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2023 Vol. 20, No. 8 Published: 2023-03-15

	7	Effects of saturated fatty acid and unsaturated fatty acid on the glucose metabolism of human lung adenocarcinoma A549 cells
		LI Huimin1 LI Ning2 WU Jun3 CHEN Xi2 HE Zhan4 ZHANG Haitao2
		DOI: 10.20047/j.issn1673-7210.2023.08.01
		Objective To analyze the effects of saturated fatty acid and unsaturated fatty acid on the glucose metabolism of lung adenocarcinoma A549 cells. Methods The liquid chromatography mass spectrometry (LC-MS/MS) assay was conducted by setting up the blank control group (cells were not treated), absolute ethanol solvent control group (the same volume of absolute ethanol as the drug in the drug treatment group was added into the cell culture medium), 120 μmol/L saturated fatty acid stearic acid group, 120 μmol/L unsaturated fatty acid docosahexaenoic acid (DHA) group, after A549 cells were treated for 24 hours respectively, and the relative content of acetyl-CoA in each group was detected; the Western blot assay was conducted by setting up the blank control group (cells were not treated), absolute ethanol solvent control group (the same volume of absolute ethanol as the drug in the drug treatment group was added into the cell culture medium), 120 μmol/L stearic acid group (A549 cells treated with 120 μmol/L stearic acid for 12, 24, 36 h respectively), 120 μmol/L DHA group (A549 cells treated with 120 μmol/L DHA for12, 24, 36 h respectively), the expression of glucose metabolism related proteins pyruvate kinase M2(PKM2), hexokinase 2(HK2), lactate dehydrogenase(LDH), pyruvate kinase M1 and pyruvate kinase M2 (PKM1/2) in A549 cells were detected. Results In LC-MS/MS assay, compared with the absolute ethanol solvent control group, the relative content of acetyl-CoA was reduced after A549 cells treated with 120 μmol/L stearic acid and DHA respectively, and the differences were statistically significant (P＜0.05). In Western blot assay, compared with the absolute ethanol solvent control group, the expression of PKM2, HK2, LDH, and PKM1/2 were reduced after A549 cells treated with 120 μmol/L stearic acid and DHA respectively for 12, 24, 36 h, and the differences were statistically significant (P＜0.05). Conclusion Saturated fatty acid and unsaturated fatty acid can inhibit the glucose metabolism of A549 cells.
		2023 Vol. 20 (8): 7-11,33 [Abstract] ( 21 ) HTML (1 KB) PDF (2390 KB) ( 35 )

	12	Changes of clock genes in the brain of vascular dementia rats in different time courses and the regulatory effect of cornel iridoid glycoside
		ZHENG Cengceng ZHANG Li LI Yali LI Lin ZHANG Lan YANG Cuicui
		DOI: 10.20047/j.issn1673-7210.2023.08.02
		Objective To observe the changes of clock genes in the brain of vascular dementia rats in different time courses and the regulatory effect of cornel iridoid glycoside (CIG)． Methods A total of 45 SPF male SD rats, 6-8 weeks old, weighing 150-180 g were selected, and 15 rats were selected as Sham operation group, the rest were established by 2-vessel occlusion (2VO) to establish the chronic cerebral ischemia model. After successful modeling, the Sham operation animals were divided into three groups, and the model animals were divided into six groups by random number table method, with five animals in each group. The specific groups were modeling 1 month group (Sham group, 2VO group, 2VO+CIG60 group, 2VO+CIG120 group, 2VO+ Butylphthalide group); modeling 1.5 months group (Sham group, 2VO group); modeling 3 months group (Sham group, 2VO group). After six hours of modeling, CIG 60 mg/(kg·d) was gavaged in 2VO+CIG60 group, CIG 120 mg/(kg·d) was gavaged in 2VO+CIG120 group, Butylphthalide 100 mg/(kg·d) was gavaged in 2VO+Butylphthalide group, and Sham group and 2VO group were gavage with the same amount of normal saline. At 1, 1.5, and 3 months after modeling, the hypothalamus and midbrain of rats were taken to detect the levels of clock genes CRY1, PER1, PER2, and NPAS2 mRNA, the changes of clock genes were observed. Results In hypothalamus, compared with Sham group, PER2 mRNA in 2VO group was decreased at 1 month after modeling (P＜0.01); clock gene PER2 mRNA and NPAS2 mRNA in 2VO group were increased at 1.5 months after modeling (P＜0.05 or P＜0.01). In midbrain, compared with Sham group, CRY1 mRNA and PER1 mRNA in 2VO group were higher at 1 month after modeling (P＜0.05 or P＜0.01); PER2 mRNA in 2VO group was increased at 3 months of modeling (P＜0.05). In hypothalamus, compared with Sham group, PER2 mRNA in 2VO group was decreased (P＜0.01); compared with 2VO group, NPAS2 mRNA in 2VO+CIG60 group was increased, PER1 mRNA in 2VO+CIG120 group was decreased (P＜0.05). In midbrain, compared with Sham group, CRY1 mRNA and PER1 mRNA in 2VO group were increased (P＜0.05 or P＜0.01); compared with 2VO group, CRY1 mRNA in 2VO+CIG120 group was decreased (P＜0.01). Conclusion Disordered expression of clock genes in the hypothalamus and midbrain of vascular dementia model rats causes disruption of the feedback loop that regulates circadian rhythm, and CIG can correct the disordered expression of clock genes in the hypothalamus and midbrain.
		2023 Vol. 20 (8): 12-16 [Abstract] ( 13 ) HTML (1 KB) PDF (1204 KB) ( 135 )

	17	Research hotspots and prevention points of immunosenescence based on bibliometric analysis
		WU Yuqing CAI Tiantian ZHAO Jing XU Jianbin ZHANG Jingan
		DOI: 10.20047/j.issn1673-7210.2023.08.03
		Objective To analyze the research status and hotspots of immunosenescence, and to summarize its prevention and treatment. Methods Literatures related to immunosenescence from January 2012 to March 2022 in the Web of Science database were retrieved, CiteSpace and Vosviewer software were used for visual analysis from multiple perspectives. Results A total of 2 454 literatures were included, and the annual pubulication volume showed an overall upward trend, a cooperative network map was formed among the authors, and there was a cooperative relationship between different countries. The literatures with the highest citation volume were related to inflammatory aging. Age, T cells, inflammation were included as keywords with high frequency, and immune checkpoint inhibitors was the largest cluster of keywords. Hot words were gut microbiota, inflammasome, nivolumab, etc. Conclusion The popularity of immunosenescence is increasing year by year. Hotspots focuses on the mechanism, influencing factors, as well as prevention and treatment. The key points of control include vaccination, inflammation amelioration and so on.
		2023 Vol. 20 (8): 17-22 [Abstract] ( 21 ) HTML (1 KB) PDF (3821 KB) ( 44 )

	23	CiteSpace-based knowledge graph visualization of breast cancer combined with anxiety and depression
		MEI Heting1 LU Wenping1 ZHANG Zehan2 CUI Yongjia1 WU Xiaoqing1
		DOI: 10.20047/j.issn1673-7210.2023.08.04
		Objective To visualize and analyze the literature related to breast cancer combined with anxiety and depression by CiteSpace software, to explore the development history and research hotspots in this field for more than 30 years, and to provide reference for future research directions. Methods The relevant literature collected on China National Knowledge Internel from January 1989 to May 2022 was searched, the search results were screened and data cleaned according to the inclusion and exclusion criteria, and the final valid literature was analyzed using CiteSpace 6.1.R2 for author and institutional collaboration networks and keyword co-occurrence, clustering, timeline graphs, and emergent terms to draw a knowledge graph. Results A total of 3 568 papers were included, involving 3 234 authors and 2 912 institutions. Overall, the number of annual publications had been steadily increasing; the collaborative network of authors represented by Wang Jing, Li Na and Wang Bei was large, and no core team had been formed in China; the research institutions were concentrated in traditional Chinese medicine universities and their affiliated hospitals, and the inter-institutional collaboration was relatively scattered. High-frequency keywords include quality of life, psychological interventions, etc. The number of traditional Chinese medicine studies was still small. The keywords formed 14 clusters regarding study indicators, interventions, causes, and concomitant symptoms. A total of 16 emergent words, psychological research began earlier, and quality of life, social support, and sleep quality were currently emerging research hotspots. Conclusion Research in the field of breast cancer combined with anxiety and depression is heating up, cooperation among different teams and institutions needs to be strengthened, and Chinese medicine treatment needs to be further explored.
		2023 Vol. 20 (8): 23-27 [Abstract] ( 19 ) HTML (1 KB) PDF (3702 KB) ( 98 )

