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2017 Vol. 14, No. 32
Published: 2017-11-15
 
 
4 Secretion and effects of angiotensin-converting enzyme 2 on pulmonary vascular remodeling in pulmonary embolism rats
DENG Yicai1 HUANG Mingchao1 CHEN Li2 YE Yongquan3 YOU Jinhui1 SU Biaokun1 CHEN Zhuo4 DONG Fang1.2
Objective To measure angiotensin-converting enzyme 2 (ACE2) concentrations in peripheral blood and pulmonary artery trunk at different time points during the pulmonary embolism in rats, in order to investigate the effects of ACE2 on pulmonary vascular remodeling. Methods 120 male rats were randomly divided into pulmonary embolism group, control group and sham surgury group by random number table, with 40 rats in each group. Then, according to the different time points after embolization, the rats in pulmonary embolism group were further divided into 5 subgroups: embolization 24 h group, embolization 1 week group, embolization 2 weeks group, embolization 4 weeks group and embolization 8 weeks group. Concentrations of ACE2 both in pulmonary artery trunk and peripheral blood were measured at the corresponding time point, as well as the pathological examinations of pulmonary artery trunks. Results Compared with control group, the concentrations of ACE2 in the pulmonary trunk and peripheral blood of the sham operation group were not statistically significant (P > 0.05). While the concentrations of ACE2 in pulmonary embolism group were significantly lower than those in control group at 1 week, 2 weeks, 4 weeks and 8 weeks after embolization (P < 0.01). Meanwhile, pathological examination results showed clearly the infiltration of inflammatory cells around pulmonary artery trunk, pulmonary fibrosis and vascular remodeling with a hyperplasia of granulation tissue. Conclusion The expression of ACE2 reduced significantly in pulmonary embolism rat model, and the low concentrations of ACE2 may aggravate pulmonary vascular remodeling.
2017 Vol. 14 (32): 4-7 [Abstract] ( 255 ) HTML (1 KB)  PDF (553 KB)  ( 221 )
8 Primary research on the protective effect of formononetin on local cerebral ischemia-reperfusion injury in rats
JIANG Cijing WU Qiuhui REN Qianyao WANG Yong CHEN Jian LU Huiling▲
Objective To investigate the protective effect of formononetin on local cerebral ischemia-reperfusion injury in rats. Methods According to the random number table method, 42 male SD rats were divided into sham group, ischemia-reperfusion group and formononetin group, with 14 rats in each group. The formononetin group was given formononetin solution 20 mg/kg by intraperitoneal injection, the sham group and ischemia-reperfusion group were injected with same dose of normal saline, for 7 days. Suture-occluded method was used to copy the model of rats with cerebral ischemia-reperfusion injury in middle cerebral artery, the ischemic time was 1.5 h. After reperfusion for 24 h, the neurologic impairment of all groups was detected; the dry/wet method was used to detect the degree of cerebral edema; 2,3,5-tripheyltetrazolium (TTC) staining was used to calculate the volume of cerebral infarction and detect the activities of plasma superoxide dismutase (SOD) and the levels of malondialdehyde (MDA). Results Compared with ischemia-reperfusion group, the score of neurologic impairment in formononetin group was decreased, the volume of cerebral infarction of the second brain slice and the degree of cerebral edema of the third brain slice were reduced, the activities of plasma SOD were increased, and the levels of MDA were declined, the differences were all statistically significant (P ＜ 0.05 or P ＜ 0.01). Conclusion Formononetin can improve the degree of neurologic impairment, reduce the volume of cerebral infarction, the mechanism may be related to the decrease of oxidative stress.
2017 Vol. 14 (32): 8-10,14 [Abstract] ( 331 ) HTML (1 KB)  PDF (549 KB)  ( 276 )
11 Research on the protective effect of ferulic acid on the apoptosis of A375 cells induced by hydrogen peroxide
LI Wei ZHENG Kun QU Yan CHEN Lijuan WANG Jiazhi
Objective To observe the effect of ferulic acid on the apoptosis of melanocyte induced by oxidative stress. Methods According to random number table, A375 cells were divided into five groups: control group, model group, and high, middle, low concentrations of ferulic acid groups. Cells in the control group were cultured normally, while peroxide hydrogen was added into the cultured A375 cells of model group and high, middle, low concentrations of ferulic acid groups at the final concentration of 0.1 mmol/L, duration for 4 hours. The cells were stained with fluorescent dye DAPI. The apoptosis of each group was observed by fluorescence microscope. Caspase active kit was used to measure the activity of Caspase in each group. Results Compared with the control group, the activities of Caspase-3, 8 and 9 in the model group were significantly increased, with statistically significant differences (P ＜ 0.01). In the model group, dense and concentrated particles and the loose light colored crescent or annular fluorescence could be seen in the nucleus and cytoplasm, which implied that hydrogen peroxide can induce apoptosis of A375 cells. Compared with the model group, the expression of Caspase-3 and Caspase-8 were significantly reduced in the high does concentration of ferulic acid group, with statistically significant differences (P < 0.05 or P ＜ 0.01), but the effect on Caspase-9 was not obvious. The nucleus of cells in the high does concentration of ferulic acid group were even bright blue, without the phenomenon of dense condensation. There were chromatin agglutination and marginalization of most cell nucleus in the low and medium does concentrations of ferulic acid groups. Conclusion Ferulic acid can protect the apoptosis of melanocyte through lower the activity of Caspase induced by hydrogen peroxide.
2017 Vol. 14 (32): 11-14 [Abstract] ( 259 ) HTML (1 KB)  PDF (663 KB)  ( 154 )
15 The expression of lncRNA MEG3 and the influence of proliferation，migration and invasion in papillary thyroid carcinoma
CUI Dawei1 JIANG Feng2 CHEN Daxin2
Objective To investigate the expression of lncRNA MEG3 in papillary thyroid carcinoma and explore the effect of MEG3 on proliferation, migration and invasion in PTC-1 cells. Methods 68 cases of papillary thyroid carcinoma specimens and paired normal tissue were collected after surgery from May 2012 to December 2015 in the Fifth Affiliated Hospital of Zunyi Medical College. The expression of MEG3 was analyzed by quantitative real-time PCR. The effect of MEG3 on proliferation in TPC-1 cells was detected by CCK-8 method. The effect of MEG3 on migration and invasion abilities of TPC-1 cells were analyzed by Transwell assays. The expression of Snail2 was detected by Western blot. Results The expression of MEG3 was lower in papillary thyroid carcinoma tissues than adjacent normal tissues (P < 0.05). The expression of MEG3 was related with TNM stage and tumor size (P < 0.05). Over expressed MEG3 significantly inhibited the proliferation of TPC-1 cells (P < 0.05). And MEG3 could decrease the abilities of migration and invasion by down regulating the expression of Snail2 (P < 0.05). Conclusion The expression of lncRNA MEG3 is lower in the papillary thyroid carcinoma and can inhibit the proliferation, migration and invasion of TPC-1 cells can be inhibited by the expression of Snail2.
2017 Vol. 14 (32): 15-18,42 [Abstract] ( 283 ) HTML (1 KB)  PDF (1126 KB)  ( 203 )
19 The research of miR-150 in tumordevelopment and progression
QU Xiao1 QIN Huanlong2
MicroRNA (miRNA) is defined as one kind of small endogenous noncoding RNA with a length of 19-25 nucleotides. At the post-transcriptional level, miRNA can influence the biological function of cell proliferation, differentiation, apoptosis etc. Also, miRNA plays an important role in regulating the development of tumor and chronic disease. The recent studies have shown that microRNA-150 (miR-150) abnormally expressed in all kinds of malignant tumors involving colon, lung and pancreas. Through a variety of molecular mechanisms, miR-150 can promote tumor cell proliferation, invasion and metastasis. Therefore, miR-150 is expected to be a candidate marker for accurate diagnosis and treatment of tumors. This article will review the biological role of miR-150 in different tumors, thus providing theoretical basis and new opinions to its clinical transformation.
2017 Vol. 14 (32): 19-22 [Abstract] ( 380 ) HTML (1 KB)  PDF (596 KB)  ( 132 )
23 General application situations of traditional Chinese medicine in endocrine therapy of breast cancer
ZHAO Na1 SHI Guangxi2 DU Xiaohong1 LIU Xiaofei2 LI Jingwei2
Taking one patient with breast cancer as an entirety, with syndrome differentiation and treatment, traditional Chinese medicine (TCM) has obvious advantages in alleviating adverse reactions of endocrine therapy. To explore the application situations of TCM in endocrine therapy of breast cancer, the author collects and synthesizes relevant reports about TCM in endocrine therapy of breast cancer in recent years, and finds that TCM has definite effects for the adverse reactions of hot flashs, osteporosis and endometrial thickening, and has extremely important clinical significance and wild application prospect in improving the quality of life and prolonging disease free survival. Although TCM has special advantages in adjuvant therapy of endocrine therapy of breast cancer, it still exists many problems, which needs more further research and clinical application.
