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2023 Vol. 20, No. 23
Published: 2023-08-15
4
Investigating the effect of “qi and blood combined treatment” acupuncture on inflammatory injury of cervical spondylotic radiculopathy rats based on TLR4/NF-κB signaling pathway
WANG Jiajia JI Bo▲ LIU Yitian SHI Tianyu GE Yunpeng XIE Yana FANG Yang ZHANG Ling
DOI: 10.20047/j.issn1673-7210.2023.23.01
Objective To investigate the therapeutic effect of qi and blood combined treatment acupuncture on inflammatory injury in rats with cervical spondylotic radiculopathy (CSR) and the correlation between toll-like receptor 4 (TLR4)/nuclear factor κB (NF-κB) signaling pathway. Methods Twenty-four 5-7-week-old healthy male SD rats (180-220 g) were divided into blank group, sham surgery group, model group, and “qi and blood combined treatment” acupuncture group by random number table method, with six rats in each group. The CSR model was prepared by spinal canal insertion method. On the 3rd day after the model was made, the “qi and blood combined treatment” acupuncture group was treated by acupuncture at ji?觃jǐ points of cervical 5 and cervical 7, zus?觃nlǐ and géshù, and the cervical ji?觃jǐ points were treated by electro-acupuncture with density wave at 2 Hz/50 Hz, with an intensity of 1.5 mA for 30 min/d for 14 days. The restrain of blank group, sham operation group, and model group were the same as those of “qi and blood combined treatment” acupuncture group, no treatment. The restrain of the gait score of all groups was compared, the ultrastructure of the spinal cord was observed by electron microscope, the contents of interleukin(IL)-1β and prostaglandin E2(PGE2) in the spinal cord were detected by enzyme-linked immunosorbent assay, and the expression of TLR4, NF-κB, and cyclocycesterase 2 (COX-2) in the spinal cord were detected by Western blot. Results After treatment, there was no significant difference in gait score between sham operation group and blank group (P＞0.05), the gait score of model group was higher than that of blank group (P＜0.01), and the gait score of “qi and blood combined treatment” acupuncture group was lower than that of model group (P＜0.05). The appearance of myelin sheath of rats in blank group and sham operation group was regular and the structure was complete. In the model group, the myelin structure was irregular, some myelin was broken and disappeared, the thickness was different, the lamellar structure was loose, twisted and broken, and the mitochondria was swollen or even partially dissolved and disappeared; in the “qi and blood combined treatment” acupuncture group, the myelin lamella was less loose, the structure was more compact, and clear mitochondria could be seen. There was no significant difference in IL-1β and PGE2 protein expression between sham operation group and blank group (P＞0.05). The expression levels of IL-1β and PGE2 in model group were higher than those in blank group (P＜0.01). The expression levels of IL-1β and PGE2 protein in “qi and blood combined treatment” acupuncture group were lower than those in model group (P＜0.01). There was no significant difference in the relative expressions of TLR4, NF-κB, and COX-2 protein between the sham operation group and the blank group (P＞0.05). The expressions of TLR4, NF-κB, and COX-2 in model group were higher than those in blank group (P＜0.01). The protein expressions of TLR4, NF-κB, and COX-2 in “qi and blood combined treatment” acupuncture group were lower than those in model group (P＜0.01). Conclusion The “qi and blood combined treatment” acupuncture method can improve the limited activity of CSR rats, probably by blocking changes in the TLR4/NF-κB signaling pathway, reducing the expression of IL-1β and PGE2, and reducing inflammatory damage.
2023 Vol. 20 (23): 4-7,22 [
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Exploration on the mechanism of inflammation and oxidative stress of Qianggu Capsules in the treatment of postmenopausal osteoporosis based on the Notch1-Hes1-Prdx protein family pathway
LU Lin1 FANG Hong2
DOI: 10.20047/j.issn1673-7210.2023.23.02
Objective To explore the mechanism of inflam- mation and oxidative stress of Qianggu Capsules in the treatment of postmenopausal osteoporosis (PMOP) based on Notch1- Hes1-Prdx protein family pathway. Methods Sixty five- month-old specific pathogen free female SD rats with body mass of (300 ± 20) g were divided into sham operation group, model control group, positive control group, and Qianggu Capsules low, medium, and high dose groups of by random number table method, with 10 rats in each group. Except for the sham operation group, the PMOP model was established by bilateral ovaries resection, and only peripheral adipose tissue of bilateral ovaries was removed in the sham operation group. The positive control group was subcutaneously injected with 200 μg/kg Estradiol, twice a week. Qianggu Capsules low, medium, and high dose groups were given 100, 200, and 300 mg/(kg·d) Qianggu Capsules by gavage, respectively; the sham operation group and model control group was given the same amount of physiological saline by gavage, the treatment lasted for 12 weeks. Bone mineral density (BMD) value, plasma inflammatory markers (interleukin [IL]-1β, IL-6, IL-8, IL-17, tumor necrosis factor-α [TNF-α]), oxidative stress markers(monoamine oxidase-A [MAOA], total antioxidant capacity [T-AOC], advanced oxidation protein products [AOPP], superoxide dismutase [SOD] ), and the protein expression level of Jagged1, Notch1, Hes1, and Prdx protein family (Prdx1-6) were compared among all groups; the mRNA and protein expressions of Jagged1, Notch1, Hes1, and Prdx1-6 in peripheral blood mononuclear cells (PBMC) and bone tissue were determined by RT-qPCR and Western blot. Results Compared with sham operation group, BMD value, T-AOC, and SOD levels of rats were decreased, IL-1β, IL-6, IL-8, IL-17, TNF-α, MAOA, and AOPP levels of rats were increased; the expression levels of Jagged1, Notch1, and Hes1 in plasma, PBMC, and bone tissue of rats were increased, while the expression levels of Prdx1 and Prdx6 of rats were decreased in model control group (P＜0.05). Compared with model control group, BMD value, T-AOC, and SOD levels of rats were increased, IL-1β, IL-6, IL-8, IL-17, TNF-α, MAOA, and AOPP levels of rats were decreased; the expression levels of Jagged1, Notch1, and Hes1 in plasma, PBMC, and bone tissue of rats were decreased, while the expression levels of Prdx1 and Prdx6 of rats were increased in Qianggu Capsules medium and high dose groups (P＜0.05). Compared with Qiangu Capsules low dose group, BMD value, T-AOC, and SOD levels of rats were increased, while IL-1β, IL-6, IL-8, IL-17, TNF-α, MAOA, and AOPP levels of rats were decreased; the expression levels of Jagged1, Notch1, and Hes1 in plasma, PBMC, and bone tissue of rats were decreased, while the expression levels of Prdx1 and Prdx6 of rats were increased in Qianggu Capsules medium and high dose groups (P＜0.05). Compared with Qianggu Capsules medium dose group, BMD value, T-AOC, and SOD levels of rats were increased, IL-1β, IL-6, IL-8, IL-17, TNF-α, MAOA, and AOPP levels of rats were decreased; the expression levels of Jagged1, Notch1, and Hes1 in plasma, PBMC, and bone tissue of rats were decreased, while the expression levels of Prdx1 and Prdx6 of rats were increased in Qiangu Capsules highdose group (P＜0.05). There were no significant differences in PRDX2-5 expressions in plasma, PBMC, and bone tissue of rats among all groups (P＞0.05). Conclusion Qianggu Capsules may down-regulate the expressions of Jagged1, Notch1, and Hes1 and up-regulate the expressions of Prdx1 and Prdx6 by inhibiting the Notch1-Hes1-Prdx signaling pathway, thus enhancing the antioxidant stress ability and improving the inflammatory response to play an anti-osteoporosis role , and the effect of Qianggu Capsules were dose-dependent.
2023 Vol. 20 (23): 8-15 [
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Study on SNHG17 regulates the malignant phenotype of glioblastoma by regulating miR-23b-3p and ZHX1
GE Beihai1 ZHOU Wei2 WEI Ninglin1 ZHANG Xian1 MO Yun1 SU Zhou1 QIN Guangping1 XU Guolong1
DOI: 10.20047/j.issn1673-7210.2023.23.03
Objective To detect detection of small nucleolar RNA host gene 17 (SNHG17) How to regulate malignant phenotype of glioblastoma (GBM) by miR-23b-3p and zinc finger structure homeobox protein 1 (ZHX1). Methods Surgical specimens of 33 patients diagnosed with GBM in the Department of Neurosurgery, the Guangxi Zhuang Autonomous Region Brain Hospital from January 2020 to October 2022 were selected. The expression of SNHG17, miR-23b-3p, and ZHX1 in GBM samples and normal tissues adjacent to tumor were detected by real-time quantitative polymerase chain reaction (qRT-PCR). Pearson correlation analysis was used to evaluate the correlation between SNHG17, miR-23b-3p, and ZHX1. GBM cell line A172 and DK-MG were used as cell models, the cells were divided into si-NC group (transfected with blank inhibitor), si-SNHG17 group (transfected with si-SNHG17#2), and si-SNHG17+miR-23b-3p inhibitor group (transfected with si-SNHG17#2 and miR-23b-3p inhibitor). The proliferation capacity of GBM cells was detected by CCK-8 and EdU methods, while the migration and invasion of GBM cells were evaluated by Transwell assay. The qRT-PCR and Western blot were used to detect the mutual regulation of SNHG17 and miR-23b-3p, and their regulatory effect on ZHX1. Results The expression levels of SNHG17 and ZHX1 in GBM tissue were higher than those in normal tissue adjacent to cancer, while the expression level of miR-23b-3p was lower than that in normal tissue adjacent to cancer, the differences were statistically significant (P＜0.05). In GBM tissues, SNHG17 expression was negatively correlated with the expression of miR-23b-3p (r=-0.711, P＜0.05), but positively correlated with the expression of ZHX1 (r=0.648, P＜0.05); the expression of miR-23b-3p and ZHX1 was negatively correlated (r=-0.637, P＜0.05). The expression of miR-23b-3p in the si-SNHG17 group was higher than that in the si-NC group, and the proliferation, migration, and invasion ability of GBM cells and the expression level of ZHX1 were lower than those in the si-NC group, the differences were statistically significant (P＜0.05); however, the expression of miR-23b-3p in the si-SNHG17 + miR-23b-3p inhibitor group was lower than that in the si-SNHG17 group, and the proliferation, migration, invasion, and expression level of ZHX1 in GBM cells were higher than those in the si-SNHG17 group, the differences were statistically significant (P＜0.05). Conclusion SNHG17 can promote the proliferation, migration and invasion of GBM cells by regulating miR-23b-3p/ZHX1 axis. This suggests that SNHG17 may be a potential therapeutic target for GBM.