	28	Study of effect in Fructus Corni extract on radiation damage of hematopoietic system in mice
		LI Wenxuan1 WANG Yue2 WANG Xinyue1 HUO Qidong1 DONG Yinping1 TANG Sheng’an2 DONG Hui1 LI Deguan1
		DOI: 10.20047/j.issn1673-7210.2023.08.05
		Objective To study the protective effect of Fructus Corni extract on hematopoietic system damage induced by radiation in mice. Methods Sixteen male SPF level C57BL/6J mice aged 6 to 8 weeks, weighing 20 to 22 g, were selected. One of them was randomly selected to isolate the femur and culture its bone marrow cells in vitro. Cell control group, cell irradiation group, 0.001 mg/ml Fructus Corni group, 0.01 mg/ml Fructus Corni group were set. The cell control group was cultured normally, the cell irradiation group was irradiated (1 Gy), the 0.001 mg/ml Fructus Corni group and 0.01 mg/ml Fructus Corni group were irradiated with corresponding concentrations of Fructus Corni extract for 30 min, and the cell vitality of the four groups was observed 18 h later, and the concentration of Fructus Corni extract was selected according to the cell vitality. The apoptotic degree and reactive oxygen species levels in cell control group, cell irradiation group, and 0.001 mg/ml Fructus Corni group were compared. The remaining 15 mice were divided into control group, irradiation group, and Fructus Corni group with five mice in each group by randomized block method. The irradiation group and Fructus Corni group were given 2 Gy total body irradiation, the Fructus Corni group was given 0.2 ml (400 mg/kg) DMSO solution of Fructus Corni extract 1 h before irradiation, and the control group and the irradiation group were given the same amount of normal saline containing 8%DMSO. After seven days of administration, routine blood and the number of bone mononuclear nucleated cell (BMNC), hematopoietic progenitor cell (HPC), hematopoietic stem cell (HSC), reactive oxygen species, and DNA (γH2AX) damage were detected in peripheral blood of the three groups. Results The cell vitality in the cell irradiation group was lower than that in the cell control group, and the proportion of apoptotic cells and the level of reactive oxygen species were higher than those in the cell control group (P＜0.05). There was no significant difference in cell viability between 0.01 mg/ml Fructus Corni group and cell irradiation group (P＞0.05). The cell vitality of 0.001 mg/ml Fructus Corni group was higher than that of cell irradiation group, and the percentage of apoptotic cells and reactive oxygen species level were lower than those of cell irradiation group (P＜0.05). The levels of white blood cell, red blood cell, platelet, HPC, and HSC in irradiation group were lower than those in control group (P＜0.05). There were no significant differences in BMNC level among the three groups (P＞0.05). The levels of red blood cell and HPC in Fructus Corni group were higher than those in irradiation group (P＜0.05), but there were no significant differences in the levels of white blood cell, platelet, and HSC between the two groups (P＞0.05). There were no significant differences in reactive oxygen species in BMNC, HPC, and HSC of three groups, and γH2AX level in BMNC of three groups (P＞0.05). γH2AX levels in HPC and HSC of irradiation group were higher than those in control group, and γH2AX levels in HPC and HSC of Fructus Corni group were lower than those in irradiation group (P＜0.05). Conclusion Fructus Corni extract can prevent radiation damage of hematopoietic system.
		2023 Vol. 20 (8): 28-33 [Abstract] ( 15 ) HTML (1 KB) PDF (1734 KB) ( 98 )

	34	Effect of Dapagliflozin on kidney injury in diabetic nephropathy mice through Caspase-1 mediated pyroptosis
		WANG Ying1 YIN Doudou1 CHAO Nan2
		DOI: 10.20047/j.issn1673-7210.2023.08.06
		Objective To investigate the effect of Dapagliflozin (DAP) on kidney injury in diabetic nephropathy (DN) mice based on the pyrocytosis mediated by cysteine aspartic acid specific protease-1(Caspase-1) pathway. Methods Thirty SPF grade C57BL/6 male mice, aged eight weeks and weighing 17-25 g, were divided into control group, model group, and DAP group with ten mice in each group according to random number table method. DN model was established in model group and DAP group, and ordinary diet was given to control group. DAP group was given 1 mg/ (kg·d) DAP by intragastric administration, while control group and model group were given the same amount of normal saline by intragastric administration for consecutive four weeks. After drug intervention, the general conditions, serum creatinine, 24 h urinary protein, and serum interleuking-18 (IL-18) levels of each group were compared. Pathological changes of kidney were observed. The expression of Caspase-1 pathway related proteins in mouse kidney was compared. Results Compared with the control group, the model group was listless, less active, occasionally shivering, urine volume was increased significantly, and thinner. Compared with model group, DAP group showed polydipsia and hyperbiosis, and the urine volume was not obvious increased and the activity was normal. Compared with control group, 24 h urinary protein, serum creatinine, serum IL-18 levels and NLR family pyrin domain containing 3 (NLRP3), Caspase-1, GSDMD, and IL-18 protein levels in model group were significantly increased (P＜0.05). Compared with model group, 24 h urinary protein, serum creatinine and serum IL-18 levels, NLRP3, Caspase-1, GSDMD, and IL-18 protein levels in DAP group were significantly decreased (P＜0.05). Conclusion DAP may protect kidney by inhibiting NLRP3/Caspase-1 signaling pathway to activate and inhibit pyrodeath.
		2023 Vol. 20 (8): 34-37 [Abstract] ( 19 ) HTML (1 KB) PDF (862 KB) ( 44 )

	38	Research progress on brain functional alterations in patients with irritable bowel syndrome treated by acupuncture-moxibustion based on functional magnetic resonance imaging
		ZHAO Jun1 LI Xia1 TIAN Junjian1 WANG Xin2 WANG Xuefei2 LI Zhigang1
		DOI: 10.20047/j.issn1673-7210.2023.08.07
		Irritable bowel syndrome (IBS) is a chronic functional gastrointestinal disease. It is not life-threatening, but affects the quality of life and increases the risk of psychiatric disorders such as depression. Therefore, it is necessary to explore the brain central pathogenesis of IBS. Functional magnetic resonance imaging is a very effective and non-invasive in vivo observation technique for studying brain function, which provides a new perspective for evaluating the abnormality of “brain-gut axis” in IBS. Although the efficacy of acupuncture-moxibustion on IBS are positive, their brain central mechanisms are still unclear. This article reviews relevant domestic and foreign literature of acupuncture-moxibustion in recent years, and summarizes the application of functional magnetic resonance imaging technology in IBS.
		2023 Vol. 20 (8): 38-41 [Abstract] ( 16 ) HTML (1 KB) PDF (557 KB) ( 79 )

	42	Research progress of low-intensity pulsed ultrasound regulation of mesenchymal stem cells in the field of tissue regeneration
		LIU Yulin1 ZHANG Gengchao1 LIAO Chengcheng2 XIANG Mingli2 LIU Jianguo3 BAI Ding4 GUAN Xiaoyan2
		DOI: 10.20047/j.issn1673-7210.2023.08.08
		Low-intensity pulsed ultrasound (LIPUS) is an economical and safe physical therapy, and usually used to treat bone discontinuities and tissue healing. Mesenchymal stem cells (MSCs) are important seed cells in regenerative medicine with high self-renewal and multi-directional differentiation ability. The combined application of LIPUS and MSCs can regulate the proliferation, migration, cell activity, multi-directional differentiation and other abilities of MSCs, effectively promote the regeneration of MSCs in bone, cartilage, blood vessels, nerves, and other tissues, and inhibit the regeneration of adipose tissue. Therefore, this article reviews the mechanism of LIPUS regulating the repair and regeneration of MSCs in different tissues in recent years, provides theoretical basis for the continuous research and clinical transformation of LIPUS in the field of tissue regeneration.
		2023 Vol. 20 (8): 42-45 [Abstract] ( 12 ) HTML (1 KB) PDF (478 KB) ( 163 )

	46	Research progress on anti-inflammatory mechanism of blood-activating and stasis-resolving traditional Chinese medicine
		CHENG Fang1 HU Kunmin1 ZHU Shan2
		DOI: 10.20047/j.issn1673-7210.2023.08.09
		Blood-activating and stasis-resolving traditional Chinese medicines are mainly used for blood stasis syndrome of the pain of internal medicine, amenorrhoea, dysmenorrhea, traumatic injury, sore and ulcer, swelling, and so on. Inflammation is the natural response of the body to various injury stimuli. Blood-activating and stasis-resolving traditional Chinese medicine has certain advantages in inhibiting inflammatory reaction. This paper analyzes the anti-inflammatory mechanism of nine traditional Chinese medicines including Corydalis Rhizoma, Chuanxiong Rhizoma, Salviae Miltiorrhizae Radix Et Rhizoma, Curcumae Radix, Olibanum, Leonuri Herba, Achyranthis Bidentatae Radix, Strychni Semen, and Hirudo by searching the literature. It is found that blood-activating and stasis-resolving traditional Chinese medicine mainly plays an anti-inflammatory role by three signal pathways of nuclear factor- κB, mitogen-activated protein kinase, nuclear transcription factor E2 related factor 2-antioxidant response element. It also provides research direction for the existing problems in this research field, and provides reliable theoretical basis for further exploring the anti-inflammatory component target and clinical application of blood-activating and stasis-resolving traditional Chinese medicines.
		2023 Vol. 20 (8): 46-49,65 [Abstract] ( 42 ) HTML (1 KB) PDF (645 KB) ( 91 )

	50	Research progress of obstructive sleep apnea hypopnea syndrome and metabolic diseases
		WU Yiwei ZHANG Kecheng SUN Yunwei WU You CHEN Yan
		DOI: 10.20047/j.issn1673-7210.2023.08.10
		There is bidirectional association between obstructive sleep apnea hypopnea syndrome (OSAHS) and metabolic diseases such as obesity, type 2 diabetes mellitus, and nonalcoholic fatty liver. In recent years, the incidence rate of OSAHS continues to rise, causing serious harm to both physical and mental health of patients. However, in previous studies, the mechanism of action related to OSAHS and metabolic diseases is not clear enough, and the treatment methods of OSAHS combined with metabolic diseases are also relatively limited. In recent years, OSAHS and metabolic diseases become research hotspots. Significant progress is made in the study of their common pathogenesis, and weight loss treatment is also gain attention. Therefore, this paper reviews the latest advances in the relationship between OSAHS and metabolic diseases and their intervention, from the aspects of incidence rate, common mechanism, treatment and so on, aiming at helping the progress of clinical treatment of metabolic diseases in OSAHS.
		2023 Vol. 20 (8): 50-53 [Abstract] ( 17 ) HTML (1 KB) PDF (534 KB) ( 125 )

