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Changes and clinical significance of cervical vascular ultrasound and serum homocysteine and cystatin C levels in patients with ischemic stroke |
WANG Zhiping1 CHEN Piaofei1 JIANG Shanshan1 HU Yuanjun1 WU Shenghao2 DAI Qian1▲ |
1.Department of Ultrasound, Huangshan People’s Hospital, Anhui Province, Huangshan 245000, China;
2.Department of Neurology, Huangshan People’s Hospital, Anhui Province, Huangshan 245000, China
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Abstract Objective To explore the changes and clinical significance of cervical vascular ultrasound (CVUS) and homocysteine (Hcy) and cystatin C (CysC) levels in patients with ischemic stroke (IS). Methods Clinical data of 79 patients with IS admitted to Huangshan People’s Hospital in Anhui Province from February 2020 to September 2022 were collected. According to the modified Rankin scale (mRS), the patients were divided into good prognosis group (mRS≤2 points) and poor prognosis group (mRS>2 points) after 7 to 10 days of treatment. The clinical data, CVUS results and serum Hcy and CysC levels of the two groups were compared. Logistic regression was used to analyze the factors affecting the prognosis of patients with IS, and receiver operating characteristic curve was used to analyze the predictive value of CVUS and serum Hcy and CysC levels for the prognosis of patients with IS. Results The levels of National Institute of Health stroke scale (NIHSS) score, Hcy, CysC, and intima-media thickness (IMT) in poor prognosis group were higher than those in good prognosis group, and the proportion of severe carotid stenosis (CS) in poor prognosis group was higher than that in good prognosis group (P<0.05). Logistic regression analysis showed that NIHSS score, Hcy, CysC, IMT levels, and CS degree were independent risk factors for poor prognosis of IS patients (OR>1,P<0.05). Receiver operating characteristic curve analysis showed that the area under the curve of Hcy, CysC and IMT to predict the prognosis of IS patients were 0.832, 0.771, 0.652, respectively, and the combined prediction area under the curve was 0.904. Conclusion The levels of IMT, CS and serum Hcy and CysC have certain predictive value for the prognosis of patients with IS, and the combined prognostic value is higher.
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