|
|
|
| Research progress on brain functional alterations in patients with irritable bowel syndrome treated by acupuncture-moxibustion based on functional magnetic resonance imaging |
| ZHAO Jun1 LI Xia1 TIAN Junjian1 WANG Xin2 WANG Xuefei2 LI Zhigang1 |
1.School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine, Beijing 100029, China;
2.Department of Acupuncture and Moxibustion, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing 102488, China
|
|
|
|
Abstract Irritable bowel syndrome (IBS) is a chronic functional gastrointestinal disease. It is not life-threatening, but affects the quality of life and increases the risk of psychiatric disorders such as depression. Therefore, it is necessary to explore the brain central pathogenesis of IBS. Functional magnetic resonance imaging is a very effective and non-invasive in vivo observation technique for studying brain function, which provides a new perspective for evaluating the abnormality of “brain-gut axis” in IBS. Although the efficacy of acupuncture-moxibustion on IBS are positive, their brain central mechanisms are still unclear. This article reviews relevant domestic and foreign literature of acupuncture-moxibustion in recent years, and summarizes the application of functional magnetic resonance imaging technology in IBS.
|
|
|
|
|
|
[1] Drossman DA，Hasler WL. Rome Ⅳ-Functional GI Disorders：Disorders of Gut-Brain Interaction [J]. Gastroenterology，2016，150（6）：1257-1261.
[2] 中华医学会消化病学分会胃肠功能性疾病协作组，中华医学会消化病学分会胃肠动力学组.2020年中国肠易激综合征专家共识意见[J].中华消化杂志，2020，40（12）：803-818.
[3] 许东，王承党，李晓青，等.腹泻型肠易激综合征合并心理异常对肠道症状的影响[J].中华消化杂志，2018，38（9）：603-608.
[4] 刘永康，方晓堃，马凯，等.基于比率低频振幅方法初步探索针刺治疗腹泻型肠易激综合征的潜在神经机制[J].中国中西医结合影像学杂志，2021，19（1）：15-18.
[5] 耿昊，翁晟捷，赵婷婷，等.基于种子点相关分析探讨调神健脾针法治疗腹泻型肠易激综合征的中枢调节机制[J].针刺研究，2021，46（4）：318-325.
[6] Ma K，Liu Y，Shao W，et al. Brain functional interaction of acupuncture effects in diarrhea-dominant irritable bowel syndrome [J]. Front Neurosci，2020，14：608688.
[7] Zhao T，Pei L，Ning H，et al. Networks are associated with acupuncture treatment in patients with diarrhea-predominant irritable bowel syndrome：a resting-state imaging study [J]. Front Hum Neurosci，2021，15：736512.
[8] Pei L，Geng H，Guo J，et al. Effect of acupuncture in patients with irritable bowel syndrome：A randomized controlled trial [J]. Mayo Clin Proc，2020，95（8）：1671-1683.
[9] Hong JY，Kilpatrick LA，Labus J，et al. Patients with chronic visceral pain show sex-related alterations in intrinsic oscillations of the resting brain [J]. J Neurosci，2013，33（29）：11994-12002.
[10] 汪立军，茅国群，程有根，等.肠易激综合征静息态脑功能MRI低频涨落振幅改变的研究[J].医学影像学杂志，2017，27（11）：2220-2223.
[11] Qi R，Liu C，Ke J，et al. Intrinsic brain abnormalities in irritable bowel syndrome and effect of anxiety and depression [J]. Brain Imaging Behav，2016，10（4）：1127-1134.
[12] Chen XF，Guo Y，Lu XQ，et al. Aberrant intraregional brain activity and functional connectivity in patients with diarrhea-predominant irritable bowel syndrome [J]. Front Neurosci，2021，15：721822.
[13] Ao W，Cheng Y，Chen M，et al. Intrinsic brain abnormalities of irritable bowel syndrome with diarrhea：a preliminary resting-state functional magnetic resonance imaging study [J]. BMC Med Imaging，2021，21（1）：4.
[14] 李静.调神健脾针法治疗腹泻型肠易激综合征的临床疗效评价及脑fMRI改变的研究[D].南京：南京中医药大学，2017.
[15] 秦梦，张庆，黄劲柏.肠易激综合征基于局部一致性的静息态脑功能成像研究[J].实用医学杂志，2017，33（20）：3455-3458.
[16] Ke J，Qi R，Liu C，et al. Abnormal regional homogeneity in patients with irritable bowel syndrome：A resting-state functional MRI study [J]. Neurogastroenterol Motil，2015， 27（12）：1796-1803.
[17] 李洁，李国熊，郭赟，等.肠易激综合征伴抑郁状态患者静息态脑功能局部一致性研究[J].中华医学杂志，2018， 98（3）：196-201.
[18] 李洁，郭赟，鲁兴启，等.腹泻型肠易激综合征患者经匹维溴铵联合氟哌噻吨美利曲辛治疗后静息态功能磁共振分析[J].中华医学杂志，2019，99（41）：3266-3267.
[19] Weng Y，Qi R，Liu C，et al. Disrupted functional connectivity density in irritable bowel syndrome patients [J]. Brain Imaging Behav，2017，11（6）：1812-1822.
[20] Icenhour A，Witt ST，Elsenbruch S，et al. Brain functional connectivity is associated with visceral sensitivity in women with irritable bowel syndrome [J]. Neuroimage Clin，2017， 15：449-457.
[21] 南姣芬，孟攀婷，宗楠楠，等.基于功能磁共振成像的肠易激综合征患者脑网络动态特性研究[J].生理学报，2021， 73（3）：355-368.
[22] 桂若虎，李盛祥，郑新平，等.肠易激综合征患者脑功能网络度中心度改变的初步研究[J].中华神经医学杂志，2015，14（11）：1148-1151.
[23] 李洁，鲁兴启，杨莹，等.肠易激综合征伴抑郁患者静息态fMRI度中心度的研究[J].影像诊断与介入放射学，2020，29（2）：102-106.
[24] Qi R，Liu C，Weng Y，et al. Disturbed interhemispheric functional connectivity rather than structural connectivity in irritable bowel syndrome [J]. Front Mol Neurosci，2016，9：141.
[25] Liu G，Li S，Chen N，et al. Inter-hemispheric functional connections are more vulnerable to attack than structural connection in patients with irritable bowel syndrome [J]. J Neurogastroenterol Motil，2021，27（3）：426-435.
[26] Fan WJ，Zhang S，Hu JH，et al. Aberrant brain function in active-stage ulcerative colitis patients：a resting-state functional MRI study [J]. Front Hum Neurosci，2019，13：107.
[27] 高璇，鲁海，高霄英，等.针刺临床研究中常用的Rs- fMRI分析方法：10年概况[J].分子影像学杂志，2020， 43（4）：568-571.
[28] Nisticò V，Rossi RE，D’Arrigo AM，et al. Functional neuroimaging in irritable bowel syndrome：a systematic review highlights common brain alterations with functional movement disorders [J]. J Neurogastroenterol Motil，2022，28（2）：185-203.
[29] 南姣芬，张亮亮，郑倩，等.基于fMRI的近似熵和ReHo在肠易激综合征检测中的敏感性和有效性比较[J].南方医科大学学报，2019，39（9）：1023-1029.
[30] 温馨，陈杰，廖晨希，等.基于动态低频振幅方法的腹泻型肠易激综合征患者脑功能时间变异性研究[J].磁共振成像，2022，13（6）：61-65. |
|
|
|