	54	Research progress of proprotein convertase subtilin Kexin-9 inhibitor in lipid-lowering therapy
		PAN Haiqiang1 CHEN Xiaojia2 LI Caihong2 ZHANG Zhizhen2
		DOI: 10.20047/j.issn1673-7210.2023.08.11
		Proprotein convertase subtilisin Kexin type 9 (PCSK9) has become an essential target for regulating low-density lipoprotein cholesterol (LDL-C) level. PCSK9 inhibitors significantly reduces plasma LDL-C level, Statins also reduces LDL-C level but raises PCSK9 level. A quantity of clinical trials has verified the efficacy and safety of Statins in combination with PCSK9 inhibitors. Although different types of PCSK9 inhibitor act in varying ways, their effects are the same in different patients, and the ongoing clinical trials will further demonstrate their safety and role in reducing cardiovascular risk.
		2023 Vol. 20 (8): 54-57 [Abstract] ( 10 ) HTML (1 KB) PDF (475 KB) ( 81 )

	58	Research progress of human epidermal growth factor receptor in metastatic colorectal cancer
		REN Yanzhen LI Ruixian
		DOI: 10.20047/j.issn1673-7210.2023.08.12
		The incidence of human epidermal growth factor receptor 2 (HER2) variants is low in patients with metastatic colon cancer (mCRC), and there is no uniform standard for detection methods. HER2 mutations can lead to resistance to anti-epidermal growth factor receptor-targeted therapy in mCRC. Single anti-HER2-targeted therapy has limited effect, however, dual anti-HER2-targeted therapy such as Trastuzumab combined with Lapatinib or Pertuzumab has shown good anti-tumor efficacy in mCRC. This article aims to review the detection, clinicopathological features, predictive value, and treatment strategies, and prospects of HER2 in mCRC.
		2023 Vol. 20 (8): 58-61 [Abstract] ( 15 ) HTML (1 KB) PDF (408 KB) ( 181 )

	62	Analysis of risk factors for mental fatigue among nursing staff in the operating room
		GUO Yunhui
		DOI: 10.20047/j.issn1673-7210.2023.08.13
		Objective To explore risk factors for mental fatigue among nursing staff in the operating room. Methods One hundred and six nursing staff from January 2018 to January 2021 in Linyi People’s Hospital, Shandong Province, were selected as observation subjects and divided into two groups based on whether mental fatigue occurred, the mental fatigue group (70 cases) and the non-mental fatigue group (36 cases). A multifactorial unconditional logistic stepwise regression analysis of risk factors for psychological fatigue among nursing staff in the operating room was performed to compare individual surveys of nursing staff in the two groups. Results The differences were statistically significant when comparing the social support, exercise habits, number of night shifts, and overtime hours between the two groups of nursing staff (P＜0.05). The logistic regression results showed that social support, exercise habits, number of night shifts, and overtime hours operating room nursing staff mental fatigue influencing factors (OR=18.016, 18.828, 0.036, 0.154, P＜0.05). Conclusion The analysis of risk factors of mental fatigue of nursing staff in the operating room can improve psychological fatigue and provide a reliable theoretical basis.
		2023 Vol. 20 (8): 62-65 [Abstract] ( 19 ) HTML (1 KB) PDF (508 KB) ( 114 )

	66	Association between non-high-density lipoprotein cholesterol levels and the degree of coronary artery lesion in elderly patients with coronary heart disease
		LI Cong GAO Yonghong▲
		DOI: 10.20047/j.issn1673-7210.2023.08.14
		Objective To analysis the association between non-high-density lipoprotein cholesterol (non-HDL-C) levels and the degree of coronary artery lesion in elderly patients with coronary heart disease. Methods A total of 252 elderly patients who underwent coronary angiography and were admitted to Beijing Aerospace General Hospital from July 2020 to July 2021 were selected, fasting venous blood before angiography was collected, four blood lipids were measured, and the non-HDL-C value was further calculated. According to the results of coronary angiography, they were divided into the coronary heart disease group (210 cases) and the non-coronary heart disease group (42 cases), according to the Gensini score, the coronary heart disease group was divided into mild to moderate disease group with 102 cases and severe disease group with 108 cases. Results The levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and non-HDL-C in severe disease group were higher than those in mild to moderate disease group and non-coronary disease group (P＜0.05); while the levels of TC, LDL-C, and non-HDL-C in moderate disease group were higher than those in non-coronary heart disease group (P＜0.05); the high-density lipoprotein cholesterol (HDL-C) in the severe disease group and the mild to moderate disease group was lower than that in non-coronary disease group (P＜0.05). There was no significant difference in TG among the three groups (P＜0.05). The degree of coronary artery lesions was positively correlated with the levels of TC, LDL-C, and non-HDL-C (r=0.669, 0.683, 0.681, P＜0.001); there was a negative correlation with HDL-C level (r=-0.221, P＜0.001), but no correlation with TG level (P＞0.05). Conclusion Non-HDL-C is closely related to the degree of coronary artery disease in elderly patients with coronary heart disease, and the detection is convenient, which can be used as an important indicator for predicting and evaluating the risk of cardiovascular disease.
		2023 Vol. 20 (8): 66-69 [Abstract] ( 19 ) HTML (1 KB) PDF (490 KB) ( 31 )

	70	Study of correlation between disease symptom cluster and the illness uncertainty in stroke patients
		WANG Fang1,2 JIN Man1 FEI Wenling1 LIU Qian3 BU Guomin2 DONG Qiong4 ZHU Xiaoping3
		DOI: 10.20047/j.issn1673-7210.2023.08.15
		Objective To explore the correlation between disease symptom cluster and illness uncertainty in stroke patients. Methods A total of 286 inpatients with stroke treated in the Shanghai Tenth People’s Hospital Affiliated to Tongji University from May to December 2021 were selected as study subjects. General information questionnaire, stroke symptom experience scale, and Chinese version of Mishel were used, questionnaire survey was conducted on the scale of uncertainty in disease, and symptom cluster were extracted by systematic cluster analysis, and the relationship between disease symptom cluster and sense of uncertainty was explored through correlation analysis. Results There were significant differences in disease uncertainty scores among stroke patients with gender, residence, education level, monthly income, smoking history, and transient ischemic attack history (P＜0.05). Systematic cluster analysis showed that stroke patients had three symptom groups: limb deformity and pain (36.71%), psychological and cognitive impairment (41.96%) and physical activity disorder (21.33%); stroke symptom cluster was positively corrected with disease uncertainty (r=0.370, P＜0.05). Conclusion There is a correlation between symptom clusters and the illness uncertain in stroke patients. Nursing staff should pay more attention to the management of symptom clusters to reduce the illness uncertainty.
		2023 Vol. 20 (8): 70-73,78 [Abstract] ( 18 ) HTML (1 KB) PDF (1018 KB) ( 41 )

	74	Meta-analysis of the efficacy and safety of Butylphthalide combined with Urinary Kallindinogenase in the treatment of acute cerebral infarction
		MA Zhongliang1 WANG Fei2 LIU Yang1 LI Zhe2 LIAN Shuai1 XUE Mengzhou1
		DOI: 10.20047/j.issn1673-7210.2023.08.16
		Objective To systematically evaluate the efficacy and safety of Butylphthalide combined with Urinary Kallindinogenase in the treatment of acute cerebral infarction. Methods Randomized controlled trials of Butylphthalide combined with Urinary Kallindinogenase in the treatment of acute cerebral infarction were searched by computer from Cochrane Library, PubMed, Web of Science, Embase, CNKI, Wanfang Data, VIP, and SinoMed database. The retrieval period was from inception to January 2022. Data extraction, quality evaluation, and meta-analysis were performed by RevMan 5.4. Results A total of 11 articles were included, involving 1 088 patients. The results of meta-analysis showed that the total response rate of the combination group was higher than that of the monotherapy group (RR=1.20, 95%CI: 1.14 to 1.27, P＜0.000 01). The National Institutes of Health stroke scale (NIHSS) score of Butylphthalein Soft Capsules combination group was lower than that of monotherapy group (MD=-3.06, 95%CI:-3.73 to -2.39, P＜0.000 01), and the NIHSS score of Butylphthalein Injection combination group was lower than that of monotherapy group (MD=-5.70, 95%CI: -6.32 to -5.08, P＜0.000 01). There was no significant difference in the incidence of adverse reactions between the two groups (RR=1.50, 95%CI: 0.78 to 2.88, P=0.22). Funnel plot of total response rate showed no significant publication bias in the included literatures. Conclusion Butylphthalein combined with Urinary Kallindinogenase in the treatment of acute cerebral infarction is better than that of Urinary Kallindinogenase monotherapy. The two are comparable in terms of security.
		2023 Vol. 20 (8): 74-78 [Abstract] ( 19 ) HTML (1 KB) PDF (4145 KB) ( 71 )

	79	Effect of acupuncture at shéntáng and nǎohù points combined with repeated transcranial magnetic stimulation in the treatment of post-stroke depression
		QIN Na HU Guoqiang
		DOI: 10.20047/j.issn1673-7210.2023.08.17
		Objective To observe the effect of acupuncture at shéntáng and nǎohù points combined with repeated transcranial magnetic stimulation in the treatment of post-stroke depression (PSD). Methods A total of 90 patients with PSD admitted to the Department of Rehabilitation, Shijiazhuang Hospital of Traditional Chinese Medicine from January 2019 to December 2021 were selected and divided into control group 1, control group 2, and observation group by random number table method, with 30 cases in each group. Control group 1 was treated with acupuncture at shéntáng and nǎohù points; control group 2 was treated with repeated transcranial magnetic stimulation; observation group was treated with acupuncture at shéntáng and nǎohù points combined with repeated transcranial magnetic stimulation. Four weeks was a course of treatment, after two courses of treatment, the changes of Hamilton depression scale (HAMD) score, National Institutes of Health stroke scale (NIHSS) score, Barthel index, traditional Chinese medicine syndrome score, and serum levels of 5-hydroxytryptamine, norepinephrine before and after treatment were compared among the three groups. Results After treatment, HAMD, NIHSS score, and traditional Chinese medicine symptom score of three groups were lower than those before treatment, while Barthel index, serum levels of 5-hydroxytryptamine and norepinephrine were higher than those before treatment, the differences were statistically significant (P＜0.05). After treatment, HAMD, NIHSS score, and traditional Chinese medicine symptom score of observation group were lower than those of control group 1 and 2, while Barthel index, serum levels of 5-hydroxytryptamine and norepinephrine were higher than those of control group 1 and 2, the differences were statistically significant (P＜0.05). The curative effect of the observation group was better than those of the control group 1 and 2, and the differences were statistically significant (P＜0.05). Conclusion Acupuncture at shéntáng and nǎohù points combined with repeated transcranial magnetic stimulation has a remarkable effect in the treatment of PSD, which can improve clinical symptoms and promote the recovery of patients.
		2023 Vol. 20 (8): 79-82,98 [Abstract] ( 12 ) HTML (1 KB) PDF (700 KB) ( 59 )