2017 Vol. 14 (32): 23-26 [Abstract] ( 317 ) HTML (1 KB)  PDF (592 KB)  ( 152 )
27 Research progress of relationship between Vaspin and obstructive sleep apnea hypopnea syndrome
ZHOU Fuming WU Haiying BAI Zhong
Vaspin, a serine protease inhibitor-derived from visceral adipose tissue, has been recently identified as a novel adipokine, which closely related to glucose and lipid metabolism. It participates the process of inflammation and endothelial function impairament, correlated with oxidative stress, simultaneouly. Vaspin is closely related to the occurrence and development of obstructive sleep apnea. This article reviews the possible mechanisms between Vaspin and obstructive sleep apnea hypopnea syndrome. At the same time, the research direction and hot spot are discussed briefly.
2017 Vol. 14 (32): 27-30 [Abstract] ( 204 ) HTML (1 KB)  PDF (590 KB)  ( 94 )
31 Research progress of the first-line treatment strategy for spontaneous coronary
HU Haiying LIU Wenjing CHANG Chao
Spontaneous coronary artery dissection (SCAD) is defined as a non-traumatic and non-iatrogenic separation of the coronary arterial walls that creates a false lumen. When managment of SCAD patients, early diagnosis is crucial so that the use of unnecessary and even potentially harmful pharmacologic therapies may be avoided. Therefore, the aim of this article is to provide a review of the first-line approaches——conservative or revascularisation for patients with SCAD.
2017 Vol. 14 (32): 31-34 [Abstract] ( 198 ) HTML (1 KB)  PDF (591 KB)  ( 54 )
35 Research progress of brain natriuretic peptide in heart failure
SHEN Yan1 GAO Ruimin1 KANG Lingling1 XU Jianfeng2 YUE Hua2 ZHANG Shoujun3
Brain natriuretic peptide (BNP) is a peptide hormone that is synthesized mainly in heart. When the heart wall pressure increases, the secretion of BNP gets increasing, thus the levels of BNP and severity of heart failure are closely related. Recently, as an important biomarker of heart failure, BNP shows amount of applications in the diagnosis, treatment, disease evaluation, treatment, prognosis and drug evaluation of heart failure. This paper summarizes the progress of BNP in the research of heart failure, and discusses the clinical significance of BNP in order to improve the insight of BNP in the treatment of heart failure.
2017 Vol. 14 (32): 35-38 [Abstract] ( 296 ) HTML (1 KB)  PDF (591 KB)  ( 269 )
39 Immune mechanism research of type 1 diabetes mellitus
CHEN Guojun1 YANG Zhonghan2 FENG Juan3▲
Type 1 diabetes mellitus (T1DM) is a kind of autoimmune disease with genetic predisposition and its incidence is gradually increasing. The pathogenesis is relatively complicated and not yet fully elucidated. It relates the mutual regulation of T lymphocytes and a variety of innate immune cells. Immune cells attack the islet beta cells reduce its damage  which is regarded as a main pathogenic factor of T1DM. The current treatments of T1DM, including traditional insulin injection, islet transplantation, immunotherapy and stem cell therapy of recent years or other methods, have the limitation. With the further study of the pathogenesis of T1DM, more effective targets and methods will be provided.
2017 Vol. 14 (32): 39-42 [Abstract] ( 278 ) HTML (1 KB)  PDF (626 KB)  ( 160 )
43 Finite element analysis of progress in application of transforaminal lumbar interbody fusion
YANG Huan1 SONG Hongxing2▲
In recent years, with the incidence of spinal degenerative diseases increasing year by year and the constant innovation of lumbar spinal fusion, the three-dimensional finite element method is becoming more and more mature. This article concludes that the application of finite element method in lumbar spinal fusion in recent 10 years and explains in detail the development history of transforaminal lumbar interbody fusion (TLIF), the introduction for constructing finite element models of spine and the application of finite element analysis of TLIF and instrumentation system.
2017 Vol. 14 (32): 43-46 [Abstract] ( 214 ) HTML (1 KB)  PDF (588 KB)  ( 99 )
47 Investigation on the prevalence and awareness of periodontal disease in diabetic patients from Fangzhuang Community in Beijing
GE Shaokun GAO Ronghuan▲
Objective To investigate the prevalence of periodontal disease and the awareness of periodontal disease in diabetic patients from Fangzhuang Community of Fengtai District in Beijing, in order to provide theoretical basis for the management of diabetes patients in future for dentists and general practitioners jointly, and also enrich the health management of diabetic patients and the connotation of family doctor service, improve the efficiency of management. Methods 1005 diabetic patients signed with Fangzhuang Community Health Service Center were selected from February 2015 to February 2016. The study was divieded into two parts: ①questionnaire was designed to investigate the oral health habits, blood sugar level and cognition of periodontal disease; ②the oral examination was operated and the data were collected to understand the periodontal health status of the diabetic population in Fangzhuang Community. Results The prevalence of periodontal disease was high in Fangzhuang Community that was shown by the detection rate of shallow periodontal pocket and deep periodontal pockets was 32.3% and 53.6% respectively. Diabetic patients had low awareness of periodontal disease, only 32.7% participants knew that diabetic patients could lead to the higher risk of periodontal disease, and only 13.6% subjects knew that periodontal disease poorly controlled would lead to impaired glycemic control. Conclusion Diabetic patients in Fangzhuang Community have high prevalence of periodontal disease and low awareness. Dentists and general practitioners should strengthen the oral health education to improve the awareness of periodontitis in diabetic patients.
2017 Vol. 14 (32): 47-50 [Abstract] ( 230 ) HTML (1 KB)  PDF (358 KB)  ( 184 )
51 Application value of percutaneous coronary intervention in ischemic cardiomyopathy
TIAN Jiaqi1 LI Jinkuang2▲
Objective To investigate the application value of percutaneous coronary intervention (PCI) in the treatment of ischemic cardiomyopathy. Methods Ninety-six patients with ischemic cardiomyopathy admitted to Zhongxiang People′s Hospital from February 2014 to April 2015 were selected and randomly divided into two groups by random coin tossing method, with 48 cases in each group. The control group received conventional drug therapy, on basis of which, the observation group was given PCI. After treatment, the biochemical indexes, cardiac function and adverse events during follow-up in the two groups were compared. Results After treatment for 1 month, the levels of brain natriuretic peptide (BNP), troponin I (TnI) and creatine kinase isoenzyme (CK-MB) in the two groups were all significantly improved compared with those before treatment, the levels of BNP, TnI, CK-MB in the observation group were significantly lower than those of control group, the differences were statistically significant (P ＜ 0.05). After treatment for 1 month, the levels of left ventricular ejection fraction (LVEF), left ventricular end diastolic diameter (LVEDD) in the two groups were all significantly improved compared with those before treatment, the levels of LVEF in the observation group were significantly higher than those of control group, the levels of LVEDD in the observation group were significantly lower than those of control group, the differences were statistically significant (P ＜ 0.05). During follow-up, there was no statistically significant difference of the incidence of acute myocardial infarction between the two groups (P ＞ 0.05); compared with control group, the incidence of heart failure, angina and readmission in the observation group was significantly decreased, the differences were statistically significant (P ＜ 0.05). Conclusion PCI in the treatment of ischemic cardiomyopathy has high application value, which can effectively improve the cardiac function and the levels of BNP, TnI and CK-MB, reduce the incidence of adverse events. It is worthy of clinical promotion. 
2017 Vol. 14 (32): 51-54 [Abstract] ( 677 ) HTML (1 KB)  PDF (495 KB)  ( 138 )
55 Early to middle term efficacy of modified aortic root plasty with valve sparing in the treatment of acute Stanford A dissection
ZHANG Dafa1,2 CHEN Yijiang1 SHAO Yongfeng1 ZHANG Shijiang1 WEI Jun2
Objective To investigate the early to middle term efficacy of modified aortic root plasty with valve sparing in the treatment of acute Stanford A dissection. Methods From January 2012 to December 2016, 32 patients were diagnosed for acute aortic dissection with Stanford A1 and A2 types in Department of Cardiothoracic Surgery, the First Affiliated Hospital of Nanjing Medical University. All patients were underwent the standard Sun's procedure. Modified aortic root plasty with valve sparing was applied in the root treatment. A fistulization was made with the adventitia wrapped around the artificial vessel and shunted to the right atrial appendage. Through the perioperative observation and postoperative follow up, disease progress, false lumen and thrombosis were all recorded. And the early-to-middle term results of the operation were assessed by comparing of preoperative and postoperative left ventricular ejection fraction (EF), left ventricular end diastolic diameter and aortic sinus diameter. Results There was no operation room death, but 4 deaths in the hospital. No serious complications such as paraplegia occurred. The discharged patients were followed up for 19-60 months. During the follow-up period, 2 patients died, 22 patients had complete thrombosis of the false lumen and 2 dilatations were observed in the descending thoracic aorta. There were no significant differences in the left ventricular EF [(56.4±6.7)% vs (59.1±8.2)%, P=0.700], left ventricular end diastolic dimension [(46.5±4.2) vs (46.9±5.7) mm, P=0.532] and aortic sinus diameter [(34.2±5.3) vs (35.5±6.1) mm, P=0.564] between the pre-operation and the last follow-up. Conclusion The pathological changes of acute aortic dissection involving the aortic root are complex. It is feasible to perform modified aortic root plasty with valve sparing in those without significant sinus extension and valve insufficiency. Improved success rate of operation and early to middle term clinical efficacy can both be achieved by the combination of accurate surgical suture and right-to-left shunt techniques.
