肺结核患者Th1/Th2/Treg/Th17免疫应答的临床研究

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Abstract Objective To study Th1/Th2/Treg/Th17 immune response in patients with tuberculosis. Methods Patients with recurrent tuberculosis and primary tuberculosis who received treatment in 458th Hospital of PLA during May 2013 to October 2016 were selected as recurrent tuberculosis group (n=38) and primary tuberculosis group (n=47) respectively; healthy volunteers who received physical examination during the same period were selected as control group (n=50). The contents of Th1, Th2, Treg and Th17 cells as well as corresponding cytokines in peripheral blood, and the contents of inflammatory mediators in serum were determined. Results Th1 and Th17 cell contents as well as IFN-γ contents inperipheral blood of recurrent tuberculosis group and primary tuberculosis group were significantly lower than those of control group while Th2 and Treg cell contents as well as IL-4, IL-5, IL-10, IL-17, TGF-β, HMGB1, sTREM1, MCP1 and HBD2 contents were significantly higher than those of control group(P < 0.05); Th1, Th17 cell contents as well as IFN-γ contents in peripheral blood of recurrent tuberculosis group were significantly lower than those of primary tuberculosis group while Th2, Treg cell contents as well as IL-4, IL-5, IL-10, IL-17, TGF-β, HMGB1, sTREM1, MCP1 and HBD2 contents were significantly higher than those of primary tuberculosis group(P < 0.05); HMGB1, sTREM1, MCP1 and HBD2 were negatively correlated with Th1 and Th17, positively correlated with Th2 and Treg (P < 0.05). Conclusion The change of tuberculosis is closely related to Th1/Th2/Treg/Th17 immune response imbalance.

Key words： Tuberculosis Immune response Helper T cell Inflammatory mediator

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	CHENG Tao1 WU Weiling2 HUANG He3

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CHENG Tao1 WU Weiling2 HUANG He3. Clinical study of Th1/Th2/Treg/Th17 immune response in patients with tuberculosis[J]. 中国医药导报, 2017, 14(26): 109-112.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2017/V14/I26/109

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