2023 Vol. 20 (23): 16-22 [
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Effect of short-chain fatty acids on M1/M2 polarization of microglia during spinal cord ischemia-reperfusion injury in rats
WANG Liping LI Fan ZHOU Kunming LIN Simeng
DOI: 10.20047/j.issn1673-7210.2023.23.04
Objective To investigate the effect of short-chain fatty acids (SCFA) on M1/M2 polarization of microglia during spinal cord ischemia reperfusion injury (IRI) in rats. Methods A total of 72 healthy male SD rats with SPF grade, aged 6 to 8 weeks and weight 200 to 250 g, were divided into sham operation group (group S), IRI group, SCFA group and SCFA+ free fatty acid receptor type 2 (FFAR2) blocker GLPG0974 group (GLPG group) by random number table method, with 18 rats in each group. The drinking water of SCFA group and GLPG group contained 25.9 mmol/L sodium acetate, 40.0 mmol/L sodium propionate and 67.5 mmol/L sodium butyrate, and the drinking water of S group and IRI group contained 133.4 mmol/L sodium chloride. After four weeks, IRI model was established in IRI group, SCFA group, and GLPG group, sham operation was performed in S group. In the GLPG group, 2 mg/kg GLPG0974 was intraperitoneally injected immediately after reperfusion and at the 1st to 6th day of reperfusion, and corresponding water was continuously supplied during the reperfusion period. Hind limb behavioral scores were performed at 1, 3, 5, and 7 days after reperfusion. Blood-spinal cord barrier (BSCB) permeability, spinal neuron survival rate, acetic acid, propionic acid, and butyric acid concentrations in stool and cerebrospinal fluid were measured at 7 d after reperfusion. The levels of spinal cord microglia differentiation cluster (CD) 86, CD206, and spinal tumor necrosis factor-α (TNF-α), interleukin(IL)-1β, IL-4, phosphorylated nuclear factor κB p65 (p-NF-κB p65), and phosphorylated signal transduction and transcriptional activator 3 (p-STAT3) were detected. Results Compared with S group, the behavioral score of the posterior limb, neuronal survival rate, acetic acid, propionic acid, and butyric acid concentrations in stool and cerebrospinal fluid were decreased in IRI group, while BSCB permeability, CD86, TNF-α, IL-1β, and P-NF-κB p65 were increased (P＜0.01). Compared with IRI group, the behavioral score, neuronal survival rate, acetic acid, propionic acid, and butyric acid concentrations in stool and cerebrospinal fluid in SCFA group were increased, BSCB permeability, CD86, TNF-α, IL-1β, and P-NF-κB p65 were decreased, while CD206, IL-4, and P-Stat3 were increased (P＜0.01). Compared with SCFA group, there was no significant difference in the concentrations of acetic acid, propionic acid, and butyric acid in stool and cerebrospinal fluid of GLPG group (P＞0.05). Conclusion SCFA can promote M1-type to M2-type polarization of microglia in rat spinal cord during IRI and reduce inflammation.
2023 Vol. 20 (23): 23-27 [
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Prognostic analysis of endometrial cancer based on long non-coding RNA associated with ferroptosis
SONG Yuying1 CUI Lin2 SUN Lei3 HE Yufeng1 ZHU Huiying1 WANG Fei3 LI Yan3
DOI: 10.20047/j.issn1673-7210.2023.23.05
Objective To construct a disease prognosis model of endometrial carcinoma (EC) by using long non-coding RNA (lncRNA) associated with ferroptosis, and to provide therapeutic targets for EC. Methods EC data was downloaded from TCGA and ferroptosis gene was downloaded from FerrDb database. Through R software, disease data and ferroptosis genes were intersected to obtain differentially expressed genes (DEGs), and GO and KEGG enrichment analysis of DEGs was performed. The lncRNA obtained according to Pearson correlation analysis. The model was constructed by Lasso-Cox, and the lncRNA used to construct the model was screened. The risk score was calculated, and the high and low risk groups were distinguished by the median value. Kaplan-Meier survival curve, receiver operating characteristics (ROC) and decision curve analysis (DCA) curves were used to evaluate the risk score of the model and clinical characteristics, and to predict the survival effect. TIMER, CIBERSORT, and other algorithms were used to analyze the immune cells and functions in high and low risk groups. R software was used to analyze the immune cell, function, checkpoint, and mRNA differential expression of m6A between the two groups of lncRNA. Results There were 248 ferroptosis genes, 1 616 lncRNA associated with ferroptosis and 80 DEGs. The results of GO analysis showed that DEGs was mainly involved in oxidative stress, regulating the basement membrane and organic anion transmembrane transporter activity. KEEG results showed that DEGs was mainly involved in ferroptosis and glutathione metabolic pathway, and so on. Univariate Cox regression analysis initially screened 45 lncRNA associated with ferroptosis. After Lasso-Cox optimization, 14 lncRNA were finally identified for the construction of prognosis models. Kaplan-Meier survival curve showed that the survival status of low risk group was better than that of high risk group (P＜0.01). ROC and DCA curves showed that risk score predicted survival better than traditional clinical characteristics; the AUC values of the first, second and third years were 0.696, 0.715, and 0.747, respectively. Univariate and multivariate Cox regression analysis results showed that model risk score was an independent influencing factor of predictor of survival in EC patients (HR [95%CI] = 1.105 [1.081-1.129]; HR [95%CI] = 1.108 [1.081-1.135], all P＜0.01). The heat map of immune cell distribution in high and low risk groups showed that there were differences in immune cell levels between the two groups (P＜0.05). The results of immune function showed that there were statistically significant differences in APC co-stimulation, CCR, and others between high and low risk groups (P＜0.05). The results of immune checkpoint showed that there were statistically significant differences in PDCD-1, CTLA-4, and others between high and low risk groups (P＜0.05). The results of m6A methylation showed that there statistically significant differences in YTHDF1, FTO and others between high and low risk groups (P＜0.05). Conclusion The 14 iron-death associated lncRNA may play an important role in tumor immunity in EC, providing potential targets for treatment of the disease.
2023 Vol. 20 (23): 28-33,42 [
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Expression and correlation analysis of forkhead box protein P3 positive regulatory T cells and programmed death-1/programmed death-ligand 1 pathway in early gastric cancer
QIN Yucui1 XIA Yun2▲
DOI: 10.20047/j.issn1673-7210.2023.23.06
Objective To investigate the expression and correlation of forkhead box protein P3 positive regulatory T cells (FOXP3+Tregs) and programmed death-1 (PD-1) / programmed death-ligand 1 (PD-L1) pathway in patients with early gastric cancer. Methods Gastric mucosa tissues of ten patients with early gastric cancer (early gastric cancer group) and ten patients with chronic gastritis (control group) admitted to Nanjing Pukou District Hospital of Traditional Chinese Medicine from October 2020 to June 2022 were collected. Tissue immunofluorescence was used to detect the expression of FOXP3+Tregs and PD-1/PD-L1 pathway in the gastric mucosa of the early gastric cancer group and the control group, and the correlation between the expression of them in early gastric cancer tissues was analyzed. Results The expression levels of FOXP3+Tregs, PD-1, and PD-L1 in the early gastric cancer group were higher than those in the control group, and the differences were statistically significant (P＜0.05 or P＜0.01). FOXP3+Tregs were positively correlated with PD-1 and PD-L1 expression in gastric mucosa of early gastric cancer group (r＞0, P＜0.01). Conclusion FOXP3+Tregs and PD-1/PD-L1 pathway are co-expressed in early gastric cancer tissues, suggesting that the combination of them can provide important reference for the determination of clinical early gastric cancer.
2023 Vol. 20 (23): 34-37 [
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Research progress of the role of oxidative stress in radiation-induced lung fibrosis and the prevention and treatment with traditional Chinese medicine
LI Zhanhong1 XU Xike2 CHEN Wei2 XIN Jiayun3 WANG Jinxin2 TIAN Saisai2 ZU Xianpeng2 WANG Shumei1
DOI: 10.20047/j.issn1673-7210.2023.23.07
Radiation-induced lung fibrosis (RILF) is the major clinical complication of radiotherapy for thoracic tumor, seriously endangering the lives of patients. A large amount of evidence shows that the oxidative stress induced by ionizing radiation is closely related to the occurrence and development of RILF. Reactive oxygen species (ROS), the initial product of oxidative stress, runs throughout the pathogenesis of RILF, and has a direct promoting effect on RILF. This paper summarizes the important role of ROS in the pathological progression of RILF, including DNA damage, inflammation, autophagy, epithelio-mesymal transformation, and extracellular matrix deposition, and summarizes the research progress of traditional Chinese medicine and its active ingredients in the treatment of RILF through antioxidant mechanisms, aiming to provide ideas and theoretical support for the prevention, and treatment of RILF by traditional Chinese medicine.