2017 Vol. 14 (32): 55-58 [Abstract] ( 227 ) HTML (1 KB)  PDF (497 KB)  ( 114 )
59 Study on the correlation of ox-LDL and LDL system with the attack of coronary heart disease in hyperuricemia
LU Rongrong HU Xiaolong Alimujiang·Abulimiti XIA Mengjun ZHANG Ping Wahafu·Mamuti▲
Objective To investigate the correlation of oxidized low density lipoprotein (ox-LDL) and low density lipoprotein (LDL) system with the attack of coronary heart disease in hyperuricemia. Methods One hundred patients with hyperuricemia treated in Kashi Prefecture Second People's Hospital, Xinjiang Uygur Autonomous Region ("our hospital" for short) from October 2014 to October 2016 were selected as research objects, among whom, there were 38 cases with coronary heart disease (CHD) (CHD group) and 62 cases without CHD (no CHD group). 50 healthy controls examined in our hospital at the same time were selected as control group. The enzyme-linked immunosorbent assay (ELISA) was used to detect ox-LDL, enzymic method was used to detect LDL. The levels of blood ox-LDL and LDL in the three groups were compared, and the correlation of ox-LDL and LDL system with CHD was analyzed. Results The levels of blood ox-LDL and LDL in CHD group were significantly higher than those of no CHD group and control group, the differences were all statistically significant (all P ＜ 0.05), and the levels of blood ox-LDL and LDL in no CHD group were significantly higher than those of control group, the differences were all statistically significant (all P ＜ 0.05). By Spearman analysis, ox-LDL, LDL were positively correlated with the incidence of coronary heart disease (r = 0.572, 0.628, all P ＜ 0.05). Conclusion ox-LDL and LDL are positively correlated with the attack of coronary heart disease in hyperuricemia. During the course of treatment, it is necessary to strengthen the anti-oxidant treatment and observe the changes of ox-LDL and LDL dynamically.
2017 Vol. 14 (32): 59-61 [Abstract] ( 269 ) HTML (1 KB)  PDF (488 KB)  ( 92 )
62 Meta analysis of mitral valve repair versus replacement in patients with rheumatic heart disease
LI Xingchen1 TANG Bufu2 LIU Jianzhou1 ZHANG Chaoji1▲
Objective To evaluate the suitability of mitral valve repair (MVP) and mitral valve replacement (MVR) for treating rheumatic heart disease (RHD), in order to provide a guideline for clinical treatment. Methods The Cochrane Library, PubMed, EMbase, CBM, CNKI, VIP, and Wanfang databases had been searched from establishment of the data bases to February 2017 for all clinical trials comparing the outcomes of MVP and MVR for RHD. After being organized and evaluated, data were analyzed by using RevMan 5.3 statistical software. The 30-day mortality rate, long-term survival, reoperation rates and postoperative complications were evaluated by performing a Meta-analysis. Results There were 11 retrospective studies including 4287 patients (1465 MVP cases and 2822 MVR cases). The results of Meta-analysis, which showed that MVP had improved 30 day mortality (OR=0.51, 95%CI [0.34, 0.78], P=0.002), increased long-term survival (HR=0.71, 95%CI [0.55, 0.91], P=0.007), and reduced postoperative complications (HR=0.63, 95%CI [0.50, 0.80], P=0.0002). However, MVP had a significantly higher rate of reoperation (HR=2.03, 95%CI [1.71, 2.41], P < 0.00001). Conclusion MVP is superior to MVR for short-term and long-term survival and valve-related complications. It has higher possibility for MVP patients received to suffer from reoperation, but authors still recommend that RHD patients should be considered for MVP if it is technically feasible.
2017 Vol. 14 (32): 62-67 [Abstract] ( 289 ) HTML (1 KB)  PDF (1467 KB)  ( 131 )
68 Clinical effect of external counterpulsation combined with Donepezil Hydrochloride in the treatment of Alzheimer disease
PANG Liangliang CAI Guang LI Bin WEI Dongqi CHEN Wen
Objective To observe the curative effect of external counterpulsation combined with Donepezil Hydrochloride in the treatment of Alzheimer disease (AD). Methods Fifty-eight patients with AD admitted to 303rd Hospital of People's Liberation Army from March 2015 to September 2016 were randomly divided into control group and observation group, with 29 cases in each group. The control group was given Donepezil Hydrochloride, on basis of control group, the observation group was given external counterpulsation. The clinical efficacy after treatment for 6 months and adverse reactions between the two groups were compared. Results After treatment, the scores of activities of daily living (ADL) and Alzheimer disease assessment scale - cognitive (ADAS-cog) of both groups were significantly lower than those before treatment, and the scores of mini-mental state examination (MMSE) of both groups were significantly higher than those before treatment, the differences were statistically significant (P ＜ 0.05). After treatment, the scores of ADL and ADAS-cog in the observation group were significantly lower than those of the control group, the scores of MMSE were significantly higher than those of the control group, the differences were statistically significant (P ＜ 0.05). The incidence of adverse reactions in the control group was 13.79%, which of observation group was 17.25%, there was no statistically signfiicant difference between the two groups (P ＞ 0.05). Conclusion The effect of external counterpulsation combined with Donepezil Hydrochloride in the treatment of AD is better than the simple drug therapy, which can effectively improve the cognitive memory function and activities of daily living.
2017 Vol. 14 (32): 68-70 [Abstract] ( 246 ) HTML (1 KB)  PDF (423 KB)  ( 108 )
71 Curative effect of stereotactic surgery in the treatment of hypertensive intracerebral hemorrhage
LIU Jialin WANG Gesheng LI Nannan ZHOU Yujia LIU Xiaohan DONG Fei LI Yajing PENG Peng
Objective To investigate the efficacy of CT stereotactic minimally invasive soft channel catheterization combined with urokinase in the treatment of hypertensive intracerebral hemorrhage. Methods The clinical data of 80 patients with hypertensive intracerebral hemorrhage admitted to Dongfang Hospital, Beijing University of Chinese Medicine from October 2012 to May 2017 was analyzed retrospectively. 40 cases of patients taken conservative treatment of internal medicine were set as control group, 40 cases of patients treated with CT stereotactic minimally invasive soft channel catheterization combined with urokinase were set as observation group. The activities of daily living (ADL), Glasgow outcome score (GOS), Glasgow coma scale (GCS), Barthel index in the two groups were compared. Results There was no statistically significant difference of the improvement of ADL grading between the two groups (P ＞ 0.05). The scores of GOS after treatment for 30, 90 days, and the scores of GCS after treatment for 5 days in the observation group were all higher than those of control group, and the difference of Barthel index before and after treatment for 30 days in the observation group was higher than that of control group, the differences were all statistically significant (all P ＜ 0.05). The incidence of complications in the observation group was lower than that of control group, the difference was statistically significant (P ＜ 0.05). Conclusion The effect of CT stereotactic microvascular catheterization combined with urokinase in the treatment of hypertensive intracerebral hemorrhage is significantly better than the conservative treatment, which can improve the activities of daily living, reduce complications, with a positive clinical use value.
2017 Vol. 14 (32): 71-74 [Abstract] ( 271 ) HTML (1 KB)  PDF (597 KB)  ( 138 )
75 The relationship between expression of WBC count， CRP， IL-22 and its receptor with chorioamnionitis in serum of patients with premature rupture of membranes
WANG Junlan1 ZHU Yanhong1 ZHOU Xin2 WANG Yuzhen3
Objective To investigate the relationship between expression of IL-22, IL-22R1, CRP and WBC in serum of patients with premature rupture of membranes and chorioamnionitis. Methods A total of 100 patients with premature rupture of membranes who were treated in Cangzhou Maternal and Child Health Care Hospital ("our hospital" for short) from October 20 to September 2017 were selected as subjects, and they were divided into clinical chorioamnionitis group (38 cases), subclinical chorioamnionitis group (33 cases) and no chorionic amnioticitis group (29 cases) according to whether infected with chorioamnionitis and infection degree. Another 30 cases of normal full-term pregnant women in our hospital were randomly selected as a control group. The serum levels of IL-22, IL-22R1, CRP and WBC of pregnant women in four groups were tested. The diagnostic value of each index by ROC curve were analyzed. Results Serum WBC: clinical chorioamniositis group, subclinical chorioamnitis group, chorionic amniotic inflammation group were higher than the control group. Clinical chorioamniositis group was higher than subclinical chorioamniositis group (P < 0.05), while without significant difference between the subclinical chorioamnionitis group and the chorionic amniotic group (P > 0.05). Serum CRP, IL-22 and IL-22R1: the levels of them in the clinical chorioamniositis group, subclinical chorioamnionitis group and no chorionic amniotic inflammation group were higher than those in the control group. The levels in the clinical chorioamnitis group was higher than subclinical chorioamnionitis group and no chorionic amniotic inflammation group (P < 0.05). There was also a remarkable difference between the subclinica chorioamniositis group and no chorionic amniotic inflammation group (P < 0.05). The area under the curve (AUC) of WBC, CRP, IL-22 and IL-22R1 in the serum of the four groups was 0.717, 0.778, 0.909 and 0.916 (P = 0.049, 0.028, 0.000 and 0.000). Conclusion There is a definite clinical significance of IL-22, IL-22R1, CRP, WBC in the prediction of premature rupture of membranes with chorioamniositis, of which IL-22 and IL-22R1 has the highest predict value, especially in the prediction of patients with subclinical chorioamnionitis.
