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| Research progress of low-intensity pulsed ultrasound regulation of mesenchymal stem cells in the field of tissue regeneration |
| LIU Yulin1 ZHANG Gengchao1 LIAO Chengcheng2 XIANG Mingli2 LIU Jianguo3 BAI Ding4 GUAN Xiaoyan2 |
1.School of Stomatology, Zunyi Medical University, Guizhou Province, Zunyi 563000, China;
2.Group Two, Department of Orthodontics, Hospital of Stomatology, Zunyi Medical University, Guizhou Province, Zunyi 563000, China;
3.Special Key Laboratory of Oral Diseases Research, Higher Education Institution in Guizhou Province & Zunyi Key Laboratory of Oral Disease Research, Guizhou Province, Zunyi 563000, China;
4.Department of Orthodontics, West China School, Hospital of Stomatology Sichuan University, Sichuan Province, Chengdu 610041, China
[Abstract] |
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Abstract Low-intensity pulsed ultrasound (LIPUS) is an economical and safe physical therapy, and usually used to treat bone discontinuities and tissue healing. Mesenchymal stem cells (MSCs) are important seed cells in regenerative medicine with high self-renewal and multi-directional differentiation ability. The combined application of LIPUS and MSCs can regulate the proliferation, migration, cell activity, multi-directional differentiation and other abilities of MSCs, effectively promote the regeneration of MSCs in bone, cartilage, blood vessels, nerves, and other tissues, and inhibit the regeneration of adipose tissue. Therefore, this article reviews the mechanism of LIPUS regulating the repair and regeneration of MSCs in different tissues in recent years, provides theoretical basis for the continuous research and clinical transformation of LIPUS in the field of tissue regeneration.
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