2023 Vol. 20 (23): 38-42 [
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Research progress of targeted costimulatory receptor pathway to enhance tumor immunotherapy
WANG Huijian BAI Yu
DOI: 10.20047/j.issn1673-7210.2023.23.08
The discovery and clinical application of different types of immune checkpoint inhibitors (ICIS) have revolutionized the treatment of cancer. This approach improved the prognosis of patients with various types of advanced tumors; however, the efficacy of anti-cytotoxic T lymphocyt-associated protein 4, programmed death receptor 1, and programmed death ligand 1 in patients with different tumor types varies greatly. Therefore, more and more studies are devoted to exploring more ICIS. This article discusses the transformation potential and clinical development of drugs targeting costimulatory T cell receptors, and outlines ongoing clinical trials of novel ICIS, including costimulatory receptor associated proteins and agonists that induce T cell costimulatory receptors. Further efforts are needed to optimize the timing of combined ICIS therapy and to tailor immunotherapy to patient and tumor specificity, as well as to advance the development of immunosurveillance techniques.
2023 Vol. 20 (23): 43-46 [
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Research progress of enterovirus infection in neonatal central nervous system
JIN Fang1 XIA Shiwen2
DOI: 10.20047/j.issn1673-7210.2023.23.09
Enterovirus infection in neonatal central nervous system can be manifested as viral meningitis, encephalitis, or acute flaccid myelitis, and may be complicated by brain damage such as periventricular leukomalacia. In severe cases, it may lead to sequelae such as cognitive impairment and cerebral palsy. Enteroviruses bind to specific receptors under the action of host factors, and destroy the virus clearance and inflammatory response of the body’s immune system through immune escape mechanism. Reverse transcription-polymerase chain reaction is the gold standard for the diagnosis of enterovirus infection in the central nervous system, and clinical treatment mainly focuses on symptomatic support. This article reviews the epidemiology of enterovirus and the pathogenesis, clinical manifestations, early recognition, clinical diagnosis, prevention, treatment of enterovirus infection inneonatal central nervous system, in order to improve the understanding of the disease in the clinic.
2023 Vol. 20 (23): 47-51 [
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Research progress of ovarian cancer related susceptibility genes
WU Hui HUANG Shouguo
DOI: 10.20047/j.issn1673-7210.2023.23.10
At present, the treatment of ovarian cancer is mainly limited to surgery and chemotherapy. Due to the lack of early detection means and low drug sensitivity, the recurrence rate and death rate are still high for many years. Therefore, the development of new treatment strategies is critical. With the wide application of gene detection technology in ovarian cancer patients, studies have found that the abnormal changes of myeloid cell oncogenes, telangiectasia ataxia mutant genes, transfer-related genes 1, and lactoserine protease inhibitor genes can play an important role in the occurrence, development and drug resistance of ovarian cancer as cancer promotion or tumor suppressor genes. This article reviews the mechanism of action of the above susceptibility genes in ovarian cancer, and provides some theoretical basis for the application of gene editing and gene expression regulation technology in ovarian cancer in the future.
2023 Vol. 20 (23): 52-55 [
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Research progress of home telerehabilitation for stroke patients
WU Yanlin1 ZHU Qiang2 ZHANG Jiahong3 LUO Yun3 ZHONG Yanbiao3 WANG Maoyuan3
DOI: 10.20047/j.issn1673-7210.2023.23.11
This paper analyzes and summarizes the application of home telerehabilitation in stroke patients. This paper describes the concept of home telerehabilitation and its application in stroke patients, including telephone technology, internet communication technology, mobile application program, and virtual reality technology. This paper evaluates the compliance, satisfaction, and readmission rate of stroke patients and analyzes the influencing factors of home telerehabilitation service from three aspects, such as patients’ acceptance and compliance, technical requirements, and platform selection, so as to provide reference for giving full play to the advantages of home telerehabilitation and promot the majority of medical workers to understand and carry home telerehabilitation technology in China.
2023 Vol. 20 (23): 56-59 [
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Study of construction of post competence index system for nosocomial infection prevention and control professionals
ZHANG Xiaojie1 LI Yatan2 JIA Wei1
DOI: 10.20047/j.issn1673-7210.2023.23.12
Objective To construct a competency evaluation index system for nosocomial infection control personnel to clarify the post competency requirements and to provide theoretical basis and feasible suggestions for nosocomial infection management and curriculum system construction, based on the competence theory and motivation theory. Methods From December 2020 to May 2021, this study conducted literature research and expert interviews to extract problems and draw up a preliminary draft, and adopted the Delphi method to conduct two rounds of consultation with 21 experts in the field of nosocomial infection, and then established the post competency index system of infection control personnel. Results After two rounds of expert consultation, the questionnaire recovery rate was 100%, the authority coefficient was 0.833 and 0.863, and the final competency index system of hospital infection control personnel included four first-level indicators, 11 second-level indicators and 46 third-level indicators. Conclusion The post competency index system of infection control personnel is reasonable, reliable, scientific, and practical, comprehensive in content, and has good reliability and validity, which can provide reference for the training of application-oriented infection control personnel at grassroots level in China.
2023 Vol. 20 (23): 60-64 [
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Influence of loneliness on problematic mobile phone use in college students
LI Xue1 CHANG Kuo2 ZHANG Lei1 ZHANG Hui1
DOI: 10.20047/j.issn1673-7210.2023.23.13
Objective To explore the causal relationship and influencing mechanism between loneliness and problematic mobile phone use, and to provide basis for effective intervention of problematic mobile phone use in college students. Methods In a longitudinal design, a follow-up survey was conducted on 411 college students using the mobile phone addiction questionnaire, loneliness scale, college students’ positive-negative rumination thinking questionnaire, and avoidance motivation subscale. The first measurement time (T1) was December 2021, and the second measurement time (T2) was March 2022. Results The usage rates of problematic mobile phones among T1 and T2 students were 68.6% and 70.1%, respectively. T1 loneliness could significantly predict T2 problematic mobile phone use, while T1 problematic mobile phone use had no significant predictive effect on T2 loneliness. Loneliness could predict subsequent problematic mobile phone use through negative rumination and avoidance motivation, respectively, or through the chain mediation of negative rumination and avoidance motivation. Positive rumination significantly modulated the influence path of loneliness on avoidance motivation (P＜0.05). Conclusion Intervention measures targeting loneliness, negative rumination, and mobile phone use motivation may be an effective way to reduce the occurrence of problematic mobile phone use behaviors among college students.
2023 Vol. 20 (23): 65-69,89 [
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Effects of cognitive impairment on self-esteem and social function in patients with paranoid schizophrenia
GU Xiaomei MA Rui HU Xiaofei▲
DOI: 10.20047/j.issn1673-7210.2023.23.14
Objective To explore the effects of cognitive impairment on self-esteem and social function in patients with paranoid schizophrenia. Methods A total of 82 patients with paranoid schizophrenia treated in the Department Psychiatric of the Fuyang Third People’s Hospital, Anhui Province (hereinafter referred to as “our hospital”) from February 2020 to January 2022 were selected as the case group, and 110 healthy physical examinations in the Psychiatric Department of our hospital during the same period were selected as the healthy control group. The general information questionnaire, the MATRICS consensus cognitive battery (MCCB), the state self-esteem scale (SSES), and the personal and social performance scale (PSP) were used to investigate the patients. Pearson coefficient was used to analyze the relationship among cognitive function, self-esteem level and social function. The structural equation was constructed with AMOS 22.0, and the mediating effect was verified by Bootstrap with non-parametric percentage of deviation correction. Results The patients had cognitive impairment (56.17±7.24) points, self-esteem (54.54±5.62) points, and social function (70.13±3.40) points. The results of Pearson analysis showed that cognitive impairment was negatively correlated with self-esteem and social function (r=-0.986, -0.977, P＜0.05), and self-esteem was positively correlated with social function (r=0.982, P＜0.05). The Bootstrap intermediary effect validation results showed that the self-esteem to predict social function had a direct effect, direct effect was 67.00% (95%CI：0.254, 0.542), and cognitive function defects in the level of self-esteem and social functions played a role of partial mediation, effect value of 33.00% (95%CI：0.017, 0.812). Conclusion The level of self-esteem can directly affect the social function of patients with paranoid schizophrenia, and can also indirectly affect the social function of patients by regulating cognitive function. Nurses should improve patients’ self-esteem from the perspective of positive psychology, and can also use cognitive function as a starting point to improve patients’ social function and help patients return to society as soon as possible.
2023 Vol. 20 (23): 69-72 [
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Sinicization and validation of emergency trauma assessment tools in the United States
JIN Ye ZHANG Yuqin WANG Tao ZHANG Chunyan
DOI: 10.20047/j.issn1673-7210.2023.20.15
Objective To analyze the reliability and validity of the Chinese version of generalized emergency trauma assessment criteria of America (GETAC) in single centers in China. Methods A total of 153 emergency trauma patients from Beijing Jishuitan Hospital from January to June 2020 were selected for retrospective analysis using the Chinese version of GETAC. The evaluation index includes evaluator reliability, retest reliability, content validity, and structure validity. Pearson correlation test was used for reliability analysis and exploratory factor analysis was used for validity analysis. Results The inter-rater reliability of GETAC was 0.900, the mean Pearson coefficient of Grade Ⅰ retest reliability items was 0.818, and the total Pearson correlation coefficient was 0.881. The mean Pearson coefficient of GradeⅡitems was 0.954, and the total Pearson coefficient was 0.828. The single item content validity index (I-CVI) of GETAC was 0.857 to 1.000, the I-CVI of each item was ＞0.780, and the scale content validity index was 0.916. A total of eight common factors were extracted by factor analysis, and the cumulative contribution rate was 65.63%. The factor load of each item on the corresponding common factor was ＞0.4. Conclusion GETAC has good reliability and validity, which can be applied to the early evaluation of patients in trauma emergency department in China.