	83	Significance of serum neuron-specific enolase in evaluating severity and short-term prognosis of patients with acute cerebral infarction
		ZHU Jian1 CAI Jian2 YANG Jin1 ZHAO Pei1 ZHU Desheng2
		DOI: 10.20047/j.issn1673-7210.2023.08.18
		Objective To investigate the significance of serum neuron-specific enolase (NSE) in evaluating the severity and short-term prognosis of acute cerebral infarction patients. Methods A total of 126 patients diagnosed with acute cerebral infarction in the Department of Neurology, Baoshan Branch, Renji Hospital, Shanghai Jiao Tong University School of Medicine (hereinafter referred to as “our hospital”) from January 2019 to April 2020 were selected as the acute cerebral infarction group, and 55 physical healthy subjects in our hospital during the same period were selected as the control group. The clinical data of acute cerebral infarction group and control group were compared. The acute cerebral infarction group was classified as mild (46 cases), medium (47 cases), and severe (33 cases) according to the score of the National Institutes of Health stroke scale (NIHSS). Then, according to the degree of neurological impairment at discharge, the patients were divided into significant improvement (41 cases), improvement (40 cases), and no change (45 cases). The difference of serum NSE level in patients with different severity and short-term prognosis was compared, and the correlation between NSE level and the score of NIHSS, the neurological deficit in acute cerebral infarction group was analyzed. The area under the receiver operating characteristic curve (AUC), optimal critical value, sensitivity, and specificity of NSE in determining the severity and short-term prognosis of patients with acute cerebral infarction were evaluated. Results The level of NSE in acute cerebral infarction group was higher than that in control group, and the difference was statistically significant (P＜0.05). The level of NSE in mild, moderate, and severe patients was increased gradually, and the level of NSE in patients with significant improvement, improvement, and no change was increased gradually, the differences were statistically significant (P＜0.05). The level of NSE in acute cerebral infarction group was positively correlated with NIHSS score (r＞0, P＜0.05), and negatively correlated with the score of neurological deficit (r＜0, P＜0.05). Serum NSE level had a certain value in predicting the severity and short-term prognosis of patients with acute cerebral infarction (AUC＞0.5, P＜0.5). Conclusion Serum NSE level is valuable for evaluating the severity of central nervous system injury and short-term clinical prognosis of patients with acute cerebral infarction, and can be used as a reliable biomarker for evaluating the severity of acute cerebral infarction and short-term clinical prognosis.
		2023 Vol. 20 (8): 83-86 [Abstract] ( 15 ) HTML (1 KB) PDF (732 KB) ( 45 )

	87	Effect of Compound Cistanche Yizhi Capsules on mild and moderate Alzheimer’s disease with deficiency of liver and kidney and phlegm-stasis blocking collaterals
		HONG Liang SUN Ping YANG Yanfu FANG Wujie
		DOI: 10.20047/j.issn1673-7210.2023.08.19
		Objective To explore the effect of Compound Cistanche Yizhi Capsules on mild and moderate Alzheimer’s disease (AD) with deficiency of liver and kidney and phlegm-stasis blocking collaterals. Methods A total of 120 patients with mild and moderate AD with deficiency of liver and kidney and phlegm-stasis blocking collaterals admitted to Lu’an Hospital of Traditional Chinese Medicine from May 2020 to March 2021 were selected, they were divided into control group and study group by random number table method, with 60 cases in each group. The control group was treated with Donepezil Hydrochloride Tablets, while the study group was treated with Compound Cistanche Yizhi Capsules on the basis of the control group, the course of treatment was six months. The clinical efficacy of the two groups after treatment was compared, the cognitive function, self-care ability, estradiol (E2), and hypoxia-inducible factor 1-α (HIF1-α) levels were compared between the two groups before and after treatment, and the adverse reactions during the treatment were recorded in the two groups. Results The clinical efficacy of the study group was better than that of the control group (P＜0.05). After treatment, the mini-mental state scale and Barthel index scores in the two groups were higher than those before treatment, and the study group were higher than those in the control group (P＜0.05); after treatment, E2 in the two groups increased, while HIF1-α decreased, and E2 in the study group was higher than that in the control group, and HIF1-α was lower than that in the control group (P＜0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P＞0.05). Conclusion Compound Cistanche Yizhi Capsules in the treatment of mild and moderate AD with deficiency of liver and kidney and phlegm-stasis blocking collaterals can significantly improve patients’ cognitive function and self-care ability, with definite curative effect and good safety.
		2023 Vol. 20 (8): 87-90 [Abstract] ( 19 ) HTML (1 KB) PDF (660 KB) ( 27 )

	91	Predictive value of carotid plaque superb micro- vascular imaging combined with carotid color Doppler flow imaging hemodynamic parameters in progressive ischemic stroke
		WU Fangling1 HU Jinhua1▲ HUANG Juxia1 YU Yi1 CHENG Yangmei1 YU Yaohong2
		DOI: 10.20047/j.issn1673-7210.2023.08.20
		Objective To investigate the predictive value of carotid plaque superb micro- vascular imaging (SMI) combined with carotid color Doppler flow imaging (CDFI) hemodynamic parameters in progressive ischemic stroke (PIS). Methods A total of 147 patients with acute ischemic stroke admitted to Anqing First People’s Hospital, Anhui Province from January 2020 to March 2022 were selected and they were divided into PIS group (40 cases) and non-PIS group (107 cases) according to the change of National Institutes of Health stroke scale score within seven days of hospitalization. Relevant clinical data and laboratory test indicators were collected, and the influencing factors of PIS in patients were analyzed. Receiver operating characteristic curve was used to evaluate the predictive value of carotid plaque SMI combined with carotid CDFI hemodynamic parameters in PIS. Results They were statistically significant in diabetes history, SMI grade, fibrinogen, resistance index (RI), peak systolic velocity (PSV), and end-diastolic velocity (EDV) between two groups (P＜0.05). Diabetes history, SMI grade 2, RI, PSV, and EDV were the influencing factors of PIS (P＜0.05). The area under the curve of carotid plaque SMI combined with carotid CDFI hemodynamic parameters for predicting PIS was higher than that of each index alone (P＜0.05). Conclusion Carotid plaque SMI combined with carotid CDFI hemodynamic parameters has a high predictive value in PIS.
		2023 Vol. 20 (8): 91-94 [Abstract] ( 15 ) HTML (1 KB) PDF (793 KB) ( 117 )

	95	Effect of trigger point releasing therapy on postpartum pelvic floor muscle spasm constipation
		ZHU Yinjie MAO Yeran FAN Wenjun LIU Zhidan
		DOI: 10.20047/j.issn1673-7210.2023.08.21
		Objective To observe the effect of trigger point release therapy on postpartum spastic pelvic floor muscle syndrome. Methods A total of 60 patients with postpartum spastic pelvic floor syndrome from the Postpartum Rehabilitation Clinic, Shanghai Baoshan Hospital of Integrated Traditional Chinese and Western Medicine from February 2020 to January 2022 were selected as research objects. The patients were divided into observation group and control group by envelope method, with 30 cases in each group. The control group received Kegel exercise and electromyographic biofeedback treatment, and observation group received trigger point releasing therapy on the basis of control group, both groups were treated for five weeks. Visual analogue scale (VAS) score, constipation scoring system (CSS) score and patient assessment of constipation quality of life (PAC-QOL) score of two groups were compared before and after treatment. Results After treatment, VAS, CSS, and PAC-QOL scores in two groups were lower than those before treatment, and observation group was lower than control group, and the differences were statistically significant (P＜0.05). Conclusion Trigger point releasing therapy can improve the constipation symptoms of patients with postpartum spastic pelvic floor muscle syndrome.
		2023 Vol. 20 (8): 95-98 [Abstract] ( 23 ) HTML (1 KB) PDF (597 KB) ( 63 )

	99	Expression and clinical significance of lncRNA MNX1-AS1 and miR-218-5p in non-small cell lung cancer tissues
		WANG Qiyuan1 LI Chengyin1 ZHU Jing1 ZOU Yinshui1 ZHAO Yaying1 GUO Guanghui2
		DOI: 10.20047/j.issn1673-7210.2023.08.22
		Objective To study the expression and clinical significance of long non-coding RNA (LncRNA) MNX1-AS1 and microRNA (miR)-218-5p in non-small cell lung cancer (NSCLC) tissues. Methods A total of 120 NSCLC patients diagnosed and treated in Hubei Provincial Hospital of Traditional Chinese Medicine from January 2015 to January 2017 were selected. The expression of LncRNA MNX1-AS1 and miR-218-5p were detected by fluorescence quantitative PCR from NSCLC tissues and paracancer tissues. The correlation between LncRNA MNX1-AS1 and miR-218-5p in NSCLC tissues and its clinicopathologic features were analyzed. The mean of LncRNA MNX1-AS1 and miR-218-5p relative expression levels (2.321、1.213) were divided into high and low expression groups to analyze their effects on survival and prognosis of patients with NSCLC. Results The expression of LncRNA MNX1-AS1 and miR-218-5p in NSCLC tissues was higher than that in paracancer tissues (P＜0.05). LncRNA MNX1-AS1 was negatively correlated with miR-218-5p (r=-0.561, P＜0.01). The expression of LncRNA MNX1-AS1 and miR-218-5p in patients with different lymph node metastases and tumor stages were statistically significant (P＜0.05). The survival curve of LncRNA MNX1-AS1 high-expression group was lower than that of LncRNA MNX1-AS1 low-expression group, and the survival curve of miR-218-5p low-expression group was lower than that of miR-218-5p high-expression group (P＜0.05). Conclusion The expression of LncRNA MNX1-AS1 increased and miR-218-5p decreased in NSCLC tissues, both of which are associated with poor prognosis of patients and may serve as prognostic evaluation indicators.
		2023 Vol. 20 (8): 99-102,110 [Abstract] ( 17 ) HTML (1 KB) PDF (1068 KB) ( 35 )

