|
|
|
| Analysis of traditional Chinese medicine in the treatment of androgenetic alopecia in the past 50 years based on data mining |
| WU Chengyan1 ZHOU Wen1 REN Weiming2 ZHANG Lei3 WU Chengyu3 BIAN Yali1 |
1.Institute of Literature in Chinese Medicine, Nanjing University of Chinese Medicine, Jiangsu Province, Nanjing 210046, China;
2.the First Clinical Medical College, Nanjing University of Chinese Medicine, Jiangsu Province, Nanjing 210046, China;
3.College of Basic Medicine, Nanjing University of Chinese Medicine, Jiangsu Province, Nanjing 210046, China |
|
|
|
|
Abstract Objective To explore the characteristics of traditional Chinese medicine in treating androgenetic alopecia (AGA) in the past 50 years. Methods Through the collection and collation of Chinese medicine in the treatment of AGA published from January 1965 to December 2015, excel software was used to create a database for hair loss to study the characteristics of Chinese medicine for treating AGA in this period. Results In the frequency of drug use, commonly used oral administration included Radix Angelicae Sinensis, Radix Polygoni Multiflori, Radix Rehmanniae Preparata, Rhizoma Ligustici Chuanxiong, etc; commonly used external drugs included Cacumen Platycladi, Flos Carthami, Radix Angelicae Sinensis, Radix Polygoni Multiflori, etc. In the kinds of herbal medication, tonic drugs accounted for the first, followed by heat-clearing drugs, removing blood stasis drugs. In the properties of herbal medication, hot property took the main part, cold medicine and medicine of the second, flat end. In the channel tropism, the five-zang herbs were in the majority, among all zang viscera, the herbs to the liver channel were the most, among all fu viscera, the herbs to the stomach channel were the most. Conclusion Nearly 50 years, traditional Chinese medicine take the tonic as AGA basic treatment, on the basis of which, internal treatment is added with the methods of clearing endogenous heat, dispelling turbid dampness, promoting blood circulation for removing blood stasis, etc, and the external treatment is supplemented by promoting blood circulation for removing blood stasis, dispersing and expelling pathogenic factors, clearing away heat and removing dampness, etc. traditional Chinese medicine pay attention to the combination of internal and external treatment, and the regulating of liver-kidney and spleen-stomach, taking into account the AGA psychology, accompanied by the appropriate use of sedative drugs.
|
|
|
|
|
|
[1] 王婷琳，周城，张建中，等.我国6省雄激素性秃发流行病学调查[J].临床皮肤科杂志，2010，39（12）：743-746.
[2] Ertas R，Orscelik O，Kartal D，et al. Androgenetic alopecia as an indicator of metabolic syndrome and cardiovascular risk [J]. Blood Press，2016，25（3）：141-148.
[3] Park SY，Oh SS，Lee WS. Relationship between androgenetic alopecia and cardiovascular risk factors according to BASP classification in Koreans [J]. J Dermatol，2016，43（11）：1293-1300.
[4] Ahouansou S，Le Toumelin P，Crickx B，et al. Association of androgenetic alopecia and hypertension [J]. Eur J Dermatol，2007，17（3）：220-222.
[5] Arias-Santiago S，Gutiérrez-Salmerón MT，Castellote-Caballero L，et al. Androgenetic alopecia and cardiovascular risk factors in men and women：a comparative study [J]. J Am Acad Dermatol，2010，63（3）：420-429.
[6] Mumcuoglu C，Ekmekci TR，Ucak S. The investigation of insulin resistance and metabolic syndrome in male patients with early-onset androgenetic alopecia [J]. Eur J Dermatol，2011，21（1）：79-82.
[7] Han SH，Byun JW，Lee WS，et al. Quality of life assessment in male patients with androgenetic alopecia：result of a prospective，multicenter study [J]. Ann Dermatol，2012， 24（3）：311-318.
[8] Rathnayake D，Sinclair R. Male androgenetic alopecia [J]. Expert Opin Pharmacother，2010，11（8）：1295-1304.
[9] 高学敏.中药学[M].6版.北京：中国中医药出版社，2002.
[10] 刘道清.中药别名大辞典[M].郑州：中原农民出版社，2013.
[11] 赵国平，戴慎，陈仁寿，等.中药大辞典[M].上海：上海科技出版社，1978.
[12] 李利.男性型秃发相关因素分析——1766名汉族男性调查[J].临床皮肤科杂志，1991，20（6）：283-286.
[13] 宗全和.灵枢经[M].北京：中外文化出版公司，1988：74.
[14] （清）沈金鳌.杂病源流犀烛[M].北京：中国中医药出版社，1994：153.
[15] （清）唐容川.血证论[M].北京：中国中医药出版社，1996：11.
[16] 南京中医学院医经教研组.黄帝内经素问译释[M].上海：上海科学技术出版社，1959：71.
[17] （唐）王焘.外台秘要方[M].北京：华夏出版社，1993：307.
[18] （清）何梦瑶.医碥7卷[M].上海：上海科学技术出版社，1982：223.
[19] （清）冯兆张.冯氏锦囊秘录[M].北京：人民卫生出版社，1988：37.
[20] （清）许豫和.新安医籍丛刊 怡堂散记[M].合肥：安徽科学技术出版社，1990：19. |
|
|
|