2017 Vol. 14 (32): 75-78 [Abstract] ( 383 ) HTML (1 KB)  PDF (408 KB)  ( 219 )
79 Relationship between Ki67 and EGFR mutations and prognosis in non-small cell lung cancer
ZHANG Yukun GE Wei
Objective To investigate the relationship between Ki-67LI and EGFR gene mutation in non-small cell lung cancer (NSCLC), as well as to further analyze the effect of Ki-67LI on the survival of patients with non-small cell lung cancer (NSCLC). Methods From July 2015 to July 2016, total of 100 patients with non-small cell lung cancer were treated in Renmin Hospital of Wuhan University. And 100 patients were examined by EGFR mutation. The relationship between Ki-67LI and EGFR mutation and its relationship with prognosis were investigated. Results A total of 100 cases were detected by EGFR mutation, among them, 57 cases were mutated and the mutation rate was 57%, the incidence of which was more frequent in women, non-smokers, adenocarcinoma patients (P < 0.01), and also found that EGFR mutations were associated with Ki-67, Ki-67LI values were more likely to occur in patients with EGFR mutations-positive (P < 0.05), and Ki-67LI was also an independent factor in the prognosis of patients with non-small cell lung cancer (OR=2.503, 95%CI: 1.077-5.815, P=0.033). Conclusion The value of Ki-67LI can independently predict the prognosis of non-small cell lung cancer patients, which is has a close relationship with EGFR mutations.
2017 Vol. 14 (32): 79-81,85 [Abstract] ( 382 ) HTML (1 KB)  PDF (549 KB)  ( 113 )
82 Endoscopic manifestations and endoscopic treatments of esophageal granular cell tumors
ZHENG Xiaoling1 PAN Dangling2 LIANG Wei1 ZHONG Shishun1 GAO Liying1
Objective To investigate endoscopic features and the efficacy and safety of endoscopic treatments of esophageal granular cell tumors (GCTs). Methods Patients with GCTs who were underwent endoscopic resection and confirmed by pathology in Gastrointestinal Endoscopy Center of Fujian Provincial Hospital from January 2004 to June 2016 were selected as the study object, testing results of endoscopy, endoscopic ultrasonography examination characteristics and endoscopic treatment were observed and follow-up results were analyzed. Results There were 19 patients with esophageal GCTs in this study,included 8 males and 11 females. The patients were between 39 and 65 years old, with an average age of (50.12±9.37) years old. The lesions exhibited yellowish or white lump with smooth surface in gastroscopy, all cases presented low echo changes in endoscopic ultrasonography.14 cases were derived from mucosa and muscularis mucosa, 5 cases were derived from submucosa, the diameters of these lesions were 0.6-3.0 cm with an average of (0.8±0.57) cm. 16 cases of patients with endoscopic mucosal resection (EMR) and Three patients of endoscopic submucosal dissection (ESD), no patient showed the complications associated with endoscopic therapy. The patients were followed up for 7-144 months, with the median of 74 months, no tumor recurrence or metastasis was observed during the follow-up period. Conclusion Endoscopy and endoscopic ultrasonography are important methods for the diagnosis of esophageal GCTs, EMR and ESD are safe and effective for the treatment of esophageal GCTs.
2017 Vol. 14 (32): 82-85 [Abstract] ( 383 ) HTML (1 KB)  PDF (612 KB)  ( 335 )
86 The study of surgical treatment and prognosis of micro-thyroid carcinoma in early and middle stage
YU Yingjuan BAO Feng
Objective To investigate the effect and prognosis of miniature thyroid cancer surgery in the treatment of micro-thyroid carcinoma in early and middle stage. Methods From May 2015 to May 2016, 108 patients with micro-thyroid carcinoma in early and middle stage revealed papillary thyroid carcinoma by biopsy were selected. According to the treatment methods, they were divided into observation group and control group, with 54 cases in each group. The observation group was treated by surgical treatment, and the control group was treated by chemotherapy treatment. All patients were followed up for 1 year. The curative effects of the two groups were compared, and the quality of life were followed up. Results The total efficiency of the observation group was significantly higher than that of the control group, with statistically significant difference (P < 0.05). The quality of life scores of observation group were significantly improved after treatment than those of the control group, with statistically significant difference (P < 0.05). After 1 year of follow-up, the rates of central recurrence, the lateral neck metastasis and none radiographic evidence of increased TG of the observation group were significantly lower than those of the control group, with statistically significant difference (P < 0.05). Conclusion The effect of surgical treatment on micro-thyroid carcinoma in early and middle stage is significant, and the improvement of quality of life is better than that of chemotherapy.
2017 Vol. 14 (32): 86-88 [Abstract] ( 719 ) HTML (1 KB)  PDF (481 KB)  ( 104 )
89 A study on the diagnostic value of intranperative fast frozen sections in disease severity of patients with endometrial cancer
ZHOU Chanping1 ZHANG Pu1 CHEN Wanwan1 ZHOU Lingli1 LI Xiangyang2
Objective To explore the diagnostic value of intranperative fast frozen sections in disease severity of patients with endometrial cancer, in order to provide reference for the clinical diagnosis and treatment of endometrial carcinoma. Methods Form January 2010 to December 2016, 80 patients with endometrial cancer in the Second Affiliated Hospital of Wenzhou Medical University were selected. They were treated by normal endometrial carcinoma stage operation, histopathological examination of fast frozen sections in intraoperative procedure, routine pathological examination after surgery (gold standard). The sensitivity and specificity for fast frozen sections diagnosis of endometrial carcinoma were analyzed. Results The diagnostic results showed that fast frozen sections in the operation and postoperative pathological examination were endometrial carcinoma. The sensitiveness and specificity of low differentiated were higher than that of high differentiated and moderately differentiated (P < 0.05). The sensitiveness for type Ⅰ was higher than type Ⅱ, the specificity for type Ⅰ was lower than type Ⅱ (P < 0.05). The sensitiveness for deep muscular layer infiltration was higher than shallow muscular layer infiltrates, the specificity for deep muscular layer infiltration was lower shallow muscular layer infiltrates (P < 0.05). Conclusion It has diagnostic value for the patients with endometrial cancer by fast frozen sections in the operation, while it has some differences in the results of postoperative pathological examination.
2017 Vol. 14 (32): 89-91,96 [Abstract] ( 329 ) HTML (1 KB)  PDF (531 KB)  ( 193 )
92 Relationship between neutrophil lymphocyte ratio and monocyte count with advanced malignant tumor
LUO Meng1 SUN Qinguo2
Objective To investigate the relationship between neutrophil lymphocyte ratio (NLR), monocyte (MONO) count and advanced tumor. Methods Clinical data of 193 hospitalized patients in Wuhan Third Hospital from January 2015 to January 2016 were retrospectively analyzed, and they were divided into cancer group (102 cases) and non-tumor control group (91 cases), at the same time, the tumor group was divided into stable condition group (53 cases) andcritically ill group (49 cases) according to KPS score. The relationship between monocyte and neutrophil/lymphocyte ratio and advanced tumor was analyzed. Results The levels of MONO and NLR in the tumor group were significantly higher than those in the control group (P < 0.01). The NLR level in the stable group was lower than that in the severe risk group (P < 0.05), there was no significant difference in MONO between the two groups (P > 0.05). High levels of MONO and NLR were the risk factors for tumorigenesis [OR = 0.072, 95%CI = 0.012-0.43, P = 0.004; OR = 0.389, 95%CI = 10.212-0.712, P = 0.002], the area of ROC curve of NLR, MONO values in prediction of tumorigenesis were 0.787, 0.629. Conclusion The increase of MONO and NLR is significantly correlated with tumorigenesis.