	103	Correlation between miR129-1 expression level in peripheral blood and prognosis in patients with non-small cell lung cancer
		ZHANG Cong1 TIAN Qin2 DAI Dongmei3 HAN Dousheng1▲
		DOI: 10.20047/j.issn1673-7210.2023.08.23
		Objective To analyze the correlation between the miR129-1 expression level in peripheral blood and prognosis in patients with non-small cell lung cancer (NSCLC). Methods A total of 109 patients with NSCLC admitted to the 960th Hospital of Chinese People’s Liberation Army and followed up for three years from January to December 2017 were selected as the study objects. According to the prognosis, they were divided into death group and survival group. The clinical case characteristics of the two groups were compared, and the factors influencing the prognosis of NSCLC patients were analyzed. The survival of patients with low and high expression of miR129-1 in peripheral blood was compared. Results Of the 109 patients, seven were lost to follow-up, 37 died, and 65 survived among the remaining 102 patients. The proportion of smoking history, lymph node metastasis, low differentiation, stage Ⅲ, and low expression of miR129-1 in peripheral blood in the death group was higher than those in the survival group, the differences were statistically significant (P＜0.05). Multivariate analysis showed that lymph node metastasis, degree of differentiation, clinical stage, and peripheral blood miR129-1 expression were all influencing factors of prognosis in NSCLC patients (P＜0.05). The 3-year survival rate of patients with low expression of miR129-1 in peripheral blood was lower than that of patients with high expression, and the difference was statistically significant (P＜0.05). Conclusion Peripheral blood miR129-1 expression level is closely related to the prognosis of patients with NSCLC and is expected to be a biomarker for the diagnosis and treatment of NSCLC.
		2023 Vol. 20 (8): 103-106 [Abstract] ( 16 ) HTML (1 KB) PDF (760 KB) ( 28 )

	107	Effect of minimally invasive hypothermic plasma thyroidectomy on early laryngeal cancer involving anterior commissure
		LIU Yanmei1 TANG Junxiang2 XU Yunliang1
		DOI: 10.20047/j.issn1673-7210.2023.08.24
		Objective To investigate the effect of minimally invasive hypothermic plasma thyroidectomy on early laryngeal cancer involving anterior commissure. Methods A total of 72 patients with early laryngeal cancer involving anterior commissure admitted to Yixing People’s Hospital and Zhenjiang First People’s Hospital from February 2016 to February 2021 were selected, they were divided into observation group and conventional group, with 36 cases in each group. The observation group received minimally invasive hypothermic plasma thyroidectomy, and conventional group received conventional surgery. Operation time and intraoperative blood loss were compared between two groups; pronunciation function were compared between two groups; the scores of video fluoroscopic swallow study (VFSS) before and after surgery were compared between two groups; complications and recurrence were observed in two groups. Results The operation time of observation group was shorter than that of conventional group, and intraoperative blood loss was less than that of conventional group (P＜0.05). The pronunciation function of observation group was better than that of conventional group (P＜0.05). Three months after surgery, VFSS scores in both groups were higher than those before surgery, and observation group was higher than the control group (P＜0.05). The incidence of postoperative complications in observation group was lower than that in conventional group (P＜0.05). The recurrence rate of observation group was lower than that of conventional group (P＜0.05). Conclusion Minimally invasive hypothermic plasma thyroidectomy can effectively improve the pronunciation function and swallowing function of patients with early laryngeal cancer involving anterior commissure, which is safe and reliable, and can reduce the recurrence rate.
		2023 Vol. 20 (8): 107-110 [Abstract] ( 19 ) HTML (1 KB) PDF (521 KB) ( 9 )

	111	Analysis of the relationship between carcinoembryonic antigen level and radiotherapy effect in patients with locally advanced non-small cell lung cancer
		ZONG Chunmei ZHAO Lin SUN Wei▲
		DOI: 10.20047/j.issn1673-7210.2023.08.25
		Objective To study the relationship between the carcinoembryonic antigen (CEA) level and radiotherapy effect in patients with locally advanced non-small cell lung cancer (NSCLC). Methods A total of 89 patients with locally advanced NSCLC received radiotherapy in the Department of Oncology, Huaibei People’s Hospital, Anhui Province from January 2019 to December 2021 were selected and evaluated according to response evaluation criteria in solid tumor 1.1 one month after the end of radiotherapy. Patients with complete response and partial response were included in the radiotherapy sensitive group (41 cases). The rest were included in the radiotherapy resistance group (48 cases). The differences of serum CEA level before radiotherapy, and other clinical data between the two groups were analyzed. Logistic regression analysis and receiver operating characteristic (ROC) curve were used to evaluate the relationship between serum CEA level before radiotherapy and radiotherapy effect. Results The radiotherapy resistance rate of 89 patients was 53.93%. The age of diagnosis, the proportion of the maximum diameter of primary tumor ≥5.0 cm, the proportion of low differentiation, and the serum CEA level before radiotherapy in the radiotherapy resistance group were higher than those in the radiotherapy sensitive group, the differences were statistically significant (P＜0.05). Multivariate analysis showed that age of diagnosis, the proportion of low differentiation, and serum CEA level before radiotherapy were all factors influencing radiotherapy resistance in NSCLC patients (P＜0.05). ROC curve analysis showed that the area under the curve of serum CEA before radiotherapy in predicting radiotherapy resistance of NSCLC patients was 0.887 (P＜0.05). Conclusion Serum CEA level before radiotherapy is a influencing factor for radiotherapy resistance in patients with locally advanced NSCLC, and has a certain value in predicting radiotherapy effect.
		2023 Vol. 20 (8): 111-114 [Abstract] ( 20 ) HTML (1 KB) PDF (651 KB) ( 124 )

	115	Prognostic value of plasma von Willebrand factor combined with simplified pulmonary embolism severity index in the assessment of patients with acute pulmonary thromboembolism
		ZHAO Jie1 YANG Yan2 HE Zhengguang1 XIA Hangbiao1 DU Fawang1
		DOI: 10.20047/j.issn1673-7210.2023.08.26
		Objective To investigate the value of plasma von Willebrand factor (vWF) combined with simplified pulmonary embolism severity index (sPESI) in assessing the prognosis of patients with acute pulmonary thromboembolism (APTE). Methods A total of 153 APTE patients admitted to Suining Central Hospital from January 2019 to May 2022 were selected and they were divided into the death group and the survival group according to their 30 day survival. Plasma vWF antigen levels were detected, and sPESI was calculated. The factors affecting the prognosis of APTE patients and the evaluation value of plasma vWF combined with sPESI in the prognosis of patients were analyzed. Results The death group was older than the survival group, and the proportion of hemoptysis, syncope, cardiac arrest, chronic renal insufficiency, and white blood cell count, vWF and sPESI were higher than those in the survival group (P＜0.05). Cardiac arrest, elevated vWF, and sPESI were independent risk factors for the prognosis of APTE patients (P＜0.05). The area under the curve of plasma vWF combined with sPESI to evaluate the prognosis of APTE patients was larger than that of the two alone (P＜0.05). Conclusion Both plasma vWF and sPESI are independent risk factors for the prognosis of APTE, and their combined detection can improve the predictive power.
		2023 Vol. 20 (8): 115-118,123 [Abstract] ( 17 ) HTML (1 KB) PDF (723 KB) ( 40 )

	119	Predictive value of serum phospholipase A2, procalcitonin, and interleukin 6 and 10 factors on prognosis of patients with severe pneumonia
		SHEN Jianhua CHENG Chuji▲
		DOI: 10.20047/j.issn1673-7210.2023.08.27
		Objective To analyze the predictive value of serum phospholipase A2 (PLA2), procalcitonin (PCT), and interleukin (IL) -6, and IL-10 factors on the prognosis of patients with severe pneumonia. Methods A total of 160 patients with severe pneumonia admitted to Anqing Municipal Hospital of Anhui Province from October 2021 to May 2022 were selected. Serum levels of PLA2, PCT, IL-6, and IL-10 were detected before treatment. According to the prognosis within 28 days of admission, the patients were divided into the poor prognosis group and good prognosis group. Risk factors for poor prognosis in patients with severe pneumonia was analyzed. Serum PLA2, PCT, IL-6, IL-10 levels and their combined value in predicting poor prognosis in patients with severe pneumonia were analyzed. Results Among the 160 patients, 44 had poor prognosis within 28 days of admission, the poor prognosis rate was 27.50%, and 116 had good prognosis. The total time of invasive mechanical ventilation, pneumonia severity score, serum PLA2, PCT, IL-6, IL-10 levels and sequential organ failure assessment (SOFA) score in poor prognosis group were higher than those in good prognosis group (P＜0.05). Elevated serum PLA2, elevated PCT, elevated IL-6, elevated IL-10, and elevated SOFA score were risk factors for poor prognosis in patients with severe pneumonia (P＜0.05). Serum levels of PLA2, PCT, IL-6, and IL-10 and the area under the curve (AUC) values of the four combined to predict poor prognosis in patients with severe pneumonia were 0.729, 0.726, 0.738, 0.704, and 0.832, respectively. The predicted AUC values were all higher than those of detection alone (P＜0.05). Conclusion The levels of serum PLA2, PCT, IL-6, and IL-10 have important value in predicting the short-term prognosis of patients with severe pneumonia, and the combination of the four has higher predictive value.
		2023 Vol. 20 (8): 119-123 [Abstract] ( 18 ) HTML (1 KB) PDF (943 KB) ( 34 )

