胎膜早破患者血清白细胞计数、C反应蛋白、白介素22及其受体表达与绒毛膜羊膜炎的关系

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Abstract Objective To investigate the relationship between expression of IL-22, IL-22R1, CRP and WBC in serum of patients with premature rupture of membranes and chorioamnionitis. Methods A total of 100 patients with premature rupture of membranes who were treated in Cangzhou Maternal and Child Health Care Hospital ("our hospital" for short) from October 20 to September 2017 were selected as subjects, and they were divided into clinical chorioamnionitis group (38 cases), subclinical chorioamnionitis group (33 cases) and no chorionic amnioticitis group (29 cases) according to whether infected with chorioamnionitis and infection degree. Another 30 cases of normal full-term pregnant women in our hospital were randomly selected as a control group. The serum levels of IL-22, IL-22R1, CRP and WBC of pregnant women in four groups were tested. The diagnostic value of each index by ROC curve were analyzed. Results Serum WBC: clinical chorioamniositis group, subclinical chorioamnitis group, chorionic amniotic inflammation group were higher than the control group. Clinical chorioamniositis group was higher than subclinical chorioamniositis group (P < 0.05), while without significant difference between the subclinical chorioamnionitis group and the chorionic amniotic group (P > 0.05). Serum CRP, IL-22 and IL-22R1: the levels of them in the clinical chorioamniositis group, subclinical chorioamnionitis group and no chorionic amniotic inflammation group were higher than those in the control group. The levels in the clinical chorioamnitis group was higher than subclinical chorioamnionitis group and no chorionic amniotic inflammation group (P < 0.05). There was also a remarkable difference between the subclinica chorioamniositis group and no chorionic amniotic inflammation group (P < 0.05). The area under the curve (AUC) of WBC, CRP, IL-22 and IL-22R1 in the serum of the four groups was 0.717, 0.778, 0.909 and 0.916 (P = 0.049, 0.028, 0.000 and 0.000). Conclusion There is a definite clinical significance of IL-22, IL-22R1, CRP, WBC in the prediction of premature rupture of membranes with chorioamniositis, of which IL-22 and IL-22R1 has the highest predict value, especially in the prediction of patients with subclinical chorioamnionitis.

Key words： Premature rupture of membranes Chorioamniositis WBC CRP IL-22 IL-22R1

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	WANG Junlan1 ZHU Yanhong1 ZHOU Xin2 WANG Yuzhen3

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WANG Junlan1 ZHU Yanhong1 ZHOU Xin2 WANG Yuzhen3. The relationship between expression of WBC count， CRP， IL-22 and its receptor with chorioamnionitis in serum of patients with premature rupture of membranes[J]. 中国医药导报, 2017, 14(32): 75-78.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2017/V14/I32/75

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