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| Research progress on anti-inflammatory mechanism of blood-activating and stasis-resolving traditional Chinese medicine |
| CHENG Fang1 HU Kunmin1 ZHU Shan2 |
1.Medical College of Pediatrics, Henan University of Chinese Medicine, Henan Province, Zhengzhou 450000, China;
2.Department of Pediatrics, the Second Affiliated Hospital of Henan University of Chinese Medicine, Henan Province, Zhengzhou 450000, China
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Abstract Blood-activating and stasis-resolving traditional Chinese medicines are mainly used for blood stasis syndrome of the pain of internal medicine, amenorrhoea, dysmenorrhea, traumatic injury, sore and ulcer, swelling, and so on. Inflammation is the natural response of the body to various injury stimuli. Blood-activating and stasis-resolving traditional Chinese medicine has certain advantages in inhibiting inflammatory reaction. This paper analyzes the anti-inflammatory mechanism of nine traditional Chinese medicines including Corydalis Rhizoma, Chuanxiong Rhizoma, Salviae Miltiorrhizae Radix Et Rhizoma, Curcumae Radix, Olibanum, Leonuri Herba, Achyranthis Bidentatae Radix, Strychni Semen, and Hirudo by searching the literature. It is found that blood-activating and stasis-resolving traditional Chinese medicine mainly plays an anti-inflammatory role by three signal pathways of nuclear factor- κB, mitogen-activated protein kinase, nuclear transcription factor E2 related factor 2-antioxidant response element. It also provides research direction for the existing problems in this research field, and provides reliable theoretical basis for further exploring the anti-inflammatory component target and clinical application of blood-activating and stasis-resolving traditional Chinese medicines.
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