氧化应激在放射性肺纤维化中的作用及中药防治研究进展

doi:10.20047/j.issn1673-7210.2023.23.07

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Abstract Radiation-induced lung fibrosis (RILF) is the major clinical complication of radiotherapy for thoracic tumor, seriously endangering the lives of patients. A large amount of evidence shows that the oxidative stress induced by ionizing radiation is closely related to the occurrence and development of RILF. Reactive oxygen species (ROS), the initial product of oxidative stress, runs throughout the pathogenesis of RILF, and has a direct promoting effect on RILF. This paper summarizes the important role of ROS in the pathological progression of RILF, including DNA damage, inflammation, autophagy, epithelio-mesymal transformation, and extracellular matrix deposition, and summarizes the research progress of traditional Chinese medicine and its active ingredients in the treatment of RILF through antioxidant mechanisms, aiming to provide ideas and theoretical support for the prevention, and treatment of RILF by traditional Chinese medicine.

Key words： Radiation-induced lung fibrosis Oxidative stress Reactive oxygen species Traditional Chinese medicine Cytokine Signaling pathway

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	LI Zhanhong1 XU Xike2 CHEN Wei2 XIN Jiayun3 WANG Jinxin2 TIAN Saisai2 ZU Xianpeng2 WANG Shumei1

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LI Zhanhong1 XU Xike2 CHEN Wei2 XIN Jiayun3 WANG Jinxin2 TIAN Saisai2 ZU Xianpeng2 WANG Shumei1. Research progress of the role of oxidative stress in radiation-induced lung fibrosis and the prevention and treatment with traditional Chinese medicine[J]. 中国医药导报, 2023, 20(23): 38-42.

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https://www.yiyaodaobao.com.cn/EN/10.20047/j.issn1673-7210.2023.23.07 OR https://www.yiyaodaobao.com.cn/EN/Y2023/V20/I23/38

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