2023 Vol. 20 (23): 73-76 [
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Study on the correlation between lipid accumulation product and risk levels of atherosclerotic cardiovascular disease
LIU Tongtong1 QIAN Hang2 LI Yunpeng2 WU Wenwen3 MIN Xinwen2 YANG Handong2 CHEN Jun2 LI Dongfeng2
DOI: 10.20047/j.issn1673-7210.2023.23.16
Objective To investigate the correlation between lipid accumulation product (LAP) and the risk levels of atherosclerotic cardiovascular disease (ASCVD). Methods A total of 2 266 workers of Dongfeng Motor Co., Ltd. who underwent physical examination in Dongfeng General Hospital Affiliated to Hubei University of Medicine from June 2021 to April 2022 were selected and divided into low risk group (1 334 workers), medium risk group (434 workers), and high risk group (498 workers) according to the risk level of ASCVD within ten years. Clinical data, laboratory biochemical indicators, and the differences of LAP among the three groups were collected and compared, and the correlation between LAP and other clinical indicators was analyzed, and the correlation between LAP and the risk levels of ASCVD within ten years was further analyzed. Results The distribution of gender, smoking, drinking, hypertension, metabolic syndrome and levels of age, systolic blood pressure, diastolic blood pressure, total cholesterol, high density lipoprotein-cholesterol, low density lipoprotein-cholesterol, body mass index, hip circumference, creatinine, fasting blood glucose, LAP, and white blood cell count among the three groups were compared, and the differences were statistically significant(P＜0.05). LAP was positively correlated with gender, age, systolic blood pressure, diastolic blood pressure, smoking, drinking, total cholesterol, low density lipoprotein-cholesterol, hypertension, body mass index, hip circumference, creatinine, fasting blood glucose, and white blood cells (rs＞0, P＜0.05), and negatively correlated with high density lipoprotein-cholesterol (rs＜0, P＜0.05). The results of multifactor analysis showed that LAP was an independent factor influencing the risk level of ASCVD within ten years after adjusting for confounding factors (P＜0.05). Linear trend test showed that LAP classification (L1: ≤14.88; L2:＞14.88-26.58; L3:＞26.58-44.90; L4: ＞44.90) had a linear relationship with risk level of ASCVD (P＜0.05), and a positive correlation (r＞0, P＜0.05). Conclusion LAP is an independent risk factor for the risk levels of ASCVD within ten years and has a linear relationship with it, so clinical attention should be paid to it.
2023 Vol. 20 (23): 77-80 [
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Effect of Levosimendan combined with continuous static infusion of Fur- osemide on serum levels of soluble suppression of tumorigenicity-2, neuron- specific enolase in patients with acute decompensated heart failure
LI Yaping LI Haiyang ZHENG Gaomei
DOI: 10.20047/j.issn1673-7210.2023.23.17
Objective To investigate the effects of Levosimendan combined with continuous static infusion Furosemide on serum levels of soluble suppression of tumorigehicity 2 (sST-2) and neuron-specific enolase (NSE) in patients with acute decompensated heart failure (ADHF). Methods A total of 140 ADHF patients diagnosed and treated in Fuyang People’s Hospital of Anhui Province from January 2019 to October 2020 were selected and they were divided into Furosemide group (continuous static infusion Furosemide) and combination group (continuous static infusion Furosemide + Levosimendan) according to random number table method, with 70 cases in each group. Both groups were given conventional treatment and were treated for one week. The heart rate, left ventricular fractional shortening rate (LVFS), left ventricular ejection fraction (LVEF), sST-2, NSE, amino terminal brain natriuretic peptide precursor (NT-proBNP), right atrial pressure (RAP), pulmonary capillary wedge pressure (PCWP), and mean pulmonary artery pressure (PAMP) were compared between the two groups before and after treatment. The incidence of adverse reaction was compared between the two groups. Results After treatment, the heart rate, sST-2, NSE, NT-proBNP, RAP, PCWP, and PAMP in both groups were lower than before treatment, LVFS and LVEF levels were higher than before treatment and the heart rate, sST-2, NSE, NT-proBNP, RAP, PCWP, and PAMP in combination group were lower than those in Furosemide group, LVFS and LVEF levels were higher than those in Furosemide group (P＜0.05). There was no significant difference in the total incidence of adverse reactions between the two groups (P＞0.05). Conclusion Levosimendan combined with continuous static infusion Furosemide has significant therapeutic effect on ADHF patients, reducing the levels of sST-2 and NSE, improving hemodynamics and cardiac function of patients, which is worthy of clinical promotion.
2023 Vol. 20 (23): 81-84 [
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Effect of thumbtack needling therapy on clinical symptoms and inflammatory factors of unstable angina pectoris with syndrome of blood stasis due to qi deficiency in patients with coronary heart disease after percutaneous coronary intervention
DAI Yu YANG Jing LEI Dongxue LIU Huaying
DOI: 10.20047/j.issn1673-7210.2023.23.18
Objective To investigate the effect of thumbtack needling therapy on clinical symptoms and inflammatory factors in unstable angina pectoris with syndrome of blood stasis due to qi deficiency in patients with coronary heart disease after percutaneous coronary intervention (PCI). Methods According to the random number table method, 112 unstable angina pectoris patients with syndrome of blood stasis due to qi deficiency with coronary heart disease after PCI in Tangshan Traditional Chinese Medicine Hospital in Hebei Province from March 2021 to March 2022 were divided into control group (56 cases) and study group (56 cases). The control group was treated with routine treatment, and the study group was treated with routine treatment and thumbtack needling therapy. Both two groups were treated for one month. The curative effect was compared between the two groups, and the traditional Chinese medicine syndrome score, inflammatory factor levels were compared between the two groups before and after treatment, and the occurrence of adverse events was recorded. Results The clinical efficacy of the study group was better than that of the control group, and the difference was statistically significant (P＜0.05). After treatment, the scores of chest stabbing pain, chest distress, shortness of breath, malaise, palpitations, pale complexion, and burnout in the two groups were lower than those before treatment, and those in the study group were lower than those in the control group, and the differences were statistically significant (P＜0.05). After treatment, the levels of serum high-sensitivity C-reactive protein, human cartilage glycoprotein, and interleukin-6 in the two groups were lower than those before treatment, and those in the study group were lower than those in the control group, and the differences were statistically significant (P＜0.05). No serious adverse events occurred in the two groups during the treatment. Conclusion The thumbtack needling therapy can effectively improve the clinical symptoms of unstable angina pectoris with syndrome of blood stasis due to qi deficiency in patients with coronary heart disease after PCI, reduce the levels of inflammatory factors, and has high safety.
2023 Vol. 20 (23): 85-89 [
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Event-related potentials study of N2 and P3a in children with tic disorders with or without attention deficit hyperactivity disorder
REN Yongying1 LIU Ziqi2 ZHANG Fan3 WANG Xiaoyue2 YANG Wenmin2 SUN Jing2 ZHANG Jianzhao2 WANG Xin2 YANG Jian1
DOI: 10.20047/j.issn1673-7210.2023.23.19
Objective To explore the effects of comorbid attention deficit hyperactivity disorder (ADHD) on response inhibition and attention function in children with tic disorders (TD), and to provide a new reference for the study of cognitive function in children with TD. Methods A total of 95 children were selected from March to September 2022 from the outpatient Department of Neurology and the Department of Health Care in the Children’s Hospital Capital Institute of Pediatrics. They were divided into simple TD group (47 cases), TD comorbid with ADHD group (19 cases), and normal group (29 cases). All children were tested for event-related potentials N2 and P3a. The amplitude and latency of ERP components N2 and P3a were analyzed by statistics software SPSS 26.0. Results The amplitude of N2 at C3 point in TD+ADHD group was lower than that in control group, and the difference was statistically significant (P＜0.05). The P3a amplitude at Pz point in TD+ADHD group was lower than that in control group, and the difference was statistically significant (P＜0.05). The P3a amplitude at Oz point in chronic TD group and chronic TD+ADHD group was significantly lower than that in control group, and the difference was statistically significant (P＜0.05). Conclusion Comorbid ADHD can lead to the impairment of response inhibition function in children with TD, and impaired attentional cognitive function exists in children with chronic TD.