	124	Effectiveness and safety of closure of wounds with Tolstoy’s skin retractor closure for soft tissue defects of limbs
		LI Peng1 QIU Xing2 ZHANG Shan3 SUN Letian1▲
		DOI: 10.20047/j.issn1673-7210.2023.08.28
		Objective To study the effectiveness and safety of the Tolstoy’s skin retracor closure for soft tissue defects of the extremities. Methods Eighty patients with soft tissue defects of the extremities admitted to the 971st Naval Hospital of Chinese People’s Liberation Army from June 2018 to June 2021 were included in the study, and were divided into two groups of 40 cases each group, according to the random number table method. In the control group, flap repair was performed after negative pressure suction of the trauma. In the observation group, the trauma was closed with a torso skin retraction closure. The first-stage healing and the average healing time in the two groups were observed, and the hospitalization time, hospitalization cost, and drug exchange cost between the two groups were compared. The recovery of sensory function at the defect site and the treatment efficacy of the two groups were analyzed, and the occurrence of complications in the two groups were compared. Results The one-stage healing rate was higher in the observation group than in the control group (P＜0.05). All patients with non-healing stage Ⅰ were repaired by stage Ⅱ surgery. The mean healing time and hospitalization time of superficial Ⅱ degree and deep Ⅱ degree wounds in the observation group were shorter than those in the control group, and the hospitalization cost was lower than that in the control group, with statistically significant differences (P＜0.05). The recovery of sensory function at the defect site was better in the observation group than in the control group, and the difference was statistically significant (P＜0.05). The treatment effect of the observation group was better than that of the control group, and the difference was statistically significant (P＜0.05). The incidence of complications in the observation group was lower than that in the control group, and the difference was statistically significant (P＜0.05). Conclusion The use of Tolstoy’s skin retraction closure device for soft tissue defects of the extremities can effectively promote defective tissue repair, shorten wound healing time, with less risk of complications and better safety, and is worthy of clinical promotion.
		2023 Vol. 20 (8): 124-127 [Abstract] ( 15 ) HTML (1 KB) PDF (544 KB) ( 13 )

	128	Factors influencing catheter-associated infections in hemodialysis patients
		ZHANG Juan WANG Tingting GUO Ruirui HU Qiongfen LIU Yang YU Min▲
		DOI: 10.20047/j.issn1673-7210.2023.08.29
		Objective To investigate the factors influencing catheter-associated infections (CRI) in hemodialysis patients. Methods Four hundred and eighty patients who underwent hemodialysis from January 2018 to December 2021 in the Department of Nephrology, the Fifth Medical Center, Chinese People’s Liberation Army General Hospital were selected, the CRI rate of patients was recorded, and the CRI rate of patients with different clinical characteristics was compared. Multi-factor analysis was used to determine the influencing factors of CRI. Results A total of 46 patients out of 480 patients developed CRI, with an infection rate of 9.58%. There were 17 tunnel infections (36.96%), 14 catheter colonization infections (26.67%), 9 exit infections (19.57%), and 6 bloodstream infections (13.04%). There was a statistically significant difference in the rate of CRI in hemodialysis patients with different age, number of punctures, duration of catheter retention, combined diabetes mellitus and hypoproteinemia, length of hospital stay, and application of antimicrobial drugs (P＜0.05). Multifactorial logistic regression analysis showed that, age (OR=2.254), diabetes (OR=2.315), hypoproteinemia (OR=3.015), number of punctures (OR=2.708), duration of indwelling catheter (OR=2.937), length of hospital stay (OR=2.830), and antimicrobial drug application (OR=2.401) were blood purification influencing factors of CRI in patients (P＜0.05). Conclusion Patients with older age, combined diabetes mellitus and hypoproteinemia, more invasive operations, longer hospital stay, and not using antimicrobial drugs are more prone to CRI, so the clinic should pay attention to the management of comorbidities in hemodialysis patients and reduce invasive operations and use antimicrobial drugs reasonably to reduce CRI.
		2023 Vol. 20 (8): 128-131 [Abstract] ( 17 ) HTML (1 KB) PDF (485 KB) ( 15 )

	132	Construction and indexing application of acupuncture and moxibustion indexing template based on knowledge element indexing
		LU Fulu1 YU Dou2 ZENG Cailing1 LIU Binlan1 CHEN Xinchang1 AI Jun1
		DOI: 10.20047/j.issn1673-7210.2023.08.30
		Ancient books of acupuncture and moxibustion are important components in the information resource base of traditional Chinese medicine, and also valuable heritage and wealth in the Chinese medicine. In order to excavate the value of ancient books of acupuncture and moxibustion, promote the digitalization of ancient books, and improve the clinical application of ancient books of acupuncture and moxibustion, this study built a “acupuncture and moxibustion” indexing template based on the knowledge element theory and combined with the indexing requirements of ancient books of this subject. The template takes “meridian - acupoint - treat” as the core of the idea, and according to the style form and content characteristics of ancient books of acupuncture and moxibustion, set up 15 metadata: name, meridian, acupoint, synonym, interpretation, location, function, indications, concerted application, acupuncture technique, moxibustion, other therapies, curative effect, prognosis, contraindications, applied to the online indexing of ancient books of acupuncture and moxibustion. The construction and application of this template can provide examples for the research on the indexing of ancient books of acupuncture and moxibustion, which is conducive to the discovery of acupuncture and moxibustion knowledge.
		2023 Vol. 20 (8): 132-136 [Abstract] ( 21 ) HTML (1 KB) PDF (1876 KB) ( 29 )

	137	Discussion on regulative effects of Zuogui Pills and Yougui Pills on immune system from the theory of vital gate water and fire
		ZOU Jixuan1 ZHAO Pei1 SONG Ying2 CAO Xintian1 WANG Mingjing2 LIU Weiyi2 LYU Yan2 HU Xiaomei2
		DOI: 10.20047/j.issn1673-7210.2023.08.31
		“Immunity” is a defense mechanism used by the body to resist foreign bodies and recognize and deal with abnormal cells. It is highly similar in function to “yang qi” in traditional Chinese medicine. And yang qi mainly originates from the vital gate. Zuogui Pills and Yougui Pills, created by Zhang Jingyue based on his theory of vital gate water and fire, are famous prescriptions for regulating and supplementing zhenyin and yuanyang of vital gate. Therefore, based on the theory of vital gate water and fire, combined with modern research progress, this paper discusses the regulatory effects of Zuogui Pills and Yougui Pills on immune system. It is found that the functions of the vital gate are highly similar to those of the central immune organs. It can be said that the zhenyin of the vital gate is the concentrated embodiment of the material basis of immune activities, and the bioactive molecules such as cytokines secreted by various cells in the bone marrow are the specific manifestations of the vital gate yuanyang. Zuogui Pills and Yougui Pills can regulate the vital gate water and fire, restore the imbalance of yin and yang to the equilibrium state of mutual root and mutual use, and play a role in regulating the body’s immune system disorder. It is feasible to use Zuogui Pills and Yougui Pills to treat some autoimmune diseases with deficiency syndrome as the main syndrome, and it is worth further exploration and popularization.
		2023 Vol. 20 (8): 137-140,145 [Abstract] ( 20 ) HTML (1 KB) PDF (690 KB) ( 30 )

	141	Study on the origin of wilting disease
		CUI Yizhi1 ZHAO Jiaqi1 DONG Xu2 WANG Dongyan2
		DOI: 10.20047/j.issn1673-7210.2023.08.32
		People with wilting disease, limbs, hands, and feet are soft and useless, flaccid and thin. The disease condition of wilting disease is complex, and many reasons cause muscle, sinew and vessel loss in irrigation moisten and cause the disease. In this paper, through combing the ancient literature related to wilting disease, from the disease name, etiology, treatment principles of several places to make a textual research on the origin of the wilting disease. The pathogenesis of wilting disease is always caused by the imbalance of qi, blood, yin, and yang, and its location of zang-fu viscera can be classified as liver, kidney, lung, and stomach. The principle of treating wilting disease is mainly to supplement deficiency and strengthening vital qi, harmonizing qi and blood, to clear heat, remove dampness, activate collages, and to seek evidence to treat Yangming, expulsing pathogen and elimination of disease. This paper analyzes the understanding of the doctors of the past dynasties on the wilting disease, and summarizes its treatment methods, in order to provide reference for the understanding and diagnosis of the wilting disease in clinical and scientific research.
		2023 Vol. 20 (8): 141-145 [Abstract] ( 18 ) HTML (1 KB) PDF (824 KB) ( 18 )

	146	Analysis on the concept of protection of traditional knowledge of Chinese medicine
		WANG Liuqing1 LIU Qian1 ZHANG Zhen2 AN Hong1 QIN Peijie1 SHI Xueqin1 ZHANG Fengxia1 LIU Jianfeng1
		DOI: 10.20047/j.issn1673-7210.2023.08.33
		Traditional knowledge of traditional Chinese medicine is a subordinate concept of traditional knowledge, which has the basic characteristics of subject diversity, inheritance, regionality, personal dependence, and tradition. It includes static traditional knowledge of traditional Chinese medicine and active traditional knowledge of traditional Chinese medicine. Among them, static knowledge refers to a certain form of solidified knowledge set, such as traditional medical literature, medical instruments, etc. Active knowledge refers to the knowledge set with potential improvement space, such as traditional Chinese medicine theory, secret recipe, diagnosis and treatment technology, processing technology, health care technology, etc. The protection of traditional knowledge of traditional Chinese medicine is different from intangible cultural heritage and intellectual property rights. While protecting cultural traditions and economic interests, it also protects the existing conditions of traditional knowledge. The feasible schemes for the protection of traditional Chinese medicine include legal means, administrative means, and intellectual property means to confirm the intellectual property rights of the above-mentioned static and active traditional knowledge of traditional Chinese medicine at the national, industrial, and social levels, prevent improper possession, promote and publicize, and inherit and develop.
		2023 Vol. 20 (8): 146-149 [Abstract] ( 19 ) HTML (1 KB) PDF (633 KB) ( 81 )