2017 Vol. 14 (32): 92-96 [Abstract] ( 445 ) HTML (1 KB)  PDF (546 KB)  ( 93 )
97 Comparison the effect of silver ion dressing and antiseptic gauze in patients with venous leg ulceration
ZHU Hua LIU Liping
Objective To compare the clinical effect of silver ion dressing and antiseptic gauze in patients with venous leg ulceration. Methods A total of 120 cases of patients with venous leg ulceration from May 2014 to December 2016 treated in Outpatient Department, the First Affiliated Hospital of Chongqing Medical University were selected and divided into the control group and the observation group by random number table, with 60 cases in each group. The control group was treated with antiseptic gauze and the observation group was treated with silver ion dressing. The degree of pain, the reduction rate of ulcer area, the skin around the impregnation rate and medical expenses were compared between the two groups. Results Before treatment, there was no statistically significant difference in the score of VAS between the two groups (P ＞ 0.05), after treatment of 7, 15, 21 d and 30 d, the score of VAS in the observation group were all lower than that of control group (P ＜ 0.05). After treatment of 10 d, 20 d and 30 d, the reduction rate of ulcer area in the observation group were all lower than that of control group (P ＜ 0.05). Before treatment, there was no statistically significant difference in the skin around the impregnation rate(P ＞ 0.05), after treatment of 10, 20 d and 30 d, the impregnation rate of skin around in the observation group was all lower than those of control group ( P ＜ 0.05). The medical expenses in the observation group was lower than that of control group (P ＜ 0.05). Conclusion The effect of silver ion dressing in the treatment of venous leg ulceration is better than antiseptic gauze. It can reduce the pain level, narrow down the ulcer area, reduce the medical expenses. It is worthy of promotion and application.
2017 Vol. 14 (32): 97-99 [Abstract] ( 289 ) HTML (1 KB)  PDF (577 KB)  ( 98 )
100 Clinical study of moxibustion on abdominal acupoints in the treatment of chronic kidney disease combined with functional constipation
MA Weizhong SU Zhuowei QU Zhanhang
Objective To explore the clinical effects of moxibustion on abdominal acupoints in the treatment of chronic kidney disease combined with functional constipation. Methods From January 2015 to February 2016, a total of 50 patients with chronic kidney disease combined with functional constipation diagnosed in Guangdong Province Traditional Chinese Medical Hospital were divided into the observation group and the control group by random number table, with 25 cases in each group. The control group was given routine treatment with mosapride citrate tablets by oral treatment and the observation group was given abdominal acupoints with moxibustion on the basis of the control group. After treatment for 1 month, the main clinical symptoms of the two groups were evaluated by the constipation symptom and efficacy evaluation questionnaire. The indexes of electrogastrography and the levels of gastrointestinal hormones were compared between the two groups. Resuts Before treatment, there were no statistically significant differences in the scores of defecation difficulty, stool character, defecation time, abnormal feeling, defecation frequency and bloating between the two groups (P ＞ 0.05). After treatment, the scores of the symptoms above in the two groups were all lower than those of before treatment, and those above in the observation group were all lower than those of control group, with statistically significant differences (all P ＜ 0.05). Before treatment, there were no statistically significant differences in the ascending colon amplitude and frequency and transverse colon amplitude and frequency between the two groups (P ＞ 0.05). After treatment, the indexes above were all higher than those of control group, and those in the observation group were much higher than those of control group, with statistically significant differences (all P ＜ 0.05). Before treatment, there were no statistically significant differences in the serum MTL, NO and SP levels (all P ＞ 0.05). After treatment, the MTL and SP were much higher than those of before treatment, the NO was much lower than that of before treatment, and those indexes above changed much more significant, with statistically significant differences (all P ＜ 0.05). Conclusion The clinical effects of moxibustion on abdominal acupoints in the treatment of chronic kidney disease combined with functional constipation is good, can regulate the patients′ gastrointestinal hormone disorder, improve the gastrointestinal function, relieve the constipation symptoms.
2017 Vol. 14 (32): 100-103 [Abstract] ( 236 ) HTML (1 KB)  PDF (587 KB)  ( 135 )
104 The influences of nutrition support on clincal efficacy and quality of life in elderly patients with acute exacerbation of chronic obstructive pulmonary disease
LIU Xinyan TUO Xiping
Objective To explore the influences of nutrition support on clincial efficacy and quality of life in elderly patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD). Methods A total of 62 elderly patients with AECOPD treated in Putuo District Central Hospital of Shanghai from August to September 2016 were randomly divided into conventional treatment group and nutrition intervention group by random number table, with 31 cases in each group. The conventional treatment group was given conventional drug treatment and the nutrition intervention group was given nutrition support for 4 weeks additionally on the bases of conventional treatment group. Short form mini-nutritional assessment (MNA-SF), COPD assessment test (CAT) and St. George respiratory questionnaire (SGRQ) were used to evaluate the nutritional status, acute episodes, hospitalization and quality of life before and after treatment. Results Before treatment, there were no statistically significant differences in the two groups in the level of ALB, PA,Hb and scores of MNA-SF (P ＞ 0.05). After treatment for 4 weeks, the indicators above in the nutrition intervention group were all higher than those of before treatment, after treatment for 2 weeks and the conventional treatment group, with statistically significant differences (all P ＜ 0.05). The hospitalization is much shorter than that of conventional treatment group, with statistically significant differences (P ＜ 0.05). Before treatment, there was no statistically significant difference between the two groups in the scores of CAT (P ＞ 0.05). After treatment for 4 weeks, the scores of CAT in the nutrition intervention group was lower than that of conventional treatment group, with statistically significant differences(P ＜ 0.05). Before treatment, there were no statistically significant differences in the scores of all items and total score of quality of life between the two groups (P ＞ 0.05). After treatment for 4 weeks, the scores of those above were all decreased and those in the nutrition intervention group were much lower than those of conventional treatment group, with statistically significant differences(P ＜ 0.05). Conclusions Nutrition support can improve the nutritional status in the treatment of elderly patients with AECOPD, promote the clinical curative effect and quality of life.
2017 Vol. 14 (32): 104-107,111 [Abstract] ( 283 ) HTML (1 KB)  PDF (640 KB)  ( 258 )
108 Effect of methotrexate and leflunomide combined with finger exercises on relieving morning numb in patients with active rheumatoid arthritis
LIU Jingyi LIU Qihuan

Objective To investigate the effect of methotrexate and leflunomide combined with finger exercises on relieving morning numb in patients with active rheumatoid arthritis. Methods From January 2015 to January 2017, 98 clinical data of patients with active rheumatoid arthritis treated in Dongfeng Hospital Affiliated to Hubei University of Medicine were retrospectively analyzed and divided into the control group and the observation group, with 49 cases in each group according to the treatment methods. The control group was given methotrexate combined with leflunomide and the observation group was given finger exercises on the basis of the control group. The clinical efficacy, finger and wrist pain, morning stiffness, hand function improvement and adverse reaction in the two groups were compared. Results The total curative rate in the observation group (95.91%) was significantly higher than that of control group (83.67%), with statistically significant difference (P ＜ 0.05). After treatment, the VAS score, morning stiffness time and signals of functional impairment score (SOFI) in the two groups were all lower than those of before treatment, the indicators above in the observation group were all lower than those of control group, with statistically significant differences (P ＜ 0.05). There were no severe adverse reactions in the two groups during the treatment. Conclusion Methotrexate and leflunomide combined with finger exercises in the treatment of patients with active rheumatoid arthritis is good. It can effectively improve the stiffness symptoms. It is worthy of clinical promotion.
2017 Vol. 14 (32): 108-111 [Abstract] ( 276 ) HTML (1 KB)  PDF (586 KB)  ( 128 )
112 Clinical features of drug -induced liver failure：forty-four cases report
DONG Peiling LI Hongjing GAO Jirong
Objective To analyze the clinical features, prognosis associated with factors retrospectively in order to improve the curative efficacy of drug-induced liver failure. Methods From December 2012 to December 2014, forty-four clinical data of patients with drug-induced liver failure in Beijing You'an Hospital, Capital Medical University were reviewed according to the drug history, clinical features, laboratory tests, complications and prognosis associated factors. Results The incidence of drug-induced liver failure in the female was higher than that of male, the onset age was mainly middle-aged and old. The predominant etiological drugs were the traditional Chinese medicine (56.8%) and anti-tubercular agent (18.2%). The predominant types of liver failure were acute liver failure (9.1%) and sub-acute liver failure (86.4%), and the common complications were ascites, electrolyte disturbance and hepatic encephalopathy. 7 patients were died (15.9%). The incidences of hepatic encephalopathy and electrolyte disturbance in the healing group was lower than those of ineffective group, with highly statistically significant differences (P ＜ 0.01). The prothrombin activity level in the healing group was higher than those of ineffective group, with highly statistically significant differences (P ＜ 0.01). There were no significant differences in total bilirubin, cholinesterase and total cholesterol (P ＞ 0.05). Conclusion Traditional Chinese medicine and anti-tubercular agent are the main etiologies of drug-induced liver failure. The onset of hepatic encephalopathy and electrolyte disorder prompting poor prognosis. Clinical doctors should attach great importance to drug damage potential of liver, especially in the process of using traditional Chinese medicine and the liver function should be monitored regularly.
