Effect of Levosimendan combined with continuous static infusion of Fur- osemide on serum levels of soluble suppression of tumorigenicity-2, neuron- specific enolase in patients with acute decompensated heart failure
LI Yaping LI Haiyang ZHENG Gaomei
Department of Cardiology, Fuyang People’s Hospital, Anhui Province, Fuyang 236000, China
Abstract Objective To investigate the effects of Levosimendan combined with continuous static infusion Furosemide on serum levels of soluble suppression of tumorigehicity 2 (sST-2) and neuron-specific enolase (NSE) in patients with acute decompensated heart failure (ADHF). Methods A total of 140 ADHF patients diagnosed and treated in Fuyang People’s Hospital of Anhui Province from January 2019 to October 2020 were selected and they were divided into Furosemide group (continuous static infusion Furosemide) and combination group (continuous static infusion Furosemide + Levosimendan) according to random number table method, with 70 cases in each group. Both groups were given conventional treatment and were treated for one week. The heart rate, left ventricular fractional shortening rate (LVFS), left ventricular ejection fraction (LVEF), sST-2, NSE, amino terminal brain natriuretic peptide precursor (NT-proBNP), right atrial pressure (RAP), pulmonary capillary wedge pressure (PCWP), and mean pulmonary artery pressure (PAMP) were compared between the two groups before and after treatment. The incidence of adverse reaction was compared between the two groups. Results After treatment, the heart rate, sST-2, NSE, NT-proBNP, RAP, PCWP, and PAMP in both groups were lower than before treatment, LVFS and LVEF levels were higher than before treatment and the heart rate, sST-2, NSE, NT-proBNP, RAP, PCWP, and PAMP in combination group were lower than those in Furosemide group, LVFS and LVEF levels were higher than those in Furosemide group (P＜0.05). There was no significant difference in the total incidence of adverse reactions between the two groups (P＞0.05). Conclusion Levosimendan combined with continuous static infusion Furosemide has significant therapeutic effect on ADHF patients, reducing the levels of sST-2 and NSE, improving hemodynamics and cardiac function of patients, which is worthy of clinical promotion.
LI Yaping LI Haiyang ZHENG Gaomei. Effect of Levosimendan combined with continuous static infusion of Fur- osemide on serum levels of soluble suppression of tumorigenicity-2, neuron- specific enolase in patients with acute decompensated heart failure[J]. 中国医药导报, 2023, 20(23): 81-84.
