中药熏蒸联合耳穴贴压对2型糖尿病相关干眼患者的临床疗效及炎症反应的影响

doi:10.20047/j.issn1673-7210.2023.08.36

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Abstract Objective To observe the effects of Chinese medicine fumigation combined with auricular point sticking on clinical efficacy and inflammatory reaction in patients with type 2 diabetic dry eyes. Methods One hundred and twenty patients with type 2 diabetic dry eyes treated in Hebei Eye Hospital from June to December 2021 were selected as the research objects. According to the random number table method, they were divided into Chinese medicine fumigation group, auricular point sticking group, and Chinese medicine fumigation combined with auricular point sticking group, with 40 cases in each group. The scores of ocular surface disease index (OSDI), schirmer I test (SIt), fluorescein break-up time (FBUT), corneal fluorescein staining (CFS) and the levels of interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), matrix metalloproteinase-9 (MMP-9) in each group before and after treatment were compared. Conjunctival epithelial cell nuclear factor kappa B (NF-κB) expression in each group was detected. Results After treatment, OSDI scores of three groups were lower than those before treatment, and OSDI score of Chinese medicine fumigation combined with auricular point sticking group was lower than that of Chinese medicine fumigation group and auricular point sticking group, the differences were statistically significant (P＜0.05). After treatment, SIt of three groups were more than those before treatment, FBUT of three groups were longer than those before treatment, and CFS scores of three groups were lower than those before treatment, and SIt of Chinese medicine fumigation combined with auricular point sticking group was more than that of Chinese medicine fumigation group and auricular point sticking group, FBUT of Chinese medicine fumigation combined with auricular point sticking group was longer than that of Chinese medicine fumigation group and auricular point sticking group, CFS score of Chinese medicine fumigation combined with auricular point sticking group was lower than that of Chinese medicine fumigation group and auricular point sticking group, the differences were statistically significant (P＜0.05). After treatment, the levels of TNF-α, IL-1β, MMP-9 in three groups were lower than those before treatment, and Chinese medicine fumigation combined with auricular point sticking group was lower than that of Chinese medicine fumigation group and auricular point sticking group, the differences were statistically significant (P＜0.05). Conjunctival epithelial cell NF-κB expression of Chinese medicine fumigation combined with auricular point sticking group was lower than that of Chinese medicine fumigation group, auricular point sticking group, the differences were statistically significant (P＜0.05). Conclusion The combination of Chinese medicine fumigation and auricular point sticking can obviously improve the ocular symptoms of patients with type 2 diabetic dry eyes, increase the amount of tear secretion and the tear film stability, alleviate the local inflammatory reaction. It is worthy of recommendation.

Key words： Type 2 diabetic dry eyes Chinese medicine fumigation Auricular point sticking Inflammation

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	LI Weina1 MIAO Hui1 WANG Lifang1 DONG Ping1 YIN Huisu1 LI Jing2 WANG Qiao2

Cite this article:

LI Weina1 MIAO Hui1 WANG Lifang1 DONG Ping1 YIN Huisu1 LI Jing2 WANG Qiao2. Effects of Chinese medicine fumigation combined with auricular point sticking on clinical efficacy and inflammatory reaction in patients with type 2 diabetic dry eyes[J]. 中国医药导报, 2023, 20(8): 158-162.

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https://www.yiyaodaobao.com.cn/EN/10.20047/j.issn1673-7210.2023.08.36 OR https://www.yiyaodaobao.com.cn/EN/Y2023/V20/I8/158

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