2017 Vol. 14 (32): 112-115 [Abstract] ( 209 ) HTML (1 KB)  PDF (585 KB)  ( 169 )
116 Clinical analysis of 160 cases of Penicillium marneffei infection
ZHANG Dongwei1 LAN Bing1 YE Ping 2 KONG Jinliang 2▲
Objective To investigate the clinical characteristics and clinical outcomes of 160 cases Zhuang Autonomous Region marneffei (PSM). Methods From January 2003 to December 2015, clinical data of 160 patients with PSM in the First Affiliated Hospital of Guangxi Medical University and Liuzhou People′s Hospital were reviewed and analyzed. Results A total  of 160 cases of PSM were diagnosed, including 33 cases of immunocompetent and 127 cases of immunodeficiency. The first clinical manifestations of PSM were fever (92.1%), anemic appearance (89.3%), weight loss (88.1%), fatigue (86.2%), cough (80.0%) , sputum (76.3%), skin lesions (64.3%), superficial lymphadenopathy (61.2%), hepatomegaly (17.5%), chest pain (16.2%), osteoarthritis (15.6%), splenomegaly (12.5%), dyspnea (11.2%). The common detected sites were blood（61.7%），skin lesion secretions smear （59.3%），bone marrow culture (57.1%), skin secretion smear (46.9%), biopsy histopathology (43.5%), bone marrow smear (32.0%), alveolar lavage cultivation (28.3%), sputum (28.7%), sputum smear (19.4%). There were 123 cases with abnormal pulmonary lesions through the first CT scan and the lesions mainly located at the same side or both sides and most of those located in the lower left lobe and right middle lobe, followed by the right lower lobe and the upper right lobe. The focus of the lesion was nodular or mass, followed by the patchy exudative, double diffuse miliary lesions and double lung diffuse ground-glass opacity. After treatment, 82 cases of patients were complete remission or partial remission , 19 cases of progression and 31 cases of death. In the immunized normal group, there were 24 cases of remission, 2 cases of progression and 3 cases of death. While in the immunized damage group were 58 cases of remission, 17 cases of progression and 28 cases of death. The prognosis in the immunized damage group was worse than that of the immunized normal group, with statistically significant difference (χ2=6.732，P ＜ 0.05). Conclusion The clinical manifestations of PSM are complex and diverse, lack of specificity and could involving the whole system. The most commen detected sites are blood, skin lesions, bone marrow.
The chest imaging performance is lack of specificity, The disease relief rate is low and the recurrence rate of death is high. Clinical and bacterial room, radiologists should pay much attention to the clinical characteristics of the disease and the pathogen examination, reduce the risk of recurrence and deterioration of death.
2017 Vol. 14 (32): 116-119 [Abstract] ( 295 ) HTML (1 KB)  PDF (632 KB)  ( 161 )
120 Analysis of 308 cases of adverse drug reactions in a third-grade class-A hospital
LI Rui1 LI Jinyue2 ZHAO Yao1 LI Shengqian1 LIU Fu1
Objective To analyze the regularity and characteristics of adverse drug reactions (ADR) in the Affiliated Hospital of North Sichuan Medical College ("our hospital" for short), in order to promote clinical rational drug use and make sure patients′medication safety. Methods From January to December 2016, 308 cases of ADR reports in our hospital were analyzed retrospectively. Results Of 308 ADR cases, males (54.55%) showed higher proportion than females (45.45%). ADR of patients aged >40-60 were the most, accounted for 43.51%. The type of the most was "general ADR", accounted for 52.92%. Most of ADR cases were induced by anti-infective agents, accounted for 30.21%. ADR cases most easily induced by injection, accounted for 77.78%. Lesions of skin and its appendants were the most common clinical manifestations of ADR, accounted for 36.94%. A total of 98.7% patients were improvement and recovery after ADR occurred. Conclusion Clinical attention should be paid to the monitor and report of ADR, improve the ability to detect and dispose of ADR, minimize and avoid its occurrence.
2017 Vol. 14 (32): 120-123 [Abstract] ( 207 ) HTML (1 KB)  PDF (545 KB)  ( 180 )
124 Utilization analysis of specialized antibacterial drugs of inpatients in a tertiary hospital in Xinjiang from 2014 to 2016
DING Nan ZHU Qingfang MA Yunfang LIN Xiaoqi
Objective To investigate the application of specialized antibacterial drugs in the First Affiliated Hospital of Xinjiang Medical University (“our hospital” for short), in order to provide reference for rational use of specialized antibacterial drugs. Methods The utilization of specialized antibacterial drugs in our hospital from 2014 to 2016 was analyzed statistically in respect of the consumption sum, DDDs and AUD. Results The consumption sum of specialized antibacterial drugs increased from 30080700 Yuan to 42317800 Yuan. DDDs increased from 44398.61 to 56681.47 over three years of 2014-2016. The most frequently used specialized antibacterial drugs were carbopenems. The Department of Hematology was the most used department. Conclusion The application of specialized antibacterial drugs is reasonable basically, but management still should be strengthened and reasonable selection of perioperative preventive medicine. Consultation system of specialized antibacterial drugs should be implemented strictly.
2017 Vol. 14 (32): 124-127,132 [Abstract] ( 281 ) HTML (1 KB)  PDF (562 KB)  ( 141 )
128 Consideration on the construction of drug traceability system
LIU Chuanxu1 WEN Zhanquan1▲ ZHANG Yanzhao1 CAO Changying1 LIU Wei2
By reviewing the development of electronic supervision code and its abolishment in China, reflects on the existing problems in electronic monitoring code, and further concludes the background and current situation of the construction of drug traceability system in China. Meantime, analyzes the main difficulties in the construction of drug traceability system in China, and refers on the mature measures in the important domestic areas. Furthermore, draws on the success of foreign drug traceability system construction experience. Last but not least, this articel puts forward suggestions to strengthen the construction of drug traceability system in China, and stead fastly to promote the construction of drug traceability system in China in a sustainable and healthy way.
2017 Vol. 14 (32): 128-132 [Abstract] ( 317 ) HTML (1 KB)  PDF (547 KB)  ( 206 )
133 Discussion on the therapeutic effect and mechanism of Deanxit in inflammatory bowel disease
HU Yiting ZHANG Jian JIA Guicong HOU Hongtao SU Shaohui BAI Yun WANG Yuzhen
Objective To explore the clinical effect and mechanism of Deanxit in inflammatory bowel disease (IBD). Methods The clinical data of 60 cases of patients with IBD admitted to Department of Gastroenterology, Hebei General Hospital from September 2015 to January 2017 was analyzed retrospectively. According to the treatment, they were divided into Deanxit group and control group, with 30 patients in each group. The scores of self-rating anxiety scale (SAS) and self-rating depression scale (SDS) before and after treatment in the two groups were observed, and the survival improvement after treatment was evaluated by inflammatory bowel disease questionnaire (IBDQ). The changes of blood inflammatory markers before and after treatment in the two groups were compared. Results After treatment, the scores of SAS and SDS in Deanxit group were significantly lower than those before treatment (P ＜ 0.05), which were significantly lower than those in the control group (P ＜ 0.05). There were no statistically significant differences of SAS and SDS within the control group before and after treatment (P ＞ 0.05). After treatment, the IBDQ scores in the two groups were all higher than those before treatment (P ＜ 0.05), and the IBDQ score in Deanxit group was increased more significantly (P ＜ 0.05). After treatment, the levels of platelet count (PLT) and C-reactive protein (CRP) in the two groups were all significantly lower than those before treatment (P ＜ 0.05), and the levels of PLT and CRP in Deanxit group were all significantly lower than those of control group (P ＜ 0.05). Conclusion The antidepressant / anxiety treatment can significantly improve the anxiety and depression in IBD patients, enhance the quality of life and reduce the inflammatory levels of patients with IBD.
2017 Vol. 14 (32): 133-136 [Abstract] ( 303 ) HTML (1 KB)  PDF (438 KB)  ( 219 )
137 Effects of Clarithromycin combined with Tiotropium Bromide for the levels of procalcitonin, C reactive protein in elderly patients with acute exacerbation of chronic obstructive pulmonary disease
XU Yinghui1 LI Xiang1 XU Dan2
Objective To observe the effects of Clarithromycin combined with Tiotropium Bromide for the levels of procalcitonin, C reactive protein in elderly patients with acute exacerbation of chronic obstructive pulmonary disease (COPD). Methods Sixty elderly patients with acute exacerbation of COPD treated in Fushun Central Hospital of Liaoning Province from October 2014 to January 2015 were selected and randomly divided into observation group and control group, with 30 cases in each group. The control group received Tiotropium Bromide Dry Powder Inhalation, on basis of which, the observation group received Clarithromycin orally. The improvement of levels of procalcitonin, C reactive protein and lung function [forced expiratory volume in the first second (FEV1), the percentage of forced expiratory volume in the first second accounted for forced vital capacity (FEV1/FVC)] and the conditions of side effects of the two groups were observed and compared. Results There were statistically significant differences of effects between groups, time effects and interaction effects of procalcitonin, C reactive protein in the two groups (P ＜ 0.05). After treatment for 10, 20 d, the levels of procalcitonin, C reactive protein in the two groups were all lower than those on admission, which after treatment for 20 d were lower than those after treatment for 10 d, the differences were all statistically significant (P ＜ 0.05). After treatment for 10, 20 d, the levels of procalcitonin, C reactive protein in the observation group were significantly lower than those of control group (P ＜ 0.05). After treatment, the levels of FEV1, FEV1/FVC in the two groups were all higher than those before treatment (P ＜ 0.05), which of observation group was higher than that of control group (P ＜ 0.05). Both groups had no serious adverse reactions. Conclusion Clarithromycin combined with Tiotropium Bromide has significant effects on the levels of procalcitonin and C reactive protein expression in elderly patients with acute exacerbation of COPD, which can improve the pulmonary function of patients, thus it is worthy of promotion and application in clinic.
