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| Clinical effect of external counterpulsation combined with Donepezil Hydrochloride in the treatment of Alzheimer disease |
| PANG Liangliang CAI Guang LI Bin WEI Dongqi CHEN Wen |
| Ward 2 of Geriatric Disease, 303rd Hospital of People's Liberation Army, Guangxi Zhuang Autonomous Region, Nanning 530021, China |
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Abstract Objective To observe the curative effect of external counterpulsation combined with Donepezil Hydrochloride in the treatment of Alzheimer disease (AD). Methods Fifty-eight patients with AD admitted to 303rd Hospital of People's Liberation Army from March 2015 to September 2016 were randomly divided into control group and observation group, with 29 cases in each group. The control group was given Donepezil Hydrochloride, on basis of control group, the observation group was given external counterpulsation. The clinical efficacy after treatment for 6 months and adverse reactions between the two groups were compared. Results After treatment, the scores of activities of daily living (ADL) and Alzheimer disease assessment scale - cognitive (ADAS-cog) of both groups were significantly lower than those before treatment, and the scores of mini-mental state examination (MMSE) of both groups were significantly higher than those before treatment, the differences were statistically significant (P ＜ 0.05). After treatment, the scores of ADL and ADAS-cog in the observation group were significantly lower than those of the control group, the scores of MMSE were significantly higher than those of the control group, the differences were statistically significant (P ＜ 0.05). The incidence of adverse reactions in the control group was 13.79%, which of observation group was 17.25%, there was no statistically signfiicant difference between the two groups (P ＞ 0.05). Conclusion The effect of external counterpulsation combined with Donepezil Hydrochloride in the treatment of AD is better than the simple drug therapy, which can effectively improve the cognitive memory function and activities of daily living.
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