脂肪蓄积指数与动脉粥样硬化性心血管疾病风险水平的相关性研究

doi:10.20047/j.issn1673-7210.2023.23.16

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Abstract Objective To investigate the correlation between lipid accumulation product (LAP) and the risk levels of atherosclerotic cardiovascular disease (ASCVD). Methods A total of 2 266 workers of Dongfeng Motor Co., Ltd. who underwent physical examination in Dongfeng General Hospital Affiliated to Hubei University of Medicine from June 2021 to April 2022 were selected and divided into low risk group (1 334 workers), medium risk group (434 workers), and high risk group (498 workers) according to the risk level of ASCVD within ten years. Clinical data, laboratory biochemical indicators, and the differences of LAP among the three groups were collected and compared, and the correlation between LAP and other clinical indicators was analyzed, and the correlation between LAP and the risk levels of ASCVD within ten years was further analyzed. Results The distribution of gender, smoking, drinking, hypertension, metabolic syndrome and levels of age, systolic blood pressure, diastolic blood pressure, total cholesterol, high density lipoprotein-cholesterol, low density lipoprotein-cholesterol, body mass index, hip circumference, creatinine, fasting blood glucose, LAP, and white blood cell count among the three groups were compared, and the differences were statistically significant(P＜0.05). LAP was positively correlated with gender, age, systolic blood pressure, diastolic blood pressure, smoking, drinking, total cholesterol, low density lipoprotein-cholesterol, hypertension, body mass index, hip circumference, creatinine, fasting blood glucose, and white blood cells (rs＞0, P＜0.05), and negatively correlated with high density lipoprotein-cholesterol (rs＜0, P＜0.05). The results of multifactor analysis showed that LAP was an independent factor influencing the risk level of ASCVD within ten years after adjusting for confounding factors (P＜0.05). Linear trend test showed that LAP classification (L1: ≤14.88; L2:＞14.88-26.58; L3:＞26.58-44.90; L4: ＞44.90) had a linear relationship with risk level of ASCVD (P＜0.05), and a positive correlation (r＞0, P＜0.05). Conclusion LAP is an independent risk factor for the risk levels of ASCVD within ten years and has a linear relationship with it, so clinical attention should be paid to it.

Key words： Atherosclerotic cardiovascular disease Lipid accumulation product Multiple logistic regression model Linear trend test

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	LIU Tongtong1 QIAN Hang2 LI Yunpeng2 WU Wenwen3 MIN Xinwen2 YANG Handong2 CHEN Jun2 LI Dongfeng2

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LIU Tongtong1 QIAN Hang2 LI Yunpeng2 WU Wenwen3 MIN Xinwen2 YANG Handong2 CHEN Jun2 LI Dongfeng2. Study on the correlation between lipid accumulation product and risk levels of atherosclerotic cardiovascular disease[J]. 中国医药导报, 2023, 20(23): 77-80.

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https://www.yiyaodaobao.com.cn/EN/10.20047/j.issn1673-7210.2023.23.16 OR https://www.yiyaodaobao.com.cn/EN/Y2023/V20/I23/77

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