	150	Wang Qingguo’s experience in treating palpitation based on the combination of “disease, syndrome, and symptom”
		LI Ting1 TANG Xuechun2 SUN Zijin2 OUYANG Huan2 CHENG Fafeng2 WANG Qingguo2
		DOI: 10.20047/j.issn1673-7210.2023.08.34
		Palpitation is one of the common clinical diseases, which seriously affects the physical and mental health and interferes with the life and work of patients. Meanwhile, traditional Chinese medicine treatment plays a particular therapeutic role. Professor Wang Qingguo, who has been conducting medical practice for more than 50 years and has rich clinical experience, recommends the diagnosis and treatment strategy by organically combining “disease, syndrome, and symptom”, so that doctors could grasp the main contradiction of palpitation, predict the trend of the disease evolution and use targeted drugs to minimize the patient’s suffering. This article introduces Professor Wang Qingguo’s understanding of the etiology and pathogenesis of palpitation and summarizes his academic thinking and commonly used prescriptions from three aspects: combining Chinese and Western medicine to identify the disease, identifying the syndrome and choosing the therapy based on the outline of deficiency and excess, and adjusting the medication prescription to restore the heart rhythm according to the symptoms. Besides, a typical clinical case is also attached for reference.
		2023 Vol. 20 (8): 150-153,162 [Abstract] ( 17 ) HTML (1 KB) PDF (776 KB) ( 22 )

	154	Experience summary of Professor Hu Guoheng in treating impediment disease based on collateral disease theory
		XIE Jinru1 CHEN Ya2 HU Guoheng3
		DOI: 10.20047/j.issn1673-7210.2023.08.35
		Impediment disease is a common clinical chronic disease and senile disease, often with pain as the main symptom. Professor Hu Guoheng has rich experience in the diagnosis and treatment of this disease. On the basis of the understanding of “collateral disease theory”“treatment of impediment disease using collateral theory”, and “viscera deficiency and collateral obstruction”, he believes that collateral obstruction should be based on “yin collaterals”, the root of impediment disease is deficiency of kidney-essence and qi, and obstruction of kidney collaterals, the key to the pathogenesis is the deficiency of heart-qi and blood, and the obstruction of heart collaterals, and the pathological basis is the obstruction of the heart and kidney collaterals, which is blocked by phlegm and blood stasis. In terms of treatment, emphasis is placed on nourishing the heart and kidney, regulating qi and blood, and advocating the combination of rigidity and softness on the principles of diffusing impediment and dredging collateral, resolving phlegm and dispelling blood stasis. The clinical effect is quite good. It verifies the feasibility and effectiveness of treating impediment disease using collateral theory from “heart and kidney”. Therefore, this article introduces Professor Hu’s clinical experience in impediment disease combined with a clinical medical case.
		2023 Vol. 20 (8): 154-157 [Abstract] ( 15 ) HTML (1 KB) PDF (645 KB) ( 26 )

	158	Effects of Chinese medicine fumigation combined with auricular point sticking on clinical efficacy and inflammatory reaction in patients with type 2 diabetic dry eyes
		LI Weina1 MIAO Hui1 WANG Lifang1 DONG Ping1 YIN Huisu1 LI Jing2 WANG Qiao2
		DOI: 10.20047/j.issn1673-7210.2023.08.36
		Objective To observe the effects of Chinese medicine fumigation combined with auricular point sticking on clinical efficacy and inflammatory reaction in patients with type 2 diabetic dry eyes. Methods One hundred and twenty patients with type 2 diabetic dry eyes treated in Hebei Eye Hospital from June to December 2021 were selected as the research objects. According to the random number table method, they were divided into Chinese medicine fumigation group, auricular point sticking group, and Chinese medicine fumigation combined with auricular point sticking group, with 40 cases in each group. The scores of ocular surface disease index (OSDI), schirmer I test (SIt), fluorescein break-up time (FBUT), corneal fluorescein staining (CFS) and the levels of interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), matrix metalloproteinase-9 (MMP-9) in each group before and after treatment were compared. Conjunctival epithelial cell nuclear factor kappa B (NF-κB) expression in each group was detected. Results After treatment, OSDI scores of three groups were lower than those before treatment, and OSDI score of Chinese medicine fumigation combined with auricular point sticking group was lower than that of Chinese medicine fumigation group and auricular point sticking group, the differences were statistically significant (P＜0.05). After treatment, SIt of three groups were more than those before treatment, FBUT of three groups were longer than those before treatment, and CFS scores of three groups were lower than those before treatment, and SIt of Chinese medicine fumigation combined with auricular point sticking group was more than that of Chinese medicine fumigation group and auricular point sticking group, FBUT of Chinese medicine fumigation combined with auricular point sticking group was longer than that of Chinese medicine fumigation group and auricular point sticking group, CFS score of Chinese medicine fumigation combined with auricular point sticking group was lower than that of Chinese medicine fumigation group and auricular point sticking group, the differences were statistically significant (P＜0.05). After treatment, the levels of TNF-α, IL-1β, MMP-9 in three groups were lower than those before treatment, and Chinese medicine fumigation combined with auricular point sticking group was lower than that of Chinese medicine fumigation group and auricular point sticking group, the differences were statistically significant (P＜0.05). Conjunctival epithelial cell NF-κB expression of Chinese medicine fumigation combined with auricular point sticking group was lower than that of Chinese medicine fumigation group, auricular point sticking group, the differences were statistically significant (P＜0.05). Conclusion The combination of Chinese medicine fumigation and auricular point sticking can obviously improve the ocular symptoms of patients with type 2 diabetic dry eyes, increase the amount of tear secretion and the tear film stability, alleviate the local inflammatory reaction. It is worthy of recommendation.
		2023 Vol. 20 (8): 158-162 [Abstract] ( 15 ) HTML (1 KB) PDF (715 KB) ( 33 )

	163	Application effect of targeted all-round nursing intervention in phototherapy of children with neonatal hyperbilirubinemia
		WANG Liwei1 ZHOU Zhiqing2
		DOI: 10.20047/j.issn1673-7210.2023.08.37
		Objective To explore the application effect of targeted all-round nursing intervention in phototherapy of children with neonatal hyperbilirubinemia. Methods From March 2020 to March 2021, 80 children with neonatal hyperbilirubinemia admitted to Anhui Taihe People’s Hospital were divided into control group and experimental group by random number table method, with 40 cases in each group. The control group was given routine nursing, and the experimental group was given targeted comprehensive nursing intervention on the basis of the control group, all nursing for one week. The clinical effect, neurological dysfunction, comfort improvement, and nursing satisfaction of family members were compared after nursing. Results The total effective rate of the experimental group was higher than that of the control group, and the jaundice receding time and hospitalization time of the experimental group were shorter than that of the control group, the differences were statistically significant(P＜0.05); after nursing, the scores of the children’s version of the event impact scale and bilirubine-induced neurological dysfunction of the two groups were lower than those of before nursing, and the scores of the experimental group were lower than those of the control group, the differences were statistically significant (P＜0.05); the satisfaction rate of family members of the experimental group was higher than that of the control group, and the difference was statistically significant（P＜0.05）. Conclusion Targeted comprehensive nursing intervention can improve the efficacy and comfort of phototherapy for neonates with hyperbilirubinemia, relieve pain and neurological dysfunction, and improve the satisfaction of children’s families.
		2023 Vol. 20 (8): 163-166 [Abstract] ( 45 ) HTML (1 KB) PDF (616 KB) ( 33 )

	167	Effects of web-based extended follow-up care on breastfeeding behaviors and negative emotions in primiparous mothers
		QIAN Junting WANG Beibei▲
		DOI: 10.20047/j.issn1673-7210.2023.08.38
		Objective To study the effects of web-based extended follow-up care on breastfeeding behaviors and negative emotions in primiparous mothers. Methods In this study, 200 cases of primigravida were recruited from February 2021 to February 2022 in Hangzhou Fuyang Maternal and Child Health Hospital, and were divided into observation and control groups according to the random number table method, with 100 cases in each group. Routine nursing care measures was used during hospitalization in both groups. The control group was discharged with routine discharge instructions, and the observation group was given web-based extended follow-up care. The breastfeeding rates, breastfeeding satisfaction, and Edinburgh postpartum depression scale (ＥＰＤＳ) scores at 1, 2, 3, and 4 months postpartum were compared between the two groups. At a month postpartum, the maternal feeding behavior scores, self-care knowledge acquisition rate, and correct newborn care rate were compared between the two groups. Results The breastfeeding rate at 1, 2, 3, and 4 months postpartum in the observation group were higher than those in the control group, and the differences were statistically significant (P＜0.05). At a month postpartum, the feeding behavior score, behavioral intention score, and total feeding behavior score in the observation group were higher than those in the control group, and the differences were statistically significant (P＜0.05). The differences were statistically significant when comparing maternal breastfeeding satisfaction between groups, time, and interaction(P＜0.05). In the intra-group comparison, the satisfaction level at 2, 3, and 4 months after delivery were higher than that at a month after delivery; in the inter-group comparison, the satisfaction level at 2, 3, and 4 months after delivery in the observation group were higher than those in the control group, and the differences were statistically significant (P＜0.05). The differences were statistically significant when comparing maternal breastfeeding EPDS scores between groups, time, and interaction (P＜0.05). When comparing within groups, EPDS scores at 2, 3, and 4 months postpartum were lower than that at 1 month postpartum; when comparing between groups, EPDS scores in the observation group at 2, 3, and 4 months postpartum were lower than those in the control group, with statistically significant differences (P＜0.05). The rate of maternal self-care knowledge in the observation group was higher than that in the control group, and the difference was statistically significant (P＜0.05). The correct rate of umbilical cord care, correct rate of newborn bathing, while rate of newborn touching were higher in the observation group than in the control group, and the differences were statistically significant (P＜0.05). Conclusion Web-based follow-up care can improve breastfeeding behavior, negative maternal emotions and knowledge of postpartum care, and improve maternal self-care and newborn care.
		2023 Vol. 20 (8): 167-170,175 [Abstract] ( 22 ) HTML (1 KB) PDF (674 KB) ( 91 )