2023 Vol. 20 (23): 90-93,98 [
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Analysis of clinical features and genetic variants in a family with developmental and epileptic encephalopathy induced by PIGS gene mutation
CHEN Chaohong WANG You LI Chengyan LIU Ling AO Dang▲
DOI: 10.20047/j.issn1673-7210.2023.23.20
Objective To summarize and analyzes the clinical features and genetic variants of two children in a family with developmental and epileptic encephalopathy (DEE) induced by phosphatidylinositol glycan anchor biosynthesis, class S (PIGS) gene mutation. Methods Clinical data and family history of two patients visited the outpatient of the Affiliated Hospital of Guangdong Medical University due to “recurrent seizures” from 2021 to 2022 were collected, peripheral blood samples of patients and family members were extracted. Whole exome sequencing and Sanger sequencing were carried out to detect the potential mutation. Results Case 1, female, sister (witness), 8 years old, case 2 female, sister, 6 years old, all of them were infantile onset, presented with frequent generalized tonic-clonic seizures, accompanied by severe developmental lag, physical examination found special facial features (arched eyebrow, almond eyes, wide eye distance, low nose bridge, long middle, wide tongue) and hypotonia, abnormal video EEG and skull magnetic resonance imaging results. All genetic tests indicated homozygous mutation of PIGS gene c.1141_1164dup (P.SP381_val388dUP), and Sanger verified that the parents were heterozygous mutations. Combined with the clinical phenotype and genetic detection results, 2 cases were confirmed as DEE-95 (PIGS gene mutation). Convulsions improved after treatment with vitamin B6 and antiepileptic combination. Conclusion Homozygous mutation of PIGS gene is the cause of DEE95. Whole exome sequencing is of great value for the diagnosis of DEE-95. Most of the patients need combination therapy, which is effective with the addition of vitamin B6.
2023 Vol. 20 (23): 94-98 [
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Changes and clinical significance of cervical vascular ultrasound and serum homocysteine and cystatin C levels in patients with ischemic stroke
WANG Zhiping1 CHEN Piaofei1 JIANG Shanshan1 HU Yuanjun1 WU Shenghao2 DAI Qian1▲
DOI: 10.20047/j.issn1673-7210.2023.23.21
Objective To explore the changes and clinical significance of cervical vascular ultrasound (CVUS) and homocysteine (Hcy) and cystatin C (CysC) levels in patients with ischemic stroke (IS). Methods Clinical data of 79 patients with IS admitted to Huangshan People’s Hospital in Anhui Province from February 2020 to September 2022 were collected. According to the modified Rankin scale (mRS), the patients were divided into good prognosis group （mRS≤2 points） and poor prognosis group （mRS＞2 points） after 7 to 10 days of treatment. The clinical data, CVUS results and serum Hcy and CysC levels of the two groups were compared. Logistic regression was used to analyze the factors affecting the prognosis of patients with IS, and receiver operating characteristic curve was used to analyze the predictive value of CVUS and serum Hcy and CysC levels for the prognosis of patients with IS. Results The levels of National Institute of Health stroke scale (NIHSS) score, Hcy, CysC， and intima-media thickness (IMT) in poor prognosis group were higher than those in good prognosis group, and the proportion of severe carotid stenosis (CS) in poor prognosis group was higher than that in good prognosis group (P＜0.05). Logistic regression analysis showed that NIHSS score, Hcy, CysC, IMT levels， and CS degree were independent risk factors for poor prognosis of IS patients (OR＞1，P＜0.05). Receiver operating characteristic curve analysis showed that the area under the curve of Hcy, CysC and IMT to predict the prognosis of IS patients were 0.832, 0.771, 0.652, respectively, and the combined prediction area under the curve was 0.904. Conclusion The levels of IMT, CS and serum Hcy and CysC have certain predictive value for the prognosis of patients with IS, and the combined prognostic value is higher.
2023 Vol. 20 (23): 99-102 [
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Effects of low-frequency repetitive transcranial magnetic stimulation combined with Balance-Trainer training on balance function and lower limb motor function after stroke
ZHAI Jiajia SHI Wei ZHU Dongyan ZHOU Sanlian LIANG Li CAO Hui LU Hongjian▲
DOI: 10.20047/j.issn1673-7210.2023.23.22
Objective To explore the effects of low-frequency repetitive transcranial magnetic stimulation (rTMS) combined with Balance-Trainer training on balance function and lower limb motor function of patients after stroke. Methods A total of 70 stroke patients who were hospitalized in the Department of Rehabilitation Medicine, the Second Affiliated Hospital of Nantong University from January 2021 to January 2022 were selected, and they were divided into BT group (23 cases), rTMS group (24 cases), and combined group (23 cases). Patients of three groups received the conventional rehabilitation treatments, in addition, BT group added Balance-Trainer training, rTMS group added rTMS treatment, combined group added rTMS treatment and BT training. The Berg balance scale (BBS), Fugl-Meyer assessment scale for lower extremity (FMA-LE), modified Barthel index scale (MBI), and stability index (SI) scores were compared among three groups before and after treatment; the occurrence of adverse reactions among three groups were observed. Results After treatment, BBS, FMA-LE, and MBI scores of three groups were higher than those before treatment, SI score was lower than that before treatment; and BBS, FMA-LE, MBI scores of combination group were higher than those of BT group and rTMS group, SI score was lower than that of BT group and rTMS group(P＜0.05). No adverse reactions such as epilepsy occurred in all patients during treatment. Conclusion Low-frequency rTMS combined with Balance-Trainer training can significantly improve the balance function and lower limb motor function of patients after stroke, and improve their abilities of daily life.
2023 Vol. 20 (23): 103-106 [
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Effects of symmetrical weight-bearing sit-stand transfer training on sit-stand transfer stability and gait symmetry in post-stroke hemiplegia patients
FANG Shengsheng1 ZHANG Fangfang1▲ HU Xing2
DOI: 10.20047/j.issn1673-7210.2023.23.23
Objective To investigate the effects of symmetrical weight-bearing sit-stand transfer training on sit-stand transfer stability and gait symmetry in post-stroke hemiplegia patients. Methods A total of 101 patients with post-stroke hemiplegia admitted to Huaian First People’s Hospital from February 2019 to February 2022 were selected, and they were divided into control group (50 cases) and study group (51 cases) according to the random number table method. The control group received conventional bipedal parallel sit-stand transfer training, and study group received symmetrical weight-bearing sit-stand transfer training. Both groups continued training for four weeks. Breg balance scale (BBS), stroke quality of life scale (QOF), modified Barthel index scale (MBI), step size deviation, the ratio of swing between sick and healthy sides, the ratio of support between healthy and sick sides before and after training were compared between two groups; the maximum swing of the body’s center of gravity on the sagittal plane (COGX), the time from standing to sitting, and the time from sitting to standing were compared between two groups after training. Results After training, the BBS score, QOF score, and MBI score of two groups were higher than those before training, and study group was higher than control group (P＜0.05); the ratio of swing between sick and healthy sides, the ratio of support between healthy and sick side, and step size deviation of two groups were lower than those before training, and study group was lower than control group (P＜0.05). COGX of study group was higher than that of control group, and the time from standing to sitting and the time from sitting to standing were shorter than those of control group (P＜0.05). Conclusion Symmetrical weight-bearing sit-stand transfer training can improve the balance ability, quality of life, self-care ability, sit-stand transfer stability, and gait symmetry of post-stroke hemiplegia patients, and can shorten the sit-stand transfer time.
2023 Vol. 20 (23): 107-110 [
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Effect of double-layer continuous suture and single-layer continuous suture of uterine incision on recovery after secondary cesarean section and the formation of incision scar diverticulum
ZHONG Lin1 HU Xinyu2 JIANG Mei2
DOI: 10.20047/j.issn1673-7210.2023.23.24
Objective To explore the effect of double-layer continuous suture and single-layer continuous suture on recovery after second cesarean section and the formation of incision scar diverticulum. Methods A total of 102 cases of second cesarean section women admitted the First People’s Hospital of Neijiang of Sichuan Province from April 2020 to April 2021 were selected, and they were divided into control group (single-layer continuous suture, 51 cases) and study group (double-layer continuous suture, 51 cases) according to the random number table method. The perioperative indicators, postoperative recovery condition, menstrual recovery condition, incision scar diverticulum formation, and complication were compared between two groups. Results There were no significant differences in operation time, intraoperative blood loss, and postoperative maximum body temperature between two groups (P＞0.05); the rate of postpartum hemorrhage in study group was lower than that of control group (P＜0.05). There was no significant difference in postoperative hospital stay between two groups (P＞0.05); the duration of lochia time in study group were shorter than that of control group (P＜0.05). There was no significant difference in menstrual duration between two groups (P＞0.05); the time of postoperation menstruation was shorter than that of control group, menstrual blood volume and the incidence of abnormal menstruation in study group were lower than those of control group (P＜0.05). The incidence of uterine incision scar diverticulum and the volume of scar diverticulum in study group were lower than those of control group, and the residual myometrial thickness of scar diverticulum in study group was higher than that of control group (P＜0.05). The total incidence of complications in study group was lower than that of control group (P＜0.05). Conclusion Compared with single-layer continuous suture, double-layer continuous suture is better for postpartum recovery with second cesarean section, has less impact on menstruation, and it can reduce the risk of uterine incision scar diverticula formation and incidence of complications.
