针刺结合游泳训练对大脑中动脉缺血再灌注大鼠认知功能的影响

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Abstract Objective To observe the influence of acupuncture combined with swimming training for the cognitive function in middle cerebral artery ischemia-reperfusion rats. Methods SD rats were made into the model of right middle cerebral artery ischemia-reperfusion. After evaluation of neurological function test and water maze test operation, the 28 successful model rats were divided into model group, acupuncture group, swimming training group, and integrated acupuncture and swimming training group by random number table, with 7 rats in each group, 7 rats of sham-operation group were set separately. There was no treatment for sham-operation group and model group, the acupuncture group was given acupuncture therapy on GV 20, once per day, while the swimming training group was given swimming training, once per day, and integrated acupuncture and swimming training group was given integrated acupuncture therapy on GV 20 and swimming training, once per day. Total treatment time was 6 days. Each day before treatment, weight and neural functional test were evaluated. After treatment for 6 days, water maze test was detected for the ability of learning and remembering, after all treatment and evaluation, the brains were taken, then TUNEL staining was used to observe the cell apoptosis in hippocampus. Results After treatment, there was no interactive effect between acupuncture and swimming training (P ＞ 0.05), the neural function score of integrated acupuncture and swimming training group was lower than that of model group (P ＜ 0.05), the number of step through in water maze test of integrated acupuncture and swimming training group was more than that of model group (P ＜ 0.05). Conclusion The influence of acupuncture and swimming training for the cognitive function in middle cerebral artery ischemia-reperfusion rats may be better than acupuncture or swimming training only, more research needs to be done in the future.

Key words： Middle cerebral artery ischemia-reperfusion Rats Acupuncture Swimming training Morris water maze Hippocampus Cell apoptosis

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	CUI Jiawen MA Shujie CHU Lixi

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CUI Jiawen MA Shujie CHU Lixi. The influence of acupuncture combined with swimming training for the cognitive function in middle cerebral artery ischemia-reperfusion rats[J]. 中国医药导报, 2017, 14(26): 25-28.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2017/V14/I26/25

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