2017 Vol. 14 (32): 137-140,155 [Abstract] ( 263 ) HTML (1 KB)  PDF (777 KB)  ( 131 )
141 Influences of continuous care health education on the cognitive level and satisfaction in patients underwent breast surgery
LIU Xinhua ZHOU Lizhi LI Jianjun ZHANG Fengping LI Li
Objective To investigate the effect of continuous care health education on the cognitive level and satisfaction in patients underwent breast surgery. Methods A total of 840 patients underwent breast surgery from January 2016 to February 2017 in the Department of Breast, Tangshan People′s Hospital were divided into the control group and the observation group by random digital table, with 420 cases in each group. The control group was given conventional nursing and the observation group was given continuous care health education on the basis of control group. The scores of disease knowledge acquisition and nuring skills, compliance, the score of nursing satisfaction and the incidence of complications were compared between the two groups. Results The scores of disease knowledge acquisition and nursing skills in observation group were higher than those of control group, with statistically significant differences(P ＜ 0.05); the nursing satisfaction in the observation group (92.9%) was higher than that of control group (80.0%), with statistically significant difference (P ＜ 0.05). The compliance in the observation group was higher than that of control group, the hospitalization time was shorter than that of control group and the incidence of complications was lower than that of control group, with statistically significant differences (all P ＜ 0.05). Conclusion Continuous care health education can improve the cognitive level and compliance of patients underwent breast surgery, promote nursing satisfaction of patients. It is worth popularizing clinically.
2017 Vol. 14 (32): 141-144 [Abstract] ( 208 ) HTML (1 KB)  PDF (573 KB)  ( 131 )
145 The effect of evidence-based nursing on nursing satisfaction and quality of life in elderly patients underwent chemotherapy after colon cancer surgery
JIANG Yan YIN Hongzhuan▲ YANG Donghui LI Yan
Objective To explore the effect of evidence-based nursing on nursing satisfaction and quality of life in elderly patients underwent chemotherapy after colon cancer surgery. Methods Ninety cases of elderly patients underwent chemotherapy after colon cancer surgery from April 2015 to April 2017 treated in Shengjing Hospital of Chinese Medical University were selected and divided into the control group and the observation group by different nursing method, with 45 cases in each group. The control group was given routine nursing and the observation group was given evidence-based nursing. Both groups were given continuous care for 2 months. The nursing satisfaction and quality of life were compared between the two groups. Results The nursing satisfaction in observation group was higher than that of control group, with statistically significant difference (P ＜ 0.05). After nursing, the scores of physical function, role function, cognitive function, emotional function and social function were all higher than those of before nursing, and those in observation group were all higher than those of control group, with statistically significant differences(P ＜ 0.05) Conclusion Evidence-based nursing can improve the nursing satisfaction in elderly patients underwent chemotherapy after colon cancer surgery, promote the quality of life. It is worthy of clinical promotion and application.
2017 Vol. 14 (32): 145-147 [Abstract] ( 281 ) HTML (1 KB)  PDF (537 KB)  ( 163 )
148 The effects of psychological intervention of watching anesthesia-related video on the stress response in patients underwent laparoscopic hysterectomy
WANG Lihong1 QUAN Hujie2 DUAN Haixia1 JIANG Wanwei1
Objective To explore the effects of psychological intervention of watching anesthesia-related video on the stress response in patients underwent laparoscopic hysterectomy. Methods Sixty cases of patients underwent laparoscopic hysterectomy from September 2015 to April 2016 in Affiliated Zhongshan Hospital of Dalian University were enrolled as research objects and divided into two groups by random number table, with 30 cases in each group. The control group was given conventional anesthesia and the observation group added with preoperative psychological intervention by watching anesthesia-related video. Self-rating anxiety scale (SAS) was used to evaluate the anxiety status of the patients in preoperative visit and before anesthesia. Interleukin-2 (IL-2) , interleukin-6 (IL-6) , mean blood press (MAP) and the heart rate (HR) were compared at different time points such as before anesthesia induction (T0), endotracheal intubation immediately (T1) and 30 minutes after pneumoperitoneum (T2). Results There was no statistically significant difference in the scores of SAS between the two groups in preoperative visit (P ＞ 0.05). Before anesthesia, the score of SAS in the control group was increased and was higher than that of preoperative visit, with statiscally significant difference (P ＜ 0.05) , and that in the observation group was decreased, with statiscally significant difference compared with that of preoperative visit (P ＜ 0.05). MAP and HR at the time point of T1 were all higher than that of T0 and reduced at T2 in the two groups, with statiscally significant difference (P ＜ 0.05) , and MAP , HR at the time point of T0 and T1 in the observation group were all lower than those of control group, with statiscally significant differences (P ＜ 0.05). There was no statistically significant difference of IL-2 at the time point of T1 and T2 compared to T0 in the two groups (P ＞ 0.05) . At the point of T0, T1 and T2,  the IL-2 in the observation group were all higher than those of control group, with statiscally significant differences (P ＜ 0.05). At the time poin of T1 and T2, IL-6 were all higher than T0 in the two groups, with statiscally significant differences (P ＜ 0.05), and that in observation group were all lower than those of control group, with statiscally significant differences (P ＜ 0.05). At the time point of T0, T1 and T2, the IL-6 in the observation group were all lower than those of control group, with statiscally significant differences (P ＜ 0.05). The satisfaction rate in the observation group (93.33%) was higher than that of control group (73.33%), with statiscally significant difference (P ＜ 0.05). Conclusion Preoperative psychological intervention by watching anesthesia-related video can effectively reduce the stress level of patients underwent laparoscopic surgery and promote the satisfaction. It is worthy of promotion and application.
2017 Vol. 14 (32): 148-151 [Abstract] ( 280 ) HTML (1 KB)  PDF (552 KB)  ( 102 )
152 Effects of humanized nursing education on nursing service in surgical outpatients
ZHANG Runfang DUAN Peifang LIU Rui ZHANG Ye
Objective To explore the effects of humanized nursing education on nursing service in surgical outpatients. Methods A total of 120 cases of patients from January to December 2015 in the Affiliated Hospital of Inner Mongolia Medical University were selected and divided into the control group and the observation group according to the random number table. The control group received routine nursing care and the observation group received humanized nursing service on the basis of the control group. The incidence of nursing adverse reaction, the scores of nursing satisfaction (including hospital environment, nursing skills, nursing service attitude and behavior ) and nursing quality (including nursing skills, nursing service, rehabilitation guidance and the imagine of nursing staff) were compared between the two groups. Results The incidence of nursing adverse reaction in the observation group was lower than that of control group, the scores of nursing satisfaction and nursing quality in the observation group were all higher than those of control group, with statistically significant differences (all P ＜ 0.05). Conclusion Humanized nursing education can significantly improve the nursing quality and nursing satisfaction in surgical outpatients, reduce the incidence of nursing adverse reaction. It is worthy of promotion and application.
2017 Vol. 14 (32): 152-155 [Abstract] ( 186 ) HTML (1 KB)  PDF (545 KB)  ( 160 )
156 The effects of health education combined with psychological counseling on anxiety and depression in outpatients with cataract
FANG Hui CHEN Na▲ JIA Zhiyan
Objective To explore the effects of health education combined with psychological counseling on anxiety and depression in outpatients with cataract. Methods A total of 90 cases of cataract outpatients from April 2015 to April 2017 in the First Affiliated Hospital of Harbin Medical University were selected as research objects and divided into the control group and the observation group by random number table, with 45 cases in each group. The control group was given routine nursing care and the observation group was given health education combined with psychological counseling on the basis of control group. The nursing satisfaction, scores of self-rating anxiety scale (SAS) and self-rating depression scale (SDS), scores of self-esteem scale (SES) were compared between the two groups. Results The nursing satisfaction in the observation group(93.33%) was higher than that of control group(75.56%), with statistically significant difference (P ＜ 0.05). Before nursing, there were no statistically significant differences in the scores of SAS, SDS and SES  between the two groups (P ＞ 0.05). After nursing, the score of SAS and SDS were all lower than those of before nursing, the score of SES was higher than that of before nursing, and the scores above in the observation group changed more significantly, with statistically significant differences (P ＜ 0.05). Conclusion Health education combined with psychological counseling can effectively alleviate the anxiety and depression of cataract outpatients, promote the self-esteem and nursing satisfaction. It is worthy of promotion and application.
