超声靶向破坏微泡定位释放技术促基因转染最佳参数的研究进展

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Abstract The optimization of parameters is the most important in ultrasound-targeted microbubble destruction (UTMD), this parameter should achieve both high transfection efficiency while at the same time most of the cells without damage. At present, many studies have focused on optimizing the transfection parameters for those with high transfection efficiency and small tissue damage. However, there are many factors that affect the transfection effect, such asultrasound intensity, duty cycle, irradiation time, microbubble concentration, microbubble properties, plasmid concentration, different cell types. This article reviewes the best parameters of gene transfection in UTMD, and expectes to provide a basis for UTMD to be better applied to gene therapy.

Key words： Ultrasound Microbubbles Transfection Parameter

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	MA Jie MU Yuming

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MA Jie MU Yuming. Research progress of ultrasound-targeted microbubble destruction technology promoting gene transfection with optimal parameters[J]. 中国医药导报, 2017, 14(26): 33-36.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2017/V14/I26/33

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