miR-150在肿瘤发生发展中作用机制研究进展

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Abstract MicroRNA (miRNA) is defined as one kind of small endogenous noncoding RNA with a length of 19-25 nucleotides. At the post-transcriptional level, miRNA can influence the biological function of cell proliferation, differentiation, apoptosis etc. Also, miRNA plays an important role in regulating the development of tumor and chronic disease. The recent studies have shown that microRNA-150 (miR-150) abnormally expressed in all kinds of malignant tumors involving colon, lung and pancreas. Through a variety of molecular mechanisms, miR-150 can promote tumor cell proliferation, invasion and metastasis. Therefore, miR-150 is expected to be a candidate marker for accurate diagnosis and treatment of tumors. This article will review the biological role of miR-150 in different tumors, thus providing theoretical basis and new opinions to its clinical transformation.

Key words： Mir-150 Tumor Diagnosis Prognosis Treatment

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	QU Xiao1 QIN Huanlong2

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QU Xiao1 QIN Huanlong2. The research of miR-150 in tumordevelopment and progression[J]. 中国医药导报, 2017, 14(32): 19-22.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2017/V14/I32/19

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