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| Relationship between neutrophil lymphocyte ratio and monocyte count with advanced malignant tumor |
| LUO Meng1 SUN Qinguo2 |
1.Hubei University of Chinese Medicine, Hubei Province, Wuhan 430065, China;
2.Department of Traditional Chinese Medicine, Tongren Hospital of Wuhan University (Wuhan Third Hospital), Hubei Province, Wuhan 430060, China |
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Abstract Objective To investigate the relationship between neutrophil lymphocyte ratio (NLR), monocyte (MONO) count and advanced tumor. Methods Clinical data of 193 hospitalized patients in Wuhan Third Hospital from January 2015 to January 2016 were retrospectively analyzed, and they were divided into cancer group (102 cases) and non-tumor control group (91 cases), at the same time, the tumor group was divided into stable condition group (53 cases) andcritically ill group (49 cases) according to KPS score. The relationship between monocyte and neutrophil/lymphocyte ratio and advanced tumor was analyzed. Results The levels of MONO and NLR in the tumor group were significantly higher than those in the control group (P < 0.01). The NLR level in the stable group was lower than that in the severe risk group (P < 0.05), there was no significant difference in MONO between the two groups (P > 0.05). High levels of MONO and NLR were the risk factors for tumorigenesis [OR = 0.072, 95%CI = 0.012-0.43, P = 0.004; OR = 0.389, 95%CI = 10.212-0.712, P = 0.002], the area of ROC curve of NLR, MONO values in prediction of tumorigenesis were 0.787, 0.629. Conclusion The increase of MONO and NLR is significantly correlated with tumorigenesis.
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[1] 方东，王志红.中性粒细胞/淋巴细胞比值在大肠癌癌变进展中的指示价值[J].实用肿瘤学杂志，2015，29（1）：44-48.
[2] Koh YW，Shin SJ，Park C，et al. Absolute monocyte count predicts overall survival in mantle cell lymphomas：correlation with tumour-associated macrophages [J]. Hematol Oncol，2014，32（4）：178-186.
[3] Kaasa T，Loomis J，Gillis K，et al. The Edmonton Functional Assessment Tool： preliminary development and evaluation for use in palliative care [J]. J Pain Symptom Manage，1997， 13（1）：10-19.
[4] Roxburgh CS，Mcmillan DC. Role of systemic inflammatory response in predicting survival in patients with primary operable cancer [J]. Future Oncol，2010，6（1）：149-163.
[5] 李天翔，吴力群，蒋晓，等.中性粒细胞与淋巴细胞比值在预测HBV相关肝细胞癌术后患者预后中的价值[J].中华肝脏外科手术学电子杂志，2014，3（1）：12-15.
[6] Coussens LM，Werb Z. Inflammation and cancer [J]. Nature，2002，420（6917）：860-867.
[7] Queen MM，Ryan RE，Holzer RG，et al. Breast cancer cells stimulate neutrophils to produce oncostatin M：potential implications for tumor progression [J]. Cancer Res，2005，65（19）：8896-8904.
[8] Sarraf KM，Belcher E，Raevsky E，et al. Neutrophil/lymphocyte ratio and its association with survival after complete resection in non-small cell lung cancer [J]. J Thorac Cardiovasc Surg，2009，137（2）：425-428.
[9] Walsh SR，Cook EJ，Goulder F，et al. Neutrophil-lymphocyte ratio as a prognostic factor in colorectal cancer [J]. J Surg Oncol，2005，91（3）：181-184.
[10] Shimada H，Takiguchi N，Kainuma O，et al. High preoperative neutrophil-lymphocyte ratio predicts poor survival in patients with gastric cancer [J]. Gastric Cancer，2010， 13（3）：170-176.
[11] Sharaiha RZ，Halazun KJ，Mirza F，et al. Elevated preoperative neutrophil：lymphocyte ratio as a predictor of postoperative disease recurrence in esophageal cancer [J]. Ann Surg Oncol，2011，18（12）：3362-3369.
[12] 叶斯斯，尹雅琪，白莉.术前外周血中性粒细胞/淋巴细胞比值与胰腺导管腺癌患者根治术后预后关系的分析[J].肿瘤，2016，36（3）：310-318.
[13] Gu XB，Tian T，Tian XJ，et al. Prognostic significance of neutrophil-to-lymphocyte ratio in non-small cell lung cancer：a meta-analysis [J]. Sci Rep，2015，5：12493.
[14] Kinoshita A，Onoda H，Imai N，et al. Comparison of the prognostic value of inflammation-based prognostic scores in patients with hepatocellular carcinoma [J]. Br J Cancer，2012，107（6）：988-993.
[15] 徐燕梅，崔天祥，张晓晶，等.外周血单核细胞数量与肺癌放疗近、远期疗效的相关性分析[J].中华肺部疾病杂志：电子版，2014，7（2）：159-164.
[16] 冯阿磊.MCP-1调节的CD14~+CD16~+单核细胞在乳腺癌中的作用研究[D].济南：山东大学，2012.
[17] 胡旭，初同伟，廖通权，等.单核细胞趋化蛋白-1在恶性骨肿瘤中高表达[J].第三军医大学学报，2011，33（9）：924-927.
[18] 蔡智慧，裴毅.恶性肿瘤患者不同病期阶段外周血单核细胞CD14和TLR4的表达研究[J].医学研究杂志，2009， 38（12）：36-38.
[19] 柯少迎.结肠癌患者外周血单核细胞CD24表达的检测及意义[J].福建医药杂志，2015，37（4）：65-66.
[20] 杨瑞峰，张艳.食管癌患者外周血单核细胞比例与淋巴结转移观察[J].中国医师杂志，2011，13（5）：704-705.
[21] 李敏超，张和生，汤为学.肺癌患者肺泡巨噬细胞和外周血单核细胞表达IL-10及其临床意义[J].中国肺癌杂志，2004，7（2）：158-160. |
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