	171	Application of 4R crisis management theory combined with hierarchical management model in operating room management, and its impact on comfort and adverse events
		ZHANG Zehao1 YANG Minli2 FENG Yuanyuan3 WANG Yu1▲
		DOI: 10.20047/j.issn1673-7210.2023.08.39
		Objective To explore the application of 4R crisis management theory combined with hierarchical management model in operating room management and its impact on comfort and adverse events. Methods A total of 80 patients and 42 nurses in the operating room of the First Affiliated Hospital of Air Force Medical University from March 2021 to March 2022 were selected as the research objects, nurses and patients were divided into control group and study group according to random number table method, control group (40 patients, 21 nurses) and study group (40 patients, 21 nurses). The control group adopted 4R crisis management theory mode, and the research group adopted 4R crisis management theory combined hierarchical management mode. Both groups were intervened for two months. The differences of operating room theory and performance of operating skills, nursing quality, comfort level, and occurrence of adverse events were compared. Results The results of nurses’ operating room theory, and operating skills in the study group were higher than those in the control group (P＜0.05). The nursing quality of study group was higher than that of control group (P＜0.05). After intervention, social, environmental, psychological, physiological, and total scores in two groups were higher than those of before intervention, and the study group was higher than the control group (P＜0.05). The incidence of total adverse reactions in study group was lower than that in control group (P＜0.05). onclusion 4R crisis management theory combined with hierarchical management mode applied in operating room management can effectively improve the theoretical and operational skills of nursing staff, improve nursing quality and patient comfort, and reduce the probability of adverse events.
		2023 Vol. 20 (8): 171-175 [Abstract] ( 18 ) HTML (1 KB) PDF (649 KB) ( 93 )

	176	Application effect of nursing intervention in interventional treatment of acute cerebral infarction under quality control theory
		XIAO Shuli LIU Qihui▲ XIA Mengdi WU Yuefu
		DOI: 10.20047/j.issn1673-7210.2023.08.40
		Objective To explore the application effect of nursing intervention in interventional treatment of acute cerebral infarction (ACI) under quality control theory. Methods A total of 120 patients with ACI received interventional therapy in Hainan Provincial People’s Hospital from February 2019 to December 2021 were selected as study subjects. The patients were divided into routine group and intervention group by random number table method, with 60 cases in each group. The routine group was given routine nursing intervention, and the intervention group was given nursing intervention based on quality control theory on the basis of routine nursing, the incidence of complications (rash, cerebral hemorrhage, venous thrombosis, etc.), neurological function (National Institutes of Health stroke scale [NIHSS]), and nursing satisfaction (self-designed satisfaction questionnaire), etc. were compared between the two groups. Results After nursing, the incidence of cerebral hemorrhage, subcutaneous hematoma at puncture site, and transition perfusion syndrome in intervention group was lower than that in conventional group, and the differences were statistically significant (P＜0.05), NIHSS scores of the two groups were lower than those of before intervention, and the intervention group was lower than the conventional group, the differences were statistically significant (P＜0.05). The nursing satisfaction score of intervention group was higher than that of conventional group, and the difference was statistically significant (P＜0.05). Conclusion The implementation of nursing intervention based on quality control theory during the interventional therapy of ACI patients can significantly reduce the complications of interventional therapy, promote better improvement of patients’ neurological function, and improve patients’ nursing satisfaction.
		2023 Vol. 20 (8): 176-179 [Abstract] ( 13 ) HTML (1 KB) PDF (575 KB) ( 16 )

	180	Management effect of ADOPT mode combination with group intervention in the patients with rectal cancer colostomy
		LI Fen1 LI Mingxia2▲ HUANG Zhaohui1 ZHOU Chunmei1
		DOI: 10.20047/j.issn1673-7210.2023.08.41
		Objective To analyze the management effect of attitude-definition-open mind-plan-test (ADOPT) mode combination with group intervention in the patients with rectal cancer colostomy. Methods A total of 200 patients with rectal cancer were selected from Union Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, and Hanyang Clinic of Stomatological Hospital of Wuhan University from February 2019 to February 2021, according to random number table method, they were divided into control group and study group, with 100 cases in each group. Both groups underwent colostomy surgery for rectal cancer. The control group was treated with a comprehensive nursing intervention, and the study group was treated with ADOPT model combined with group intervention, after nursing, stool, quality of life, anxiety, postoperative complications, and disease recovery were compared between the two groups. Results The incidence of postoperative defecation discomfort and bloody stool in study group were lower than those in control group, and the incidence of defecation regularity was higher than that in control group (P＜0.05). After nursing, the self rating anxiety scale and quality of life score of both groups were lower than those before nursing, and the study group was lower than the control group (P＜0.05). The length of hospital stay in the study group was shorter than that in the control group (P＜0.05). The incidence of postoperative complications in the study group was lower than that in the control group (P＜0.05). Conclusion ADOPT in combination with group intervention can reduce anxiety index, alleviate symptoms and reduce complications in patients with colorectal cancer after colostomy.
		2023 Vol. 20 (8): 180-183 [Abstract] ( 15 ) HTML (1 KB) PDF (608 KB) ( 27 )

	184	Effect of double heart nursing on self-care ability and health behavior of patients with acute myocardial infarction treated by emergency PCI
		ZHANG Hui1 ZHANG Lei2 JIAO Qiqi3 GAO Ruizhe4 WANG Xin1▲
		DOI: 10.20047/j.issn1673-7210.2023.08.42
		Objective To explore the effect of double heart nursing on self-care ability and health behavior of patients with acute myocardial infarction (AMI) treated by emergency percutaneous coronary intervention (PCI). Methods A total of 78 patients with AMI treated in the interventional Department of Interventional Diagnosis and Treatment, Shandong Provincial Hospital Affiliated to Shandong First Medical University from February 2019 to March 2022 were selected as the research subjects. They were divided into routine nursing group and double heart nursing group by random number table method, with 39 cases in each group. The conventional care group was given conventional care, and the double heart nursing group was given double heart nursing on the basis of the conventional care group, and both of them were intervened for two weeks. Results After two weeks of intervention, the scores of Hamilton anxiety scale and Hamilton depression scale in the two groups were lower than those before the intervention, and the double heart nursing group were lower than those of the routine nursing group, the differences were statistically significant (P＜0.05); the exercise of self-care agency scale scores of the two groups were higher than those before the intervention, and the scores of the double heart nursing group were higher than those of the routine nursing group, the differences were statistically significant (P＜0.05). Conclusion The double heart nursing model is introduced in the emergency PCI treatment of AMI patients to play a good role in psychological adjustment and self-care ability.
		2023 Vol. 20 (8): 184-187 [Abstract] ( 15 ) HTML (1 KB) PDF (551 KB) ( 16 )

	188	Exploring the application of machine learning in predicting the effect of acupuncture for insomnia based on brain functional connectivity
		YIN Xuejiao1 JIANG Tongfei1 CHEN Zhaoyi1 SONG Zhangxiao2 LI Bin1 GUO Jing1
		DOI: 10.20047/j.issn1673-7210.2023.08.43
		Acupuncture is one of the effective ways to treat insomnia, but because it is based on clinical experience, the treatment protocol has yet to be optimized, and the efficacy is mainly subjective assessment, with significant differences in individual efficacy. Therefore, it is important to screen effective populations for individual identification markers to predict efficacy and optimize acupuncture treatment protocols. Machine learning (ML) for classification and prediction algorithms are rapidly becoming tools for disease diagnosis, prediction, and classification. In contrast, magnetic resonance imaging has revealed that the brain functional connectivity (FC) of insomniac individuals is highly specific, with specific patterns of change before and after acupuncture, and can be used as a marker to track treatment response. This paper proposes to explore the feasibility of using the classification algorithm model in ML to predict the efficacy of acupuncture treatment for insomnia based on FC technology, in order to break the bottleneck of “empirical treatment” and optimize the acupuncture treatment plan.
		2023 Vol. 20 (8): 188-191,196 [Abstract] ( 21 ) HTML (1 KB) PDF (618 KB) ( 87 )

	192	Summary of evidence on the practice of discharge preparation services for patients with myocardial infarction
		HAN Qiong1 CHEN Yuan2 ZHANG Yu2
		DOI: 10.20047/j.issn1673-7210.2023.08.44
		Objective To retrieve, evaluate, and integrate evidence related to discharge preparation services for patients with myocardial infarction. Methods Computer searches of guidelines, evidence summaries, systematic reviews, recommended practices, and expert consensus on the use of discharge preparation services in patients with myocardial infarction in relevant guideline networks, society websites, and English and Chinese databases were conducted to evaluate the quality of the included literature and to extract and summarize evidence according to themes. Results A total of seven papers were included, including three guidelines, one expert consensus, two systematic reviews, and one recommended practice, summarizing a total of 17 pieces of evidence on seven topics: establishment of a multidisciplinary service team, at admission, during hospitalization, before discharge, after discharge, importance of patient and caregiver involvement, and training. Conclusion This study summarizes the formation of a practice protocol for discharge preparation services for patients with myocardial infarction, and the best evidence can be selected for clinical implementation to serve and benefit patients according to the actual situation.
		2023 Vol. 20 (8): 192-196 [Abstract] ( 17 ) HTML (1 KB) PDF (1367 KB) ( 35 )

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