2023 Vol. 20 (23): 111-114 [
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Diagnostic value of tuberculosis molecular biological detection of bronchoalveolar lavage fluid and peripheral blood T cell spot test in the sputum smear negative pulmonary tuberculosis patients
ZHANG Yan1 WANG Hua2 HOU Jing1 WANG Qing1
DOI: 10.20047/j.issn1673-7210.2023.23.25
Objective To explore the diagnostic value of tuberculosis molecular biological detection of bronchoalveolar lavage fluid and peripheral blood T cell spot test in the sputum smear negative pulmonary tuberculosis patients. Methods A total of 198 patients with suspected pulmonary tuberculosis and negative acid-fast bacilli stain on sputum smears admitted to the Anhui Chest Hospital from January 2020 to April 2021 were selected as the study objects. All patients underwent tracheoscopy, local bronchoalveolar lavage fluid samples were taken for tuberculosis (TB)-DNA, TB-RNA, Xpert MTB/RIF detection and peripheral blood T cell spot test, respectively, diagnosis of criteria pulmonary tuberculosis WS 288—2017 was as the gold standard . The consistency of the above four tests with the gold standard was compared, and the consistency of the combination of Xpert MTB/RIF detection in bronchoalveolar lavage fluid and peripheral blood T cell spot test with the gold standard was compared. The diagnostic efficacy of each test was analyzed. Results Among 198 patients, 153 were diagnosed as pulmonary tuberculosis. The four single tests and the combination of Xpert MTB/RIF detectionin bronchoalveolar lavage fluid and peripheral blood T cell spot test all had certain consistency with the gold standard (Kappa=0.512, 0.449, 0.327, 0.373, 0.793, P＜0.05). The sensitivity and specificity of the combination of Xpert MTB/RIF detection in bronchoalveolar lavage fluid and peripheral blood T cell spot test were 90.20% and 97.78%, respectively. Conclusion Bronchoalveolar lavage fluid Xpert MTB/RIF detection combined with peripheral blood T cell spot test in the diagnosis of sputum smear negative pulmonary tuberculosis patients is consistent with the gold standard, and the sensitivity and specificity are good, which can be used for clinical auxiliary examination.
2023 Vol. 20 (23): 115-118,124 [
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Study on the application of cone beam CT in the anatomic system of the first premolar of mandible
ZHENG Wenwen QIU Xiaoling
DOI: 10.20047/j.issn1673-7210.2023.23.26
Objective To study the morphological characteristics of the root and root canal of the first premolar of mandible by cone beam CT (CBCT) scanning. Methods The imaging parameters of the first premolar of mandible in 376 patients who underwent CBCT examination in Boai Hospital of Zhongshan, Guangdong Province from June 2021 to January 2022 were retrospectively analyzed, the imaging parameters included the number of roots, root canal classification, root length, root canal curvature, starting position of root sulcus, appearance of root sulcus, and intersection angle between the line of buccal pulp angle and buccal enamelo-cemental junction and the buccal-lingual enamelo-cemental junction (BB-BL). The differences of CBCT imaging parameters were compared in patients with different genders (188 males and 188 females) and different ages (126 patients aged 16-25 years, 90 patients aged ＞25-35 years, 73 patients aged ＞35-45 years, 51 patients aged ＞45-55 years, and 36 patients aged ＞55 years) and their correlation with gender and age were analyzed. The anatomical structure symmetry of the first premolar of mandible in patients with different sex, age, and number of roots was analyzed. Results Root canal length of the right mandibular first premolar in 376 patients was (15.19±1.55) mm; BB-BL was (38.10±6.14)°, and the proportion of single root, type Ⅰ root canal, secondary root curvature, and no root sulcus were higher. In 99 patients with the presence of root sulcus, the proportion of starting position of root sulcus which at 1/3 of the root tip, and the root sulcus which located at the mesial root were higher. There were significant differences in root canal classification, tooth root length, and BB-BL among different gender patients (P＜0.05). There was statistical significance in the appearance of root sulcus between different genders of patients with the presence of root sulcus (P＜0.05). The BB-BL of patients of different ages was compared, and the difference was statistically significant (P＜0.05). The age of male and female patients were both negatively correlated with BB-BL (r＜0, P＜0.05). The rate of root canal symmetry in patients with single root was higher than that in patients with double root, and the difference was statistically significant (P＜0.05). Conclusion The root and root canal morphology of the first premolar of mandible are different. CBCT is helpful to the examination of root and root canal morphology and can provide reference for root canal treatment.
2023 Vol. 20 (23): 119-124 [
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Visual analysis of research status of self-perception of aging based on CiteSpace
YANG Shuhui DUAN Meiwen YANG Jie CHEN Le BI Qingquan
DOI: 10.20047/j.issn1673-7210.2023.23.27
Objective To analyze the research status, hot spots, and frontier trends of self-perception of aging in recent five years. Methods Relevant literature of self-perception of aging from January 2017 to December 2021 in the Web of Science core collection database was searched, and the CiteSpace 6.1.R3 software was used to make visual analysis of countries, institutions, authors, and key words and reference. Results A total of 845 articles were included in recent five years. The number of publications and citation frequency in this field have shown an overall rising trend. The United States is high-impact countries, and the University of Toronto is the institution which has a large number of publications. The most publications published is author Barnett. Research on the field focuses on the relationship between self-perception of aging and various variables (health, quality of life), study population, literature processing study. The relationship between self-perceived aging and self-efficacy, quality of life, the formulation of intervention programs are the future development trend. Conclusion This study uses the visualization map to intuitively show the hot spots and frontiers of this field, which to provide the reference for further development of the fields in the future.
2023 Vol. 20 (23): 125-130 [
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Influence of diabetes, cirrhosis, and their interaction on acute kidney injury in patients with sepsis
TONG Lizhen LIN Mingjiang XING Bo
DOI: 10.20047/j.issn1673-7210.2023.23.28
Objective To explore the impact of diabetes, cirrhosis, and their interaction on patients with sepsis complicated by acute kidney injury (AKI). Methods Patients with sepsis admitted to the emergency intensive care unit of the Second Affiliated Hospital of Hainan Medical College from January 2016 to December 2021 were included and divided into two groups according to whether they had concurrent AKI. Clinical data, biochemical indicators, sequential organ failure assessment (SOFA) score, and vital signs were compared between the two groups. Binary logistic regression model was used to analyze the independent risk factors of AKI in patients with sepsis. The effects of diabetes, cirrhosis, and their interaction on AKI in patients with sepsis were analyzed by multiplicative model and additive model. Results After adjusting for confounding factors such as gender, age, underlying diseases, laboratory indicators, SOFA score, and vital signs, the results of binary logistic regression analysis model showed: among sepsis patients, the risk of AKI in patients with diabetes was 3.587 times (95%CI: 2.865, 4.491) that of those without diabetes, and the risk of AKI in patients with cirrhosis was 2.766 times (95%CI: 2.407, 3.261) that of those without cirrhosis. After adjusting for hypertension, white blood cell count, C-reaction protein, 1-hour lactic acid value, SOFA score, and other factors, diabetes and cirrhosis had additive and multiplicative interaction on AKI in sepsis patients. Conclusion Diabetes and cirrhosis are independent risk factors for AKI in patients with sepsis, and their multiplicative and additive interactions increase the risk of AKI in patients with sepsis.
2023 Vol. 20 (23): 131-134 [
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Effect of upper limb compression therapy on the prevention of peripherally inserted central venous catheter related thrombosis in patients with inability to exercise
XU Suiyun1 WANG Wenxu2 HAN Yan1 GAO Yang1 GUO Lei1 YAN Xianxia1
DOI: 10.20047/j.issn1673-7210.2023.23.29
Objective To observe the effect of upper limb compression therapy on the prevention of peripherally inserted central venous catheter (PICC) related thrombosis in patients with inability to exercise. Methods A total of 84 patients with inability to exercise underwent upper limb PICC catheterization and catheter maintenance in the Second Affiliated Hospital of Xi’an Jiaotong University from January 2020 to August 2022 were selected. They were divided into control group and compression group by random number table method, with 42 cases in each group. The control group was given passive activity intervention, and the compression group was given air pressure wave intervention. Color Doppler ultrasound was used to monitor the blood flow velocity of axillary vein and subclavian vein before intervention and 30 minutes after intervention in the two groups. The levels of fibrinogen, prothrombin time, and D-dimer were measured before catheterization and two weeks after catheterization. The incidence of PICC related thrombosis in the two groups was recorded. Results After 30 minutes of intervention, the blood flow velocity of axillary vein and subclavian vein in the two groups were faster than those before intervention, and that in the compression group was faster than that in the control group, and the differences were statistically significant (P＜0.05). After two weeks of catheterization, the levels of fibrinogen, prothrombin time, and D-dimer in the control group were higher than those before catheterization, and higher than those in the compression group, and the differences were statistically significant (P＜0.05). There were no significant differences in fibrinogen, prothrombin time, and D-dimer before and two weeks after catheterization in the compression group (P＞0.05). During the observation period of two weeks, the incidence of PICC related thrombosis in the compression group was lower than that in the control group, and the difference was statistically significant (P＜0.05). Conclusion Air pressure wave therapeutic instrument can effectively prevent upper extremity PICC related thrombosis in patients without exercise ability by increasing the venous blood flow velocity on the catheterization side.
2023 Vol. 20 (23): 135-138,181 [
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Visual analysis of research hot spot trends of Buyang Huanwu Decoction in the treatment of angina pectoris of coronary heart disease based on CiteSpace and VOSviewer
LI Peng1 LU Jinjin2 LI Yuxuan1 ZHANG Yuanyuan1 LI Xingxing1 LIN Qian3 LI Yan2 CUI Xiaoyun2
DOI: 10.20047/j.issn1673-7210.2023.23.30
Objective To analyze the relevant study of Buyang Huanwu Decoction in the treatment of angina pectoris of coronary heart disease based on CiteSpace and VOSviewer and to explore the research status and hot trends. Methods The research literatures on the application of Buyang Huanwu Decoction in the treatment of angina pectoris of coronary heart disease collected from CNKI, VIP, WanFang Data, China Biomedical Literature Database, PubMed, and Web of Science from January 1990 to October 2022 were searched by computer. Visualization software CiteSpace 5.5.R2 and VOSviewer 1.6.18 were used to draw the map of scientific knowledge, and the number of publications, authors, institutions, and keywords were analyzed. Results A total of 392 papers were included, and the number of published papers showed a fluctuating upward trend. Research institutions were mainly concentrated in universities and their affiliated hospitals, and high-frequency keywords included “Buyang Huanwu Decoction”, “angina pectoris”, “clinical efficacy”, and so on. There were ten cluster labels and 12 outburst words, respectively. Conclusion The current research focus on clinical research, integrated therapy of traditional Chinese and western medicine, etc., but the discussion of pharmacological mechanism still needs to be further explored. This study provides a reference for the clinical application of Buyang Huanwu Decoction in the treatment of angina pectoris of coronary heart disease angina pectoris.