2017 Vol. 14 (32): 156-158 [Abstract] ( 223 ) HTML (1 KB)  PDF (538 KB)  ( 153 )
159 Influences of full-time nursing intervention on the psychological status and complications in patients with sinusitis and nasal polyps underwent endoscopic sinus surgery
XIANG Yuanyuan ZHAO Suping ZHENG Min ZHAO Xige
Objective To investigate the influences of full-time nursing intervention on the psychological status and complications in patients with sinusitis and nasal polyps underwent endoscopic sinus surgery. Methods From June 2015 to January 2017, 104 cases of patients with sinusitis and nasal polyps treated in Chinese PLA General Hospital were selected as the research objects and divided into the observation group and the control group by random number table, with 52 cases in each group. The control group was given routine nursing intervention and the observation group was given full-time nursing intervention on the basis of control group. At the time of 24 h admission and 1 week postoperative, the psychological status of the patients were evaluated by the symptom checklist-90 (SCL-90) and the self-rating depression scale (SDS), the incidence of complications was compared between the two groups. Results At the time of 24 h admission, there were no significant differences in the scores of SCL-90 and SDS between the two groups (P ＞ 0.05). There were no significant differences in the scores of psychological factors in the control group at the adimission time and at the time of 1 week after operation, but the factors above were all decreased in the observation group and all lower than those of control group, with statistically significant differences(all P ＜ 0.05). One week after operation, the scores of SDS in the two groups were all decreased and the observation group decreased more remarkably, with statistically significant differences (P ＞ 0.05). The incidence of complications in the observation group was lower than that of control group, with statistically significant differences (P ＜ 0.05). Conclusion Full-time nursing can effectively alleviate the negative emotions in patients with sinusitis and nasal polyps underwent endoscopic sinus surgery, reduce the the incidence of complicatons. It is worthy of promotion and application.
2017 Vol. 14 (32): 159-162 [Abstract] ( 240 ) HTML (1 KB)  PDF (574 KB)  ( 87 )
163 Analysis of one case of gastric tube induced respiratory arrest in patient with cerebral infarctions
JIA Rufu1 YANG Jingyan2 CAO Zhenmin1 LI Guixin1
This article reported 1 case of cerebral infarction patient with gastric tube induced respiratory arrest. The discussion was conducted by analyzing the stomach tube quality, operation method of gastric tube and the patient′s own factors. Pathological changes of patient with respiratory arrest in his pathogenic sites of cerebral infarction (the right side of medulla oblongata) could be found accordingly. Gastric tube stimulation, sodium intake deficiency and certain degree of hypovolemia due to dehydration were connected to the patient′s own factors. It should be strictly in accordance with severe cerebrovascular disease integrated management when placing gastric tube in patients with medulla oblongata cerebral infarction. Prophylactic use of anticholinergic drugs or narcotics, or induced by drinking water should be taken into consideration to ensure blood volume in patients with adequate and alleviate psychological pressure, etc.
2017 Vol. 14 (32): 163-165 [Abstract] ( 189 ) HTML (1 KB)  PDF (374 KB)  ( 205 )
166 Analysis of traditional Chinese medicine in the treatment of androgenetic alopecia in the past 50 years based on data mining
WU Chengyan1 ZHOU Wen1 REN Weiming2 ZHANG Lei3 WU Chengyu3 BIAN Yali1
Objective To explore the characteristics of traditional Chinese medicine in treating androgenetic alopecia (AGA) in the past 50 years. Methods Through the collection and collation of Chinese medicine in the treatment of AGA published from January 1965 to December 2015, excel software was used to create a database for hair loss to study the characteristics of Chinese medicine for treating AGA in this period. Results In the frequency of drug use, commonly used oral administration included Radix Angelicae Sinensis, Radix Polygoni Multiflori, Radix Rehmanniae Preparata, Rhizoma Ligustici Chuanxiong, etc; commonly used external drugs included Cacumen Platycladi, Flos Carthami, Radix Angelicae Sinensis, Radix Polygoni Multiflori, etc. In the kinds of herbal medication, tonic drugs accounted for the first, followed by heat-clearing drugs, removing blood stasis drugs. In the properties of herbal medication, hot property took the main part, cold medicine and medicine of the second, flat end. In the channel tropism, the five-zang herbs were in the majority, among all zang viscera, the herbs to the liver channel were the most, among all fu viscera, the herbs to the stomach channel were the most. Conclusion Nearly 50 years, traditional Chinese medicine take the tonic as AGA basic treatment, on the basis of which, internal treatment is added with the methods of clearing endogenous heat, dispelling turbid dampness, promoting blood circulation for removing blood stasis, etc, and the external treatment is supplemented by promoting blood circulation for removing blood stasis, dispersing and expelling pathogenic factors, clearing away heat and removing dampness, etc. traditional Chinese medicine pay attention to the combination of internal and external treatment, and the regulating of liver-kidney and spleen-stomach, taking into account the AGA psychology, accompanied by the appropriate use of sedative drugs.
2017 Vol. 14 (32): 166-169,181 [Abstract] ( 270 ) HTML (1 KB)  PDF (707 KB)  ( 259 )
170 Application and practice of teaching and training of surgical equipment and equipment in microsurgery in medical colleges
LI Wentao REN Chunying▲ WEI Yan XIA Ming MENG Xijun
Based on the analysis of the current training methods of neurosurgery in medical colleges, this paper finds that traditional training methods are more passive and the training effect is not ideal; medical students and junior physicians lack the operation practice of hand-eye coordination under the operating microscope, the principle of the instrument and the related technical knowledge. Therefore, it is significance to explore the new way of teaching, which can make the medical students and junior doctors operate surgical equipment quickly and effectively, and ensure the smooth operation of microneurosurgery.
2017 Vol. 14 (32): 170-173 [Abstract] ( 298 ) HTML (1 KB)  PDF (548 KB)  ( 138 )
174 Analysis of dyslipidemia in 231 medical staff with hypertension in a third grade A hospital in Urumqi
HUANG Bei1 WANG Huicai2，3 XU Xiaoyu1 WANG Meixin4
Objective To understand the current situation of dyslipidemia in medical staff with primary hypertension in the First Affiliated Hospital of Xinjiang Medical University, in order to analyze its relevant factors. Methods The medical staff′ medical examination reports in 2016 were collected. The biochemical indexes of 231 cases diagnosed as primary hypertension were analyzed, as well as the dangerous factors that may cause the occurrence of dyslipidemia. Results ①The overall incidence rate of dyslipidemia among medical staff with primary hypertension reached up to 70.13%, and the proportion of men was more than that of women, which the incidence rate of hypertriglyceridemia, mixed hyperlipidemia and low HDL-C cholesterol among men was higher than that of women ( P < 0.05). ②Single factor analysis showed that gender, fasting plasma glucose, BMI, smoking, drinking and family history of hypertension were dangerous factors for dyslipidemia associated with hypertension (P < 0.05). Logistic regression analysis showed that men, impaired fasting plasma glucose, and smoking were independent dangerous factors for dyslipidemia associated with hypertension (P < 0.05). Conclusion Affected by gender, fasting plasma glucose and smoking, the incidence of dyslipidemia associated with hypertension among medical staff is relatively high. Therefore, health management of medical staff should be carefully dealt with.
2017 Vol. 14 (32): 174-177 [Abstract] ( 235 ) HTML (1 KB)  PDF (607 KB)  ( 195 )
178 Analysis of the prevalence of nonalcoholic fatty liver disease and its related diseases among faculties in a certain university in Beijing
LIU Ying1 YANG Liqiang2
Objective To explore the prevalence rate of nonalcoholic fatty liver disease (NAFLD) and the relationship between NAFLD and other diseases, in order to provide useful information for the prevention and treatment of NAFLD. Methods 2140 staffs of Beijing Institute of Technology, who underwent medical examination from October to December in 2016 at Hospital of Beijing Institute of Technology, were selected as the study objects. For each case, the height, weight, and waist circumference were measured, the biological tests of liver function, kidney function, blood lipid and blood glucose were taken，and the abdominal ultrasonography was performed. Firstly, according to their age, they were divided into two groups: age < 60 years (2099 cases) and age ≥ 60 years (41 cases). The prevalence rates of NAFLD between the two groups with different sex were compared. Then, according to the results of ultrasonography, there were 341 cases in NAFLD group and 1799 cases in non-NAFLD group. The prevalence rates of hypertension, diabetes, dyslipidemia, hyperuricemia and obesity between NAFLD group and non- NAFLD group were compared. Results The prevalence rate of NAFLD was 15.93% cases (341/2140) in this study. The prevalence rate of NAFLD in male was significantly higher than that of female before the age of 60 (P < 0.01), while there was no significant difference after the age of 60(P > 0.05). There was significantly higher morbidity rate of hypertension, diabetes, dyslipidemia, hyperuricemia and obesity in NAFLD group than that in non-NAFLD group (P < 0.05). Conclusion The prevalence rate of NAFLD in this university is at a higher level. The occurrence of NAFLD is closely related to lipid metabolic disorders. It is also a systemic disease which often combines with varies metabolic disorders, such as hypertension, diabetes, dyslipidemia, hyperuricemia and obesity. Some necessary measures should be taken for proactive prevention and treatment of NAFLD.
2017 Vol. 14 (32): 178-181 [Abstract] ( 256 ) HTML (1 KB)  PDF (694 KB)  ( 209 )
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