：208-313，328.
[18] Mohamed F，Marchettini P，Stuart OA，et al. Thermal enhancement of new chemotherapeutic agents at moderate hyperthermia [J]. Ann Surg Oncol，2003，10（4）：463-468.
[19] 刘春来，刘嘉，刘屹立，等.热疗对膀胱癌细胞耐药性的影响[J].中国医科大学学报，2011，40（1）：23-26.
[20] Lutgens L，van der Zee J，Pijls-Johannesma M，et al. Combined use of hyperthermia and radiation therapy for treating locally advanced cervical carcinoma [J]. Cochrane Database Syst Rev，2010（1）：CD006377.
[21] Perez CA，Pajak T，Emami B，et al. Randomized phase Ⅲ study comparing irradiation and hyperthermia with irradiation alone in superficial measurable tumors. Final report by the Radiation Therapy Oncology Group [J]. Am J Clin Oncol，1991，14（2）：133-141.
[22] Jones EL，Oleson JR，Prosnitz LR，et al. Randomized trial of hyperthermia and radiation for superficial tumors [J]. J Clin Oncol，2005，23（13）：3079-3085.