2023 Vol. 20 (23): 139-143 [
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Discussion on yin and yang in traditional Chinese medicine from “mass energy conversion”
YAN Xinyu WANG Junge WANG Man ZHAO Jingyi HAN Jinshuai
DOI: 10.20047/j.issn1673-7210.2023.23.31
Yin and yang are the ancient people’s high generalization and application of the “mass energy conversion” in nature. It is the most basic concept of traditional Chinese medicine theory. Different schools of traditional Chinese medicine have different theories. Taking the law of human life movement as the research object, this paper expounds the origin of yin and yang from the mass expression, energy expression and relative equilibrium state of “mass energy conversion” in the matter theory, the existing state and metabolic movement law of yin and yang in the process of human life “mass energy conversion”, as well as the specific connotation of yin and yang in human physiology, pathology, anatomy, diagnostics, and pharmacology. It is clarified in Shanghan Lun that discriminating fluid infusion, distribution, separation, and reunion are the specific application of the theory of “mass energy conversion” in clinical practice. Fluid is unitary, the root is consistent and interdependent and mutually promoting. The mass expression state of fluid is the basis of “mass energy conversion”, and the energy expression state of fluid is the function of “mass energy conversion”. “Six diseases syndrome differentiation system” in Shanghan Lun explores the physiological and pathological laws of birth, old age, illness, and death of human beings with the quality expression state of fluid expression state, energy expression state and “mass energy conversion” theory, and makes clear the pathogenesis, law of disease transmission, principle and method of treatment, and principle-method-recipe-medicines of the six diseases. Therefore, the theory of “mass energy conversion” is the basis of the classification of yin and yang in traditional Chinese medicine theory.
2023 Vol. 20 (23): 144-147 [
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Professor Wang Yuxi’s experience in treating palmoplantar pustulosis from the perspective of toxin and stasis
YUAN Rui1 XU Ke2 YAN Jingdong1 CHEN Guoming3 YANG Suqing1 SUN Qichao4
DOI: 10.20047/j.issn1673-7210.2023.23.32
Palmoplantar pustulosis is a special type of psoriasis. It is a difficult skin disease with long course and repeated attack. It is a key and difficult point in clinical treatment. Physicians over the ages believe that the etiology and pathogenesis of palmoplantar pustulosis are wind cold, dampness, blood stasis, etc. Professor Wang Yuxi’s clinical treatment of palmoplantar pustulosis starts with dampness, toxin, and stasis. He believes that the imbalance of yin and yang, as well as the imbalance of qi and blood, are the basis for the onset of the disease. The damaged functions of zang-fu viscera are mainly caused by pathogenic factors such as wind, cold, dampness, stasis, and toxin. The overall treatment principle is to strengthen the spleen and remove dampness, clear heat and detoxify, and promote blood circulation and disperse stasis. He has developed his own empirical formula, Wugong Baidu Yin, as the basic formula for treating this disease. In the later stages of the disease, attention should be paid to cultivate and replenish vital qi, and reinforcement and elimination in combination. Professor Wang Yuxi attaches great importance to the application of external treatment methods in treatment. He believes that external preparations can directly reach the disease site and achieve rapid effects. At the same time, the use of insect and rattan drugs is effective, reaching the meridians and coordinating with spleen and stomach regulating drugs to balance yin and yang, resulting in significant clinical efficacy.
2023 Vol. 20 (23): 148-151,155 [
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Discussion on the integrated traditional Chinese and western medicine in the treatment of cancer related malnutrition based on the principle of “reinforce insufficiency and reduce excessiveness”
XIE Hongting1 DUAN Kexin2 LONG Sidan1 XUE Peng1 ZHU Shijie1
DOI: 10.20047/j.issn1673-7210.2023.23.33
Cancer related malnutrion is a common complication in patients with malignant tumors, characterized by emaciation, fatigue, and anorexia. Western medicine mostly explains its pathogenesis from negative energy balance, nutrient metabolism disorder, and dysregulation of intestinal flora. Traditional Chinese medicine believes that malignant tumors are formed by the cementation of phlegm, stasis, and cancer toxin. Prolonged accumulation of these substances can damage the vital qi and cause the vital qi deficiency failing to control. These substances then flow into the meridians and blood vessels, blocking the spread of essence and blood, leading to the loss of nourishment in the organs and resulting in a state of deficiency and barrenness. This is due to the deficiency caused by excess. Therefore, treatment should be based on the fundamental principle of “reinforce insufficiency and reduce excessiveness”, using the methods of “tonifying essence, building middle” and “resolving phlegm, removing blood stasis, and detoxifying”, integrating the advantages of traditional Chinese and western medicine to improve the nutritional status of malignant tumor patients. This aims to provide ideas and methods for the clinical treatment of tumor related malnutrition.
2023 Vol. 20 (23): 152-155 [
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Discussion on the application of rattan drugs in diabetic nephropathy based on “collateral disease theory”
WEN Yaxuan LIU Hongfang JIANG Wei DONG Zhaoxi
DOI: 10.20047/j.issn1673-7210.2023.23.34
“Collateral disease theory” is an important part of traditional Chinese medicine. According to the characteristics of structure, physiological function, pathological changes, and course of disease, diabetic nephropathy is a typical category of collateral disease. Rattan drugs are criss-cross in shape, and extend and intertwine in growth, and similar to the structure characteristics and distribution mode of body collateral. Rattan drugs are widely used in the treatment of collateral disease because they are good at penetrating into the collaterals and can be used to induce the diseases. The clinical application of rattan drugs in diabetic nephropathy is mainly divided into five aspects: clearing heat and detoxifying for removing obstruction in collaterals, dispelling wind and predominant dampness for removing obstruction in collaterals, calming the liver to stop the wind for removing obstruction in collaterals, activating blood circulation to dissipate blood stasis for removing obstruction in collaterals, tonifying deficiency and nourishing blood for nourishing collaterals. Clinical use of rattan drugs in the treatment of diabetic nephropathy should pay attention to reasonable compatibility, grasp the dosage.
2023 Vol. 20 (23): 156-159,172 [
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Discussion on parameter-effect relationship of Ginseng Radix Et Rhizoma of Zhang Zhongjing’s classical prescriptions
WANG Yang1 CAO Fang1 MA Yuan1 YAN Zhi1 WANG Mingyue2 LI Yanke1 LUO Shaodong1 ZHANG Wenfeng1
DOI: 10.20047/j.issn1673-7210.2023.23.35
Treatise on Cold Pathogenic and Miscellaneous Diseases was written by Zhang Zhongjing, which is one of the traditional medical works. It is named Treatise on Cold Pathogenic Diseases and Synopsis of Golden Chambe respectively which was classified by later generation. Ancient and modern doctors have followed traditional medical books for syndrome differentiation and treatment, while also paying more attention to the parameter-effect relationship between prescriptions and medicines. There are about 42 classic formulas containing Ginseng Radix Et Rhizoma in Zhongjing’s classical prescriptions. This article attempts to analyze the parameter-effect relationship of Ginseng Radix Et Rhizoma in the classical prescriptions and summarize four levels of parameter-effect. Among them, four to six liang of Ginseng Radix Et Rhizoma are mainly used for warming the middle and expelling water evil. Three liang of Ginseng Radix Et Rhizoma is mainly used for regulating the middle and preventing or arresting vomiting, tonifying the middle and promoting fluid production. Two liang of Ginseng Radix Et Rhizoma helping sweet and warm herbs restore pulse and nourish body fluids, descend the adverse flow of qi and harmonize the stomach. Ginseng Radix Et Rhizoma below two liang is mainly used for strengthening the vital qi. This article will compare the dosage and efficacy of Ginseng Radix Et Rhizoma in Zhongjing’s classical prescriptions, explore Zhongjing’s medication thinking in clinical practice, and further expand parameter-effect theory of Zhongjing’s classical prescriptions for reference by colleagues.
2023 Vol. 20 (23): 160-163 [
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Discussion on the pathogenesis and treatment experience of endometriosis based on the theory of “unsmooth blood circulation results in water retention”
ZHONG Ying1 ZHANG Yaping2▲
DOI: 10.20047/j.issn1673-7210.2023.23.36
Endometriosis is often regarded as a difficult gynecological disease, but its diagnosis and treatment should be based on the whole. Traditional Chinese medicine theory has guiding significance for the diagnosis and treatment of endometriosis. The basic pathogenesis of endometriosis with stasis blocking uterus is closely related to unsmooth blood circulation. Based on the theory of “unsmooth blood circulation results in water retention” in traditional Chinese medicine, the treatment of endometriosis is based on syndrome differentiation and the combination of disease and syndrome, and the pathogenic characteristics of endometriosis are discussed from the perspective of “blood and water”. At the same time, around the principle of “blood and water treatment together”, analyze the theoretical basis of Zhongjing’s classical prescriptions of blood and water treatment together in the application of endometriosis, and expand new ideas for traditional Chinese medicine to treat endometriosis.
2023 Vol. 20 (23): 164-168 [
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Effect of hospital pharmacy management intervention on rational use of clinical traditional Chinese medicine injections and prescription qualification rate
YIN Chunxia1 LI Xin1 SUN Gang2 FANG Danjun1▲
DOI: 10.20047/j.issn1673-7210.2023.23.37
Objective To analysis the effect of hospital pharmacy management intervention on rational use of clinical traditional Chinese medicine injections and prescription qualification rate. Methods A retrospective analysis was performed on 1 572 traditional Chinese medicine injection prescriptions in Jingjiang People’s Hospital of Jiangsu Province from January 2019 to June 2020 that did not use pharmacy management intervention and 1 283 traditional Chinese medicine injection prescriptions from January 2021 to June 2022 that used pharmacy management intervention. The sales amount, usage quantity, sequencing ratio, defined daily dose cost (DDDC), defined daily dose (DDDs), and prescription qualification rate of traditional Chinese medicine injections before and after intervention were compared. Results After intervention, the sales amount, usage quantity, and DDDs of traditional Chinese medicine injections were lower than those before intervention; DDDC and sequencing ratio≥1 were higher than those before intervention. The prescription qualification rate of traditional Chinese medicine injections after intervention was higher than that before intervention (P＜0.05). Conclusion Hospital pharmacy management intervention can reduce the sales amount and usage quantity of clinical traditional Chinese medicine injections, improve the prescriptions qualification rate, and promote clinical rational drug use.
2023 Vol. 20 (23): 169-172 [
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Application effect of transitional nursing from neonatal intensive care unit to home in premature infants
CHENG Fangling ZHOU Yongying ZHU Li
DOI: 10.20047/j.issn1673-7210.2023.23.38
Objective To explore the effects of transitional nursing from neonatal intensive care unit to home in preterm infants. Methods A total of 98 premature infants admitted to Huaibei Maternal and Child Health Hospital in Anhui Province from January 2021 to January 2022 were selected as the study objects. They were divided into control group and observation group according to random number table method, with 49 cases in each group. The control group received routine nursing, and the observation group received transitional nursing from neonatal intensive care unit to home. The breastfeeding rate, growth, and development of preterm infants and their main caregivers’ mood and parenting skills were compared between the two groups. Results The breastfeeding rates of the observation group at discharge and 1, 3, and 6 months after discharge were higher than those of the control group (P＜0.05); the overall analysis found that the body length and head circumference differences between groups, time point comparison and interaction were statistically significant (P＜0.05); further pairwise comparison showed that there were statistically significant differences in weight, body length and head circumference between the two groups at each time point (P＜0.05); the weight, body length and head circumference of the observation group were higher than that of the control group at three and six months after discharge (P＜0.05), the length of stay, the incidence of nosocomial infection and the rate of re-hospitalization in the observation group were lower than those in the control group (P＜0.05). At discharge, the score of parenting ability of the main caregivers in both groups were higher than when admitted, and the observation group was higher than that in the control group (P＜0.05). The self-rating anxiety scale score of the two groups was lower than that of the first day of admission, and the observation group was lower than that of the control group (P＜0.05). Conclusion Transitional nursing from neonatal intensive care unit to home can increase breastfeeding rates, promote growth, and development of preterm infants, improve the parenting skills of their primary caregivers, reduce anxiety, reduce the number of days in hospital for preterm infants without increasing the risk of hospital-acquired infections.
2023 Vol. 20 (23): 173-176 [
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Application of nursing model guided by the theory of self transcendence in patients with abdominal wall ostomy after bladder cancer surgery
WANG Yadan SONG Silin▲
DOI: 10.20047/j.issn1673-7210.2023.23.39
Objective To observe the application effect of the nursing model guided by the theory of self transcendence in patients with abdominal wall ostomy after bladder cancer surgery. Methods A total of 100 patients who underwent urinary flow diversion abdominal wall ostomy for bladder cancer in Nanjing First Hospital from July 2020 to July 2022 were selected as the study objects, according to the method of random number table, they were divided into the control group and the observation group, with 50 cases in each group. The control group was treated with routine nursing intervention, and the observation group was treated with nursing intervention guided by self transcendence theory on the basis of the control group, with a total of four weeks of intervention. The self transcendence level of patients in the two groups was compared before nursing, two and four weeks of nursing (evaluated by self transcendence scale [STS]), the self-care ability of patients in the two groups was compared before nursing and four weeks of nursing (evaluated by self care ability implementation scale [ESCA]). The periostomy infection and related complications were compared between the two groups within four weeks of nursing. Results The overall analysis showed that there were significant differences between groups, time points and time points of STS evaluation between two groups (P＜0.05). There were significant differences in STS scores between the two groups at each time point (P＜0.05). The observation group was higher than the control group after two and four weeks of nursing (P＜0.05). After four weeks of nursing, the total scores of self-care skills, self-concept, self-care responsibility, health knowledge, and ESCA of patients in the two groups were higher than those before nursing, and the observation group was higher than the control group (P＜0.05). Incidence of peristomal infection and stoma-related complications in observation group was lower than that in control group (P＜0.05). Conclusion The nursing model guided by the theory of self transcendence can effectively improve the self transcendence level of patients with abdominal wall ostomy after bladder cancer surgery, enhance the patients’ ability of self-care, and reduce the incidence of infection around stoma and stoma related complications after surgery.
2023 Vol. 20 (23): 177-181 [
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Application of strengthening family support in nursing for the first delivery of advanced maternal age
XIE Ye CHEN Jia ZHAO Ling▲
DOI: 10.20047/j.issn1673-7210.2023.23.40
Objective To analyze the application of strengthening family support in nursing for the first delivery of advanced maternal age. Methods A total of 120 elderly parturients admitted to Nantong Maternal and Child Health Hospital in Jiangsu Province from January 2019 to January 2022 were selected, and they were divided into control group and experimental group, with 60 cases in each group. The control group received basic nursing countermeasures, and the experimental group received family support on this basis. The mental and psychological state of the elderly parturients during their first delivery were analyzed, and the mental resilience, adverse mood and adverse pregnancy vibration outcome before and after one month of nursing between the two groups were compared. Results According to the different mental state of the first delivery, the proportion of worry about the health of the fetus was the highest, accounting for 95.00%; the complication of cesarean section was the second concern, accounting for 85.00%; the fear of obstructed labor accounted for the lowest proportion, accounting for 41.67%. The scores of self-rating anxiety scale and self-rating depression scale in the two groups were lower than those before nursing, and those of the experimental group were lower than those of the control group, the differences were statistically significant (P＜0.05). The scores of tenacity, optimism, and self-reliance in the two groups were higher than that those before nursing, and those of the experimental group were higher than those of the control group, the differences were statistically significant (P＜0.05). The total incidence of adverse pregnancy outcome in experimental group was lower than that in control group, and the difference was statistically significant (P＜0.05). Conclusion Strengthening family support can improve mental resilience, reduce social function defects, and improve negative emotions in the nursing of the first delivery of the elderly parahernalia, which is worth promoting.
2023 Vol. 20 (23): 182-185 [
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Thoughts on the construction and practice of assessment system of medical imaging specialty practical and innovation ability
SUN Zhenting ZHAO Lei
DOI: 10.20047/j.issn1673-7210.2023.23.41
Medical imaging is a discipline with strong practicality, the progress of science and technology has led to rapid changes in medical imaging, technical innovation and practical innovation are the driving force to promote the development of the disciplines. Taking the Teaching and Research Section of Imaging Medicine and Nuclear Medicine of the First Clinical Medical College of Inner Mongolia Medical University as an example, this article has formulated a corresponding teaching system and evaluation system for the cultivation of innovative talents in imaging medicine, provided effective methods for improving the practical and innovation ability of medical imaging undergraduate students. This article summarizes and discusses the thinking and practice of the teaching and research department in cultivating applied and innovative talents in imaging medicine in recent years.
2023 Vol. 20 (23): 186-189 [
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Exploration on training mode of medical laboratory technology professionals in in vitro diagnosis industry
LI Dan1 XU Ying1 YANG Yuhan2 GUO Lijuan1 ZHANG Hong1
DOI: 10.20047/j.issn1673-7210.2023.23.42
The in vitro diagnostic is an emerging industry in China, which is the strong support in promoting the construction of a healthy China and realizing Chinese path to modernization of “precision medicine”. In post-epidemic era, cultivating high-quality talents has become extremely urgent because of the challenges suffered with in vitro diagnostic industry, such as, upstream raw material production monopolized by international enterprises, insufficient talent for technological innovation in enterprises and so on. However, talent training of medical laboratory technology based on in vitro diagnostic is suffering urgent problems to be solved, for example, single training mode, insufficient innovation ability, and insufficient integration of schools and enterprises. Therefore, by revising the training program, constructing the curriculum system, building the teaching staff and setting up the guarantee system, Chengdu Medical College explores the construction of in vitro diagnosis industry model of integrating production and education, and cultivate high-quality talents of medical laboratory technology with professional practice ability, scientific research thinking ability and post competency.
2023 Vol. 20 (23): 190-193 [
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Key points analysis of improving the prevention and control system of major infectious diseases
DENG Kai1 GUO Yongchao1▲ YU Jianping2 SUN Xingui2 YAN Yue3
DOI: 10.20047/j.issn1673-7210.2023.23.43
Public health emergencies spread quickly, affect widely, and are difficult to prevent and control. Beijing has taken the prevention and control of major infectious diseases as an opportunity to improve the management system of major infectious diseases. Under the full implementation of the relevant requirements of the Party and the government, a system for the prevention and control of major infectious diseases has been initially established, based on institutional construction, focused on connotation construction and improvement projects. This study analyze the seven core constructions of the management system, put forward relevant suggestions according to the weakness, so as to provide reference for improving the system of prevention and control of major infectious diseases.
2023 Vol. 20 (23): 194-封三 [
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